Health
Heart failure is reversed with new gene therapy in animal study: ‘Unprecedented recovery’
Heart failure has historically been irreversible, but the outcome of a new study suggests that could someday change.
At the University of Utah, scientists used a new gene therapy that was shown to reverse the effects of heart failure in a large animal study.
In the study, pigs with heart failure were found to have low levels of cardiac bridging integrator 1 (cBIN1), a critical heart protein.
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The scientists injected a harmless virus into the pigs’ bloodstreams to carry the cBIN1 gene into their heart cells, according to a university press release.
The pigs survived for the six-month duration of the study, while they would have been expected to die from heart failure without the gene therapy.
Senior study co-authors Robin Shaw, MD, PhD (left) and TingTing Hong, MD, PhD (right) are pictured in the lab. (Charlie Ehlert / University of Utah Health.)
In what the researchers called an “unprecedented recovery of cardiac function,” the IV injection appeared to improve heart function by increasing the amount of blood it can pump, which “dramatically improves survival.”
The pigs’ hearts also appeared to be “less dilated and less thinned out” after the therapy, “closer in appearance to that of non-failing hearts.”
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While previous attempts to treat heart failure improved function by just 5% to 10%, the gene therapy used in the new study resulted in 30% improvement, according to the researchers.
The study, which was funded by the National Institutes of Health, was published on Tuesday in the journal npj Regenerative Medicine.
Microscope images of failing heart cells (top) and heart cells that received gene therapy (bottom). Cell boundaries, labeled in magenta, are more organized after gene therapy, and the level of cBIN1 protein (green) is higher. (Hong Lab)
“Even though the animals are still facing stress on the heart to induce heart failure, in animals that got the treatment, we saw recovery of heart function and that the heart also stabilizes or shrinks,” said TingTing Hong, MD, PhD, associate professor of pharmacology and toxicology at the University of Utah, in the release.
“We call this reverse remodeling. It’s going back to what the normal heart should look like.”
“A possible new therapy to cure heart failure is on the way,” Hong told Fox News Digital in a statement.
“A possible new therapy to cure heart failure is on the way.”
The researchers were surprised to find that the gene therapy worked so well in large animals at such a low dose, Hong added.
Co-senior author Robin Shaw, MD, PhD, director of the Nora Eccles Harrison Cardiovascular Research and Training Institute at the University of Utah, said the “unprecedented” study ushers in a “new paradigm” for heart failure treatments.
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“Given our treatment efficacy, the complex multi-organ syndrome of heart failure can be reduced to a treatable disease of failing heart muscle,” he told Fox News Digital via email.
“The toxicity of gene therapy increases with dose, so our low dose suggests that our gene therapy approach will be safe for patients.”
While gene therapy has historically been used for rare diseases, the study results suggest that it could also be an effective approach for “acquired disease,” a researcher said. (iStock)
While gene therapy has historically been used for rare diseases, the study results suggest that it could also be an effective approach for “acquired disease,” according to Shaw.
The study did have some limitations, the researchers acknowledged.
“Dose escalation and toxicology studies are still needed for the therapy to move to the next step [toward FDA approval],” Hong noted.
It is also uncertain whether the gene therapy will work for people who have obtained a natural immunity to the virus that carries the therapy, the researchers said.
The toxicology study is currently underway, and the team plans to start human clinical trials in the fall of 2025, Hong said.
Cardiologists weigh in
Dr. Jasdeep Dalawari, interventional cardiologist and regional chief medical officer at VitalSolution, an Ingenovis Health Company based in Ohio, was not involved in the research but shared his reaction to the findings.
“Gene therapy, precision medicine and personalized health care is the future.”
“Research in the animal phase is always interesting, but the application to human test subjects is necessary in terms of understanding if this approach would have the same effect in humans,” he told Fox News Digital.
While previous attempts to treat heart failure improved function by just 5% to 10%, the gene therapy used in the new study resulted in 30% improvement, according to the researchers. (iStock)
“That said, there are many genetic modifications happening in different diseases, like cystic fibrosis and muscular dystrophy, that are looking at a similar intervention – injecting healthy genes in the hopes of finding cures,” he went on.
“Gene therapy, precision medicine and personalized health care is the future, and I look forward to learning more about this.”
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Dr. Johanna Contreras, advanced heart failure and transplant cardiologist at the Mount Sinai Fuster Heart Hospital in New York City, noted that conventional pharmacological interventions can help to alleviate cardiac stress and “systemic congestion,” but “for the most part, they do not address the pathogenic remodeling of failing heart muscle.”
About 6.7 million adults in the U.S. have heart failure, statistics show. (iStock)
“Gene therapy has emerged as a new modality that could interfere or modify the expression of several proteins, thus it could alter the pathologic remodeling of the heart muscle that exists in heart failure,” Contreras, who also was not involved in the study, told Fox News Digital.
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Contreras reiterated that human trials are needed to determine whether this therapy will be effective outside animal models and to identify any “downstream effects.”
“I will look forward to learning more and eventually learning if this could one day be applied to humans with heart failure.”
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Red light therapy has been shown to reduce brain inflammation, protecting people who experience head trauma from long-term health consequences, a University of Utah study has shown.
Brain damage from repeated impact over the years is known to cause cognitive symptoms, ranging from memory issues to full-blown dementia, particularly affecting soldiers and athletes.
Chronic traumatic encephalopathy (CTE) is a progressive, degenerative brain disease linked to repeated head impacts rather than a single injury, according to Mayo Clinic.
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More than 100 former NFL football players have been posthumously diagnosed with CTE, according to the new study, which was published in the Journal of Neurotrauma.
Other research has shown that military personnel in active combat suffer from similar issues, as do first responders and veterans.
The treatment was administered three times a week for 20 minutes using specialized headsets and intranasal devices designed to penetrate the skull. (iStock)
In the new study, the researchers recruited 26 current football players to understand more about the impact of red-light therapy on brain injuries.
The participants received either red light therapy delivered by a light-emitting headset and a device that clips into the nose, or a placebo treatment with an identical device that doesn’t produce light. Players self-administered the therapy three times a week, 20 minutes each time, for 16 weeks.
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“My first reaction was, ‘There’s no way this can be real,’” said first author Hannah Lindsey, Ph.D., in the university press release. “That’s how striking it was.”
Specific wavelengths of light are believed to enter the brain and reduce molecules that trigger inflammation, potentially halting the path toward dementia and other cognitive conditions. (iStock)
Players using the placebo treatment experienced increased brain inflammation over the course of the season. Magnetic resonance imaging (MRI) scans taken at the end of the season showed significantly more signs of inflammation than at the beginning of the season, the study found.
For players who used red-light therapy during the season, their brain inflammation didn’t increase at all.
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Previous studies have shown that red light, if powerful enough, can penetrate the skull and reach the brain, where it may reduce inflammation-related molecules.
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“When we first started this project, I was extremely skeptical,” said Elisabeth Wilde, Ph.D., the senior author on the study. “But we’ve seen consistent results across multiple of our studies, so it’s starting to be quite compelling.”
Study limitations
The study was conducted using a small sample size, which led to different levels of inflammation in the treatment and control groups, the researchers acknowledged.
While the placebo group showed increased brain inflammation during the football season, those receiving red light therapy showed no increase in inflammatory markers. (iStock)
Future large randomized clinical trials will be “crucial to back up the results” in larger populations, they noted.
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“We’ve been trying to figure out how to make sports safer, so that our kids, friends and family can participate in sports safely for the long term while they’re involved in activities that give them happiness and joy,” Carrie Esopenko, Ph.D., second author of the study, said in the release.
“And this really feels like part of the hope for protecting the brain that we’ve been searching for.”
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The team plans to recruit 300 people with persistent symptoms from TBI or concussion for a randomized controlled trial in 2026, with a focus on first responders, veterans and active-duty service members.
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Drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer, according to a study published in the journal Cancer by the American Cancer Society (ACS).
The study analyzed 20 years of data from more than 88,000 U.S. adults to determine how long-term drinking impacted the risk of developing colorectal cancer (CRC) or precancerous colorectal adenomas (polyps).
The participants reported their average weekly intake of beer, wine and liquor intake during four age periods — 18 to 24, 25 to 39, 40 to 54, and 55 and older.
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“Heavy drinkers” were identified as having more than 14 drinks per week and “moderate drinkers” had between seven and 14 drinks per week.
The observational research revealed that consistent heavy drinking over adulthood was linked to a higher risk of colorectal cancer, especially rectal cancer.
Researchers found a major association between colorectal cancer diagnosis and heavy lifetime drinking. (iStock)
Heavy lifetime drinking was associated with a 25% higher overall CRC risk and nearly double the risk of rectal cancer. Moderate lifetime drinking had a lower overall CRC risk.
Compared to light drinkers, the consistently heavy drinkers had about a 91% higher risk of CRC.
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For colorectal adenomas (precancerous polyps), higher current lifetime drinking did not show a strong pattern, although former drinkers showed a significantly lower risk of non-advanced adenoma compared to current light drinkers.
Out of the 88,092 participants, 1,679 were diagnosed with colorectal cancer.
Out of the 88,092 participants in the study, 1,679 were diagnosed with colorectal cancer. (iStock)
The authors noted that the research was limited, as it was observational and not based on a clinical trial. It also hinged on self-reported alcohol use.
The findings suggest that consistently heavy alcohol intake and higher average lifetime consumption “may increase CRC risk, whereas cessation may lower adenoma risk,” the researchers stated. Associations “may differ by tumor site,” they added.
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The link between drinking alcohol and cancer is not a new discovery, according to health experts.
In a recent episode of the podcast “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health in California, detailed how even moderate drinking can impact “nearly every organ system in the body,” due to metabolic stress, inflammation, impaired detoxification and its effect on hormones.
The link between drinking alcohol and cancer is not a new discovery, according to health experts. (iStock)
Drinking has been found to increase the risk of many cancers, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins, Hyman said.
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“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” he warned.
Reducing or eliminating alcohol can lower the risk of several cancers, according to medical experts. (Getty Images)
In a previous interview with Fox News Digital, Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, shared that taking a break from drinking alcohol for longer periods of time can “reshape health more profoundly.”
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“Over months to a year, we see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”
Chiang added, “Reducing or eliminating alcohol lowers the risk of several cancers, including breast and colorectal, over time.”
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Fox News Digital reached out to the study researchers for comment.
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A mysterious hum is reportedly plaguing the residents of Cincinnati, keeping people up at night and even disturbing them psychologically.
Residents of the Northside, Clifton and Camp Washington neighborhoods have been reporting the disturbances since December. The noises are said to be louder and more noticeable at night.
“We were hearing this siren-like quality noise — whirring, oscillating, going up and down,” said Clifton resident Shaun Herold, who contacted local news outlet WKRC about the noises.
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“My son came up to me and said, ‘Dad, the tornado sirens are going off,’” Herold said. “Usually, it starts at about 10 p.m. It can go till 3 a.m., 4 a.m. But it’s quite unpredictable.”
“It kind of stresses me out ’cause I don’t know what it is. It’s kind of scary,” added his son, Elijah Herold.
A mysterious, intermittent hum has been disturbing Cincinnati residents since December, disrupting sleep and causing psychological stress. (iStock)
Herold said he spent one entire night tracking how many times he heard the noise going on and off. The duration of the noises can vary from a few seconds to several minutes.
“I feel like it’s definitely like a foreign sound,” Northside’s Brendan Marcum told the news outlet. “Some nights it would be a little louder, some nights it would be a little quieter.”
“It kind of stresses me out because I don’t know what it is, and it’s kind of scary,” added another resident.
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Hundreds of Cincinnati residents have shared their theories about potential sources of the sound on social media, ranging from biblical to supernatural.
On Reddit, other users blamed the recycling plant. “My favorite theory is River Metals Recycling,” one person wrote, claiming that the plant moved neighborhoods when the original location “wouldn’t put up with the noise from its metal shredder any longer.”
Residents have described the sound as a siren-like, oscillating whirring that can last from seconds to several minutes. (iStock)
Others suspect the noise is coming from a failing turbocharger on a diesel train engine at the nearby CSX Queensgate, a major freight rail yard in Cincinnati.
While the yard routinely generates loud, mechanical sounds, residents say they’ve never heard anything like this before.
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WKRC reported that an anonymous source sent recordings of the locomotive, claiming it to be the source of the sound. However, a spokesperson for CSX told the news station that he “has not heard a noise like that on our property” and suggested it could be coming from another location.
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He added that any equipment requiring maintenance is “handled through established operating and mechanical protocols.”
According to a source, rail crews have reported the engine for excessive noise and believe it will be repaired. (iStock)
“We just hope to get to the bottom of it, figure out what it is, and if it’s, you know, a temporary thing or not,” Herold told the news outlet. “And hopefully the community can rally if it’s not temporary, because it’s really impacting us.”
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City officials recommend that residents report the noise to 311, the city’s non-emergency line.
Fox News Digital reached out to Cincinnati officials for updates.
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