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High blood pressure and Alzheimer’s disease could go hand in hand, study finds

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High blood pressure and Alzheimer’s disease could go hand in hand, study finds

The risk of Alzheimer’s disease could escalate along with high blood pressure, according to a new study.

Published in the medical journal Neurology, the research found that people age 60 and older who have untreated high blood pressure may be more likely to develop the common dementia type.

Although the results don’t prove that untreated high blood pressure causes the disease, they do show an association, the American Academy of Neurology stated in a press release.

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Study author Matthew J. Lennon, M.D., PhD, of the University of New South Wales in Australia, wrote in a statement that high blood pressure is a “leading cause of stroke and cerebrovascular disease, and yet it can be controlled with medication, reducing a person’s risk of these diseases.”

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The study found that people age 60 and older with untreated high blood pressure may have an increased risk of Alzheimer’s. (iStock)

While previous research has found that taking blood pressure medications can reduce dementia risk, according to Lennon, less is known about the condition’s impact on Alzheimer’s risk.

“Our meta-analysis looked at older people and found that not treating blood pressure may indeed increase a person’s risk,” he said.

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The researchers analyzed 31,250 people averaging 72 years old who were involved in studies measuring cognitive change and dementia diagnosis over time, the release stated.

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After four years, 1,415 of those individuals developed Alzheimer’s disease.

Alzheimer's PET scan

A doctor points at potential evidence of Alzheimer’s disease spotted in a PET scan at Brigham And Women’s Hospital in Boston on March 30, 2023. (REUTERS/Brian Snyder/File photo)

People with untreated high blood pressure had a 36% increased risk of Alzheimer’s compared to those without the condition, the study found.

They had a 42% increased risk in comparison to those with high blood pressure who were taking blood pressure medication.

“This relationship is not altered by increasing age, which indicates that even those in their 70s and 80s are at significantly lower risk of AD if hypertension is treated,” Lennon told Fox News Digital in an email.

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“These results suggest that treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease,” he added.

The researchers also found that there were no significant risk differences in the effects of blood pressure or medication use across different sexes or racial groups.

“This is a very promising result, as it suggests that optimal care for one group will be similar for others,” Lennon noted.

“Treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease.”

Dr. Marc Siegel, a professor of medicine at NYU Langone Medical Center and Fox News senior medical analyst, reacted to these findings in a conversation with Fox News Digital.

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Alzheimer’s involves “neuroinflammation and the formation of plaques, which interfere with neuronal communication,” noted Siegel, who was not involved in the study.

Blood test results

“We have long known that high blood pressure, high cholesterol and high glucose levels — as well as obesity, smoking and alcohol use — contribute to increased risk of heart attack, stroke and vascular dementia,” a doctor told Fox News Digital. (iStock)

Added the doctor, “High blood pressure may accelerate this development by interfering with oxygen and blood supply to the nerve cells of the brain in some areas — especially the frontal lobe, which is affected.

Dr. Elizabeth Landsverk, geriatric medicine physician and author in California, was not involved in the study but said she was not surprised by the findings.

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“We have long known that high blood pressure, high cholesterol and high glucose levels — as well as obesity, smoking and alcohol use — contribute to increased risk of heart attack, stroke and vascular dementia,” she told Fox News Digital.  

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“This new study also finds a decreased risk of Alzheimer’s disease (amyloid proteins deposing the brain) among those treated for hypertension.”

Potential study limitations

The researchers used data from 14 different longitudinal studies from around the world, Lennon noted, which means there may be some variability in the way they define dementia and high blood pressure.

“Most of the studies also did not report mortality data, and thus our analysis did not account for the competing risks of dementia and death,” the researcher told Fox News Digital.

A man sits up on an exam table as his nurse takes his blood pressure

“These results suggest that treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease,” a study researcher said. (iStock)

Factors like socioeconomic status, health literacy, access to medications, poorly managed medical conditions, and depression and other mental illnesses could also confound the association between hypertension status and dementia risk, Lennon added.

“Because the study is taken over a long period of time, any number of outside variables can alter the results, making it less reliable,” Landsverk noted.

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Hypertension is extremely common, affecting two-thirds of those over age 65 and around 1.3 billion people worldwide, Lennon noted. 

“In the vast majority of cases, it is clinically silent, causing no symptoms until you present with a heart attack, a stroke, or — as we now have shown — dementia,” Lennon said.

Blood pressure reading

Hypertension is extremely common, affecting two-thirds of those over the age of 65 and around 1.3 billion people worldwide. (iStock)

Only 28% of those with high blood pressure have it under adequate control, he noted. 

“While you might not feel the consequences of high blood pressure immediately, it is really important that you keep a close eye on it and bring it under control if you want to maximize your chance at a longer, happier, healthier life,” Lennon added.

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For those who are obese, Landsverk added, losing weight is the fastest way to decrease risk factors.

“In general, the healthiest approach is adopting a plant-based diet and exercising 30 minutes each day to reduce your risk of heart attack, stroke, dementia and now Alzheimer’s disease by as much as 40%,” she advised.

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Words and game of Scrabble keep married couple in wedded bliss for decades

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Words and game of Scrabble keep married couple in wedded bliss for decades

A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.

They’re still playing in tournaments built around the game decades after they began doing so.

Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.

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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.

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But it was a “special match” in 2000 that brought the couple together — and has kept them together now.

Graham and Helen Harding on their wedding day. They’ve been playing in Scrabble tournaments for some 30 years.  (Courtesy Graham and Helen Harding via SWNS)

Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.

They have been taking part in the UK Open Scrabble Championship in Reading this week.

“The more words you know, the more ammunition you’ve got.”

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“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.

7 HEALTHY LIFESTYLE CHANGES THAT COULD HELP REDUCE RISK OF DEPRESSION, SAYS STUDY: ‘ENORMOUS BENEFITS’

“But it is a Scrabble vocabulary — not necessarily everyday English.”

Added Helen Harding, “The more words you know, the more ammunition you’ve got.”

Graham and Helen Harding at their wedding.

Graham and Helen Harding’s wedding cake. They bonded over their love of Scrabble – and are still playing in tournaments together.  (Courtesy Graham and Helen Harding via SWNS)

The couple said they were “vague acquaintances” for about five years after they first met.

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Then they got together after a special match in Swindon.

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They maintained a long-distance relationship before they got married in 2004.

The couple even brought their Scrabble board to their wedding. 

Graham and Helen Harding at their wedding.

The couple likely have played thousands of games between them.  (Courtesy Graham and Helen Harding via SWNS)

It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”

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They each took up the hobby early in life well before they met each other. 

The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported. 

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Deep sleep can keep two big health problems at bay, new studies suggest

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Deep sleep can keep two big health problems at bay, new studies suggest

It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.

Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.

The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.

ANOTHER REASON TO GET MORE SLEEP AND THIS ONE MIGHT SURPRISE YOU

Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.

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Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”

“It’s like turning on the dishwasher before you go to bed and waking up with a clean brain.” (iStock)

The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists. 

The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.

But the scientists indicated that what drives the system was unclear until now, according to the study.

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Is all sleep created equal? The researchers wanted to find out.

To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.

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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.

The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.

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Senior couple sleeping

During deep sleep, toxic proteins that form sticky plaques linked to neurological disorders such as Alzheimer’s disease are removed, scientists say in a new study.  (iStock)

Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.” 

She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”  

‘I CAN’T SLEEP BECAUSE OF RACING THOUGHTS AT NIGHT — HOW CAN I STOP THEM?’: ASK A DOCTOR

Hauglund said she wanted to understand whether all sleep is created equal. 

To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.

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“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice. 

Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.

man sleeps in bed

Two new studies indicate the importance of getting a good night’s sleep — with one study saying a lack of sleep may be sabotaging the brain’s ability to keep intrusive thoughts at bay. (iStock)

The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.

Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.

Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”

For more Health articles, visit www.foxnews.com/health

Meanwhile, a lack of sleep may be doing more damage than just making people groggy.

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It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.

young woman asleep

Anyone who suffers from sleep deprivation may find that the brain’s defense against unwanted memories is weakened, say experts. (iStock)

Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post. 

“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss


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Kathy Bates Weight Loss: Tips That Helped Her Lose 100 Lbs | Woman’s World




















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