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Major cannabis study finds little proof for popular medical claims, flags big dangers

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Major cannabis study finds little proof for popular medical claims, flags big dangers

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Cannabis has been linked to some significant medical benefits, but recent research calls those into question.

A major new analysis published in JAMA examined more than 2,500 scientific papers from the last 15 years, including other reviews, clinical trials and guidelines focused on medical marijuana.

“While many people turn to cannabis seeking relief, our review highlights significant gaps between public perception and scientific evidence regarding its effectiveness for most medical conditions,” Dr. Michael Hsu of University of California – Los Angeles (UCLA) Health Sciences, author of the study, said in a press release.

Many medical claims about cannabis are not supported by strong scientific evidence, according to a comprehensive review published in JAMA. (iStock)

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The researchers led by UCLA with contributions from Harvard, UC San Francisco, Washington University School of Medicine and New York University set out to determine how strong the research is on the effectiveness of medical cannabis and to offer evidence-based clinical guidance.

MYSTERIOUS MARIJUANA-LINKED VOMITING DISORDER GETS OFFICIAL WHO CODE AS ER CASES JUMP

The review found that evidence supporting most medical uses of cannabis or cannabinoids is limited or insufficient, the release stated.

“Whenever a substance is widely used, there is likely to be a very wide set of outcomes,” Alex Dimitriu, MD, double board-certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine, told Fox News Digital. 

“Cannabis is now used by about 15 to 25% of U.S. adults in the past year, for various reasons ranging from recreational to medicinal. This study points to the reality that this widely used substance is not a panacea,” said Dimitriu, who was not involved in the study.

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There are very few conditions for which cannabinoid therapies have clear, well-established benefits backed by high-quality clinical data, according to the researchers.

HEAVY DRINKERS CUT ALCOHOL USE BY NEARLY 30% AFTER ADOPTING ONE NEW HABIT, STUDY FINDS

The strongest evidence supports FDA-approved cannabinoid medications for treating specific conditions, including HIV/AIDS-related appetite loss, chemotherapy-induced nausea and vomiting, and certain severe pediatric seizure disorders.

The review identified significant safety concerns, with high-potency cannabis use among young people linked to higher rates of mental health issues. (iStock)

For many other conditions that are commonly treated with cannabis — such as chronic pain, insomnia, anxiety or post-traumatic stress disorder — evidence from randomized trials did not support meaningful benefit.

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The analysis also examined safety concerns — in particular, how young people using high-potency cannabis may be more likely to suffer higher rates of psychotic symptoms and anxiety disorder.

Daily inhaled cannabis use was also linked to increased risks of coronary heart disease, myocardial infarction (heart attack) and stroke when compared with non-daily use.

Daily inhaled cannabis use is associated with increased cardiovascular risks, including coronary heart disease, heart attack and stroke. (iStock)

Based on these findings, the review emphasizes that clinicians should weigh potential benefits against known risks when discussing cannabis with patients.

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The authors suggest that clinicians screen patients for cardiovascular risk, evaluate mental health history, check for possible drug interactions and consider conditions where risks may outweigh benefits.

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They recommend open, realistic conversations and caution against assuming that cannabis is broadly effective for medical conditions.

The review highlights the need for caution, urging clinicians to weigh risks, screen patients appropriately and avoid assuming cannabis is broadly effective. (iStock)

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“Patients deserve honest conversations about what the science does and doesn’t tell us about medical cannabis,” Hsu said.

This article is a narrative review rather than a systematic review, so it did not use the strict, standardized methods that help reduce bias in how studies are selected and evaluated, the researchers noted.

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The review notes further limitations, including that some evidence comes from observational research rather than randomized trials, which means it cannot establish cause and effect.

The trial results also may not apply to all populations, products or doses.

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Detransitioner Chloe Cole shares complications after gender procedures: ‘I am grieving’

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Detransitioner Chloe Cole shares complications after gender procedures: ‘I am grieving’

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Medical victim Chloe Cole was at the center of the U.S. Department of Health and Human Services’ Thursday announcement of proposed regulatory actions to end “sex-rejecting procedures” on minors.

The proposed regulatory actions by the HHS are part of President Donald Trump‘s January executive order calling on the department to protect children from “chemical and surgical mutilation.”

The department is rolling out a series of policy updates and regulatory actions that would effectively defund hospitals that provide gender transition procedures, according to an HHS official. 

NUMBER OF YOUNG ADULTS IDENTIFYING AS TRANSGENDER PLUNGES BY NEARLY HALF IN TWO YEARS

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Cole, now 21 years old, went through the process of medical transition from female to male between the ages of 12 and 16.

The California native took to the stage alongside HHS Secretary Robert F. Kennedy Jr. and other officials Thursday to advocate for the protection of children. Afterward, she told Fox News Digital the puberty blockers, testosterone injections and double mastectomy she endured have irreversibly and permanently affected her health.

Detransitioner Chloe Cole joined HHS Secretary Robert F. Kennedy Jr. on Thursday as he announced proposed regulations ending gender treatments for children. (Fox News Digital)

“As soon as gender was in the picture, none of my doctors or psychologists asked the real questions that they should have,” said Cole. “The entire focus was on my feelings and what I wanted rather than what I really needed in that moment.”

What she needed, Cole said, was to be loved and affirmed for the way God created her — “as a young and yet tomboyish little girl.”

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She maintained that her doctors neglected to share risks, only touting the “benefits” of stopping female puberty and using testosterone to promote body hair growth, musculature and different fat distribution.

“There was nothing they could say to me that would make me understand the gravity of what I was about to go through, because I was still growing up,” said Cole. “I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way.”

“I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way,” Cole, pictured above in both pictures, told Fox News Digital. (Chloe Cole; Fox News Digital)

Cole noted that her parents never thought she was transgender, but felt like the odds were stacked against them.

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“At the time when we started going through this as a family, there really were no resources that would speak to the reality of transgenderism, especially for children,” she said. “Most people were not aware then that this was something that was even happening in our hospital systems.”

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Cole said her parents were warned that if they did not allow her to transition, she would likely commit suicide. 

“My legal guardians were forced to make this decision under duress,” she shared in a previous statement. “But even if my parents had supported transitioning medically from the start, no parent or any adult, ultimately, has a right to determine whether a child gets to be chemically sterilized or mutilated.”

“While there are only two sexes, there’s a million different ways that you can be yourself,” said Cole, pictured above during her surgeries.  (Chloe Cole)

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Cole said she’s suffered numerous complications from her medications and surgery. “My quality of life is still being impacted to this day,” she wrote in her statement.

Her fertility status now remains unknown, she said. She will not be able to breastfeed because her breasts were surgically removed.

“As an adult, I am now grieving, and on top of that, the areolar skin grafts they used in my surgery began to fail two years afterward. I must wear bandages on my chest every day,” Cole wrote. 

“As an adult, I am now grieving.”

In 2023, Cole filed a lawsuit with the Center for American Liberty (CAL) against hospitals for pushing her into what she believes is medical mutilation.

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Mark Trammell of CAL told Fox News Digital that Thursday’s HHS announcement “represents a critical acknowledgment that experimental medical interventions on children with gender distress have failed to meet basic standards of safety and effectiveness.”

Cole, who detransitioned after medical procedures, is warning others to wait and seek family support before transitioning. (Fox News Digital)

“It signals that medicine must return to its core ethical obligation: First, do no harm,” Trammell added. 

“We will continue fighting to ensure accountability for the institutions that promoted these practices and to secure justice for the children and detransitioners whose lives were forever altered.”

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In a previous statement provided to Fox News Digital, Dr. Marc Siegel, Fox News senior medical analyst, said he is in favor of a “more conservative approach” for minors.

“Long-term effects of puberty blockers may include bone loss, trouble concentrating, interference with learning and interference with fertility,” he said. “I think it makes sense in most cases to treat underlying mental health concerns before jumping into treatments, including surgery, that may be difficult to reverse.”

“It makes sense in most cases to treat underlying mental health concerns before jumping into treatments.”

The doctor also emphasized that gender issues should not be overly politicized. “This means not superimposing an ideology or pushing physicians to act in a certain way or under pressure,” Siegel said. 

Cole began the gender transition process at age 12 and received a double mastectomy surgery at 15 years old. (Fox News Digital)

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“The welfare of the child must come first. In this case, it means going very slowly and providing support to a child or teen with gender dysphoria.”

Cole shared that she hopes any children who are questioning whether they should transition wait. 

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While there are only two sexes, there are a million different ways that you can be yourself,” she added.

“God is there for you. He is the one who has created you this way, and you can seek his counsel,” Cole went on. 

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“You can continue praying, and I think ultimately it’s connecting with your family, building your purpose in this world, and looking to the gospel and up to God.”

Fox News Digital’s Emma Colton contributed reporting.

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Simple lifestyle changes could slash heart attack risk for millions, scientists report

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Simple lifestyle changes could slash heart attack risk for millions, scientists report

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Those at risk of type 2 diabetes may be able to prevent heart problems later.

A new study published in The Lancet Diabetes & Endocrinology discovered that lowering the blood sugar of those with prediabetes could reduce the risk of heart attack by half.

Diabetes researchers and endocrine experts across Europe, China and the U.S. investigated how bringing blood sugar back to normal levels affected the chances of heart problems later in life, based on a 20-year American study and a 30-year Chinese study, according to a press release.

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In both studies, the prediabetic participants were coached to make appropriate lifestyle changes to lower blood sugar (the amount of glucose in the bloodstream) through diet and exercise, also targeting weight loss.

Participants worked to lower blood sugar through diet and exercise targeted at weight loss. (iStock)

The researchers split the participants into a remission group (where blood sugar returned to normal) and a non-remission group, which included those still in the prediabetes range. They then determined who in these groups had died from heart disease or were hospitalized for heart failure.

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Participants who went into remission had a 58% lower risk of dying from heart disease and being hospitalized for heart failure. This group also had a lower risk of other major heart events and lower overall death rates.

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These heart-protective benefits lasted for decades after the program ended, the researchers found.

Those in prediabetes remission had their risk of a heart event reduced by more than half. (iStock)

“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented in the publication of the study. “Targeting remission might represent a new approach to cardiovascular prevention.”

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In an interview with Fox News Digital, Dr. Andreas Birkenfeld, study co-author and professor of medicine at the University Hospital Tübingen in Germany, reiterated that reaching prediabetes remission is not only relevant for reducing the progression of type 2 diabetes, but may also be associated with a “meaningful reduction in… heart attack risk, cardiac death and heart failure.” 

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“Importantly, this underscores that prediabetes is a modifiable stage where timely, evidence-based interventions (especially lifestyle measures, and in selected cases, medication) can make a real difference,” he added.

“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented. (iStock)

The study did have some limitations, including that it is based on analysis of trials not originally designed to measure cardiovascular outcomes, which means the results show association but cannot prove causation.

In addition, unmeasured lifestyle and health factors, population differences and lack of randomization for heart outcomes may have influenced the reduced cardiovascular risk, the researchers acknowledged.

“This underscores that prediabetes is a modifiable stage where timely, evidence-based interventions … can make a real difference.”

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Birkenfeld suggested that those with prediabetes should ask their doctors the following questions: “What is my current status? What is my personal cardiovascular risk? What is my target blood glucose level?”

Patients should also inquire about the frequency of testing for blood sugar and key risk factors like blood pressure, cholesterol and other related conditions, such as kidney function or sleep apnea, he advised.

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“If lifestyle changes aren’t enough or my risk is high, would medication be appropriate for me — and what are the benefits and downsides?” the researcher asked as an example.

About 98 million American adults, more than one in three, have prediabetes, according to CDC data. Eight in 10 of these adults are unaware that they have the disease.

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New Weight Loss Drug Beats Ozempic and Eases Joint Pain With ‘Insane’ Results, Doctors Say

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New Weight Loss Drug Beats Ozempic and Eases Joint Pain With ‘Insane’ Results, Doctors Say


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‘Triple G’ Retatrutide Shows ‘Insane’ Results on Weight Loss, Knee Pain | Woman’s World




















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