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Pediatric hepatitis outbreak cases are not above pre-COVID-19 pandemic levels: CDC

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Pediatric hepatitis outbreak cases are not above pre-COVID-19 pandemic levels: CDC

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In response to the present pediatric hepatitis outbreak presumably linked to adenovirus, the Facilities for Illness Management and Prevention (CDC) discovered present knowledge don’t recommend a rise in pediatric hepatitis instances or adenovirus varieties 40/41 from the time the outbreak started in comparison with pre-COVID-19 pandemic ranges, in keeping with a current Morbidity and Mortality Weekly Report. 

“Knowledge from 4 giant administrative databases have been analyzed to evaluate traits in pediatric hepatitis and proportion of stool specimens constructive for adenovirus sort 40/41,” the CDC stated. 

“Though this ecologic evaluation can not conclusively affirm or refute a possible affiliation between pediatric hepatitis and adenovirus, it supplies helpful context for the continuing investigation.” 

The CDC in contrast knowledge throughout the present hepatitis outbreak interval from October 2021–March 2022 with a pre-COVID-19 pandemic baseline, as a result of well being care-seeking habits might have modified throughout 2020-21 in response to the pandemic. 

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Atlanta, Georgia, USA – August 28, 2011: Shut up of entrance signal for Facilities for Illness Management and Prevention. Signal positioned close to the 1700 block of Clifton Street in Atlanta, Georgia, on the Emory College campus. Vertical composition. 
(iStock)

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After pediatric instances of hepatitis beginning being recognized in america and the UK that didn’t have a transparent etiology, CDC issued a wholesome advisory in April 2022 to report further instances. 

They discovered most of the reported instances additionally had assessments outcomes constructive for adenovirus sort 41, a virus recognized to trigger gastroenteritis, however not recognized to trigger hepatitis in youngsters with an intact immune system, per the company.  

“As a result of neither acute hepatitis of unknown etiology nor adenovirus sort 41 is reportable in america, it’s unclear whether or not both has not too long ago elevated above historic ranges,” the CDC stated. 

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So the company analyzed knowledge from 4 sources: the Nationwide Syndromic Surveillance Program (NSSP), the Premier Healthcare Database Particular Launch (PHD-SR), the Organ Procurement and Transplant Community (OPTN), and Labcorp. 

NSSP collects digital well being info from emergency departments throughout each U.S. state and the District of Columbia, representing 71% of nonfederal emergency rooms in america.  

Pediatric Cardiologist Ryan Serrano, right, talks with his patient, Richard Barnes, left, and his father Steve Barnes, during an exam Thursday, March 11, 2021, at Riley Hospital for Children. PHD-SR included records from approximately 1,000 hospitals while pediatric liver transplant data was obtained from the national registry, which is managed by OPTN.  

Pediatric Heart specialist Ryan Serrano, proper, talks along with his affected person, Richard Barnes, left, and his father Steve Barnes, throughout an examination Thursday, March 11, 2021, at Riley Hospital for Kids. PHD-SR included data from roughly 1,000 hospitals whereas pediatric liver transplant knowledge was obtained from the nationwide registry, which is managed by OPTN.  
(Fox Information)

PHD-SR included data from roughly 1,000 hospitals whereas pediatric liver transplant knowledge was obtained from the nationwide registry, which is managed by OPTN.  

Labcorp knowledge included outcomes for stool specimens examined for adenovirus varieties 40/41 however couldn’t distinguish if the sort was sort 40 or 41, however the CDC famous roughly 90% of all adenovirus instances detected within the U.S. with gastroenteritis are sort 41.  

There was no vital distinction in hospitalizations related to hepatitis or pediatric emergency division visits throughout the interval of the outbreak throughout October 2021through March 2022 in contrast earlier than the COVID-19 pandemic. 

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There was additionally no vital enhance in variety of month-to-month liver transplants or enhance within the proportion of specimens constructive for adenovirus varieties 40/41 throughout October 2021–March 2022 in contrast with pre-pandemic ranges. 

However the UK did report a rise within the variety of stool specimens constructive for adenovirus amongst youngsters 1 to 4 years previous in contrast with pre-pandemic ranges, however the company famous knowledge on whole specimens examined within the U.Okay. is unavailable so true proportion of the specimens constructive for adenovirus is unknown. 

Britain's Prime Minister Boris Johnson leaves 10 Downing Street as he makes his way to the House of Commons, in London. The United Kingdom did report an increase in the number of stool specimens positive for adenovirus among children 1–4 years old compared with pre-pandemic levels, but the agency noted data on total specimens tested in the U.K. is unavailable

Britain’s Prime Minister Boris Johnson leaves 10 Downing Avenue as he makes his method to the Home of Commons, in London. The UK did report a rise within the variety of stool specimens constructive for adenovirus amongst youngsters 1–4 years previous in contrast with pre-pandemic ranges, however the company famous knowledge on whole specimens examined within the U.Okay. is unavailable
(AP/Alberto Pezzali)

The CDC studies the info has limitations as a result of the evaluation assessed traits of hepatitis not directly via digital well being knowledge as a result of the hepatitis instances and not using a clear trigger will not be reportable in america, so an actual baseline is unknown at present.  

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In addition they be aware as a result of regardless that liver transplants are “properly documented,” there’s a two to a few month delay interval of reporting, so March 2022 knowledge could be underreported.   

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Moreover, as a result of the COVID-19 pandemic possible altered well being searching for habits, the pre-pandemic knowledge are restricted to 2017-2019, and it’s unknown if this knowledge is an correct baseline.  

The CDC additionally famous the small pattern measurement might make it tough to find out small modifications in incidence as a result of the hepatitis instances are uncommon. 

“Lastly, these outcomes are supposed to supply an outline of traits in pediatric acute hepatitis of unspecified etiology and adenovirus varieties 40/41 in america and can’t be used to deduce or disprove a causal hyperlink between these two sicknesses.” 

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Words and game of Scrabble keep married couple in wedded bliss for decades

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Words and game of Scrabble keep married couple in wedded bliss for decades

A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.

They’re still playing in tournaments built around the game decades after they began doing so.

Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.

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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.

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But it was a “special match” in 2000 that brought the couple together — and has kept them together now.

Graham and Helen Harding on their wedding day. They’ve been playing in Scrabble tournaments for some 30 years.  (Courtesy Graham and Helen Harding via SWNS)

Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.

They have been taking part in the UK Open Scrabble Championship in Reading this week.

“The more words you know, the more ammunition you’ve got.”

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“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.

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“But it is a Scrabble vocabulary — not necessarily everyday English.”

Added Helen Harding, “The more words you know, the more ammunition you’ve got.”

Graham and Helen Harding at their wedding.

Graham and Helen Harding’s wedding cake. They bonded over their love of Scrabble – and are still playing in tournaments together.  (Courtesy Graham and Helen Harding via SWNS)

The couple said they were “vague acquaintances” for about five years after they first met.

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Then they got together after a special match in Swindon.

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They maintained a long-distance relationship before they got married in 2004.

The couple even brought their Scrabble board to their wedding. 

Graham and Helen Harding at their wedding.

The couple likely have played thousands of games between them.  (Courtesy Graham and Helen Harding via SWNS)

It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”

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They each took up the hobby early in life well before they met each other. 

The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported. 

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Deep sleep can keep two big health problems at bay, new studies suggest

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Deep sleep can keep two big health problems at bay, new studies suggest

It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.

Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.

The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.

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Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.

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Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”

“It’s like turning on the dishwasher before you go to bed and waking up with a clean brain.” (iStock)

The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists. 

The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.

But the scientists indicated that what drives the system was unclear until now, according to the study.

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Is all sleep created equal? The researchers wanted to find out.

To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.

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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.

The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.

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Senior couple sleeping

During deep sleep, toxic proteins that form sticky plaques linked to neurological disorders such as Alzheimer’s disease are removed, scientists say in a new study.  (iStock)

Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.” 

She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”  

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Hauglund said she wanted to understand whether all sleep is created equal. 

To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.

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“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice. 

Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.

man sleeps in bed

Two new studies indicate the importance of getting a good night’s sleep — with one study saying a lack of sleep may be sabotaging the brain’s ability to keep intrusive thoughts at bay. (iStock)

The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.

Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.

Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”

For more Health articles, visit www.foxnews.com/health

Meanwhile, a lack of sleep may be doing more damage than just making people groggy.

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It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.

young woman asleep

Anyone who suffers from sleep deprivation may find that the brain’s defense against unwanted memories is weakened, say experts. (iStock)

Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post. 

“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss


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Kathy Bates Weight Loss: Tips That Helped Her Lose 100 Lbs | Woman’s World




















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