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Many Older People Embrace Vaccines. Research Is Proving Them Right.

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Many Older People Embrace Vaccines. Research Is Proving Them Right.

Kim Beckham, an insurance agent in Victoria, Texas, had seen friends suffer so badly from shingles that she wanted to receive the first approved shingles vaccine as soon as it became available, even if she had to pay for it out of pocket.

Her doctor and several pharmacies turned her down because she was below the recommended age at the time, which was 60. So in 2016, she celebrated her 60th birthday at her local CVS.

“I was there when they opened,” Ms. Beckham recalled. After her Zostavax shot, she said, “I felt really relieved.” She has since received the newer, more effective shingles vaccine, as well as the pneumonia shot, the R.S.V. vaccine, annual flu shots and all recommended Covid vaccinations.

Some older people are really eager to be vaccinated.

Robin Wolaner, 71, a retired publisher in Sausalito, Calif., has been known to badger friends who delay getting recommended shots, sending them relevant medical studies. “I’m sort of hectoring,” she acknowledged.

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Deana Hendrickson, 66, who provides daily care for three young grandsons in Los Angeles, sought an additional M.M.R. shot, though she was vaccinated as a child, in case her immunity to measles was waning.

For older adults who express more confidence in vaccine safety than younger groups, the past few months have brought some welcome research. Studies have found important benefits from a newer vaccine and enhanced versions of older ones, and one vaccine may confer a major bonus that nobody had foreseen.

The new studies are coming at a fraught political moment. The nation’s health secretary, Robert F. Kennedy Jr., has long disparaged certain vaccines, calling them unsafe and saying that the government officials who regulate them are compromised and corrupt.

This week, the secretary fired a panel of scientific advisers to the Centers for Disease Control and Prevention, replacing them with some who have been skeptical of vaccines. But so far, Mr. Kennedy has not tried to curb access to the shots for older Americans.

The evidence that vaccines are beneficial remains overwhelming.

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The phrase “Vaccines are not just for kids anymore” has become a favorite for Dr. William Schaffner, an infectious disease specialist at Vanderbilt University Medical Center.

“The population over 65, which often suffers the worst impact of respiratory viruses and others, now has the benefit of vaccines that can prevent much of that serious illness,” he said.

Take influenza, which annually sends from 140,000 to 710,000 older people to hospitals and is fatal in 10 percent of them.

For about 15 years, the C.D.C. has approved several enhanced flu vaccines for people over 65. More effective than the standard formulation, they either contain higher levels of the antigen that builds protection against the virus or incorporate an adjuvant that creates a stronger immune response. Or they’re recombinant vaccines, developed through a different method, with higher antigen levels.

In a meta-analysis in the Journal of the American Geriatrics Society, “all the enhanced vaccine products were superior to the standard dose for preventing hospitalizations,” said Rebecca Morgan, a health research methodologist at Case Western Reserve University and an author of the study.

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Compared with the standard flu shot, the enhanced vaccines reduced the risk of hospitalization from the flu by 11 to 18 percent in older adults. The C.D.C. advises adults over 65 to receive the enhanced vaccines, as many already do.

More good news: Vaccines to prevent respiratory syncytial virus (R.S.V.) in people over 60 are performing admirably.

R.S.V. is the most common cause of hospitalization for infants, and it also poses significant risks to older people. “Season in and season out,” Dr. Schaffner said, “it produces outbreaks of serious respiratory illness that rivals influenza.”

Because the Food and Drug Administration first approved an R.S.V. vaccine in 2023, the 2023-24 season provided “the first opportunity to see it in a real-world context,” said Dr. Pauline Terebuh, an epidemiologist at Case Western Reserve School of Medicine and an author of a recent study in the journal JAMA Network Open.

In analyzing electronic health records for almost 800,000 patients, the researchers found the vaccines to be 75 percent effective against acute infection, meaning illness that was serious enough to send a patient to a health care provider.

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The vaccines were 75 percent effective in preventing emergency room or urgent care visits, and 75 percent effective against hospitalization, both among those aged 60 to 74 and those older.

Immunocompromised patients, despite having a somewhat lower level of protection from the vaccine, will also benefit from it, Dr. Terebuh said. As for adverse effects, the study found a very low risk for Guillain-Barré syndrome, a rare condition that causes muscle weakness and that typically follows an infection, in about 11 cases per one million doses of vaccine. That, she said, “shouldn’t dissuade people.”

The C.D.C. now recommends R.S.V. vaccination for people 75 and older, and for those 60 to 74 if they’re at higher risk of severe illness (from heart disease, say).

As data from the 2024-25 season becomes available, researchers hope to determine if the vaccine will remain a one-and-done, or whether immunity will require repeated vaccination.

People over 65 express the greatest confidence in vaccine safety of any adult group, a KFF survey found in April. More than 80 percent said they were “very “or “somewhat confident” about M.M.R., shingles, pneumonia and flu shots.

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Although the Covid vaccine drew lower support among all adults, more than two-thirds of older adults expressed confidence in its safety.

Even skeptics might become excited about one possible benefit of the shingles vaccine: This spring, Stanford researchers reported that over seven years, vaccination against shingles reduced the risk of dementia by 20 percent, a finding that made headlines.

Biases often undermine observational studies that compare vaccinated with unvaccinated groups. “People who are healthier and more health-motivated are the ones who get vaccinated,” said Dr. Pascal Geldsetzer, an epidemiologist at the Knight Initiative for Brain Resilience at Stanford and lead author of the study.

“It’s hard to know whether this is cause and effect,” he said, “or whether they’re less likely to develop dementia anyway.”

So the Stanford team took advantage of a “natural experiment” when the first shingles vaccine, Zostavax, was introduced in Wales. Health officials set a strict age cutoff: People who turned 80 on or before Sept. 1, 2013, weren’t eligible for vaccination, but those even slightly younger were eligible.

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In the sample of nearly 300,000 adults whose birthdays fell close to either side of that date, almost half of the eligible group received the vaccine, but virtually nobody in the older group did.

“Just as in a randomized trial, these comparison groups should be similar in every way,” Dr. Geldsetzer explained. A substantial reduction in dementia diagnoses in the vaccine-eligible group, with a much stronger protective effect in women, therefore constitutes “more powerful and convincing evidence,” he said.

The team also found reduced rates of dementia after shingles vaccine was introduced in Australia and other countries. “We keep seeing this in one data set after another,” Dr. Geldsetzer said.

In the United States, where a more potent vaccine, Shingrix, became available in 2017 and supplanted Zostavax, Oxford investigators found an even stronger effect.

By matching almost 104,000 older Americans who received a first dose of the new vaccine (full immunization requires two) with a group that had received the earlier formulation, they found delayed onset of dementia in the Shingrix group.

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How a shingles vaccine might reduce dementia remains unexplained. Scientists have suggested that viruses themselves may contribute to dementia, so suppressing them could protect the brain. Perhaps the vaccine revs up the immune system in general or affects inflammation.

“I don’t think anybody knows,” said Dr. Paul Harrison, a psychiatrist at Oxford and a senior author of the study. But, he added, “I’m now convinced there’s something real here.”

Shingrix, now recommended for adults over 50, is 90 percent effective in preventing shingles and the lingering nerve pain that can result. In 2021, however, only 41 percent of older Americans had received one dose of either shingles vaccine.

A connection to dementia will require further research, and Dr. Geldsetzer is trying to raise philanthropic funding for a clinical trial.

And “if you needed another reason to get this vaccine,” Dr. Schaffner said, “here it is.”

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How One Woman Lost Half Her Body Fat In 60 Days With One Simple Water Trick

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Not all fiber is created equal — doctors share which kinds truly support longevity

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Not all fiber is created equal — doctors share which kinds truly support longevity

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Fiber is known to be a crucial part of a healthy diet, promoting fullness and gut health.

As trends like “fibermaxxing” make high-fiber eating more popular, understanding the best sources is increasingly important for individual health, according to nutritionists.

Longevity expert Peter Attia, a Stanford University physician based in Austin, Texas, spoke about how fiber aligns with a healthier lifestyle in a sneak peek of his newest “Ask Me Anything” episode of “The Peter Attia Drive” podcast.

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People who engage in a beneficial habit, such as eating a high-fiber diet, tend to do “many other healthy things,” according to the doctor.

“They might be exercising more, they’re much less likely to smoke, they’re probably getting more sleep,” he said. “You are very likely to be capturing other healthy habits when you’re trying to simply measure one thing.”

As trends like “fibermaxxing” make high-fiber eating more popular, understanding the best sources of fiber is increasingly important for individual health, according to nutritionists. (iStock)

For this reason, it can be difficult to “disentangle” fiber’s specific effects, Attia said, since people who eat more fiber also tend to consume other beneficial plant nutrients and make generally healthier lifestyle choices.

Different types of fiber

Different types of fiber are known to function differently in the body, according to Attia.

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“There are lots of things that are classified as fiber, [and] a wide range of physical properties that a particular fiber might have, but these different properties produce different effects on the body,” he said.

“Some fibers provide primarily microbiome support because they’re actually fermented by gut microbiomes. Some fibers can improve blood sugar … and others simply bulk up stool.”

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Soluble fiber dissolves in water, while insoluble fiber does not — and each type plays a different role in digestion.

Insoluble fiber includes vegetables, the skin of fruits, whole grains and bran, according to Attia. It will remain “largely intact” as it moves through the digestive system, adding stool bulk, reducing constipation and supporting regular bowel movements.

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Insoluble fibers are not fermented by gut bacteria, but they stimulate the gut lining to release water and mucus, which “dilutes toxins in the colon” and speeds up “intestinal transit,” the doctor said.

Vegetables typically contain more fiber than other options, according to the doctor. (iStock)

Most soluble, or viscous, fiber can absorb water and create a gel in the gut, which can lead to slower gastric emptying, reduce blood sugar spikes and potentially lower cholesterol levels, according to Attia.

Some examples of soluble fiber include pectin (found in fruits), beta-glucan (found in whole oats) and psyllium husk, which is a plant most often consumed as a supplement.

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Some soluble fibers belong to a subgroup called fermentable, or prebiotic, fibers. These fibers are broken down by gut bacteria to produce short-chain fatty acids (SCFAs) — compounds such as butyrate that help support gut health, regulate pH, improve metabolism and reduce inflammation, according to various studies.

“My mantra is ‘baby steps’ whenever I introduce fiber … a little at a time goes a long way.”

Fermentable fibers are found in foods like beans, pectin and inulin, as well as in prebiotic sources such as onions, garlic, asparagus and chicory root. They’re also present in certain resistant starches, including green bananas, legumes, and cooked, starchy foods like potatoes, rice and pasta.

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Resistant starches, while fermentable, are not soluble, Attia noted. They are categorized into several types:

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  • RS1: Found in whole grains, seeds and legumes
  • RS2: Found in raw potato starch, unripe bananas and maize (corn) starch (commonly used in fiber supplements)

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In most diets, a mix of fiber types is consumed. Plant-based foods — especially those with skins, along with oats, beans and legumes — tend to be the richest sources, Attia shared.

Beans don’t contain any single comitant fiber, but are high in fiber overall, said Attia.  (iStock)

Benefits of high-fiber diets

Some key benefits of a high-fiber diet include satiety and weight management, glycemic control, cardiovascular health and colorectal cancer prevention, Attia said. 

Robin DeCicco, a certified holistic nutritionist in New York, shared with Fox News Digital in a previous interview that increasing fiber intake can be “quite beneficial.”

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“Everything from gastrointestinal health to cardiovascular health, weight management, prevention of diabetes and certain cancers, to feeling fuller throughout the day and minimizing cravings for sugars and starches, are all major benefits of fiber intake,” she said.

“Not all fibers do the same things, and they don’t all do them equally well,” the doctor said. (iStock)

As health is individualized, DeCicco warned that those with pre-existing gastrointestinal conditions could experience complications by introducing too much fiber at once.

“If your system is not used to fiber, and you start to overload, you can easily become bloated, get cramps and have constipation,” she said.

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It’s “easier on the stomach” to spread it out, since fiber can bulk up in the stomach and cause a back-up, according to DeCicco.

“This is why it’s especially important to incorporate fiber slowly,” she said. “My mantra is ‘baby steps’ whenever I introduce fiber to any client. A little at a time goes a long way toward long-term health.”

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What Contrave Weight-Loss Medication Really Does for Women

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