Health
Ozempic patients may face dangerous risks during surgery, doctors warn
Patients who are taking GLP-1 medications such as Ozempic, Wegovy, Mounjaro and others could face complications during surgery, recent research has shown.
In one study led by UTHealth Houston, more than half of patients taking GLP-1s had “significant gastric contents” before going into surgery, even if they had followed pre-op fasting protocols, according to a press release on the university’s website.
This could lead to a potentially life-threatening condition called pulmonary aspiration, when food or liquid is inhaled into the lungs.
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GLP-1 (glucagon-like peptide) receptor agonists are commonly prescribed to patients with type 2 diabetes (to stabilize blood glucose levels) or obesity (to assist with weight loss).
“These medications slow down digestion, which means food stays in the stomach longer,” said Dr. Alfred Bonati, the founder of the Bonati Spine Institute in Florida.
Pulmonary aspiration can cause severe lung damage, infections or even death, Bonati warned.
“General anesthesia can also cause nausea, and the slowed digestion from weight-loss meds can exacerbate this, leading to a higher risk of vomiting during surgery,” he said.
“These medications slow down digestion, which means food stays in the stomach longer.”
Dr. Brett Osborn, a board-certified neurosurgeon and section chief at St. Mary’s Medical Center in Florida, always advises his patients who are taking GLP-1 agonists to stop the medication at least one week before a surgical procedure, he said.
In addition to aspiration, Osborn warned of the increased risk of postoperative ileus, a dysfunction of the intestines after surgery.
“This could predispose patients to significant problems, including bowel ischemia (a rare circulatory condition that occurs when blood flow to the intestines is reduced),” he told Fox News Digital.
Healing is a secondary concern among patients taking GLP-1s, according to Osborn.
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“Those following a hypocaloric diet, as is the case with patients on GLP-1 agonists, may potentially inhibit healing and recovery from surgery, which requires a caloric surplus, particularly from protein-laden foods,” he said.
Proper nutrition is crucial for tissue recovery, Osborn said.
“By inducing a relative state of malnutrition, these medications can be problematic in perioperative patients.”
Dr. Jean-Carlos Jimenez, medical director at Attune Med Spa in Connecticut, agreed that these medications can lead to complications during surgery.
ASK A DOCTOR: ‘WHAT SHOULD I DO, OR NOT DO, PRIOR TO SURGERY?’
“GLP-1 agonists can cause nausea, vomiting and something known as delayed gastric emptying, or gastroparesis — which means the stomach takes longer than usual to empty its contents into the small intestines,” he told Fox News Digital via email.
“Residual gastric content can increase the risk of pulmonary aspiration during anesthesia and potentially worsen post-operative recovery.”
Surgery is also known to alter blood sugar levels due to stress from the procedure, Jimenez added.
Due to these risks, doctors agree that patients should review all the medications they’re taking with their surgeon and anesthesiologist.
For surgical procedures that require patients to fast or remain on a clear liquid diet, they may need to do this for a longer period of time, said Jimenez.
“The timing of when to stop will depend on the type of GLP-1 agonists a patient uses, but can range from holding the daily dose on the day of surgery to holding the scheduled weekly dose one week before a planned procedure,” he told Fox News Digital.
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GLP-1s typically can be restarted at the next scheduled dose, but should be carefully monitored by the doctor, he advised.
The timing can depend on the type of surgery and the patient’s overall condition, according to Bonati.
“It’s crucial to follow the instructions provided by the health care providers, as they will tailor the advice to your individual health needs and the specifics of your surgery,” he added.
In June 2023, the American Society of Anesthesiologists published an announcement warning of the risks and recommending that patients consider pausing their doses in the days or weeks leading up to an elective surgical procedure.
For more Health articles, visit www.foxnews/health
The American Association of Nurse Anesthesiology has issued a similar recommendation.
Fox News Digital contacted Novo Nordisk, maker of Ozempic and Wegovy, requesting comment.
Health
Words and game of Scrabble keep married couple in wedded bliss for decades
A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.
They’re still playing in tournaments built around the game decades after they began doing so.
Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.
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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.
But it was a “special match” in 2000 that brought the couple together — and has kept them together now.
Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.
They have been taking part in the UK Open Scrabble Championship in Reading this week.
“The more words you know, the more ammunition you’ve got.”
“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.
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“But it is a Scrabble vocabulary — not necessarily everyday English.”
Added Helen Harding, “The more words you know, the more ammunition you’ve got.”
The couple said they were “vague acquaintances” for about five years after they first met.
Then they got together after a special match in Swindon.
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They maintained a long-distance relationship before they got married in 2004.
The couple even brought their Scrabble board to their wedding.
It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”
For more Health articles, visit www.foxnews.com/health
They each took up the hobby early in life well before they met each other.
The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported.
Health
Deep sleep can keep two big health problems at bay, new studies suggest
It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.
Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.
The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.
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Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.
Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”
The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists.
The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.
But the scientists indicated that what drives the system was unclear until now, according to the study.
Is all sleep created equal? The researchers wanted to find out.
To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.
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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.
The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.
Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.”
She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”
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Hauglund said she wanted to understand whether all sleep is created equal.
To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.
“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice.
Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.
The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.
Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.
Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”
For more Health articles, visit www.foxnews.com/health
Meanwhile, a lack of sleep may be doing more damage than just making people groggy.
It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.
Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post.
“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.
Health
How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss
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