Health
Patients remain cancer-free nearly 3 years after receiving experimental immunotherapy
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All participants in a trial of bowel cancer patients remained cancer-free nearly three years after receiving an experimental treatment.
Led by researchers at University College London and UCL Hospitals, the study suggests that a short course of immunotherapy before surgery could produce better results than the current standard of care for certain patients.
The trial focused on 32 patients with stage 2 or 3 bowel cancer. These patients had tumors with a specific genetic profile called MMR-deficient or MSI-high, according to a press release.
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This profile, which is found in about 10% to 15% of bowel cancer cases, indicates a faulty DNA repair system in the body, the researchers noted. However, scientists hypothesized, that could make it easier for immunotherapy drugs to find and attack the tumors.
The drug shrank tumors so effectively that 59% of patients had no signs of cancer left by their surgery date. (iStock)
Instead of receiving standard chemotherapy after surgery, these patients were given a drug called pembrolizumab before their operations. The treatment lasted up to nine weeks.
Early data showed that the drug shrank tumors so effectively that 59% of patients had no signs of cancer left by the time they went in for surgery.
The latest data confirms that 33 months later, none of those patients have seen a return of the disease, including those who still had small traces of cancer remaining after surgery that never grew or spread again.
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“Seeing that no patients have experienced a cancer recurrence after almost three years of follow-up is extremely encouraging, and strengthens our confidence that pembrolizumab is a safe and highly effective treatment to improve outcomes in patients with high-risk bowel cancers,” said chief investigator Dr. Kai-Keen Shiu, a consultant medical oncologist at UCLH and associate professor at UCL, in the release.
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With the traditional approach of surgery followed by chemotherapy, about 25% of patients with this genetic profile would see their cancer return within three years, according to the study.
The study was a small trial with only 32 people and only looked at a specific genetic subset of patients. (iStock)
The research team also used personalized blood tests to monitor the patients. These tests look for tiny fragments of tumor DNA in the bloodstream, allowing doctors to determine whether the treatment was working before the surgery.
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“When tumor DNA disappeared from the blood, patients were much more likely to have no cancer remaining, and this matched the long-term results we’re now seeing,” said first author Yanrong Jiang, a clinical PhD student at the UCL Cancer Institute, in the release.
The study did have limitations, the researchers noted. It was a small trial with only 32 people and only looked at a specific genetic subset of patients, which means the results may not apply to everyone with bowel cancer.
“We now may be able to predict who will respond to the treatment using personalized blood tests and immune profiling,” said one of the members of the research team. (iStock)
Doctors also need to follow the patients for a longer period to ensure that the cancer doesn’t return, they added.
Even so, the researchers shared their optimism about the future of personalized care.
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“What is particularly exciting is that we now may be able to predict who will respond to the treatment using personalized blood tests and immune profiling,” Shiu said.
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“These tools could help us tailor our approach, identifying patients who are doing well and may need less therapy before and after surgery.”
The results were presented at the American Association for Cancer Research (AACR) Annual Meeting 2026 in San Diego last month.
Health
5 common walking mistakes that could hurt your progress, according to an expert
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Walking is a great way to get the body moving and clear the mind — but if you’re doing it wrong, it may do more harm than good.
That’s according to Dr. Milica McDowell, author of the new book “Walk,” a guide to getting the most out of walking.
The Montana-based doctor of physical therapy, who specializes in lower extremity and orthopedics, shared in an interview with Fox News Digital how powerful walking can be.
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“Walking has incredible health benefits for your wellness today and your longevity tomorrow,” she said. “And it’s something that’s at an all-time low since the pandemic.”
“Walking improves every system in your body – gut, musculoskeletal, mental health, your hormones – and so it has an incredible power to help optimize how you’re doing.”
“Walk,” co-authored by physical therapist Milica McDowell, explores how walking can improve longevity, mobility, mental well-being and overall fitness. (Amelia Anne Photography; Hachette Book Group/Alexander Ryabintsev)
McDowell added that walking is a “phenomenal way” to support a weight-loss journey, as it’s low-impact and low-intensity. It can also boost creativity and reduce stress.
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While the health benefits of walking are evident, McDowell warned of some mistakes that could reverse progress.
No. 1: Walking while scrolling
Escaping our phones can sometimes feel impossible, but if there’s ever a time to be on do-not-disturb, it’s during a walk, according to McDowell.
Walking while scrolling is “really dangerous,” she cautioned, as you’re less aware of your surroundings and more susceptible to accidents.
Walking while scrolling is a danger to public health, the expert says. (iStock)
“You could step in a pothole. You could get hit by a car. You could trip over something. You could bump into someone,” she said. “Walking and scrolling is actually a bit of a public health crisis.”
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Scrolling also puts the neck in a downward position, making the head heavier, which changes your posture “from the top down,” McDowell said. “That can be a problem if you’re someone who struggles with neck pain, back pain or shoulder pain.”
No. 2: Wearing the wrong shoes
McDowell recommends wearing a proper shoe designed specifically for walking to support the feet, promote healthy alignment and protect musculoskeletal health.
The shoe should be “shaped like a foot” so that the toes have room to spread within a wide toe box, she said.
Having space between each toe activates more muscles in the foot and creates a “more healthy walking gait,” according to the expert.
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More than 60% of adults wear the wrong shoe size, according to McDowell, and sizing can vary significantly between brands and manufacturers. She recommends getting measured by a professional to ensure the optimal fit.
No. 3: Not balancing your routine
Walking engages important muscles that support stability and mobility, including the glutes, which help propel the body forward with each step.
But walking shouldn’t be your only form of exercise, experts say. Incorporating strength training and other forms of movement can help prevent overuse injuries, improve balance and build overall fitness.
A well-rounded fitness routine will boost the health benefits of walking, the expert said. (iStock)
“A health stack includes drinking enough water, having healthy nutrition and sleeping adequately — and walking can be added to the other activities,” she said.
Pairing walking with activities like weightlifting, pickleball, dancing or CrossFit can help create a more balanced fitness routine, according to McDowell, and are all part of building a strong “health stack.”
“A health stack includes drinking [enough] water, having healthy nutrition, sleeping adequately — and walking can be added to the other activities,” she said.
No. 4: Not considering walking speed
The speed at which we walk may tell us more about our health than we think.
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Walking speed is the sixth vital sign of health, according to McDowell. These clinical measurements also include blood pressure, heart rate and body temperature.
If your walking speed begins to decline, this could be a marker of underlying health conditions up to seven years before they occur.
A decline in walking speed could be an early warning sign of an underlying health condition. (iStock)
While most people walk at about 90 to 100 steps per minute, translating to about three miles per hour, McDowell suggested increasing your speed to reap “higher level benefits.”
This might mean taking a brisk walk at about 120 to 130 steps per minute, or three and a half to four miles an hour.
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“That can be a place where you get higher level payoff, including more calories burned, if you’re on a weight-loss journey,” she said.
No. 5: Not staying consistent
McDowell emphasized the importance of staying consistent with your walking routine.
A daily walk will have bigger payoffs than only walking once or twice a week. The expert likened walking to basic hygiene, such as brushing your teeth.
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“Everyone is at different places on their walking journey,” she said. “Don’t set the 10,000 steps per day benchmark. That is a marketing myth … Go ahead and find a step count that works well for you, maybe between 5,500 and 7,500.”
Efficiency is everything
McDowell summed up that each walk should be efficient.
“If you are an efficient walker, you are graceful, you are not wasting energy, you are walking balanced no matter your height, your weight or your age,” she said.
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As the wellness movement has emphasized the importance of just moving, McDowell commented that walking is a “pinnacle activity” in this push.
“People are recognizing that these softer, more consistent activities can provide a lot of benefit for our physical and mental health,” she said.
McDowell encourages walking with a friend for added social benefit. (iStock)
“You don’t have to go and crush yourself in the gym. You don’t have to be dripping sweat … It’s something you can do for periods of time throughout the day, little ‘snacks’ that all add up, or you can take longer walks depending on what time is available to you.”
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Walking can also be a positive social experience done with friends and loved ones, McDowell noted. This is particularly important for seniors who can benefit from the combined physical activity and social interaction.
“Walking with an older adult can help combat loneliness,” she said. “It can also help improve balance and reaction time, and reduce fall risk.”
Health
Filtered water at specific ages could add months to your lifespan decades later, new study finds
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Drinking filtered water may extend a person’s life by several months, according to a new study.
The research, published in the American Journal of Health Economics, reveals that being exposed to water filtration systems early in life can significantly increase longevity. By analyzing public health infrastructure shifts from the early 20th century, researchers found that city water filtration alone increased the lifespan of older American men by an average of 3.2 months.
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“While water quality has improved in many areas, this study shows the real impacts to communities without access to safe water, both in the U.S. and globally,” co-author Jason Fletcher, a professor at the University of Wisconsin–Madison, said in a press release.
“The consequences on human health are significant.”
“This study shows the real impacts to communities without access to safe water,” the study’s author said in a press release. (iStock)
The team analyzed data from the Social Security Administration’s Death Master Files. They tracked death records for American men born between 1975 and 2005, mapping each individual’s year and city of birth to historical water filtration records.
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By connecting early-life environments to late-life outcomes, the researchers isolated the lifelong impact of clean water.
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Beyond adding months to a person’s life, the study suggests that clean water in childhood sets off a positive chain reaction for socioeconomic and physical development.
The paper is part of a broader research initiative examining how environmental conditions earlier in life shape the modern American lifespan. (iStock)
Additional data from mid-20th-century censuses showed that early exposure to filtered water was linked to increased height, higher education and income levels later in life.
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The paper is part of a broader research initiative called the American Mortality Project, which examines how early-life conditions shape the modern American lifespan.
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The researchers exclusively analyzed historical data from American men, meaning the findings may not fully capture how early-life water filtration impacted the long-term longevity, physical growth, or cognitive scores of women from the same era.
Due to analysis of a limited dataset of American cities, this may not apply to other nations or rural communities. (iStock)
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The data is limited to public health infrastructure changes across U.S. cities during a specific window in the late 19th and early 20th centuries. Because of this, the exact timeline and magnitude of the lifespan extension (3.2 months) may not directly translate to modern developing nations, rural communities, or areas with different environments.
Health
Diet change tied to ‘younger’ biological age in older adults after 4 weeks
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Researchers have found that changing your diet — even later in life — may slow the aging process in as little as one month.
Researchers from the University of Sydney assigned 104 participants aged 65-75 to one of four diets. Two of the diets were omnivorous and included protein from both animals and plants. Two included 70% of protein from plant sources.
One omnivorous diet was high in fat, while the other emphasized carbohydrates. The two semi-vegetarian diets were distinguished in the same way. All four diets derived 14% of energy from protein.
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“Biological age” essentially means how old the body appears based on health indicators, called biomarkers, rather than how many years a person has been alive.
University of Sydney researchers found that diet changes had an effect on people’s biological ages after four weeks. (iStock/Getty Images)
The scientists measured 20 varied biomarkers, including cholesterol and insulin levels, in participants to determine how short-term diet changes affect biological aging.
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“While chronological age increases uniformly, biological aging varies between individuals, reflecting differences in health status and the body’s resilience,” a University of Sydney report on the study’s findings said.
Biomarker profiles “are often considered a better indicator of overall health and potential longevity than chronological age,” according to the report.
Older adults who ate diets rich in complex carbohydrates and plant-based food reduced their biological age, scientists found. (iStock/Getty Images)
The scientists found that, after four weeks, participants’ biological ages in three of the four diet groups dropped. Only the high-fat omnivorous dieters’ biological ages “showed no meaningful change.”
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The study, “Short-Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing,” published in Aging Cell, concluded that the most pronounced improvements came from “diets rich in complex carbohydrates and plant-based components.”
Participants who consumed an omnivorous diet high in fat did not see changes in their biological ages, though all other types of diets reduced theirs in a University of Sydney study. (iStock/Getty Images)
The research team cautioned that these results are preliminary and may represent only short-term effects.
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“It’s too soon to say definitively that specific changes to diet will extend your life,” said Caitlin Andrews, who led the study. “But this research offers an early indication of the potential benefits of dietary changes later in life.”
Fox News Digital reached out to the researchers for comment.
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