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Heart drug combining 3 medications in one is added to World Health Organization’s list of essential medicines

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Heart drug combining 3 medications in one is added to World Health Organization’s list of essential medicines

A heart drug that combines three medications in one pill — otherwise known as a polypill — has been included in the List of Essential Medicines from the World Health Organization (WHO). 

The unique polypill is designed for those who have had a prior heart attack or other heart-related event, with the goal of preventing a repeat occurrence. It took 15 years of intense study and several versions to create it.

The List of Essential Medications are those that meet the population’s “priority health care needs” and can save lives, improve health and decrease suffering, according to the WHO’s website. 

COMBO ‘POLYPILL’ CUTS HEART DISEASE DEATHS, NEW STUDY FINDS

“This cardiovascular polypill could become an integral part of global strategies to prevent cardiovascular events in patients who have suffered a heart attack and who are currently already being treated with separate mono-components,” said Valentin Fuster, M.D., PhD, president of Mount Sinai Heart and physician-in-chief of The Mount Sinai Hospital in New York City, in a news release.

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“This approach has the potential to reduce the risk of recurrent disease and cardiovascular death,” he added.

A heart drug that combines three medications in one pill, known as a polypill, has been included in the List of Essential Medicines from the World Health Organization (WHO). Experts say it “has the potential to reduce the risk of recurrent disease and cardiovascular death.” (iStock)

WHO selects the essential drugs based on the relevance to public health, prevalence of disease, evidence of clinical efficacy and safety, and comparative costs and cost-effectiveness, according to the global health organization’s website.

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“This really, I think, is a change in medicine,” Fuster, who is also general director of the Spanish National Center for Cardiovascular Research (CNIC), which spearheaded the research, told Fox News Digital in an interview.

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“The inclusion of this therapeutic solution in the WHO’s List of Essential Medicines confirms our aim to make a positive impact in society and is an important step in our mission to bring significant and differential value to people with cardiovascular disease,” Oscar Pérez, chief marketing and business development officer at Ferrer, a Spain-based pharmaceutical company involved in the polypill research, said in a news release.

The World Health Organisation

The World Health Organization’s List of Essential Medicines consists of medications that meet the population’s “priority health care needs” and can save lives, improve health and decrease suffering. (REUTERS/Denis Balibouse/File Photo)

The polypill contains three medications that are typically used to treat patients after they suffer their first heart attack, as Fox News Digital previously reported.

Researchers found it to be effective in preventing secondary adverse cardiovascular events in those who have previously had a cardiac event, according to the SECURE trial led by Fuster that was published in The New England Journal of Medicine in August 2022. 

The polypill also reduced cardiovascular mortality by 33% among patients who had previous heart attacks, the study found.

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“The SECURE results showed for the first time that the cardiovascular polypill that we helped develop led to clinically relevant reductions in recurrent cardiovascular events in patients who had suffered a myocardial infarction,” Fuster said in the release.

The three drugs contained in the polypill include acetylsalicylic acid, which helps thin the blood to prevent blood clots; ramipril, an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure; and a cholesterol-lowering drug called atorvastatin, according to Fuster.

Each year in the United States, 805,000 people suffer a heart attack. Among those individuals, 200,000 previously had a cardiac event. (iStock)

A patient is less likely to take the three separate pills on a daily basis, Fuster said, which increases the risk for another cardiovascular event. 

The polypill helps patients remain compliant with taking the prescribed medications because it is only one pill. 

The polypill “has proven its value, because increased adherence means that patients … have a lower risk of cardiovascular events.”

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Fuster’s research team found that the polypill was also just as effective as the separate pill regimen commonly given to patients after a heart attack.

“Adherence to treatment after an acute myocardial infarction is essential for effective secondary prevention,” he told Fox News Digital. 

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“This cardiovascular polypill, as a strategy that combines three of the baseline treatments for these patients, has proven its value, because increased adherence means that patients are being treated for longer and, as a result, have a lower risk of cardiovascular events,” Fuster noted in the release.

It took 15 years of intense study and several versions to develop this polypill, Fuster told Fox News Digital.

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Heart medication

This unique polypill is designed for those who have already had a prior heart attack or other heart-related event, with the goal of preventing a repeat occurrence. (iStock)

It is sold under the brand names Trinomia, Sincronium and Iltria, depending on the country. 

“The 3% reduction in cardiovascular mortality demonstrates the efficacy of treatment with Trinomia compared to standard treatment,” Ferrer’s Perez said in the report.

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The polypill is commercially available right now in 25 countries, but the Food and Drug Administration (FDA) has not yet cleared it for use in the U.S.

“Since our groundbreaking study was published, we have seen an increase in polypill usage across the world, and we are looking forward to having this medicine available in the United States and the rest of the countries where it is not available yet,” Fuster said.

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Each year in the United States, 805,000 people suffer a heart attack. 

Among those individuals, 200,000 previously had a cardiac event, according to the Centers for Disease Control and Prevention (CDC).

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

Though Mr. Kennedy’s embrace of recovery farms may be novel, the concept stretches back almost a century. In 1935, the government opened the United States Narcotic Farm in Lexington, Ky., to research and treat addiction. Over the years, residents included Chet Baker and William S. Burroughs (who portrayed the institution in his novel, “Junkie: Confessions of an Unredeemed Drug Addict”). The program had high relapse rates and was tainted by drug experiments on human subjects. By 1975, as local treatment centers began to proliferate around the country, the program closed.

In America, therapeutic communities for addiction treatment became popular in the 1960s and ’70s. Some, like Synanon, became notorious for cultlike, abusive environments. There are now perhaps 3,000 worldwide, researchers estimate, including one that Mr. Kennedy has also praised — San Patrignano, an Italian program whose centerpiece is a highly regarded bakery, staffed by residents.

“If we do go down the road of large government-funded therapeutic communities, I’d want to see some oversight to ensure they live up to modern standards,” said Dr. Sabet, who is now president of the Foundation for Drug Policy Solutions. “We should get rid of the false dichotomy, too, between these approaches and medications, since we know they can work together for some people.”

Should Mr. Kennedy be confirmed, his authority to establish healing farms would be uncertain. Building federal treatment farms in “depressed rural areas,” as he said in his documentary, presumably on public land, would hit political and legal roadblocks. Fully legalizing and taxing cannabis to pay for the farms would require congressional action.

In the concluding moments of the documentary, Mr. Kennedy invoked Carl Jung, the Swiss psychiatrist whose views on spirituality influenced Alcoholics Anonymous. Dr. Jung, he said, felt that “people who believed in God got better faster and that their recovery was more durable and enduring than people who didn’t.”

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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The debate about the benefits and risks of fluoride is ongoing, as RFK Jr. — incoming President Trump’s pick for HHS secretary — pushes to remove it from the U.S. water supply.

“Fluoride is an industrial waste associated with arthritis, bone fractures, bone cancer, IQ loss, neurodevelopmental disorders and thyroid disease,” RFK wrote in a post on X in November.

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A new study published in JAMA Pediatrics on Jan. 6 found another correlation between fluoride exposure and children’s IQs.

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Study co-author Kyla Taylor, PhD, who is based in North Carolina, noted that fluoridated water has been used “for decades” to reduce dental cavities and improve oral health.

Fluoride exposure has been linked to a variety of negative health effects, yet benefits oral health. (iStock)

“However, there is concern that pregnant women and children are getting fluoride from many sources, including drinking water, water-added foods and beverages, teas, toothpaste, floss and mouthwash, and that their total fluoride exposure is too high and may affect fetal, infant and child neurodevelopment,” she told Fox News Digital.

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The new research, led by scientists at the National Institute of Environmental Health Sciences (NIEHS), analyzed 74 epidemiological studies on children’s IQ and fluoride exposure.

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The studies measured fluoride in drinking water and urine across 10 countries, including Canada, China, Denmark, India, Iran, Mexico, Pakistan, New Zealand, Spain and Taiwan. (None were conducted in the U.S.)

The meta-analysis found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores, according to Taylor.

“[It showed] that the more fluoride a child is exposed to, the more likely that child’s IQ will be lower than if they were not exposed,” she said.

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Little girl drinking water from a glass

Scientists found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores. (iStock)

These results were consistent with six previous meta-analyses, all of which reported the same “statistically significant inverse associations” between fluoride exposure and children’s IQs, Taylor emphasized.

The research found that for every 1mg/L increase in urinary fluoride, there was a 1.63-point decrease in IQ. 

‘Safe’ exposure levels

The World Health Organization (WHO) has established 1.5mg/L as the “upper safe limit” of fluoride in drinking water.

“There is concern that pregnant women and children are getting fluoride from many sources.”

Meanwhile, the U.S. Public Health Service recommends a fluoride concentration of 0.7 mg/L in drinking water.

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“There was not enough data to determine if 0.7 mg/L of fluoride exposure in drinking water affected children’s IQs,” Taylor noted.

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Higher levels of the chemical can be found in wells and community water serving nearly three million people in the U.S., the researcher noted.

She encouraged pregnant women and parents of small children to be mindful of their total fluoride intake.

little boy filling fresh water from water tap in sports bottle

Nearly three million people have access to wells and community water with fluoride levels above the levels suggested by the World Health Organization. (iStock)

“If their water is fluoridated, they may wish to replace tap water with low-fluoride bottled water, like purified water, and limit exposure from other sources, such as dental products or black tea,” she said.

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“Parents can use low-fluoride bottled water to mix with powdered infant formula and limit use of fluoridated toothpaste by young children.”

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While the research did not intend to address broader public health implications of water fluoridation in the U.S., Taylor suggested that the findings could help inform future research into the impact of fluoride on children’s health.

Dental health expert shares cautions

In response to this study and other previous research, Dr. Ellie Phillips, DDS, an oral health educator based in Austin, Texas, told Fox News Digital that she does not support water fluoridation.

Mother and her toddler drinking a glass with water from the tap

The study researcher encouraged parents of small children to be mindful of their total fluoride intake. (iStock)

“I join those who vehemently oppose public water fluoridation, and I question why our water supplies are still fluoridated in the 21st century,” she wrote in an email.

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“There are non-fluoridated cities and countries where the public enjoy high levels of oral health, which in some cases appear better than those that are fluoridated.”

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Phillips called the fluoride debate “confusing” even among dentists, as the American Dental Association (ADA) advocates for fluoride use for cavity prevention through water fluoridation, toothpaste and mouthwash — “sometimes in high concentrations.”

mother checks son's brushed teeth

Fluoride is used in water, toothpaste and mouthwash to help prevent cavities. (iStock)

“[But] biologic (holistic) dentists generally encourage their patients to fear fluoride and avoid its use entirely, even if their teeth are ravaged by tooth decay,” she said.

“Topical fluoride is beneficial, while systemic consumption poses risks.”

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Phillips encouraged the public to consider varying fluoride compounds, the effect of different concentrations and the “extreme difference” between applying fluoride topically and ingesting it.

“Topical fluoride is beneficial, while systemic consumption poses risks,” she cautioned. 

“Individuals must take charge of their own oral health using natural and informed strategies.”

The study received funding from the National Institute of Environmental Health Sciences (NIEHS), the National Institutes of Health (NIH) and the Intramural Research Program.

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World


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