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Loss of smell could be warning sign for future Alzheimer’s disease, researchers say

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Loss of smell could be warning sign for future Alzheimer’s disease, researchers say

Loss of the sense of smell could be a warning sign of future Alzheimer’s disease, as a recent study published in Neurology, the medical journal of the American Academy of Neurology, noted.

Those who carry the APOE4 gene have a higher risk of both developing Alzheimer’s and of losing the ability to detect odors, the findings stated.

“Testing a person’s ability to detect odors may be a useful way to predict future problems with cognition,” said study author Matthew S. GoodSmith, M.D., of the University of Chicago, in the journal entry discussing the findings. 

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“While more research is needed to confirm these findings and determine what level of smell loss would predict future risk, these results could be promising, especially in studies aiming to identify people at risk for dementia early in the disease,” he also said. 

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In the study, more than 865 participants completed two home surveys, taken five years apart, that measured their ability to detect and identify odors. 

Loss of a sense of smell could be a warning sign of future Alzheimer’s disease, as a recent study published in Neurology, the medical journal of the American Academy of Neurology, revealed. (iStock)

At the same intervals, they also took skill tests to gauge their memory and cognitive function.

The participants also submitted DNA samples so the researchers could determine whether they carried the APOE4 gene.

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Those who had the gene variant were 37% less likely to detect odors than those who did not, the researchers found. 

Reduced sense of smell was first noticed between the ages of 65 and 69. 

That group also showed “more rapid declines in their thinking skills,” the study findings stated.

Man smelling coffee

“Testing a person’s ability to detect odors may be a useful way to predict future problems with cognition,” said the author of a new study.  (iStock)

“Identifying the mechanisms underlying these relationships will help us understand the role of smell in neurodegeneration,” GoodSmith said.

The study did not include people who had severe dementia.

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“These results could be promising, especially in studies aiming to identify people at risk for dementia early in the disease.”

Dr. Shailaja Shah, a geriatric psychiatrist at the Carrier Clinic, a behavioral health campus that is part of Hackensack Meridian Health in New Jersey, did not participate in the research but reviewed the findings.

“Olfaction, or the sense of smell, declines with normal aging,” she told Fox News Digital. 

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“However, to date, there are quite a few studies that indicate olfaction declines early on in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia, to name a few.”

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Alzheimer's patient

The most common type of dementia, Alzheimer’s disease affects more than six million people in the U.S., according to the Alzheimer’s Association. (iStock)

“We also know that pathological changes, including plaques and tangles, occur a few decades prior to clinical symptoms and signs of Alzheimer’s disease.”

Shah emphasized the need for a non-invasive test and biomarker to detect and diagnose Alzheimer’s disease in its early stages — as well as a clinical, easily available, inexpensive test to study the efficacy of drugs to treat dementia.

Although the APOE4 gene is a risk factor for developing Alzheimer’s disease, not all people with the gene will develop dementia.

“More studies are needed to determine the specificity and sensitivity of an olfactory test in the diagnosis of Alzheimer’s disease, because many other conditions can contribute to a decline in olfaction, such as sinus infections, smoking, side effects of certain medications and COVID, to name a few,” she said.

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Although the APOE4 gene is a risk factor for developing Alzheimer’s disease, Shah pointed out that not all people with the gene will go on to develop dementia.

Alzheimer’s disease is the most common type of dementia, affecting more than six million people in the U.S., according to the Alzheimer’s Association.

It is expected that this number will exceed 12 million by 2050.

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

Though Mr. Kennedy’s embrace of recovery farms may be novel, the concept stretches back almost a century. In 1935, the government opened the United States Narcotic Farm in Lexington, Ky., to research and treat addiction. Over the years, residents included Chet Baker and William S. Burroughs (who portrayed the institution in his novel, “Junkie: Confessions of an Unredeemed Drug Addict”). The program had high relapse rates and was tainted by drug experiments on human subjects. By 1975, as local treatment centers began to proliferate around the country, the program closed.

In America, therapeutic communities for addiction treatment became popular in the 1960s and ’70s. Some, like Synanon, became notorious for cultlike, abusive environments. There are now perhaps 3,000 worldwide, researchers estimate, including one that Mr. Kennedy has also praised — San Patrignano, an Italian program whose centerpiece is a highly regarded bakery, staffed by residents.

“If we do go down the road of large government-funded therapeutic communities, I’d want to see some oversight to ensure they live up to modern standards,” said Dr. Sabet, who is now president of the Foundation for Drug Policy Solutions. “We should get rid of the false dichotomy, too, between these approaches and medications, since we know they can work together for some people.”

Should Mr. Kennedy be confirmed, his authority to establish healing farms would be uncertain. Building federal treatment farms in “depressed rural areas,” as he said in his documentary, presumably on public land, would hit political and legal roadblocks. Fully legalizing and taxing cannabis to pay for the farms would require congressional action.

In the concluding moments of the documentary, Mr. Kennedy invoked Carl Jung, the Swiss psychiatrist whose views on spirituality influenced Alcoholics Anonymous. Dr. Jung, he said, felt that “people who believed in God got better faster and that their recovery was more durable and enduring than people who didn’t.”

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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The debate about the benefits and risks of fluoride is ongoing, as RFK Jr. — incoming President Trump’s pick for HHS secretary — pushes to remove it from the U.S. water supply.

“Fluoride is an industrial waste associated with arthritis, bone fractures, bone cancer, IQ loss, neurodevelopmental disorders and thyroid disease,” RFK wrote in a post on X in November.

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A new study published in JAMA Pediatrics on Jan. 6 found another correlation between fluoride exposure and children’s IQs.

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Study co-author Kyla Taylor, PhD, who is based in North Carolina, noted that fluoridated water has been used “for decades” to reduce dental cavities and improve oral health.

Fluoride exposure has been linked to a variety of negative health effects, yet benefits oral health. (iStock)

“However, there is concern that pregnant women and children are getting fluoride from many sources, including drinking water, water-added foods and beverages, teas, toothpaste, floss and mouthwash, and that their total fluoride exposure is too high and may affect fetal, infant and child neurodevelopment,” she told Fox News Digital.

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The new research, led by scientists at the National Institute of Environmental Health Sciences (NIEHS), analyzed 74 epidemiological studies on children’s IQ and fluoride exposure.

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The studies measured fluoride in drinking water and urine across 10 countries, including Canada, China, Denmark, India, Iran, Mexico, Pakistan, New Zealand, Spain and Taiwan. (None were conducted in the U.S.)

The meta-analysis found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores, according to Taylor.

“[It showed] that the more fluoride a child is exposed to, the more likely that child’s IQ will be lower than if they were not exposed,” she said.

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Little girl drinking water from a glass

Scientists found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores. (iStock)

These results were consistent with six previous meta-analyses, all of which reported the same “statistically significant inverse associations” between fluoride exposure and children’s IQs, Taylor emphasized.

The research found that for every 1mg/L increase in urinary fluoride, there was a 1.63-point decrease in IQ. 

‘Safe’ exposure levels

The World Health Organization (WHO) has established 1.5mg/L as the “upper safe limit” of fluoride in drinking water.

“There is concern that pregnant women and children are getting fluoride from many sources.”

Meanwhile, the U.S. Public Health Service recommends a fluoride concentration of 0.7 mg/L in drinking water.

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“There was not enough data to determine if 0.7 mg/L of fluoride exposure in drinking water affected children’s IQs,” Taylor noted.

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Higher levels of the chemical can be found in wells and community water serving nearly three million people in the U.S., the researcher noted.

She encouraged pregnant women and parents of small children to be mindful of their total fluoride intake.

little boy filling fresh water from water tap in sports bottle

Nearly three million people have access to wells and community water with fluoride levels above the levels suggested by the World Health Organization. (iStock)

“If their water is fluoridated, they may wish to replace tap water with low-fluoride bottled water, like purified water, and limit exposure from other sources, such as dental products or black tea,” she said.

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“Parents can use low-fluoride bottled water to mix with powdered infant formula and limit use of fluoridated toothpaste by young children.”

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While the research did not intend to address broader public health implications of water fluoridation in the U.S., Taylor suggested that the findings could help inform future research into the impact of fluoride on children’s health.

Dental health expert shares cautions

In response to this study and other previous research, Dr. Ellie Phillips, DDS, an oral health educator based in Austin, Texas, told Fox News Digital that she does not support water fluoridation.

Mother and her toddler drinking a glass with water from the tap

The study researcher encouraged parents of small children to be mindful of their total fluoride intake. (iStock)

“I join those who vehemently oppose public water fluoridation, and I question why our water supplies are still fluoridated in the 21st century,” she wrote in an email.

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“There are non-fluoridated cities and countries where the public enjoy high levels of oral health, which in some cases appear better than those that are fluoridated.”

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Phillips called the fluoride debate “confusing” even among dentists, as the American Dental Association (ADA) advocates for fluoride use for cavity prevention through water fluoridation, toothpaste and mouthwash — “sometimes in high concentrations.”

mother checks son's brushed teeth

Fluoride is used in water, toothpaste and mouthwash to help prevent cavities. (iStock)

“[But] biologic (holistic) dentists generally encourage their patients to fear fluoride and avoid its use entirely, even if their teeth are ravaged by tooth decay,” she said.

“Topical fluoride is beneficial, while systemic consumption poses risks.”

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Phillips encouraged the public to consider varying fluoride compounds, the effect of different concentrations and the “extreme difference” between applying fluoride topically and ingesting it.

“Topical fluoride is beneficial, while systemic consumption poses risks,” she cautioned. 

“Individuals must take charge of their own oral health using natural and informed strategies.”

The study received funding from the National Institute of Environmental Health Sciences (NIEHS), the National Institutes of Health (NIH) and the Intramural Research Program.

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World


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Treating Other Diseases With Ozempic? Experts Weigh In | Woman’s World




























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