Health
Omicron COVID-19 variant gives little immunity boost to those infected: researchers
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Researchers revealed within the British Medical Journal (BMJ) have discovered an infection or vaccination with the omicron variant of COVID-19 do little or nothing to guard in opposition to future infections.
In response to the research’s findings, well being care employees who had been contaminated with the alpha variant of COVID-19 produced a much less highly effective antibody response to the omicron variant. In actual fact, contaminated sufferers from the start of the pandemic had zero immune boosting in opposition to omicron.
“Individuals contaminated with the omicron variant present poor immunity boosting in opposition to future COVID-19 an infection, researchers have discovered,” the BMJ wrote in a report on the efficacy of vaccine boosters.
The report continued, “This may increasingly clarify why breakthrough and repeat infections have been a typical characteristic of the omicron wave of the pandemic, even amongst individuals who have been triple vaccinated.”
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Danny Altman, a coauthor of the research from Imperial School London, stated the omicron variant is especially troublesome to immunize in opposition to.
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“The analysis workforce analyzed blood samples from 731 U.Ok. well being care employees who acquired three doses of mRNA vaccine and had completely different SARS-CoV-2 an infection histories, to analyze antibody, T cell, and B cell immunity in opposition to omicron,” the BMJ reported.
The workforce’s analysis confirmed that an infection or vaccination doesn’t present enough safety in opposition to contracting the illness sooner or later.
“Getting contaminated with omicron doesn’t present a potent enhance to immunity in opposition to reinfection with omicron sooner or later. Earlier SARS-CoV-2 an infection impacts on the flexibility to spice up immunity in opposition to subsequent SARS-CoV-2 an infection by means of a course of referred to as ‘immune imprinting,’ and this may increasingly apply to subvariants of omicron together with BA.4 and BA.5,” stated lead creator Rosemary Boyton.
Greater than 82 million COVID-19 vaccine doses have reportedly gone to waste because the starting of the pandemic, in accordance with media studies.
The Facilities for Illness Management and Prevention (CDC) shared the info, which signifies that simply over 11% of doses the federal authorities distributed between December 2020 by means of mid-Might had been discarded, with NBC Information.
That is practically 20 million extra doses wasted than the 65 million The Related Press reported wasted in February.
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The vaccines are available in a vial and have a brief shelf life. As soon as opened, they’ve for use pretty rapidly earlier than they must be thrown away.
Nationwide, greater than 751 million doses have been distributed and 221.5 million folks have been absolutely vaccinated, in accordance with the CDC. Nonetheless, lower than half of all these absolutely vaccinated have acquired their first booster shot.
Health
Words and game of Scrabble keep married couple in wedded bliss for decades
A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.
They’re still playing in tournaments built around the game decades after they began doing so.
Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.
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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.
But it was a “special match” in 2000 that brought the couple together — and has kept them together now.
Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.
They have been taking part in the UK Open Scrabble Championship in Reading this week.
“The more words you know, the more ammunition you’ve got.”
“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.
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“But it is a Scrabble vocabulary — not necessarily everyday English.”
Added Helen Harding, “The more words you know, the more ammunition you’ve got.”
The couple said they were “vague acquaintances” for about five years after they first met.
Then they got together after a special match in Swindon.
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They maintained a long-distance relationship before they got married in 2004.
The couple even brought their Scrabble board to their wedding.
It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”
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They each took up the hobby early in life well before they met each other.
The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported.
Health
Deep sleep can keep two big health problems at bay, new studies suggest
It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.
Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.
The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.
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Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.
Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”
The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists.
The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.
But the scientists indicated that what drives the system was unclear until now, according to the study.
Is all sleep created equal? The researchers wanted to find out.
To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.
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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.
The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.
Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.”
She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”
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Hauglund said she wanted to understand whether all sleep is created equal.
To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.
“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice.
Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.
The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.
Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.
Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”
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Meanwhile, a lack of sleep may be doing more damage than just making people groggy.
It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.
Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post.
“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.
Health
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