Health
More patients demand ‘unvaccinated’ blood, doctors warn of growing health risks
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An increasing number of patients are requesting “unvaccinated” blood for transfusions, which can delay care and pose risks to patients’ health, experts warn.
There is no evidence that unvaccinated blood presents any safety benefit, according to a new study published in the journal Transfusion.
There is currently no process for checking whether donated blood comes from vaccinated or unvaccinated donors, experts say.
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Vanderbilt University in Tennessee, which conducted the research, received 15 requests for unvaccinated blood between Jan. 1, 2024, and Dec. 31, 2025. The median age of patients was 17 years old and more than half were children, the university reported.
An increasing number of patients are requesting “unvaccinated” blood for transfusions, which can delay care and pose risks to patients’ health, experts warn. (iStock)
Thirteen of the patients received blood donated specifically for them by family members, which is known as “direct donation.” This can be risky, because most direct donors are giving blood for the first time, and their donations are more likely to contain “potentially harmful pathogens,” the authors noted.
“Despite being framed as ‘safer,’ directed donations may paradoxically increase risk.”
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Among the studied patient group, two became much sicker after refusing a standard blood transfusion.
One patient developed anemia, a condition where the body lacks enough healthy red blood cells to carry adequate oxygen. The other developed hemodynamic shock, a serious condition in which there is insufficient blood flow and oxygen to the body’s tissues, potentially leading to organ failure.
“Despite being framed as ‘safer,’ directed donations may paradoxically increase risk.”
Requests for unvaccinated blood spiked after the approval of COVID-19 vaccines, posing a “recurring challenge for transfusion services and clinicians,” the researchers stated.
“These requests were associated with care delays, escalation and inefficiencies,” they indicated.
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The researchers recommend that health systems create standardized policies to handle these types of requests.
“Regulatory and professional organizations have opposed these non-evidence-based policies, emphasizing that blood centers do not record or convey donor COVID-19 vaccination status and that evidence demonstrates transfusion from vaccinated donors poses no unique risk.”
Requests for unvaccinated blood spiked after the approval of COVID-19 vaccines, posing a “recurring challenge for transfusion services and clinicians,” the researchers stated. (Reuters/Dado Ruvic/Illustration/File Photo)
The Vanderbilt study had some limitations, the researchers noted. It looked at a small number of cases and only included situations where special blood donations made it to the blood bank, so it doesn’t show how often people made this request overall.
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It also didn’t include cases where concerns were resolved through conversations with doctors or ethics teams, the team noted.
As this was an observational study and not a controlled experiment, it only showed an association and could not prove that refusing standard blood directly caused any specific patient outcomes.
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Several states have introduced proposals aimed at allowing patients to receive blood specifically from donors who have not received COVID-19 vaccines.
In Oklahoma, one such proposal called for the creation of a state-run blood bank dedicated to collecting and distributing blood from unvaccinated donors. Despite these efforts, none of the measures have been enacted into law.
The notion that receiving blood from someone who had the vaccine would be harmful is not based on any scientific studies, doctors say. (iStock)
Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the research, but said these types of requests are “part of an ongoing fear culture.”
“It is also very difficult to test for, because the antibodies may be positive from COVID itself as well as the vaccine, and it can be difficult to tell the difference,” he told Fox News Digital.
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The notion that receiving blood from someone who had the vaccine would be harmful is not based on any scientific studies, the doctor reiterated.
“If people want to group up to get blood from other unvaccinated people, I respect that choice, though it will be expensive and will limit options,” Siegel added.
“Requests for unvaccinated blood are something we’ve seen wax and wane since the introduction of the COVID vaccine,” an expert said. (iStock)
Diane Calmus, vice president of government affairs for America’s Blood Centers in Washington, D.C., said that requests for direct donations are “exceedingly rare” – representing about 0.06% of the U.S. blood supply.
“Requests for unvaccinated blood are something we’ve seen wax and wane since the introduction of the COVID vaccine,” Calmus, who also was not involved in the Vanderbilt study, told Fox News Digital. “The challenge is that there’s no way to tell whether someone’s blood has been vaccinated – there’s no test that exists.”
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Any situation where someone requires a blood transfusion is most likely a “very scary time,” she noted.
“Family members want to be cautious, and this is why it’s so important that people talk to a transfusion medicine-trained doctor,” the expert advised. “These are physicians who have a specialty in blood transfusions … and who can answer those questions that any individual will have.”
“Blood has to be prescribed. You can’t just show up at the blood center and say, ‘I would like my sister to donate for me,’” an expert said. (iStock)
Calmus pointed out that it takes some time to facilitate a direct donation, and that there is a specific process in place.
“Blood has to be prescribed. You can’t just show up at the blood center and say, ‘I would like my sister to donate for me,’” she said. “There needs to be a prescription. It needs to go through the hospital … they need to make sure it is the right blood for the right patient.”
“We need people – vaccinated or not vaccinated – to show up and donate blood, because it is the blood on the shelves that saves lives.”
Calmus emphasized that the U.S. blood supply is “meticulously tracked,” and that there have been no indications of a lack of safety. She also stressed the ongoing need for blood donors.
“We need people – vaccinated or not vaccinated – to show up and donate blood, because it is the blood on the shelves that saves lives.”
Fox News Digital reached out to the Vanderbilt researchers for comment.
Health
Doctors warn of ‘looksmaxxing’ dangers after influencer’s livestream emergency
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“Clavicular,” the controversial “looksmaxxing” influencer, was reportedly hospitalized due to a suspected overdose Tuesday night during a livestream.
The Miami content creator, 20, posted a photo of his bloody face and commented on X Wednesday.
“Just got home, that was brutal. All of the substances are just [to] cope, trying to feel neurotypical while being in public, but obviously, that isn’t a real solution. The worst part of tonight was my face descending from the life support mask.”
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The influencer, whose real name is Braden Peters, was hospitalized after his livestream was cut short when he began slurring his words and repeating phrases, according to reports.
What is ‘looksmaxxing’ and why is it trending?
Looksmaxxing is a social media trend focused on enhancing appearance, ranging from basic skin care to extreme practices like hitting cheekbones with hammers to alter facial structure.
Looksmaxxing is a social media trend focused on enhancing appearance, ranging from basic skin care to extreme practices like hitting cheekbones with hammers to alter facial structure. (iStock)
The potentially dangerous trend has been popular with young males, plastic surgeons told Fox News Digital.
“In my practice, we’ve seen it primarily in young men in their 20s,” Dr. Josef Hadeed, a plastic surgeon in Beverly Hills, California, told Fox News Digital. “We have had a few women, but I’d say by and large, it’s been mostly men who have come into our office wanting these various looksmaxxing procedures.”
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“Patients are increasingly seeking to align how they look with how they feel,” he said. “The difference today is that the tools and technologies available to achieve that have never been more advanced or more accessible.”
Looksmaxxing can be divided into two categories: “softmaxxing” and “hardmaxxing,” according to Hadeed. Softmaxxing is a more simple, non-invasive approach to improving one’s looks.
The potentially dangerous trend has been popular with young males, plastic surgeons told Fox News Digital. (iStock)
“It’s really like self-care or grooming – things like going to the gym on a regular basis to try to improve your body composition, or using various skincare products to try to improve your skin texture,” the surgeon said.
Softmaxxing techniques – which can also include teeth whitening, beard grooming, or upgrading a wardrobe or hairstyle – are not usually a problem, according to Hadeed. Hardmaxxing, which involves more extreme measures, can have riskier consequences.
“Even minimally invasive treatments carry real risks if performed incorrectly or by an untrained provider.”
Some individuals in the looksmaxxing online community do things like “bone smashing,” Hadeed said.
“[It’s] literally what it sounds like, where you smash the bones to change the facial structure, and that is obviously not recommended because it can lead to potential complications,” he warned.
“Once you cross that line and start getting into more extreme things, I feel like that’s where most plastic surgeons should draw the line.”
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Dr. C. Bob Basu, president of the American Society of Plastic Surgeons, said the biggest safety risks with the looksmaxxing trend come from pursuing treatments without proper medical guidance.
Looksmaxxing can be divided into two categories: “softmaxxing” and “hardmaxxing.” Softmaxxing is a more simple, non-invasive simple approach to improving one’s looks. (iStock)
“Social media can make procedures seem easy or risk-free, but even minimally invasive treatments carry real risks if performed incorrectly or by an untrained provider,” the Houston-based plastic surgeon told Fox News Digital.
To achieve quality results, it is critical to be treated by a board-certified plastic surgeon who understands both safety and anatomy, Basu advised.
What’s driving the trend?
The convergence of social media, constant digital visibility and “unprecedented access to aesthetic treatments” – along with a cultural shift toward optimizing wellness and longevity – are fueling the looksmaxxing trend, according to Basu.
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Hadeed agreed, noting that social media puts pressure on individuals to look perfect.
“People are constantly comparing themselves to other people online,” he told Fox News Digital. “It can quickly develop into body dysmorphia for a lot of people, and that’s when they start pursuing more and more procedures that they don’t need by any stretch – it’s kind of like keeping up with the Joneses.”
Both plastic surgeons emphasized the importance of taking a responsible approach when considering the looksmaxxing trend. (iStock)
Dr. Nancy Frye, a professor in the psychology department at Long Island University in Brookville, New York, also weighed in on what’s driving the looksmaxxing craze.
“We figure out how attractive we might be by comparing what we see in ourselves to what we see in others,” she told Fox News Digital. “This social comparison is especially problematic with social media and filters, as people compare themselves to filtered versions of others.”
Healthier approach
While experts warn of the risks of looksmaxxing, they say a thoughtful approach can have some benefits, including pride in one’s appearance and health.
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The most tangible benefits are associated with the softmaxxing approach, which includes following a fitness routine, eating a clean diet and following regular skin care routines, according to Hadeed.
“The goal should always be thoughtful self-improvement, not perfection.”
With healthy guidance, aesthetic care can “enhance confidence and self-esteem, helping patients feel more aligned with their sense of self,” Basu added.
Both plastic surgeons emphasized the importance of taking a responsible approach when considering the looksmaxxing trend.
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“The goal should always be thoughtful self-improvement, not perfection,” Basu said. “It should never be about looking like someone else or a filtered version of yourself, but rather about becoming a confident, natural and authentic version of you.”
Anyone considering this trend should consult a licensed healthcare professional rather than relying on advice from social media influencers, the doctors advised.
Health
Peptides may soon be easier to get amid RFK Jr’s push, but experts warn of risks
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The Food and Drug Administration (FDA) will reportedly weigh easing restrictions on peptides in anticipated talks.
The meeting, which is expected to be held in July, will discuss relaxing limits on more than a half dozen peptide injections.
Peptides are short chains of amino acids — the building blocks of proteins — that play key roles in biological functions, according to the National Institutes of Health. Peptide drugs are lab-made versions of natural molecules in the body that are designed to mimic or influence biological signals to treat disease, experts say.
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In a federal notice released Wednesday, the FDA identified these drugs — used for conditions ranging from insomnia to obesity — for potential inclusion on a list of substances that can be safely compounded by pharmacies.
Human Services Secretary Robert F. Kennedy Jr. does pull-ups during a conference at Ronald Reagan Washington National Airport in Arlington, Va., on Dec. 8, 2025, discussing the launch of the “Make Travel Family Friendly Again” campaign. (Heather Diehl/Getty Images)
This follows Health and Human Services Secretary Robert F. Kennedy Jr.’s push to deregulate peptides, which he’s spoken about publicly, although most peptides have not been reviewed for safety by the FDA.
Kennedy has discussed using the substances for personal injuries. In a recent interview on “The Joe Rogan Experience” podcast, he stated that he’s a “big fan of peptides.”
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The HHS secretary mentioned that he’s “very anxious” to making some peptides “more accessible.”
“My hope is that they will get moved to a place where people have access from ethical suppliers,” Kennedy said, alluding to the FDA taking action.
What to know about peptides
Peptides have gained popularity among wellness influencers and fitness gurus as a means of building muscle, healing injuries or appearing younger, the AP reported.
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Peptides act like a signal to hormones and the human body. Similar to how GLP-1s (glucagon-like peptide-1 agonists), such as Ozempic, suppress appetite and trigger weight loss, peptides can signal other functions, like the release of growth hormones.
Peptides have gained popularity for outcomes like building muscle, healing injuries or appearing younger, the AP reported. (iStock)
Certain peptides up for review by the FDA, like BPC-157, are marketed for tendon healing, gut healing (in cases like ulcerative colitis), injury recovery and inflammation reduction, although the FDA has warned about the risk of unapproved peptide treatments.
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The FDA wrote in a February advisory that “compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug.”
“Patients should obtain a prescription from their doctor and fill the prescription at a state-licensed pharmacy,” the agency wrote.
The FDA wrote in a February advisory that “compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug.” (Sarah Silbiger/Getty Images)
The current peptide market has been referred to as the “Wild West” due to lack of regulation. In an interview with AP, Dr. Peter Lurie, a former FDA official who now leads the Center for Science in the Public Interest in Washington, D.C., commented that “the Wild West is about to become wilder.”
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“I don’t see why one would take the path of proper drug approval if there is now this less rigorous, alternative path to market,” he said.
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Under the Biden administration, the FDA added nearly 20 peptides to a list of substances that should not be produced by compounding pharmacies, according to the AP.
The panel of pharmacy advisers at the time noted that the peptides did not meet criteria for safety.
Health
This could be why your weight-loss medication isn’t delivering results
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The skyrocketing popularity of GLP-1 receptor agonists has transformed the weight-loss industry, but not all shots are created equal in terms of how they work.
A study published in Nature investigated how genes affect the success of modern weight-loss drugs — specifically, GLP-1s like semaglutide and tirzepatide.
In analyzing genetic data and self-reported weight loss from over 27,000 users, researchers pinpointed a specific variation in the GLP-1 receptor gene (GLP1R) that acts as a “booster” for the drug’s effectiveness.
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Individuals carrying one copy of this variant lost an average of 1.6 pounds more than those without it, according to the findings.
This suggests that genetic testing could eventually help doctors steer sensitive patients toward medications they are more likely to tolerate.
Individuals carrying one copy of a specific genetic variant lost an average of 1.6 pounds more than those without it. (iStock)
“We believe these reports are a step forward in meeting an unmet need for a more informed and personalized approach to weight management,” said study co-author Noura Abul-Husn, chief medical officer at the 23andMe Research Institute in California, in a press release.
While this genetic “boost” is measurable, it remains relatively modest when compared to the total average weight loss of 24 pounds observed across the study population, the researchers noted.
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Beyond genetics, other factors such as age, sex and specific medications remain much stronger predictors of success.
For instance, the study found that women generally saw a higher body mass index (BMI) reduction (12.2%) compared to men (10.0%).
Traditional factors such as age, sex and specific medications remain much stronger predictors of success. (iStock)
The study may also reveal why certain patients experience stomach issues. Scientists identified a different genetic variant that was linked to increased reports of nausea and vomiting.
The presence of this side effect did not impact the drug’s effectiveness, however. Patients with variants in the GLP1R and GIPR genes lost just as much weight as those without it; they simply felt more sick during the process, the study found.
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“GLP-1 treatment decisions are complex, and having access to clinical expertise to help contextualize your genetic results alongside your full health picture is exactly the kind of guidance this report is designed to support,” said Abul-Husn.
Patients with the variant lost just as much weight as those without it; they simply felt more sick during the process, the study found. (iStock)
Dr. Peter Balazs, MD, a hormone and weight-loss specialist serving the New York and New Jersey area, was not involved in the study but reiterated the role of the genetic variants in treatment response and side effects.
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“Notably, there appears to be a drug-specific effect: The GIPR variant associated with these side effects is observed with tirzepatide, but not with semaglutide,” he told Fox News Digital.
Balazs said he was surprised by the extremely wide nausea risk range (5%–78%). “Additionally, the drug-specific genetic dissociation was unexpected,” he added.
Study limitations
The data relied on participants reporting their own weight, which could be subject to bias.
“The data is self-reported and not medically verified, which may affect its reliability firstly,” Balazs told Fox News Digital. “It also does not account for key treatment variables, such as titration, discontinuation or dosing schedules.”
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The 23andMe participant pool may not reflect a diverse, real-world population, he added.
“The study also lacks data on important clinical endpoints, such as diabetes progression, and severe adverse effects, such as gastroparesis or pancreatitis,” Balazs pointed out. “Many of its findings also have not been supported by more clinically and statistically robust studies.”
Patients with the variant lost just as much weight as those without it; they simply felt more sick during the process, the study found. (iStock)
For example, a sub-study comparing these reports to objective iPhone health data suggested that participants might over-report their progress. While users reported an 11.8% loss, electronic data in that subset showed a 5.8% loss.
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As an observational study rather than a controlled clinical trial, it could not definitively prove that the genetic variants caused the difference in weight loss, only that they are associated with it, the researchers noted.
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“I think this article is interesting, raising the possibility of genetic factors, and the use of genetic testing incorporated into further decision-making when picking weight-loss medications,” Balazs said. “However, I would be careful to draw conclusions solely based on this study.”
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