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Mpox outbreak that is rapidly spreading through Congo may be a new form of the disease

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Mpox outbreak that is rapidly spreading through Congo may be a new form of the disease

Congo is struggling to contain its biggest mpox outbreak, and scientists say a new form of the disease detected in a mining town might more easily spread among people.

Since January, Congo has reported more than 4,500 suspected mpox cases and nearly 300 deaths, numbers that have roughly tripled from the same period last year, according to the World Health Organization. Congo recently declared the outbreak across the country a health emergency.

An analysis of patients hospitalized between October and January in Kamituga, eastern Congo, suggests recent genetic mutations in mpox are the result of its continued transmission in humans; it’s happening in a town where people have little contact with the wild animals thought to naturally carry the disease.

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“We’re in a new phase of mpox,” said Dr. Placide Mbala-Kingebeni, the lead researcher of the study, who said it will soon be submitted to a journal for publication. Mbala-Kingebeni heads a lab at Congo’s National Institute of Biomedical Research, which studies the genetics of diseases.

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The lesions reported by most patients are milder and on the genitals, Mbala-Kingebeni said, making the disease trickier to diagnose. In previous outbreaks in Africa, lesions were mostly seen on the chest, hands and feet. He also said that the new form seems to have a lower death rate.

A patient shows the rash marks on his hands due to the 1996 to 1997 monkeypox outbreak in the Democratic Republic of the Congo. (CDC/Brian W.J. Mahy/Handout via REUTERS)

In a report on the global mpox situation this week, WHO said the new version of the disease might require a new testing strategy to pick up the mutations.

With experts pointing out that fewer than half of people in Congo with mpox are tested, Mbala-Kingebeni said: “The risk is that unless patients themselves come forward, we will have a silent transmission of the disease and nobody will know.”

Mbala-Kingebeni said most people were infected via sex, with about a third of mpox cases found in sex workers. It was not until the 2022 global emergency of mpox that scientists established the disease was spread via sex, with most cases in gay or bisexual men. In November, WHO confirmed sexual transmission of mpox in Congo for the first time.

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There are two kinds, or clades, of mpox, which is related to smallpox and endemic to central and west Africa. Clade 1 is more severe and can kill up to 10% of people infected. Clade 2 triggered the 2022 outbreak; more than 99% of people infected survived.

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Mbala-Kingebeni and colleagues said they have identified a new form of clade 1 that may be responsible for more than 240 cases and at least three deaths in Kamituga, a region with a significant transient population traveling elsewhere in Africa and beyond.

Dr. Boghuma Titanji, an infectious diseases expert at Emory University who is not connected to the research, said the new mutations are concerning.

“This suggests the virus is adapting to spread efficiently in humans and could cause some pretty consequential outbreaks,” she said.

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Although the mpox epidemics in the West were contained with the help of vaccines and treatments, barely any have been available in Congo. Congo’s minister of health has authorized the use of vaccines in high-risk provinces, said Cris Kacita Osako, coordinator of Congo’s Monkeypox Response Committee. He said officials are in talks with donor countries like Japan to help buy the shots.

“Once a sufficient quantity of vaccines is available … vaccination will be implemented as part of the response,” Kacita Osako said.

Dr. Dimie Ogoina, an mpox expert at Niger Delta University, said the new research is an unsettling reminder of an earlier — but different — outbreak.

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“The notable spread among sex workers is reminiscent of the early stages of HIV,” he said, explaining that prejudices attached to treating sexually transmitted infections and the reluctance of people with mpox to come forward were worrying.

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WHO’s emergencies chief, Dr. Michael Ryan, said last week that despite the ongoing spread of mpox in Africa and elsewhere, “there has not been a single donor dollar invested.”

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Hantavirus exposure risk may be higher than believed in parts of US, study finds

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Hantavirus exposure risk may be higher than believed in parts of US, study finds

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Researchers found unusually high hantavirus levels in rodents in the Pacific Northwest, suggesting greater exposure risk in the surrounding agricultural communities.

The area with the biggest prevalence is the Palouse region, which includes parts of eastern Washington and north-central Idaho in the Pacific Northwest.

Researchers from Washington State University’s College of Veterinary Medicine found unexpectedly high levels of Sin Nombre virus (SNV), which is the strain most strongly linked to hantavirus pulmonary syndrome (HPS) — among local rodent populations. 

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In summer 2023, they collected samples from 189 deer mice, voles and chipmunks at eight farms and two forest sites.

Nearly 30% of sampled rodents showed evidence of prior exposure and about 10% had active infections, according to the study press release. The rodents that tested positive were from both agricultural environments (farms) and natural settings (wilderness).

Researchers found unusually high hantavirus levels in rodents in the Pacific Northwest, suggesting greater exposure risk in the surrounding agricultural communities. (iStock)

While deer mice are the primary carriers of hantavirus pulmonary syndrome, the researchers found infections across multiple rodent species.

This suggests that Sin Nombre virus may be more widespread in the region than previously thought.

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The findings were published in 2026 in Emerging Infectious Diseases, a peer-reviewed journal from the Centers for Disease Control and Prevention.

“We were surprised both by how common the virus was locally and by how little data existed for the Northwest,” said Stephanie Seifert, the study’s corresponding author and principal investigator of the Molecular Ecology of Zoonotic and Animal Pathogens lab in the College of Veterinary Medicine’s Paul G. Allen School for Global Health, in the press release. 

“We’re really just beginning to understand how widespread and complex this virus is in rodent populations here.”

The hantavirus detected in this study is different from the Andes virus, the strain linked to the recent outbreak on board the MV Hondius cruise ship. (Getty Images)

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The Sin Nombre virus, the most common hantavirus in the U.S., is typically spread to humans through inhalation of aerosolized rodent urine, droppings or saliva and is not known to spread person-to-person.

This is different from the Andes virus, the strain linked to the recent outbreak on board the MV Hondius cruise ship. Andes virus is the only hantavirus that is capable of spreading between people through close, prolonged contact.

“People may be exposed more often than we realize, but severe cases are more likely to be tested for hantavirus.”

Dr. Sonja Bartolome, an expert in pulmonary and critical care at UT Southwestern Medical Center in Dallas, pointed out that since national tracking began in 1993, the illness has remained rare, with 864 cases reported between 1993 and 2022.

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“Most cases have occurred in Colorado, New Mexico and Arizona, and 94% have been reported in states west of the Mississippi River,” Bartolome, who was not involved in the study, told Fox News Digital.

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“It is important to conduct research that expands our understanding of how the virus spreads,” she went on. “Studies like this – which obtain and compare viral genetic sequences across regions and animals – help clarify how the virus moves geographically and between species.”

The researchers recommend efforts to prevent rodent exposure for living and farming in rural areas. (AP Photo/Godofredo A. Vásquez, File)

Although similar findings have been reported in other regions, this is the first study to reveal the pattern in this part of the country, Bartolome noted.

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“Because humans most commonly contract hantavirus through exposure to aerosolized rodent urine or droppings, precautions remain essential when cleaning areas with evidence of rodent activity,” she added.

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The study presented some limitations, primarily that it only measured the infection in rodents and did not evaluate human transmission risk.

Additionally, the samples were only taken in the Palouse region and may not be generalized to all the Pacific Northwest.

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The research was also conducted during a single season, which means the conclusions don’t reflect year-round data.

The study suggests the need for expanded hantavirus monitoring in the Pacific Northwest, especially in agricultural areas. 

The study presented some limitations, primarily that it only measured the infection in rodents and did not evaluate human transmission risk. (iStock)

The researchers recommend efforts to prevent rodent exposure for living and farming in rural areas. Longer-term studies could help clarify how environmental conditions and seasonal changes affect prevalence of the virus, they added.

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“People may be exposed more often than we realize, but severe cases are more likely to be tested for hantavirus,” said Pilar Fernandez, a co-author on the study and a disease ecologist in the Allen School whose research focuses on the eco-epidemiology of zoonotic diseases, in the release.

“Understanding that gap — how exposure translates into disease — is the next big step.”

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Finding the sleep ‘sweet spot’ could help you live longer, study suggests

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Finding the sleep ‘sweet spot’ could help you live longer, study suggests

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How long you sleep could be linked to how long you’ll live.

A new study, published in the journal Nature, found that people who slept too little or too long showed signs of “older biology.”

Researchers from Columbia University in New York used global biobank data from about 500,000 people who disclosed self-reported sleep duration in a 24-hour period, including naps.

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Reported sleep times were compared with 23 biological aging clocks, estimating whether various parts of the body looked biologically older or younger than the individual’s actual age.

Short and long sleep were both linked with signals of a higher biological age. They were also associated with a higher risk of future diseases and all-cause mortality, the researchers found.

According to study results, short sleep and long sleep were both linked with signals of higher biological age. (iStock)

In nine of the aging clocks, the researchers found “statistically significant” links between sleep and aging, including in the brain, heart, immune system and skin.

Those with the “lowest biological age gap” were women who slept for 6.5 to 7.8 hours and men who slept for 6.4 to 7.7 hours, according to the study.

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Longer sleep had a stronger link to psychiatric-related outcomes, while short sleep had more physical impacts on cardiovascular, metabolic, musculoskeletal, psychiatric, neurological, pulmonary and gastrointestinal conditions.

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The U-shaped results also showed that shorter sleep led to a 50% higher relative risk for all-cause mortality, while longer sleep had about a 40% higher risk.

The researchers noted that self-reported sleep poses a limitation to the study. As it was observational in design, it does not prove that sleeping exactly six to eight hours will slow aging.

Both women and men who slept roughly six to eight hours showed the lowest signals for biological aging. (iStock)

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Saema Tahir, MD, a New York-based board-certified sleep medicine physician, reflected on these findings in an interview with Fox News Digital.

“Sleep is really when the body does its most critical repair work, including cellular restoration, immune regulation, hormonal balance, and even clearing out metabolic waste from the brain through what we call the glymphatic system,” said Tahir, who was not involved in the study.

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“When sleep is consistently too short or too long, those processes get disrupted. Over time, that disruption accumulates at the cellular level.”

This effect is proven in increased inflammatory markers and cellular changes, which are “hallmarks of accelerated aging,” Tahir noted.

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“So, the relationship isn’t just correlational; there are real physiological mechanisms connecting poor sleep to the body aging faster than it should.”

“Sleep is really when the body does its most critical repair work,” the doctor noted. (iStock)

Tahir cautions her patients not to treat the six- to eight-hour recommendation as a “rigid prescription,” as sleep is individualized.

For example, a healthy 25-year-old and a 70-year-old with cardiovascular disease have “very different sleep architecture and needs,” according to the expert.

DO WOMEN NEED MORE SLEEP THAN MEN? HERE’S WHAT EXPERTS THINK

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“What I tell my patients is to use that range as a starting framework, but pay attention to how you feel,” she advised. “Are you waking up refreshed? Can you stay alert throughout the day without caffeine propping you up? Those functional cues matter just as much as the number on the clock.”

For certain people, like pregnant women, athletes and people recovering from illness, these sleep needs can shift “considerably.”

As sleep is individualized, a rigid six- to eight-hour framework may not work for everyone. (iStock)

“Sleep duration is important, but … getting adequate sleep and REM sleep that allows our bodies to heal, clear, process and repair is much more important,” Tahir said.

Regardless of sleep time, those who don’t achieve quality sleep often struggle, she shared.

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“I’ve seen patients who log seven hours but spend most of that time in light sleep, barely touching the deep slow-wave or REM stages that are most restorative,” Tahir said. “They age just as poorly, sometimes worse, than someone getting six hours of genuinely consolidated, high-quality sleep.”

Deep sleep is the phase when growth hormone is released and tissue repair peaks, and REM sleep is “critical” for cognitive health and emotional regulation, according to the expert.

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“So, chasing hours without addressing sleep fragmentation, sleep apnea or poor sleep architecture is missing the bigger picture,” she said.

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The takeaway from this study, according to Tahir, is that sleep is not a “lifestyle luxury,” but a “biological necessity with measurable consequences for how we age and how healthy we are.”

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There’s still a cultural tendency to see sleep deprivation as a “badge of productivity,” which she pushes back against. “But I also want people to avoid the other extreme — health anxiety about their sleep can actually make sleep worse.”

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The sleep expert concluded that “consistent, good-quality sleep is one of the most accessible tools we have for healthy aging.”

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“It doesn’t require a prescription or expensive intervention — it requires prioritization.”

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‘Wild West’ peptide craze surges beyond GLP-1s as FDA faces pressure to ease access

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‘Wild West’ peptide craze surges beyond GLP-1s as FDA faces pressure to ease access

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As GLP-1 weight-loss medications gain traction, the peptide market is experiencing a surge in interest.

A variety of peptides — commonly marketed for weight loss, muscle building, injury recovery and other uses — have emerged as largely unregulated drugs sold through both licensed compounding pharmacies and unverified vendors.

The U.S. Food and Drug Administration is set to evaluate whether to loosen regulations on several peptides during a meeting this summer.

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Peptides are short chains of amino acids — the building blocks of proteins — that play key roles in biological functions, according to the National Institutes of Health. Peptide drugs are lab-made versions of natural molecules in the body that are designed to mimic or influence biological signals to treat disease, experts say.

GLP-1s are “incredibly effective at what they do when it comes to changing body composition, benefiting metabolic health, cardiovascular health [and] neurologic health,” the expert said. (iStock)

Though the peptide market has been described as the “Wild West,” demand remains strong, potentially challenging pharmaceutical giants that dominate the GLP-1 market.

Dr. Alex Tatem, an Indiana-based board-certified urologist with expertise in men’s health and peptides, discussed how “life-changing” GLP-1s kicked off the rise of peptides.

“These were all medications that were designed to help people live well and live as healthy as possible.”

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“They are incredibly effective at what they do when it comes to changing body composition, benefiting metabolic health, cardiovascular health [and] neurologic health,” he said. “These are truly miracle compounds, and as a result we’ve seen an explosion of interest – not just on the pharmaceutical side or the doctor’s side, but from the general public.”

According to Tatem, the challenge is that nearly all commercial GLP-1 products are administered in a single-dose weekly pen, which works for the “overwhelmingly majority” of patients, but not for everyone.

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“There are patients I can prescribe tirzepatide to and they can do OK with a once-a-week [dose], but they end up developing nausea with that initial injection – and then by the end of the week, they’re hungry again.”

Because some patients respond better to smaller, more frequent doses — an option not offered by commercial drugs — compounding, or the customization of medications, has grown in popularity, Tatem said.

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Several GLP-1 weight loss medications have been approved by the FDA with positive results from consumers. (iStock)

“We’ve had compounding pharmacies that have now developed compounded versions of semaglutide and tirzepatide that allow that sort of dosing flexibility,” he said.

“The reason compounders had to do this was because there was so much demand for GLP-1s that there was actually a national shortage.”

Current legislation allows compounders to step in during widespread national shortages, according to Tatem, prompting the industry to invest millions of dollars into developing and manufacturing these drugs.

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Once commercial pharmaceutical companies could catch back up, compounders continued making these medications in smaller batches for custom doses, allowing for more patient accessibility.

“That creates a huge clash between commercial pharmaceutical companies and compounders, because commercial pharmaceutical companies view that as an infringement of their property,” Tatem noted.

The expert noted a “huge clash” between pharmaceutical companies and compounding pharmacies in peptide production. (iStock)

Tatem raised concerns about the FDA’s regulation of compounding pharmacies, warning that it could limit patients’ access to customized medications.

“That is a real concern for clinicians like me who really care more about patient access, making sure we can get the right medication to the right patients at the right time,” he said.

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Some peptides have been widely administered for more than a decade without major health complications like toxicity or cancer, according to Tatem.

“These are compounds that haven’t gone through the full FDA approval process that you would normally see for a commercial drug, [yet] we didn’t see anything adverse,” he said.

The FDA plans to consider loosening restrictions on several peptides during a summer 2026 meeting. (Issam Ahmed/AFP)

In September 2023, the FDA “quietly” tightened regulation of 19 peptides, making them illegal to manufacture and cutting off patient access.

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“They seemed to be working and seemed to be efficacious for patients, and all of a sudden they were banned, which inadvertently ended up contributing to this surge in interest,” Tatem said. “We kind of saw the same thing happen with peptides that we saw with prohibition.”

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While the rising popularity of GLP-1 drugs has fueled growing public and regulatory interest in peptides, most of the so-called “trendy” peptides still are not available by prescription, according to Tatem.

They may help with injury recovery, skin rejuvenation, sleep improvements and boosting of natural growth hormones, he said.

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“These were all medications that were designed to help people live well and live as healthy as possible,” the doctor told Fox News Digital. “And in reality, that was also their downfall in the American healthcare system, because if you are going to get a drug approved and to market, it has to treat a disease state.”

“These were all medications that were designed to help people live well and live as healthy as possible,” Tatem told Fox News Digital. (iStock)

Tatem confirmed that he’s seen a shift in patients confronting more than just baseline ailments, seeking advice on how to feel their best through new modes like testosterone therapy.

“The desire to function at our highest level is something that we all feel,” he said.

While nothing replaces the fundamentals — getting eight hours of sleep, eating a high-protein diet and maintaining a fitness routine that blends resistance training and cardio — Tatem said individualized treatments such as peptides may help support those healthy habits.

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“If you end up pulling a tendon or pulling a hamstring, and you’re just now starting to get some momentum in the gym, that’s really where peptides start to step in,” he added.

Experts advise consumers to avoid gray-market products, to work only with qualified physicians and reputable pharmacies, and to treat peptides as part of a broader health plan — not a shortcut or risk-free supplement.

Semaglutide (GLP-1) weight-loss drug Wegovy, made by pharmaceutical company Novo Nordisk, is designed to treat type 2 diabetes, but is widely known for its effect on weight loss. Picture date: Wednesday, October 16, 2024. (James Manning/PA Images via Getty Images)

In a statement shared with Fox News Digital, a Novo Nordisk spokesperson said the drugmaker is committed to working with regulators, law enforcement and “other key stakeholders” to ensure “affordable access to safe, effective and FDA-approved GLP-1 obesity medication like Wegovy and to protect patients from unapproved and untested knockoff drugs.”

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“The desire to function at our highest level is something that we all feel.”

“Novo Nordisk supports FDA’s recent thorough scientific analysis and conclusion that there is no medical basis or clinical need for the continued mass compounding of unapproved semaglutide and liraglutide drugs,” they went on.

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“The agency’s decision reaffirms that compounding is meant to be a rare and limited exception to FDA’s gold-standard drug approval framework that ensures that medicines in the U.S. are safe and effective.”

Fox News Digital reached out to the FDA and Eli Lilly for comment.

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