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New weekly injection for Parkinson's could replace daily pill for millions, study suggests

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New weekly injection for Parkinson's could replace daily pill for millions, study suggests

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A new weekly injectable drug could transform the lives of more than eight million people living with Parkinson’s disease, potentially replacing the need for daily pills.

Scientists from the University of South Australia (UniSA) developed a long-acting injectable formulation that provides two key Parkinson’s medications for an entire week.

There is currently no cure for Parkinson’s, which is the second-most common neurological disorder, affecting more than one million Americans, according to the Parkinson’s Foundation.

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To manage symptoms like tremors, rigidity and slow movement, patients typically take daily oral medications, such as levodopa and carbidopa, according to the university’s press release.

This method can be especially difficult for individuals who have trouble swallowing or are otherwise unable to take the pills consistently, leading to irregular medication levels, increased side effects and reduced effectiveness.

Scientists from the University of South Australia developed a long-acting injectable formulation that provides two key Parkinson’s medications for an entire week. (iStock)

Levodopa is the “gold-standard therapy for Parkinson’s,” according to lead researcher Professor Sanjay Garg at UniSA, but its short lifespan means it must be taken several times a day.

The researchers tested an injectable gel implant that combines an FDA-approved biodegradable substance with a pH-sensitive substance to achieve a controlled and sustained drug release.

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The gel is injected through a single shot under the skin or into the muscle tissue, which means there’s no need for a surgical implant and discomfort is minimal, they noted.

The team found that the gel gradually released the key Parkinson’s medications (90% of the levodopa drug and 81% of the carbidopa) over the course of one week.

The findings were published in the journal Drug Delivery and Translational Research.

To manage symptoms like tremors, rigidity and slow movement, patients typically take daily oral medications. (iStock)

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“Reducing the frequency of dosing from multiple times a day to a weekly injection is a major step forward in Parkinson’s therapy,” Garg said in the release. “We’re not just improving how the drug is delivered; we’re improving patients’ lives.”

Extensive lab tests confirmed the system’s effectiveness and safety.

“We’re not just improving how the drug is delivered; we’re improving patients’ lives.”

The implant degraded by over 80% within a week and showed no significant toxicity in cell viability tests.

“The implications of this research are profound,” Garg added.

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Deepa Nakmode, a PhD student at the University of South Australia, noted that this method is designed to release both levodopa and carbidopa steadily over one week, maintaining consistent plasma levels and reducing the risks associated with fluctuating drug concentrations.

“After years of focused research, it’s incredibly rewarding to see our innovation in long-acting injectables for Parkinson’s disease reach this stage,” he said in the release. 

The team’s invention has now been filed for an Australian patent, Nakmode added.

Extensive lab tests confirmed the new medication’s effectiveness and safety, the researchers noted. (iStock)

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The technology could also be adapted for other chronic conditions, such as cancer, diabetes, neurodegenerative disorders, chronic pain and infections that require long-term drug delivery, according to Garg.

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The system can be tuned to release drugs over a period ranging from a few days to several weeks, depending on therapeutic needs.

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Scientists hope to start clinical trials in the near future and are exploring opportunities to make the gel commercially available.

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Health

Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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