Health
Ozempic patients may face dangerous risks during surgery, doctors warn
Patients who are taking GLP-1 medications such as Ozempic, Wegovy, Mounjaro and others could face complications during surgery, recent research has shown.
In one study led by UTHealth Houston, more than half of patients taking GLP-1s had “significant gastric contents” before going into surgery, even if they had followed pre-op fasting protocols, according to a press release on the university’s website.
This could lead to a potentially life-threatening condition called pulmonary aspiration, when food or liquid is inhaled into the lungs.
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GLP-1 (glucagon-like peptide) receptor agonists are commonly prescribed to patients with type 2 diabetes (to stabilize blood glucose levels) or obesity (to assist with weight loss).
“These medications slow down digestion, which means food stays in the stomach longer,” said Dr. Alfred Bonati, the founder of the Bonati Spine Institute in Florida.
Patients who are taking GLP-1 medications such as Ozempic, Wegovy, Mounjaro and others could face complications during surgery, recent research has shown. (iStock; Getty Images)
Pulmonary aspiration can cause severe lung damage, infections or even death, Bonati warned.
“General anesthesia can also cause nausea, and the slowed digestion from weight-loss meds can exacerbate this, leading to a higher risk of vomiting during surgery,” he said.
“These medications slow down digestion, which means food stays in the stomach longer.”
Dr. Brett Osborn, a board-certified neurosurgeon and section chief at St. Mary’s Medical Center in Florida, always advises his patients who are taking GLP-1 agonists to stop the medication at least one week before a surgical procedure, he said.
In addition to aspiration, Osborn warned of the increased risk of postoperative ileus, a dysfunction of the intestines after surgery.
GLP-1 (glucagon-like peptide) receptor agonists are commonly prescribed to patients with type 2 diabetes, to stabilize blood glucose levels — or patients with obesity, to assist with weight loss. (iStock)
“This could predispose patients to significant problems, including bowel ischemia (a rare circulatory condition that occurs when blood flow to the intestines is reduced),” he told Fox News Digital.
Healing is a secondary concern among patients taking GLP-1s, according to Osborn.
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“Those following a hypocaloric diet, as is the case with patients on GLP-1 agonists, may potentially inhibit healing and recovery from surgery, which requires a caloric surplus, particularly from protein-laden foods,” he said.
Proper nutrition is crucial for tissue recovery, Osborn said.
Proper nutrition is essential to healing after surgery, a doctor said. (iStock)
“By inducing a relative state of malnutrition, these medications can be problematic in perioperative patients.”
Dr. Jean-Carlos Jimenez, medical director at Attune Med Spa in Connecticut, agreed that these medications can lead to complications during surgery.
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“GLP-1 agonists can cause nausea, vomiting and something known as delayed gastric emptying, or gastroparesis — which means the stomach takes longer than usual to empty its contents into the small intestines,” he told Fox News Digital via email.
“Residual gastric content can increase the risk of pulmonary aspiration during anesthesia and potentially worsen post-operative recovery.”
Surgery is known to alter blood sugar levels due to stress from the procedure, a doctor noted. (iStock)
Surgery is also known to alter blood sugar levels due to stress from the procedure, Jimenez added.
Due to these risks, doctors agree that patients should review all the medications they’re taking with their surgeon and anesthesiologist.
For surgical procedures that require patients to fast or remain on a clear liquid diet, they may need to do this for a longer period of time, said Jimenez.
“The timing of when to stop will depend on the type of GLP-1 agonists a patient uses, but can range from holding the daily dose on the day of surgery to holding the scheduled weekly dose one week before a planned procedure,” he told Fox News Digital.
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GLP-1s typically can be restarted at the next scheduled dose, but should be carefully monitored by the doctor, he advised.
The timing can depend on the type of surgery and the patient’s overall condition, according to Bonati.
Due to the risks, doctors say patients should review all their medications with the surgeon and anesthesiologist. (iStock)
“It’s crucial to follow the instructions provided by the health care providers, as they will tailor the advice to your individual health needs and the specifics of your surgery,” he added.
In June 2023, the American Society of Anesthesiologists published an announcement warning of the risks and recommending that patients consider pausing their doses in the days or weeks leading up to an elective surgical procedure.
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The American Association of Nurse Anesthesiology has issued a similar recommendation.
Fox News Digital contacted Novo Nordisk, maker of Ozempic and Wegovy, requesting comment.
Health
Change to nightly eating habits may help protect your heart, study suggests
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Abstaining from food three hours before bedtime could benefit heart health, according to a recent study by Northwestern University.
Extending an overnight fast for two hours, dimming the lights and not eating for three hours prior to sleep were shown to improve cardiovascular and metabolic health.
The results were observed among middle-aged and older adults, who are at a higher risk for cardiometabolic disease, as stated in a university press release.
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Time-restricted eating has recently surged in popularity due to its potential to improve heart health and aid in weight loss, the researchers noted.
“But most studies have focused on how long people fast, not how their fast lines up with their sleep schedule — a key factor in metabolic regulation,” the study authors wrote.
Catering time-restricted eating to a sleep cycle could improve heart health, research found. (iStock)
The nearly eight-week study, published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, examined 39 overweight and obese participants between 36 and 75 years old. The intervention group was made up of 80% women.
The participants completed either an extended overnight fasting intervention — 13 to 16 hours — or a “habitual fast” of 11 to 13 hours. Both groups dimmed the lights three hours before bedtime.
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People who finished eating at least three hours before going to bed saw “meaningful improvements” compared to participants who continued with their usual eating routines.
Those improvements included a 3.5% drop in blood pressure and a 5% drop in heart rate, as well as a “more natural drop” in both measures during sleep, which is “an important sign of cardiovascular health,” the researchers found.
People who did not eat three hours before bedtime saw a dip in blood pressure and heart rate. (iStock)
The fasting participants’ hearts also beat faster during the day when they were active and slowed at night during rest — a pattern that’s linked to better heart health.
Those who abstained from eating also had better daytime blood sugar control, meaning the pancreas responded “more efficiently” when challenged with glucose, “suggesting it could release insulin more effectively and keep blood sugar steadier.”
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First author Dr. Daniela Grimaldi, research associate professor of neurology in the division of sleep medicine at the Northwestern University Feinberg School of Medicine, commented on these findings in a statement.
“Timing our fasting window to work with the body’s natural wake-sleep rhythms can improve the coordination between the heart, metabolism and sleep, all of which work together to protect cardiovascular health,” she said.
Intervention participants experienced lower heart rates during rest. (iStock)
Grimaldi noted that she and her fellow researchers were “genuinely excited” about the consistent improvements shown.
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“Seeing that a relatively simple change in meal timing could simultaneously improve nighttime autonomic balance, blood pressure dipping, heart rate regulation and morning glucose metabolism, all without calorie restriction or weight loss, was remarkable,” she told Fox News Digital.
Grimaldi noted that the three-hour pre-sleep fasting window is “critical,” because that’s when melatonin rises and the body transitions toward sleep, “a period when eating disrupts metabolism.”
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Sleep expert Dr. Wendy Troxel, RAND Corporation senior behavioral specialist and a licensed clinical psychologist in Utah, emphasized the study’s high adherence rate, at nearly 90%.
“High rates of compliance suggest that this approach may be both feasible and sustainable in real life and could have a demonstrable impact on improving cardiometabolic health,” Troxel, who was not involved in the study, told Fox News Digital.
The three-hour pre-sleep fasting window is “critical,” because that’s the time period when melatonin rises and the body transitions toward sleep, a researcher noted. (iStock)
The findings add to growing research linking sleep and circadian rhythms to cardiovascular health, she added. “In fact, the American Heart Association now recognizes healthy sleep as one of its Life’s Essential 8 pillars for heart health.”
Limitations and future research
Looking ahead, the researchers plan to expand the study to larger, multi-center trials to determine whether the benefits persist or “translate into reduced cardiovascular events or diabetes.”
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Future studies could also explore the potential benefits of extending time-restricted eating.
“We also want to test this specifically in people with hypertension or diabetes, [who] might benefit most,” Grimaldi shared. “And exploring how this combines with other behavioral interventions, like exercise or morning light exposure, could help us develop more comprehensive strategies for cardiometabolic health.”
The fasting participants’ hearts beat faster during the day when they were active and slowed at night during rest, a pattern that’s linked to better heart health. (iStock)
The high percentage of women poses a study limitation, as it limits the ability to draw “definitive conclusions” about gender differences, Grimaldi acknowledged.
“We need studies powered to examine sex differences,” she said. “Additionally, our 7.5-week intervention was long enough to show physiological changes, but not long enough to see effects on weight or long-term health outcomes.”
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Northwestern University reported that only 6.8% of adults in the U.S. had optimal cardiometabolic health from 2017 to 2018.
These conditions can lead to chronic illness, including type 2 diabetes, cardiovascular diseases and non-alcoholic fatty liver disease. Heart disease is the No. 1 global killer, according to the CDC.
Health
Eating oatmeal for two days has unexpected impact on heart health, study suggests
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Eating oats for just a short period of time could have a profound impact on cholesterol levels, according to a recent study.
Researchers from the University of Bonn in Germany conducted a trial in which adults consumed a calorie-reduced diet of almost exclusively oatmeal for two days.
All participants suffered from a metabolic syndrome associated with a risk of diabetes, including a combination of high body weight, high blood pressure, elevated blood glucose or elevated blood lipid levels, according to a university press release.
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The 32 participants ate oatmeal, previously boiled in water, three times a day, for a total of 300 grams. They were only permitted to add fruits or vegetables to their meals and consumed around half of their normal caloric intake.
A control group was put on a calorie-reduced diet that did not include oats. Although both groups benefited, the cholesterol levels of those on the oat diet “improved significantly.” After six weeks, this effect “remained stable.”
A new study found that eating oats for two days reduced bad cholesterol. (iStock)
Study author Marie-Christine Simon, junior professor at the Institute of Nutritional and Food Science at the University of Bonn, shared in a statement that the level of LDL, or “bad” cholesterol, among the oatmeal-eating group was reduced by 10%.
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“That is a substantial reduction, although not entirely comparable to the effect of modern medications,” Simon said. “They also lost two kilos in weight on average, and their blood pressure fell slightly.”
The authors concluded that the diet influenced microorganisms in the gut, leading to the positive reaction. The results were published in the journal Nature Communications.
Oats significantly reduced cholesterol levels, although not as much as modern medicine. (iStock)
Simon concluded that a short-term oat-based diet at regular intervals “could be a well-tolerated way to keep the cholesterol level within the normal range and prevent diabetes.”
“As a next step, it can now be clarified whether an intensive oat-based diet repeated every six weeks actually has a permanently preventative effect,” she said.
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Certified holistic nutritionist Robin DeCicco, who was not involved in the study, said the findings “make sense” because oats have been known to potentially lower LDL cholesterol.
Oats contain prebiotic fiber that feeds beneficial gut bacteria. When those bacteria ferment the fiber, they produce compounds that support digestive health, according to the expert.
“The more beneficial gut bacteria you have in your stomach, in your environment, the more that can reduce or inhibit the production of LDL bad cholesterol,” New York-based DeCicco told Fox News Digital.
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Oats are also a whole grain that is naturally low in saturated fat and rich in fiber and provides a good amount of plant-based protein.
“All those things are good for a heart-healthy, cholesterol-lowering diet,” DeCicco noted.
Oats are a whole grain that is naturally low in saturated fat and rich in fiber and provides a good amount of plant-based protein, all of which are good for heart health. (iStock)
DeCicco did warn that those who are diabetic or prediabetic should “be careful” when eating oats.
“While oats can lower cholesterol, they are an overly high-carbohydrate food,” she said. “A recommendation for anyone who’s watching their blood sugar, and especially who’s diabetic, is to eat foods that are lower in starch and higher in protein and fiber, [and to get] their carbohydrates more from vegetables and nuts.”
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Megan Wroe, registered dietitian at the Wellness Center at Providence St. Jude Medical Center in Orange County, California, agreed that oat consumption “does seem to lower cholesterol levels for all studied populations, with the greatest impact shown in those with elevated levels.”
“There are no significant risks, but some people may experience cramping or indigestion if they have not previously eaten much fiber and suddenly start eating oats every day,” Wroe, who also was not involved in the study, told Fox News Digital. “Also, those requiring a gluten-free diet will want to ensure that the oats they eat are certified gluten-free.”
The nutritionist also shared the concern that oatmeal is commonly made with water or milk and eaten with added sugar and fruit, which makes it a “potentially very high-glycemic meal.”
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“Knowing this, my recommendation is to eat oats as often as you like, choosing steel-cut or rolled oats, using fruit for sweetness or a low-glycemic sweetener if needed, such as monk fruit,” she advised.
Wroe also suggests finding a way to add protein to balance out the carbohydrates.
“This can be done by adding chia or flax seeds to the oats, mixing in protein powder or topping with Greek yogurt to serve,” she said.
Health
Menopause Weight-Loss Breakthrough: Meet 4 Women Over 50 Who Lost 374 Lbs by Building Muscle
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