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Ozempic and Wegovy overdose calls have spiked, experts say — here’s what to know about dangerous doses

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Ozempic and Wegovy overdose calls have spiked, experts say — here’s what to know about dangerous doses

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As the popularity of semaglutide weight-loss medications continues to grow, so does the rate of potentially dangerous overdoses, experts are warning. 

Reported overdoses of semaglutide products such as Ozempic and Wegovy more than doubled between 2022 and 2023, according to America’s Poison Centers in Virginia.

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“U.S. Poison Centers have documented 3,316 exposures to products containing semaglutide through Dec. 31, 2023, more than two times the number of cases reported in 2022,” Dr. Kait Brown, clinical managing director of America’s Poison Centers, told Fox News Digital via email.

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“These cases include exposures to prescription semaglutide, compounded semaglutide and counterfeit semaglutide,” he said. 

“Most of these cases are associated with accidental therapeutic errors in adults.”

Reported overdoses of semaglutide products like Ozempic and Wegovy more than doubled between 2022 and 2023, according to America’s Poison Centers in Virginia. (iStock)

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What’s causing the overdoses?

Semaglutide medications are intended to be given in a low dose and increased slowly over a four-week period, according to Dr. Seth Kipnis, director of bariatric and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center in Neptune, New Jersey.

“If people jump right to the high dose, they will have more initial negative side effects,” he told Fox News Digital. 

U.S. poison centers have documented 3,316 exposures to products containing semaglutide through Dec. 31, 2023, more than two times the number of cases reported in 2022.

In some cases, people who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication, the doctor noted.

People with a semaglutide prescription should follow the manufacturer’s and prescribing physician’s instructions, Kipnis advised. 

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“The dose is weekly,” he said. “If it is taken daily, it is too much.”

Compounded versions of these drugs dispensed in multi-dose vials present a greater overdose risk, experts warned. (iStock)

Dr. Maryann Amirshahi, co-medical director of the National Capital Poison Center in Washington, D.C., confirmed that there has been a large overall increase in semaglutide overdoses reported to poison centers nationally. 

“In addition, I have noticed a similar increase at my individual center,” Amirshahi, who is also professor of emergency medicine at the Georgetown University School of Medicine, told Fox News Digital.

The doctor attributes the increase to several factors, chiefly the “huge increase” in semaglutide prescribing.

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“Secondarily, it is available in several different forms, which can cause confusion,” Amirshahi noted. 

“Ozempic is a dial-up pen with multiple doses — while Wegovy is a single-dose pen.”

Another source of confusion is that many people are using compounded products. 

The most commonly reported overdose symptoms of semaglutide medication use include nausea, vomiting, abdominal pain, dizziness and diarrhea. (iStock)

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“Compounded versions have their own unique risks when it comes to a potential overdose, especially when they’re dispensed in multi-dose vials,” noted Alyssa Billingsley, PharmD, Missouri-based director of pharmacy content at GoodRx.

“These injections are often dispensed in vials, so there’s a greater opportunity for dosing errors since you’re measuring out your specific dose with a syringe,” she warned. 

“In some cases, the vial may contain as much as 10 times the amount of semaglutide as a single-use injection pen.”

Warning signs and symptoms

The most commonly reported overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea, Brown noted. 

“Some people have reported hypoglycemia (low blood sugar), which can be life-threatening,” she said.

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Danish multinational pharmaceutical company Novo Nordisk A/S office building is located in Fremont, California. Novo Nordisk provided a statement to Fox News Digital about the reported overdoses. (iStock)

Symptoms of low blood sugar include confusion, tremor, lightheadedness and palpitations, according to Amirshahi. 

“Semaglutide slows stomach emptying, which can lead to nausea, vomiting and abdominal pain,” she said.

In some cases, the stomach becomes almost paralyzed, a condition called gastroparesis, which can lead to dehydration, abnormal electrolytes and kidney damage, said Amirshahi. 

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Another potential effect of semaglutide overdose is inflammation of the pancreas. 

“Symptoms of pancreatitis are very similar and can include nausea, vomiting, abdominal pain and dehydration,” Amirshahi noted. 

These signs and symptoms can also occur among patients taking normal doses of the medication as well as in overdoses, she added.

Wegovy is an injectable semaglutide prescription weight-loss medicine that has helped people with obesity. (Michael Siluk/UCG/Universal Images Group via Getty Images)

While any drug overdose can be serious, experts noted that taking too much semaglutide is rarely fatal. 

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“Semaglutide is generally well-tolerated in overdose compared to other diabetes medications,” Amirshahi said.

“Anything is possible when an FDA-approved drug is taken inappropriately.”

However, for people who develop gastroparesis or pancreatitis, potential complications can include dehydration and kidney damage. 

“While low blood sugar is rare with semaglutide overdose, if it is not detected and treated early, it can lead to seizures,” Amirshahi added.

Kipnis noted that in terms of adverse effects, “anything is possible when an FDA-approved drug is taken inappropriately.”

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What to do in an overdose event

Anyone who is taking a prescribed semaglutide should have a primary care physician or medical provider to provide close follow-up support, especially in the first several weeks as the dose increases, Kipnis advised. 

Although there is no specific antidote for a semaglutide overdose, the primary course of action is to treat the abdominal symptoms with nausea and pain medications, correct electrolytes, and give fluids for dehydration, said Amirshahi.

In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, experts said. (iStock)

“We also treat the low blood sugar by giving glucose or dextrose,” she said. “The care is really supportive until the effects of the medication wear off.”

In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, Billingsley noted. 

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“For example, severe vomiting can result in serious dehydration and electrolyte imbalances, which can be dangerous if left untreated,” she told Fox News Digital. “Severe cases of hypoglycemia can also be life-threatening.”

To prevent an overdose, Billingsley said to make sure you feel comfortable and confident using the injection pen and selecting your specific dose. 

People with a semaglutide prescription should follow the manufacturer’s and prescribing physician’s instructions, a doctor advised.  (Camerique/ClassicStock/Getty Images)

“Understand how often you should be injecting your dose, and consider using alarms, medication reminder apps, or other tools to help keep you on track,” she recommended. “Your pharmacist can be a helpful resource if any questions come up.”

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For emergency assistance, call Poison Help at 1.800.222.1222 to speak with a poison expert or visit PoisonHelp.org for support and resources.

When contacted by Fox News Digital regarding the potential for overdoses, Novo Nordisk, maker of Ozempic and Wegovy, provided a statement.

“Novo Nordisk is the only company in the U.S. with FDA-approved products containing semaglutide, identified under the trade names Wegovy, Ozempic and RYBELSUS, and should only be prescribed after a close consultation between a health care provider and a patient and should only be taken under the supervision of a health care provider,” the company said.

It added, “Novo Nordisk stands behind the safety and efficacy of our FDA-approved semaglutide medicines when used as indicated and when taken under the care of a licensed health care professional.”

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Denise Austin’s 10-Minute Pool Exercises for Weight Loss Melt Fat Fast

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Everyday task may help detect early dementia signs before diagnosis, study finds

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Everyday task may help detect early dementia signs before diagnosis, study finds

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A simple writing test could detect cognitive impairment in older individuals before more serious symptoms occur, scientists have discovered.

Writing is a complex, brain-heavy workout that requires the mind to process information, organize thoughts and send precise signals to the fingers all at once, according to experts.

Because writing draws on so many complex mental functions, researchers believe that small changes in how people write could provide early warning signs for cognitive impairment.

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Researchers in Portugal wanted to see if analyzing the process of writing — such as how long a person pauses or how they organize their strokes — could catch cognitive changes earlier than traditional paper-and-pencil tests, which usually only grade the final answer.

The study looked at 58 older adults between the ages of 62 and 92 living in care homes, according to a press release.

Researchers hoped to catch cognitive changes earlier than traditional paper-and-pencil tests, which usually only focus on the final output. (iStock)

Among the participants, 38 had already been diagnosed with cognitive impairment. Each volunteer was asked to complete various writing exercises using an ink pen on a specialized digital tablet that tracked their precise hand movements.

The tests covered basic pen control, copying sentences from a flashcard, and writing sentences that others spoke aloud, the researchers said.

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Simple tasks, like drawing lines or copying text, did not reveal major differences between the two groups. Because these activities rely mostly on basic motor skills, the team hypothesized that they weren’t mentally challenging enough to expose subtle cognitive issues.

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When writing from dictation, older adults with cognitive impairment had writing patterns that were noticeably slower, more fragmented and less coordinated.

“Dictation tasks are more sensitive because they require the brain to do multiple things at once: listen, process language, convert sounds into written form and coordinate movement,” Dr. Ana Rita Matias, the study’s senior author from the University of Évora, stated in the press release.

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When writing from dictation, older adults with cognitive impairment showed noticeably slower, more fragmented and less coordinated writing patterns. (iStock)

As a sentence became more complex, the brain struggled to keep up. Adults with cognitive decline took longer to start writing, paused more frequently and struggled with stroke organization, the study found.

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Currently, diagnosing cognitive decline often involves expensive brain scans or lengthy psychological testing.

“The long-term goal is to develop a tool that is easy to administer, time-efficient and affordable, allowing integration into everyday healthcare contexts without requiring specialized or expensive equipment,” Matias said.

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Researchers did not account for the participants’ medication use, which could potentially impact both handwriting and brain function. (iStock)

The study did have some limitations, including that it was relatively small. As it was limited to 58 older adults living in care homes, larger and more diverse groups need to be tested to confirm the findings, the researchers noted.

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The study also did not account for the participants’ use of medications, which could potentially impact both handwriting and brain function.

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The study was published in Frontiers in Human Neuroscience.

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Sleep doctor reveals the brutal health downside of daylight saving time

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Sleep doctor reveals the brutal health downside of daylight saving time

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The Trump administration is taking another look at ending biannual clock changes, with an eye toward making daylight saving time (DST), or the “summer clock,” permanent.

On May 21, the House Energy and Commerce Committee advanced legislation that would make daylight saving time permanent in a 48-1 vote, part of a largely bipartisan push to end twice-yearly clock changes.

Although gaining extra winter evening daylight might seem like a win, health experts say permanent daylight saving time could disrupt people’s natural circadian rhythms.

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In an interview with Fox News Digital, Dr. Wendy Troxel, a licensed clinical psychologist and senior behavioral scientist at RAND based in Utah, said science is being “misconstrued” in this decision.

“Ending the biannual clock change is something most sleep scientists and the public would welcome,” she said. “The disruption of springing forward every March is associated with real, measurable harm — spikes in car crashes, heart attacks and sleep deprivation.”

The Trump administration is taking another look at ending semiannual clock changes, with an eye toward making daylight saving time, or the “summer clock,” permanent. (iStock)

However, Troxel noted, implementing permanent daylight saving time is “not supported by science.” Instead, evidence “strongly supports” permanent standard time, or the “winter clock,” according to the expert.

Major sleep medicine organizations, including the American Academy of Sleep Medicine, have previously supported adopting permanent standard time over permanent daylight saving time.

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“Standard time is more closely aligned with human circadian biology, meaning the relationship between light, darkness and our internal clocks remains intact,” Troxel said.

“Permanent DST simply shifts an hour of morning sunlight to the evening, and there are significant health and safety costs of that trade.”

“Standard time is more closely aligned with human circadian biology,” the expert said. (iStock)

The U.S. attempted permanent DST in the early 1970s, but the plan was aborted in part due to these “morning consequences,” according to the sleep expert.

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“Within a year, the law was repealed amid public displeasure with commuting to work and school in the dark and increases in morning car crashes, and with no demonstrable impact on energy savings,” Troxel told Fox News Digital.

Why morning sunlight matters

Human circadian rhythms are primarily “anchored” by morning light, Troxel said. Under permanent DST, most people waking up for work or school would be rising before the sun, which forces a “chronic misalignment between the body’s internal clock and the external world.”

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“You cannot override that biology by simply shifting external clocks forward,” the expert said. “What you get instead is a population that is effectively waking up in the middle of their biological night, every single day.”

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The public has typically supported having more daylight in winter evenings, which could alleviate mental health conditions such as seasonal depression.

Supporters of permanent daylight saving time argue that later evening daylight could encourage outdoor activity, recreation and consumer spending after work or school.

Morning light is “crucial to regulate sleep, [boost] alertness and support mental health,” according to a sleep expert. (iStock)

Troxel agreed that light is a “powerful regulator” for sleep and moods, but noted that not all types have the same benefits.

“Morning light is crucial to regulate sleep, alertness and support mental health, and this would be sacrificed with permanent daylight saving time,” she noted.

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In some areas of the country, like Utah, Americans wouldn’t see the sunrise until about 9 a.m. in the winter, which some research has linked to higher rates of depression and seasonal mood challenges.

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“More evening light may feel enjoyable, in part because we equate it with lovely summer evenings, but permanent daylight saving time does not mean permanent summer,” Troxel emphasized. “It just means we will get less morning sunlight and more evening sunlight.”

“Exposure to light in the evening further pushes circadian rhythms later, making it more difficult to fall asleep and harder to wake up in the morning.”

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Risks for vulnerable groups

Permanent daylight saving time can intensify people’s habit of “bedtime procrastination,” deepen sleep deprivation and contribute to the widespread public health issue of insufficient sleep already identified by the Institute of Medicine, according to Troxel.

Teens are most at risk of mental health complications if permanent DST extends darkness in the morning. (iStock)

Various studies have shown that people typically sleep less in summer compared to winter. Troxel said this is particularly concerning in a society where one in three people are already getting insufficient shuteye.

“This is especially alarming for teenagers, a population the U.S. surgeon general has identified as being in a mental health crisis,” she cautioned.

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For example, a teen waking up at 6:30 a.m. for an 8 a.m. school start time under permanent DST would be rising biologically at 5:30 a.m., Troxel noted, which is “in the middle of their biological night.”

“Framing permanent DST as a fix for seasonal depression gets the science exactly backwards,” she added.

Fox News Digital’s Alex Nitzberg contributed to this report.

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