Health
Killer condition lands in top 10 leading causes of death as global cases surge
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Chronic kidney disease has been named the ninth leading cause of global death.
Record numbers of men and women are currently estimated to have reduced kidney function, according to new research following a study published in the journal The Lancet.
Researchers at NYU Langone Health, the University of Glasgow, and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington analyzed the rise of kidney disease worldwide.
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They examined 2,230 published papers and health datasets from 133 countries, searching for diagnoses, mortality and the toll of disability from the disease.
From 1990 to 2023, cases rose from 378 million to 788 million, landing the disease in the top 10 of most deadly diseases in the world for the first time.
The largest risk factors for kidney disease include high blood sugar, high blood pressure and high body mass index (BMI). (iStock)
The research, conducted as part of the Global Burden of Disease 2023 study, also revealed that about 14% of the world’s adult population has chronic kidney disease. About 1.5 million people died from kidney disease in 2023, an increase of more than 6% since 1993.
Most people in the study were in early stages of the disease, which can be improved with drugs and lifestyle changes before dialysis or surgery becomes necessary, the researchers noted.
The research, which was presented last week at the American Society of Nephrology’s annual Kidney Week conference, marks “the most comprehensive estimate of the condition in nearly a decade,” according to the authors.
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Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood, NYU Langone detailed.
Mild cases may not show any symptoms, but those in the most advanced stages can require dialysis, kidney replacement therapy or an organ transplant.
Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood. (iStock)
Impaired kidney function was also identified as a key risk factor for heart disease, contributing to about 12% of global cardiovascular mortality.
The largest risk factors for kidney disease, based on the study findings, include high blood sugar, high blood pressure and high body mass index (BMI).
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Study co-senior author Josef Coresh, M.D., Ph.D., director of NYU Langone’s Optimal Aging Institute, said these results classify chronic kidney disease as “common, deadly and getting worse as a major public health issue.”
“These findings support efforts to recognize the condition alongside cancer, heart disease and mental health concerns as a major priority for policymakers around the world,” he said in a statement.
Kidney disease may show no symptoms, yet can ultimately require dialysis or organ transplantation. (iStock)
Study co-lead author Morgan Grams, M.D., Ph.D., the Susan and Morris Mark Professor of Medicine at the NYU Grossman School of Medicine, also commented that chronic kidney disease is “underdiagnosed and undertreated.”
“Our report underscores the need for more urine testing to catch it early and the need to ensure that patients can afford and access therapy once they are diagnosed,” she wrote.
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New medications have recently become available that can slow disease progression and reduce the risk of heart attack, stroke and heart failure, although it may take time to see the global impact, Grams added.
A doctor urged physicians to be more aware of kidney function and the impact of certain medications. (iStock)
Fox News senior medical analyst Dr. Marc Siegel commented on the “dramatic increase” in an interview with Fox News Digital, agreeing that kidney disease is “vastly underestimated and underdiagnosed,” in part due to lack of symptoms in early stages.
“The kidneys are filters of waste and managers of electrolytes and acid/base balance,” said Siegel, who was not involved in the study. “They are very sensitive to changes in blood pressure and blood flow, and can lead to loss of protein and electrolytes when damaged.”
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“High blood pressure, obesity, heart disease, diabetes and low blood pressure all impact basic kidney function, so there is a high degree of secondary kidney disease and failure in addition to primary damage to the kidneys themselves,” the doctor added.
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Siegel urged physicians to be more aware of kidney function and the impact of certain medications.
This study was funded by the National Institutes of Health, the Gates Foundation and the National Kidney Foundation.
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Health
Not all fiber is created equal — doctors share which kinds truly support longevity
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Fiber is known to be a crucial part of a healthy diet, promoting fullness and gut health.
As trends like “fibermaxxing” make high-fiber eating more popular, understanding the best sources is increasingly important for individual health, according to nutritionists.
Longevity expert Peter Attia, a Stanford University physician based in Austin, Texas, spoke about how fiber aligns with a healthier lifestyle in a sneak peek of his newest “Ask Me Anything” episode of “The Peter Attia Drive” podcast.
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People who engage in a beneficial habit, such as eating a high-fiber diet, tend to do “many other healthy things,” according to the doctor.
“They might be exercising more, they’re much less likely to smoke, they’re probably getting more sleep,” he said. “You are very likely to be capturing other healthy habits when you’re trying to simply measure one thing.”
As trends like “fibermaxxing” make high-fiber eating more popular, understanding the best sources of fiber is increasingly important for individual health, according to nutritionists. (iStock)
For this reason, it can be difficult to “disentangle” fiber’s specific effects, Attia said, since people who eat more fiber also tend to consume other beneficial plant nutrients and make generally healthier lifestyle choices.
Different types of fiber
Different types of fiber are known to function differently in the body, according to Attia.
“There are lots of things that are classified as fiber, [and] a wide range of physical properties that a particular fiber might have, but these different properties produce different effects on the body,” he said.
“Some fibers provide primarily microbiome support because they’re actually fermented by gut microbiomes. Some fibers can improve blood sugar … and others simply bulk up stool.”
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Soluble fiber dissolves in water, while insoluble fiber does not — and each type plays a different role in digestion.
Insoluble fiber includes vegetables, the skin of fruits, whole grains and bran, according to Attia. It will remain “largely intact” as it moves through the digestive system, adding stool bulk, reducing constipation and supporting regular bowel movements.
Insoluble fibers are not fermented by gut bacteria, but they stimulate the gut lining to release water and mucus, which “dilutes toxins in the colon” and speeds up “intestinal transit,” the doctor said.
Vegetables typically contain more fiber than other options, according to the doctor. (iStock)
Most soluble, or viscous, fiber can absorb water and create a gel in the gut, which can lead to slower gastric emptying, reduce blood sugar spikes and potentially lower cholesterol levels, according to Attia.
Some examples of soluble fiber include pectin (found in fruits), beta-glucan (found in whole oats) and psyllium husk, which is a plant most often consumed as a supplement.
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Some soluble fibers belong to a subgroup called fermentable, or prebiotic, fibers. These fibers are broken down by gut bacteria to produce short-chain fatty acids (SCFAs) — compounds such as butyrate that help support gut health, regulate pH, improve metabolism and reduce inflammation, according to various studies.
“My mantra is ‘baby steps’ whenever I introduce fiber … a little at a time goes a long way.”
Fermentable fibers are found in foods like beans, pectin and inulin, as well as in prebiotic sources such as onions, garlic, asparagus and chicory root. They’re also present in certain resistant starches, including green bananas, legumes, and cooked, starchy foods like potatoes, rice and pasta.
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Resistant starches, while fermentable, are not soluble, Attia noted. They are categorized into several types:
- RS1: Found in whole grains, seeds and legumes
- RS2: Found in raw potato starch, unripe bananas and maize (corn) starch (commonly used in fiber supplements)
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In most diets, a mix of fiber types is consumed. Plant-based foods — especially those with skins, along with oats, beans and legumes — tend to be the richest sources, Attia shared.
Beans don’t contain any single comitant fiber, but are high in fiber overall, said Attia. (iStock)
Benefits of high-fiber diets
Some key benefits of a high-fiber diet include satiety and weight management, glycemic control, cardiovascular health and colorectal cancer prevention, Attia said.
Robin DeCicco, a certified holistic nutritionist in New York, shared with Fox News Digital in a previous interview that increasing fiber intake can be “quite beneficial.”
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“Everything from gastrointestinal health to cardiovascular health, weight management, prevention of diabetes and certain cancers, to feeling fuller throughout the day and minimizing cravings for sugars and starches, are all major benefits of fiber intake,” she said.
“Not all fibers do the same things, and they don’t all do them equally well,” the doctor said. (iStock)
As health is individualized, DeCicco warned that those with pre-existing gastrointestinal conditions could experience complications by introducing too much fiber at once.
“If your system is not used to fiber, and you start to overload, you can easily become bloated, get cramps and have constipation,” she said.
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It’s “easier on the stomach” to spread it out, since fiber can bulk up in the stomach and cause a back-up, according to DeCicco.
“This is why it’s especially important to incorporate fiber slowly,” she said. “My mantra is ‘baby steps’ whenever I introduce fiber to any client. A little at a time goes a long way toward long-term health.”
Health
What Contrave Weight-Loss Medication Really Does for Women
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