Health
Heart failure is reversed with new gene therapy in animal study: ‘Unprecedented recovery’
Heart failure has historically been irreversible, but the outcome of a new study suggests that could someday change.
At the University of Utah, scientists used a new gene therapy that was shown to reverse the effects of heart failure in a large animal study.
In the study, pigs with heart failure were found to have low levels of cardiac bridging integrator 1 (cBIN1), a critical heart protein.
BRAIN BLEED SENT JAMIE FOXX INTO A STROKE — WHAT TO KNOW ABOUT THE DANGEROUS CONDITION
The scientists injected a harmless virus into the pigs’ bloodstreams to carry the cBIN1 gene into their heart cells, according to a university press release.
The pigs survived for the six-month duration of the study, while they would have been expected to die from heart failure without the gene therapy.
In what the researchers called an “unprecedented recovery of cardiac function,” the IV injection appeared to improve heart function by increasing the amount of blood it can pump, which “dramatically improves survival.”
The pigs’ hearts also appeared to be “less dilated and less thinned out” after the therapy, “closer in appearance to that of non-failing hearts.”
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While previous attempts to treat heart failure improved function by just 5% to 10%, the gene therapy used in the new study resulted in 30% improvement, according to the researchers.
The study, which was funded by the National Institutes of Health, was published on Tuesday in the journal npj Regenerative Medicine.
“Even though the animals are still facing stress on the heart to induce heart failure, in animals that got the treatment, we saw recovery of heart function and that the heart also stabilizes or shrinks,” said TingTing Hong, MD, PhD, associate professor of pharmacology and toxicology at the University of Utah, in the release.
“We call this reverse remodeling. It’s going back to what the normal heart should look like.”
“A possible new therapy to cure heart failure is on the way,” Hong told Fox News Digital in a statement.
“A possible new therapy to cure heart failure is on the way.”
The researchers were surprised to find that the gene therapy worked so well in large animals at such a low dose, Hong added.
Co-senior author Robin Shaw, MD, PhD, director of the Nora Eccles Harrison Cardiovascular Research and Training Institute at the University of Utah, said the “unprecedented” study ushers in a “new paradigm” for heart failure treatments.
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“Given our treatment efficacy, the complex multi-organ syndrome of heart failure can be reduced to a treatable disease of failing heart muscle,” he told Fox News Digital via email.
“The toxicity of gene therapy increases with dose, so our low dose suggests that our gene therapy approach will be safe for patients.”
While gene therapy has historically been used for rare diseases, the study results suggest that it could also be an effective approach for “acquired disease,” according to Shaw.
The study did have some limitations, the researchers acknowledged.
“Dose escalation and toxicology studies are still needed for the therapy to move to the next step [toward FDA approval],” Hong noted.
It is also uncertain whether the gene therapy will work for people who have obtained a natural immunity to the virus that carries the therapy, the researchers said.
The toxicology study is currently underway, and the team plans to start human clinical trials in the fall of 2025, Hong said.
Cardiologists weigh in
Dr. Jasdeep Dalawari, interventional cardiologist and regional chief medical officer at VitalSolution, an Ingenovis Health Company based in Ohio, was not involved in the research but shared his reaction to the findings.
“Gene therapy, precision medicine and personalized health care is the future.”
“Research in the animal phase is always interesting, but the application to human test subjects is necessary in terms of understanding if this approach would have the same effect in humans,” he told Fox News Digital.
“That said, there are many genetic modifications happening in different diseases, like cystic fibrosis and muscular dystrophy, that are looking at a similar intervention – injecting healthy genes in the hopes of finding cures,” he went on.
“Gene therapy, precision medicine and personalized health care is the future, and I look forward to learning more about this.”
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Dr. Johanna Contreras, advanced heart failure and transplant cardiologist at the Mount Sinai Fuster Heart Hospital in New York City, noted that conventional pharmacological interventions can help to alleviate cardiac stress and “systemic congestion,” but “for the most part, they do not address the pathogenic remodeling of failing heart muscle.”
“Gene therapy has emerged as a new modality that could interfere or modify the expression of several proteins, thus it could alter the pathologic remodeling of the heart muscle that exists in heart failure,” Contreras, who also was not involved in the study, told Fox News Digital.
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Contreras reiterated that human trials are needed to determine whether this therapy will be effective outside animal models and to identify any “downstream effects.”
“I will look forward to learning more and eventually learning if this could one day be applied to humans with heart failure.”
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Health
Brain bleed sent Jamie Foxx into a stroke — what to know about the dangerous condition
Actor and Grammy winner Jamie Foxx opened up about a medical emergency that was nearly fatal.
In his Netflix comedy special, “Jamie Foxx: What Had Happened Was,” Foxx revealed that he suffered a brain bleed in April 2023 that put him into a coma for several weeks.
“I was fighting for my life,” Foxx said. “April 11, I was having a bad headache, and I asked my boy for an aspirin … before I could get the aspirin … I went out. I don’t remember 20 days.”
JAMIE FOXX SUFFERED ‘BRAIN BLEED THAT LED TO A STROKE,’ DIDN’T ‘REMEMBER 20 DAYS’ DURING WEEKSLONG COMA
Foxx received surgery to respond to the brain bleed that led to a stroke.
Foxx’s doctor at Piedmont Hospital reportedly declared, “If I don’t go in his head right now, we’re going to lose him.”
“On May 4, I woke up. When I woke up, I found myself in a wheelchair. I couldn’t walk,” Foxx went on.
In time, and with the help of his family and faith, Foxx slowly recovered in what he considered to be a “miracle.”
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Three months after he privately battled his “medical complication,” the actor spoke out about the matter in a video he posted to Instagram, in which he admitted he went to “hell and back.”
What is a brain bleed?
Foxx’s experience was no joke, according to Dr. Paul Saphier, M.D., a neurosurgeon and founder of Coaxial Neurosurgical Specialists in New Jersey.
In a conversation with Fox News Digital, Saphier shared the dangers of brain bleeds, or hemorrhagic stroke, which account for 10% to 15% of all strokes.
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The condition affects approximately 70,000 to 80,000 U.S. patients per year.
A brain bleed causes blood to pool between the brain and skull, which prevents oxygen from reaching the brain, according to Cleveland Clinic.
The first symptom of a brain bleed is a sudden, severe headache, but can also include nausea and vomiting, confusion, dizziness, slurred speech, sleepiness and lack of energy.
Some potential causes of a brain bleed include head trauma, blood clots, a weak spot in a blood vessel, a brain tumor and other abnormal occurrences, per Cleveland Clinic.
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They can also occur due to issues related to high blood pressure, high cholesterol, diabetes, smoking, alcohol abuse and age, Saphier stated.
“These bleeds can also be related to blood vessel issues, such as brain aneurysms and vascular malformations,” he added.
As brain bleeds and heart health go hand in hand, Saphier promotes heart-healthy living as a way to decrease risk.
“For patients with a strong family history of intracranial hemorrhages, the American Heart [Association] and American Stroke Association recommend screening for brain aneurysms and vascular malformations for early detection and prevention,” the doctor noted.
Quick treatment is essential
Nearly 45% of patients with a “spontaneous intracerebral hemorrhage,” or brain bleeding, do not survive, according to Saphier.
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About two-thirds of these survivors reportedly do not return to their “pre-hemorrhagic stroke baseline.”
If a brain bleed is not treated quickly, it can lead to permanent damage, including memory loss, difficulty swallowing and speaking, coordination challenges, numbness or weakness in body parts, vision loss, and emotional changes, Cleveland Clinic states.
To reduce the risk of brain bleeding, Cleveland Clinic recommends managing blood pressure, lowering cholesterol levels, maintaining a healthy weight, limiting alcohol consumption, stopping smoking, eating a balanced diet and exercising regularly.
“A general principle that I tell my patients is that any type of lifestyle activities that are considered heart-healthy are also healthy for the brain and its blood vessels,” Saphier advised.
“If someone does have a strong family history of brain aneurysms, or [intracranial] hemorrhages, they should discuss [it] with a primary care doctor, as they may be a candidate for brain aneurysm screening and prevention,” he added.
Fox News Digital’s Stephanie Giang-Paunon contributed to this report.
Health
Deadly virus samples went missing from lab in ‘major biosecurity breach,’ say authorities
Hundreds of deadly virus samples are missing from a laboratory in Australia, the Queensland government announced on Monday.
The government has instructed Queensland Health — Australia’s public health department — to launch an investigation into what’s being described as a “major historical breach of biosecurity protocols,” according to the online media statement.
It was reported that 323 vials of multiple infectious viruses — including Hendra virus, Lyssavirus and Hantavirus — went missing from Queensland’s Public Health Virology Laboratory in August 2023.
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Hendra is a zoonotic (animal-to-human) virus that has only been found in Australia.
Hantavirus is a family of viruses that can lead to serious illness and death, according to the Centers for Disease Control and Prevention, while Lyssavirus is a group of viruses that can cause rabies.
The lab where the samples went missing provides “diagnostic services, surveillance and research for viruses and mosquito and tick-borne pathogens of medical importance,” the release stated.
It is not known whether the infectious samples were stolen or destroyed, the statement said, and there is “no evidence of risk to the community.”
The government has launched a “Part 9 investigation.”
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“With such a serious breach of biosecurity protocols and infectious virus samples potentially missing, Queensland Health must investigate what occurred and how to prevent it from happening again,” Minister Timothy Nicholls said in the release.
“The Part 9 investigation will ensure nothing has been overlooked in responding to this incident and examine the current policies and procedures in operation today at the laboratory.”
“This investigation will also consider regulatory compliance and staff conduct.”
Nicholls added that Queensland Health has taken “proactive measures,” including retraining staff on required regulations and conducting audits to ensure correct storage of materials.
Sam Scarpino, PhD, director of AI and life sciences at Northeastern University in Boston, confirmed that the situation in Australia amounts to a “critical biosecurity lapse.”
“Given the limited ability for any of these pathogens to transmit from person to person, the risk of an epidemic is very low.”
“The pathogens reported missing are all high-consequence and could pose a threat to the public,” he told Fox News Digital.
The three pathogens can have very high fatality rates in humans, Scarpino said, but they do not transmit readily from person to person.
“Some hantaviruses have case fatality rates of up to 15%, or over 100 times more lethal than COVID-19, while others are more similar to COVID-19 in terms of severity,” he said.
There is also a high risk to animals and livestock from all three pathogens, he added.
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The Lyssavirus family contains the rabies virus, which is almost universally fatal in humans if they do not receive treatment in time, the expert noted.
“Given the limited ability for any of these pathogens to transmit from person to person, the risk of an epidemic is very low,” Scarpino said.
“However, Hendra virus — along with certain members of the Hantavirus and Lyssavirus family — can be very severe in humans and animals.”
Chief Health Officer Dr. John Gerrard reiterated in the media statement that there is no evidence of public risk.
“It’s important to note that virus samples would degrade very rapidly outside a low temperature freezer and become non-infectious,” he said.
“It’s very unlikely that samples were discarded in general waste, as this would be completely outside routine laboratory practice.”
There have been no human cases of Hendra or Lyssavirus in Queensland over the past five years, Gerrard noted, and no confirmed Hantavirus infections “ever in Australia.”
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Despite the low risk, Scarpino said, “It’s important to understand where these samples ended up, to confirm that there is no longer a risk of exposure.”
“While I applaud the Australian government for taking this seriously, it’s unacceptable that it took over a year for news of the breach to be made public.”
“The pathogens reported missing are all high-consequence.”
There have been similarly high-profile biosecurity lapses in the U.S., Scarpino noted.
“It’s clear that we need quite a bit more investment and transparency related to pathogen biosecurity,” he added.
For more Health articles, visit www.foxnews.com/health
Fox News Digital reached out to the Queensland government requesting further comment.
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