Health
Killer condition lands in top 10 leading causes of death as global cases surge
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Chronic kidney disease has been named the ninth leading cause of global death.
Record numbers of men and women are currently estimated to have reduced kidney function, according to new research following a study published in the journal The Lancet.
Researchers at NYU Langone Health, the University of Glasgow, and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington analyzed the rise of kidney disease worldwide.
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They examined 2,230 published papers and health datasets from 133 countries, searching for diagnoses, mortality and the toll of disability from the disease.
From 1990 to 2023, cases rose from 378 million to 788 million, landing the disease in the top 10 of most deadly diseases in the world for the first time.
The largest risk factors for kidney disease include high blood sugar, high blood pressure and high body mass index (BMI). (iStock)
The research, conducted as part of the Global Burden of Disease 2023 study, also revealed that about 14% of the world’s adult population has chronic kidney disease. About 1.5 million people died from kidney disease in 2023, an increase of more than 6% since 1993.
Most people in the study were in early stages of the disease, which can be improved with drugs and lifestyle changes before dialysis or surgery becomes necessary, the researchers noted.
The research, which was presented last week at the American Society of Nephrology’s annual Kidney Week conference, marks “the most comprehensive estimate of the condition in nearly a decade,” according to the authors.
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Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood, NYU Langone detailed.
Mild cases may not show any symptoms, but those in the most advanced stages can require dialysis, kidney replacement therapy or an organ transplant.
Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood. (iStock)
Impaired kidney function was also identified as a key risk factor for heart disease, contributing to about 12% of global cardiovascular mortality.
The largest risk factors for kidney disease, based on the study findings, include high blood sugar, high blood pressure and high body mass index (BMI).
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Study co-senior author Josef Coresh, M.D., Ph.D., director of NYU Langone’s Optimal Aging Institute, said these results classify chronic kidney disease as “common, deadly and getting worse as a major public health issue.”
“These findings support efforts to recognize the condition alongside cancer, heart disease and mental health concerns as a major priority for policymakers around the world,” he said in a statement.
Kidney disease may show no symptoms, yet can ultimately require dialysis or organ transplantation. (iStock)
Study co-lead author Morgan Grams, M.D., Ph.D., the Susan and Morris Mark Professor of Medicine at the NYU Grossman School of Medicine, also commented that chronic kidney disease is “underdiagnosed and undertreated.”
“Our report underscores the need for more urine testing to catch it early and the need to ensure that patients can afford and access therapy once they are diagnosed,” she wrote.
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New medications have recently become available that can slow disease progression and reduce the risk of heart attack, stroke and heart failure, although it may take time to see the global impact, Grams added.
A doctor urged physicians to be more aware of kidney function and the impact of certain medications. (iStock)
Fox News senior medical analyst Dr. Marc Siegel commented on the “dramatic increase” in an interview with Fox News Digital, agreeing that kidney disease is “vastly underestimated and underdiagnosed,” in part due to lack of symptoms in early stages.
“The kidneys are filters of waste and managers of electrolytes and acid/base balance,” said Siegel, who was not involved in the study. “They are very sensitive to changes in blood pressure and blood flow, and can lead to loss of protein and electrolytes when damaged.”
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“High blood pressure, obesity, heart disease, diabetes and low blood pressure all impact basic kidney function, so there is a high degree of secondary kidney disease and failure in addition to primary damage to the kidneys themselves,” the doctor added.
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Siegel urged physicians to be more aware of kidney function and the impact of certain medications.
This study was funded by the National Institutes of Health, the Gates Foundation and the National Kidney Foundation.
Health
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Health
Want to age better? Researchers say 4-minute routine may help prevent dangerous falls
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Just four minutes of daily strength exercises can dramatically improve mobility, balance and leg strength in older adults, per new research from the Penn State College of Medicine.
Standard public health guidelines recommend at least 150 minutes of moderate exercise per week. However, the study suggests that fewer than one in five older adults meet the recommended muscle-strengthening guidelines.
The research team designed a home-based program called Functional Activity Strength Training, or FAST-2. They evaluated 97 sedentary participants 65 and older, with an average age of 74.
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Before entering the study, these individuals were averaging just 18 minutes of total physical activity each week.
The older adults were randomly split into two groups, with one group performing the daily exercise routine and the other serving as a control group that received no intervention, according to the study’s press release.
Just four minutes of daily home strength training can significantly improve mobility, balance and leg strength in older adults, according to a Penn State College of Medicine study. (iStock)
Participants performed four basic movements for 30 seconds each, separated by 30-second rest intervals. The entire routine lasted exactly four minutes. The circuit consisted of push-ups, chair stands, two-arm resistance-band rows and stair stepping.
To keep the routine accessible, researchers provided written explanations and simple modifications. For example, participants could perform push-ups against a kitchen counter or wall, or use their hands on their knees for support during chair stands.
Participants were also given four elastic resistance bands and an adjustable step platform.
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“Exercise is actually really complicated, because you have to decide how many repetitions, how far, how many sets, how much rest and how many times per week,” co-author Smita Dandekar, associate professor of pediatrics at Penn State College of Medicine, said in the press release.
“It’s hard work … so if we can make it short, we’re part [of the] way there.”
The program consisted of four basic movements: push-ups, chair stands, resistance-band rows and stair stepping. (iStock)
As the participants grew stronger, they were encouraged to progress to higher levels of difficulty, such as transitioning away from modifications or increasing the height of the stepper.
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After 12 weeks, the results suggested that a tiny dose of regular exercise could yield noticeable physical benefits. In a 30-second chair-stand test, the exercise group performed an average of 4.2 more repetitions than the control group.
“These indicators … give you a sense of whether or not you’re going to be able to be active in the future.”
The adults doing the exercises also shaved 2.3 seconds off their time during a test measuring how they could stand up and sit down five times consecutively. Furthermore, they extended their one-legged balance time by an average of 3.6 seconds.
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The researchers emphasized that these specific measurements are critical medical indicators of an older adult’s future health.
By keeping the routine ultra-short, researchers eliminated common barriers like time constraints and exhaustion, resulting in an exceptionally high 81% workout completion rate. (iStock)
“These indicators predict your future ability to go into a nursing home, your future likelihood of falling and of developing difficulty walking,” noted lead author Christopher Sciamanna, professor of medicine and of public health at Penn State College of Medicine, in the press release.
“They give you a sense of whether or not you’re going to be able to be active in the future.”
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While traditional home exercise programs generally see low engagement, the participants in this study successfully completed their workouts on 81% of the tracked days, according to the researchers.
After 12 weeks, exercising seniors gained the ability to complete an average of four more chair-stand repetitions than those who did not exercise. (iStock)
The study had several noted limitations. As it tracked a relatively small sample size of fewer than 100 individuals over a brief 12-week time frame, it is unknown whether these mobility gains can be sustained long-term.
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Additionally, the researchers did not specify the exact dropout rates or detail how the routine might affect seniors who already relied on assistive devices like walkers or canes.
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Because the final trial results reflected a specific group of participants who met the entry criteria, further investigation is required to determine whether the short routine can safely benefit older adults facing more severe physical limitations or cognitive decline.
The study was published in the journal PLOS One.
Health
Popular mommy blogger dies at 48 two years after devastating cancer diagnosis
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Jill Smokler, founder of Scary Mommy, has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer.
The popular “mommy blogger” had been fighting the disease for the past two years, according to an announcement posted on ScaryMommy.com on Monday.
The stay-at-home mother of three launched the blog in 2008 as a place to share the “joys and pitfalls” of parenting, according to the article.
As Scary Mommy expanded from a personal blog into a major parenting brand, Smokler built a following with her honest, often self-deprecating take on motherhood. She went on to speak at blogging conferences, author bestselling books, appear on national television programs and earn three Webby Awards, her biography states.
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“Jill spent her life telling the truth about motherhood — that it could be wonderful and impossible in the very same breath — and in doing so, she gave millions of women permission to stop pretending and feel a little less alone,” her family shared in a statement following her passing.
Jill Smokler, founder of Scary Mommy (pictured in 2018), has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer. (Lloyd Fox/Baltimore Sun/ZUMA Press Wire / Shutterstock)
“She was funny, fearless, generous and entirely herself. More than anything she built, Jill was proudest of her three children, Lily, Ben and Evan. We are heartbroken to lose her, and endlessly proud of the mark she left on the world.”
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Smokler’s first sign of the disease was in April 2024, when she experienced a sudden seizure. She then underwent surgery to remove a brain tumor, after which she didn’t recognize her own children, she previously shared with Today.
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“I am definitely grateful that I don’t remember the looks on their faces when I didn’t recognize them,” she said. “That must have been gutting.”
Smokler was diagnosed with glioblastoma, the most common malignant primary brain tumor in adults and one of the deadliest forms of brain cancer. There is currently no cure.
About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. (iStock)
Following surgery, the blogger underwent radiation and chemotherapy, during which she was open about her treatment side effects, including fatigue and hair loss. Additional surgeries and clinical trials followed, according to previous interviews.
“Thank you, Jill, for everything. May you rest in peace,” the Scary Mommy post concluded.
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About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. More than 12,000 new cases are diagnosed in the U.S. each year.
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Median survival is approximately 12 to 18 months after diagnosis, even with treatment. Only about 5% to 7% of patients survive five years after diagnosis, data shows.
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