Health
Mpox outbreak that is rapidly spreading through Congo may be a new form of the disease
Congo is struggling to contain its biggest mpox outbreak, and scientists say a new form of the disease detected in a mining town might more easily spread among people.
Since January, Congo has reported more than 4,500 suspected mpox cases and nearly 300 deaths, numbers that have roughly tripled from the same period last year, according to the World Health Organization. Congo recently declared the outbreak across the country a health emergency.
An analysis of patients hospitalized between October and January in Kamituga, eastern Congo, suggests recent genetic mutations in mpox are the result of its continued transmission in humans; it’s happening in a town where people have little contact with the wild animals thought to naturally carry the disease.
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“We’re in a new phase of mpox,” said Dr. Placide Mbala-Kingebeni, the lead researcher of the study, who said it will soon be submitted to a journal for publication. Mbala-Kingebeni heads a lab at Congo’s National Institute of Biomedical Research, which studies the genetics of diseases.
The lesions reported by most patients are milder and on the genitals, Mbala-Kingebeni said, making the disease trickier to diagnose. In previous outbreaks in Africa, lesions were mostly seen on the chest, hands and feet. He also said that the new form seems to have a lower death rate.
A patient shows the rash marks on his hands due to the 1996 to 1997 monkeypox outbreak in the Democratic Republic of the Congo. (CDC/Brian W.J. Mahy/Handout via REUTERS)
In a report on the global mpox situation this week, WHO said the new version of the disease might require a new testing strategy to pick up the mutations.
With experts pointing out that fewer than half of people in Congo with mpox are tested, Mbala-Kingebeni said: “The risk is that unless patients themselves come forward, we will have a silent transmission of the disease and nobody will know.”
Mbala-Kingebeni said most people were infected via sex, with about a third of mpox cases found in sex workers. It was not until the 2022 global emergency of mpox that scientists established the disease was spread via sex, with most cases in gay or bisexual men. In November, WHO confirmed sexual transmission of mpox in Congo for the first time.
There are two kinds, or clades, of mpox, which is related to smallpox and endemic to central and west Africa. Clade 1 is more severe and can kill up to 10% of people infected. Clade 2 triggered the 2022 outbreak; more than 99% of people infected survived.
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Mbala-Kingebeni and colleagues said they have identified a new form of clade 1 that may be responsible for more than 240 cases and at least three deaths in Kamituga, a region with a significant transient population traveling elsewhere in Africa and beyond.
Dr. Boghuma Titanji, an infectious diseases expert at Emory University who is not connected to the research, said the new mutations are concerning.
“This suggests the virus is adapting to spread efficiently in humans and could cause some pretty consequential outbreaks,” she said.
Although the mpox epidemics in the West were contained with the help of vaccines and treatments, barely any have been available in Congo. Congo’s minister of health has authorized the use of vaccines in high-risk provinces, said Cris Kacita Osako, coordinator of Congo’s Monkeypox Response Committee. He said officials are in talks with donor countries like Japan to help buy the shots.
“Once a sufficient quantity of vaccines is available … vaccination will be implemented as part of the response,” Kacita Osako said.
Dr. Dimie Ogoina, an mpox expert at Niger Delta University, said the new research is an unsettling reminder of an earlier — but different — outbreak.
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“The notable spread among sex workers is reminiscent of the early stages of HIV,” he said, explaining that prejudices attached to treating sexually transmitted infections and the reluctance of people with mpox to come forward were worrying.
WHO’s emergencies chief, Dr. Michael Ryan, said last week that despite the ongoing spread of mpox in Africa and elsewhere, “there has not been a single donor dollar invested.”
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More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.
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Health
Heart disease threat projected to climb sharply for key demographic
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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