Health
Lurking dementia risk exposed by breakthrough test 25 years before symptoms
Study finds link between obesity and vascular dementia
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A new blood test could determine a woman’s dementia risk as early as 25 years before symptoms emerge.
That’s according to new research from the University of California San Diego, which found that a specific biomarker protein associated with early pathological processes of Alzheimer’s disease was “strongly linked” to future dementia risk.
The researchers analyzed blood samples from 2,766 participants in the Women’s Health Initiative Memory Study in the late 1990s, according to the study’s press release.
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The women ranged from 65 to 79 years of age and showed no signs of cognitive decline at the start of the study.
After tracking the participants for up to 25 years, the researchers concluded that the biomarker phosphorylated tau 217 (p-tau217) was “strongly associated” with future mild cognitive impairment and dementia.
A new blood test could determine a woman’s dementia risk as early as 25 years before symptoms emerge. (iStock)
Women who had higher levels of p-tau217 at the beginning of the study were “much more likely” to develop the disease. The findings were published today in JAMA Network Open.
“The key takeaway is that our study suggests it may be possible to detect risk of dementia two decades in advance using a simple blood test in older women,” first author Aladdin H. Shadyab, a UC San Diego associate professor of public health and medicine, told Fox News Digital.
“These biomarkers may help us identify who is at greatest risk and develop strategies to delay or prevent dementia.”
“Our findings show that the blood biomarker p-tau217 could help identify individuals at higher risk for dementia long before symptoms begin,” he added.
This long lead time could open the door to earlier prevention strategies and more targeted monitoring, rather than waiting until memory problems are already affecting daily life, according to Shadyab.
A specific biomarker protein associated with early pathological processes of Alzheimer’s disease was “strongly linked” to future dementia risk. (iStock)
“As the research advances, these biomarkers may help us identify who is at greatest risk and develop strategies to delay or prevent dementia,” he said.
This risk relationship wasn’t the same across the board, however. Women over 70 with higher p-tau217 levels had “poorer cognitive outcomes” compared to those under 70, as did those with the APOE ε4 gene, which is a known risk factor for Alzheimer’s disease.
The study also found that p-tau217 was a stronger predictor of dementia in women who were randomly assigned to receive estrogen and progestin hormone therapy compared to those who received a placebo.
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“Blood-based biomarkers like p-tau217 are especially promising because they are far less invasive and potentially more accessible than brain imaging or spinal fluid tests,” said senior author Linda K. McEvoy, senior investigator at Kaiser Permanente Washington Health Research Institute and professor emeritus at the Herbert Wertheim School of Public Health, in the release.
“Blood-based biomarkers like p-tau217 are especially promising because they are far less invasive and potentially more accessible than brain imaging or spinal fluid tests,” a researcher said. (iStock)
“This is important for accelerating research into the factors that affect the risk of dementia and for evaluating strategies that may reduce risk.”
Blood tests for Alzheimer’s disease are still being studied and are not recommended for routine screening in people without symptoms, Shadyab noted.
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More research is needed before this approach can be considered for clinical use prior to cognitive symptoms.
Future studies should investigate how other factors — like genetics, hormone therapy and age-related medical conditions — might interact with plasma p-tau217, the researchers added.
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“The study examined only older women, so the findings may not necessarily apply to men or younger populations,” Shadyab noted. “We also examined overall dementia outcomes rather than specific subtypes such as Alzheimer’s disease.”
Health
At least 46 children dead amid measles outbreak as virus spreads globally
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Public health officials are warning of measles exposure as the disease spreads on a global scale.
At least 46 children have died in Bangladesh, with about 684 measles cases confirmed in the country since late January, according to Reuters.
Government officials recently announced deaths linked to measles after laboratory testing of 33 samples.
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“Of the tested samples, 15 deaths have been directly linked to measles infection,” said Health Services Division Secretary Kamruzzaman Chowdhury in a statement.
Bangladesh has modified its vaccine schedule after health officials found a significant share of measles cases were occurring in infants younger than 9 months, who are not yet eligible for routine vaccination, according to local reports.
At least 46 children have died in Bangladesh, with about 684 measles cases confirmed in the country since late January. (MH Akash/Drik/Getty Images)
World Health Organization guidance recommends that children receive two doses of the measles, usually given at 9 months of age in countries where measles is common and at 12-15 months in other countries. The second dose should usually be administered at 15-18 months.
In the U.S., as of March 26, 1,575 confirmed measles cases had been reported by the Centers for Disease Control and Prevention.
There have been 16 new outbreaks reported this year, with 94% of confirmed cases deemed outbreak-associated, per the CDC.
As of March 26, 1,575 confirmed measles cases had been reported by the Center for Disease Control and Prevention in the U.S. (iStock)
The agency attributes the spike in measles activity to a trend of lower “herd immunity” in communities — meaning vaccination rates have fallen below the roughly 95% threshold needed to prevent outbreaks.
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“U.S. national MMR coverage among kindergartners has decreased and is now below the 95% coverage target,” the CDC states on its website.
World Health Organization guidance recommends that children should receive two doses of the measles vaccine, usually given at 9 months of age in countries where measles is common and 12-15 months in other countries. (iStock)
Measles symptoms include a high fever, cough, runny nose, watery and red eyes, and a rash that usually appears between three and five days after symptoms start, according to medical sources.
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The rash usually begins as flat red spots that appear on the face at the hairline and spread downward to the neck, torso, arms, legs and feet.
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The airborne virus can spread when someone coughs or sneezes. Measles is known to stay in the air for up to two hours after an infected person leaves the area.
Reuters contributed to this report.
Health
Ozempic Hair Loss? The Real Reason You’re Shedding and How To Fix It
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Health
Fatal drug combination sparks alert as ‘rhino tranq’ spreads across US
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Health and government officials are warning of a potential deadly substance in the illegal drug supply.
The Centers for Disease Control and Prevention (CDC) and the White House Office of National Drug Control Policy (ONDCP) issued a health advisory on Thursday about reports of medetomidine being detected in fentanyl.
Also known as “rhino tranq,” “mede” or “dex,” medetomidine is a veterinary sedative that causes severe, prolonged sedation. Classified as an alpha-2 agonist, it acts on the nervous system similar to other veterinary sedatives, like xylazine, and can cause life-threatening withdrawal symptoms.
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The advisory is based on surveillance data, including forensic drug testing, wastewater analysis, clinical case reports and overdose investigations.
In 2023, there were 247 incidences of medetomidine detected in drug samples, which rose to 2,616 in 2024 and 8,233 in 2025 – a more than 3,000% increase. Forensic drug reports showed that about 98% of medetomidine-positive samples also contained fentanyl.
Health and government officials are warning of a potential deadly substance in the illegal drug suppl (iStock)
The drug has been detected in at least 18 states and Washington, D.C., with a concentration in the Northeast and Midwest regions of the U.S., per the CDC alert.
Dr. Adam Scioli, chief medical officer of Caron Treatment Centers in Pennsylvania, said the alert highlights a “concerning and rapidly evolving development” in the illicit opioid supply.
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“Its co‑occurrence with fentanyl significantly complicates overdose presentation and withdrawal management, further increasing both clinical acuity and unpredictability,” he told Fox News Digital.
“Medetomidine is not routinely detected on standard toxicology screens, increasing the risk of under‑recognition without a high index of clinical suspicion.”
The drug has been detected in at least 18 states and Washington, DC, with a concentration in the Northeast and Midwest regions of the U.S. (iStock)
Naloxone (Narcan), known for its overdose reversal effects, does not counteract medetomidine, the advisory warned.
“While naloxone remains essential for reversing opioid‑induced respiratory depression, it does not address the sedative effects of medetomidine,” Scioli confirmed.
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The initial effects of the drug include deep sedation or decreased consciousness, bradycardia (slow heart rate), hypotension (low blood pressure) and respiratory depression, especially when combined with fentanyl and other opioids.
Withdrawal symptoms typically begin about a few hours after taking medetomidine. They can be severe and rapid, peaking at about 18-36 hours, according to experts.
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Initial withdrawal symptoms include rising blood pressure, tachycardia, agitation and nausea/vomiting, gradually leading to severe hypertension, altered mental status, and possible cardiac or neurologic complications, per the alert.
Severe cases require intensive care in a hospital. “Management may require ICU‑level monitoring and care,” said Scioli.
Naloxone (Narcan), known for its overdose reversal effects, does not counteract medetomidine, the advisory warned. (Reuters/Andrew Kelly)
In a May 2024 example cited by the CDC, medetomidine in the illegal opioid supply was linked to a cluster of overdoses in Chicago, potentially exceeding 175. At least 16 people were hospitalized and one died.
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There were some limitations to the surveillance, the agency acknowledged. Surveillance systems rely on small samples that may not be representative of all areas.
There is also the chance that the numbers could be overestimated due to contamination or repeated use of drug paraphernalia. Conversely, numbers could actually be higher than recorded, as medetomidine is rapidly metabolized in the body and is not typically tested in clinical settings.
An expert noted that the alert highlights the need for “careful assessment beyond standard opioid toxicity models,” as well as close coordination with toxicology, emergency medicine and public health partners. (iStock)
The surveillance was conducted by the CDC with support from federal public health programs and collaboration with other agencies.
Scioli noted that the alert highlights the need for “careful assessment beyond standard opioid toxicity models,” as well as close coordination with toxicology, emergency medicine and public health partners.
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“The drug supply is evolving in ways that strain traditional opioid‑focused frameworks and demand greater clinical vigilance,” he said.
“From a treatment perspective, this is another clear example of why addiction care must be adaptive, medically sophisticated, and grounded in whole‑person, long‑term recovery — not solely acute stabilization,” he added.
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