Health
Fasting-like diet could slow the aging process, study suggests: ‘Living longer and healthier’
Could adopting a fasting-like diet help slow down aging?
That’s the claim of researchers from the USC Leonard Davis School of Gerontology in Los Angeles, who led a study on the benefits of a “fasting-mimicking diet” (FMD).
In addition to reducing biological age and immune system aging, the diet was linked to reductions in insulin resistance and liver fat, according to a press release from the university.
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The findings, published in Nature Communications on Feb. 20, were based on clinical trials that included 100 men and women between 18 and 70 years old.
Half of the group was randomly assigned to the FMD, adhering to the diet for five days followed by 25 days of normal eating for three or four cycles.
A fasting-mimicking diet was found to reduce biological age and immune system aging, as well as insulin resistance and liver fat, in a new study. (iStock)
The control group ate either a normal diet or a Mediterranean-style diet.
The people in the FMD group showed decreased abdominal and liver fat, as well as reduced risk of metabolic syndrome, which can lead to heart disease, stroke and diabetes.
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Those on the experimental diet also showed signs of a more youthful immune system.
Overall, the FMD adopters’ biological age was reduced by an average of 2.5 years based on the functioning of their cells and tissues, the researchers found.
In the USC study, the fasting-mimicking diet included energy bars, plant-based soups, chip snacks, energy drinks and tea. (iStock)
“I think it is surprising that three cycles of the FMD done for only five days a month (15 days total) — which allow people to have modified/low calorie but regular meals and without changing the normal diet of the participants for the rest of the month — can have such an effect on biological age, body fat and a range of disease risk factors,” senior author Valter Longo, USC Leonard Davis School Professor, told Fox News Digital.
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If the cycles were continued for three cycles a year for 20 years, Longo projected that the FMD could reduce biological age by 11 years and reduce the risk of cancer, cardiovascular disease and diabetes by 10% to 30%.
“However, these are only simulations — and additional studies are necessary to confirm this potential of the FMD cycles,” he added.
Half of the group was randomly assigned to the FMD, adhering to the diet for five days followed by 25 days of normal eating for three or four cycles. (iStock)
Prior studies in mice have identified additional benefits of the FMD, including reduced risk of age-related diseases like cancer, heart disease and diabetes, Vongo pointed out.
The diet has been previously to reduced chemo side effects, greater stem cell regeneration and reduced signs of dementia, the release stated.
What is the fasting-mimicking diet?
Originally developed by Longo, the FMD is a five-day diet that is low in overall calories, protein and carbohydrates and high in unsaturated fat.
The eating plan is designed to mimic a pure fast while still allowing consumption of essential nutrients.
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“The fasting-mimicking diet (FMD), also known as the ProLon Diet, has been around for approximately seven years and has been studied in multiple clinical trials,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.
“By following a structured, very low-calorie nutrition plan for five days, the goal is to provide the benefits of a prolonged fast while still allowing individuals to eat,” said Palinski-Wade, who was not involved in the USC study.
“The diet is designed to transition the body into a fasting state while nourishing it with specific nutrients to avoid activating food-sensing pathways.”
“[The diet] allows for physical, biological and epigenetic benefits without the need for prolonged water-only fasts,” an expert said. (iStock)
In the USC study, the fasting-mimicking diet included energy bars, plant-based soups, chip snacks, energy drinks and tea, according to the release.
The FMD group also received a supplement with “high levels of minerals, vitamins and essential fatty acids.”
The specific diet that was tested in the two trials is commercially available, but Longo said that university rules prevent him from sharing the name of the product.
“In an era obsessed with superficial youth and quick fixes, the fasting-mimicking diet offers a tangible method to systematically reverse aging and enhance metabolic health.”
“I think it is important to begin to consider the plant-based FMD intervention described here for two to three times a year as a way to prevent and treat some diseases, together with the right type of drugs,” Longo said.
This could aid in “returning to full health and living longer and healthier, rather than continuing to take progressively more drugs as we age,” he added.
For people aiming to prevent or treat diseases through the use of an FMD, Longo said people should first talk to a doctor.
Other experts weigh in on the diet
Melanie Avalon, an Atlanta-based health influencer who hosts “The Intermittent Fasting Podcast,” was not involved in the study, but noted that the research provides “solid data” on how dietary and lifestyle changes affect the aging process.
“Our society’s fascination with youth and longevity is well-known; however, measuring progress and biological improvements is often subjective,” she told Fox News Digital.
While fasting is often pursued for its visible weight loss benefits, an expert noted that this study highlights its extended benefits for metabolic health. (iStock)
“The concept of ‘chronological age’ can mislead when assessing the body’s aging rate and predicting lifespan,” Avalon went on.
“For the first time, this study reveals that a fasting-mimicking diet can reduce one’s biological age.”
While traditional fasting can be daunting for some, FMD can be a more feasible alternative.
“It allows for physical, biological and epigenetic benefits without the need for prolonged water-only fasts,” she said.
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While fasting is often pursued for its visible weight loss benefits, Avalon noted that this study highlights FMD’s extended benefits for metabolic health.
“In an era obsessed with superficial youth and quick fixes, the fasting-mimicking diet offers a tangible method to systematically reverse aging and enhance metabolic health,” she said.
“Unlike the costly and extreme measures of ‘biohacking,’ the FMD provides an accessible and practical solution to reduce biological age.”
Potential risks and limitations
Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, who practices as The Lupus Dietitian, cautioned that she would not recommend the fasting-mimicking diet to any person who has struggled with an eating disorder in the past or who has trouble controlling their blood sugar.
“Restricting and changing eating patterns may have negative effects,” she said.
The fasting-mimicking diet could aid in “returning to full health and living longer and healthier, rather than continuing to take progressively more drugs as we age,” the study author said. (iStock)
Palinski-Wade agreed that those with underlying health conditions should speak to their physician before considering a restrictive diet plan.
“A very low-calorie diet may not be appropriate for those with uncontrolled diabetes, a history of hypoglycemia, a history of disordered eating, or those who are pregnant or nursing,” she said.
Before making any dietary changes, Freirich stressed the need for “extensive education” to be provided.
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“While changing the timing and amount of our food intake is an approach worth examining, it is also important to remember to choose health-promoting foods daily,” the dietitian continued.
“The food choices we make daily have a large impact on our weight, blood sugars, heart health, immune system and more. If fasting doesn’t feel like the right choice for you, speaking with a registered dietitian about the dietary changes for your health is always recommended.”
Before making any dietary changes, a nutritionist (not pictured) told Fox News Digital that people need “extensive education” to be provided. (iStock)
The study had some limitations, both dietitians noted.
“It was a small sample size of healthy young-ish individuals,” Freirich said. “The results may be helpful and useful for other people after more research is completed in a larger age range and including people with other medical concerns.”
Palinski-Wade reiterated that the studies on FMD have included smaller sample sizes of generally healthy adults, which means the results cannot be generalized to all populations.
“FMD may offer promising benefits and may be an excellent tool to consider for those looking to improve long-term health and reduce future disease risk, but more research is needed on larger and more diverse populations to fully understand the benefits it may offer,” she added.
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Creatine, the common muscle-building supplement, may help improve depression symptoms, new research suggests.
A systematic review, published in Genomic Press’ Brain Medicine, found that creatine monohydrate may be beneficial as an add-on treatment for major depressive disorder, although the evidence remains preliminary.
The Canada-based researchers analyzed data from five randomized controlled trials, evaluating the impact of creatine monohydrate intake on mental health.
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Four of the trials studied major depressive disorder, and another looked at bipolar disorder with a current depressive episode.
In one trial of women with depression who took 5 grams of creatine per day, plus the antidepressant escitalopram, there was greater improvement after eight weeks. Another study revealed benefit when creatine was added to cognitive behavioral therapy.
One study saw benefit when creatine was added to cognitive behavioral therapy. (iStock)
Other studies involving teen girls found no benefit from a variety of creatine dosages after eight weeks. The bipolar depression study also found no significant improvements when 6 grams of creatine was added to medication after six weeks.
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In a press release, the researchers said previous studies have found that people with mood disorders process creatine differently in the brain. Because creatine helps produce energy, some scientists believe disruptions in this process may contribute to depression.
Although creatine has also been associated with boosting dopamine and serotonin, which most antidepressants target, the authors stressed that the link between brain creatine and mood “remains correlational,” as depression has “many moving parts.”
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Lead study author Bassam Jeryous Fares, a student in the Faculty of Medicine at the University of Ottawa, commented in a statement that the signal is “interesting, but not a verdict.”
“Two trials pointed one way and three pointed another,” he said. “That is not the kind of evidence on which you change clinical practice. It is the kind that tells you the question is worth further exploration.”
Although creatine has also been associated with boosting dopamine and serotonin, which most antidepressants target, the authors stressed that the link between brain creatine and mood “remains correlational.” (iStock)
Nicholas Fabiano, corresponding author and a psychiatry resident at the University of Ottawa, added in the same press release that creatine “appears to be a safe intervention,” noting that side effects were limited to mild stomach pain.
“We cannot yet reliably say that creatine helps with depressive symptoms or if the findings are generalizable to everyone,” he added as a caveat.
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Dr. Thea Gallagher, psychologist and director of wellness programs at NYU Langone, said that although creatine is best known for supporting muscle performance, it also helps the brain produce and use energy.
“Researchers believe that some people with depression may have alterations in brain energy metabolism, and creatine could help support these energy-producing pathways,” Gallagher, who was not involved in the study, told Fox News Digital. “There is also emerging evidence that it may influence neurotransmitters and reduce oxidative stress and inflammation, although these mechanisms are still being investigated.”
Creatine should be considered a “promising addition” to depression treatments, a doctor said. (iStock)
The research suggests that creatine may be most helpful when combined with established depression treatments rather than as a replacement, Gallagher emphasized.
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“This research is encouraging because it adds to a growing body of evidence suggesting that supporting brain energy metabolism may be another pathway for improving depression symptoms,” she said.
“It’s exciting whenever we identify another potential tool that could complement existing treatments, particularly one that is relatively inexpensive and widely available.”
Limitations and caveats
The new study is a review of prior research rather than a new clinical trial, which can pose a limitation, the researchers acknowledged, adding that “larger, well-controlled trials are still needed.”
Gallagher noted that creatine should be considered as a potentially promising addition to treatment, rather than a substitute for psychotherapy, antidepressant medication, regular exercise or healthy sleep habits.
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“While creatine has a strong safety profile for most healthy adults, it’s still important to talk with your healthcare provider before starting any supplement — particularly if you have kidney disease, are pregnant or have other medical conditions,” she advised.
For those experiencing signs of depression, Gallagher recommends seeking evidence-based mental healthcare.
“While creatine has a strong safety profile for most healthy adults, it’s still important to talk with your healthcare provider before starting any supplement – particularly if you have kidney disease, are pregnant or have other medical conditions,” a doctor advised. (iStock)
The doctor noted that depression is a “highly heterogeneous condition, so we still don’t know which patients are most likely to benefit or what the optimal treatment approach looks like.”
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Gallagher also cautioned that supplements have been known to generate “early enthusiasm” before larger studies have revealed “more modest effects.”
“Right now, I’d describe creatine as promising but not definitive,” she concluded. “It’s an area that deserves continued research, but it’s not something people should view as a standalone treatment for depression.”
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A decades-long effort to develop a vaccine against one of the world’s leading causes of severe digestive illness has reached a milestone, according to new research.
Scientists recently developed a technology targeting enterotoxigenic Escherichia coli (ETEC), a bacterium responsible for millions of diarrheal illnesses each year.
The technology has now been licensed to French vaccine manufacturer Valneva for further development.
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The findings come after decades of research led by scientists at the University of Bergen and the Norwegian Research Center (NORCE).
One of the most common bacterial causes of severe diarrhea worldwide, ETEC is known to disproportionately affect children in low- and middle-income countries. Despite years of research, there is currently no broadly effective vaccine to prevent the infection, according to the study.
Researchers have made a major breakthrough in the decades-long effort to develop a vaccine against ETEC, a leading cause of diarrheal disease worldwide. (iStock)
The researchers focused on a toxin produced by ETEC that has long been considered one of the biggest obstacles to vaccine development.
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James Fleckenstein, MD, a professor of medicine and molecular microbiology at the Washington University School of Medicine in St. Louis, said the findings represent a promising step.
“We still have a lot of work to do to translate these findings to an actual vaccine,” Fleckenstein, who was not involved in the research, told Fox News Digital. “But the approach does look promising in the sense that the proteins elicit strong antibody responses that appear to offer protection against diarrheal illness after the first infection in children in developing countries.”
ETEC is a leading bacterial cause of severe diarrhea worldwide, especially among children in low- and middle-income countries. (iStock)
If the vaccine eventually reaches patients, researchers hope it could help protect children against some of the most severe forms of diarrheal disease caused by ETEC.
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In the meantime, Fleckenstein said travelers can take steps to reduce their risk of diarrheal illnesses. He recommends avoiding high-risk foods — including meals from street vendors in areas where sanitation may be poor — drinking bottled water in higher-risk regions, and practicing good hand hygiene.
While a vaccine is still years away, experts recommend avoiding high-risk foods, drinking bottled water and washing your hands to reduce the risk of ETEC. (iStock)
Fleckenstein also noted that vaccines are available to protect against typhoid fever, and said travelers should consult their physician before traveling internationally.
The research did have some limitations, the researchers noted.
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The technology is still in development and has not yet been tested as an approved vaccine among the public.
While the licensing agreement allows Valneva to continue advancing the research, additional laboratory studies, clinical trials and regulatory review will be required before the vaccine becomes available.
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Bryan Johnson, a biohacker and longevity guru who has claimed “we may be the first generation who won’t die,” revealed he has an autoimmune condition causing his stomach to “eat itself.”
The Los Angeles-based tech entrepreneur, 48, has previously shared publicly that he is hoping to live until the year 2140, when he would in theory be 160 years old.
Now, Johnson says he has been diagnosed with autoimmune gastritis (AIG), a chronic autoimmune disease in which the immune system attacks the stomach’s acid-producing parietal cells, reducing stomach acid and impairing vitamin B12 absorption, according to Nature Reviews Disease Primers.
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“My stomach is eating itself,” he wrote in an Instagram post. Johnson also shared that anywhere from 2% to 5% of people likely have this disease.
“I’m going to try to solve it,” Johnson went on. “Will share all.”
Bryan Johnson, a biohacker and longevity guru who has claimed “we may be the first generation who won’t die,” revealed he has an autoimmune condition causing his stomach to “eat itself.” (Getty Images)
The biohacker shared that as a child, he ate sugary cereal, drank sugary soda and “gobbled down fast food.”
“I became a young father of three and began building a business,” Johnson went on. “Juggling that stress and grind, I let my health slip and gained 40 lbs. Within a few years I’d fallen into a deep, chronic depression.”
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“Somewhere in that timeline, my body began developing an autoimmune process affecting my thyroid and then my stomach lining,” he added.
Fox News Digital reached out to Johnson for comment.
AIG can remain hidden and can be challenging to diagnose, Johnson noted, often surfacing years after damage has already occurred to the stomach. It can cause iron deficiency, B12 deficiency and anemia, and can also increase the risk of stomach cancer, the expert warned.
“Low iron stores get normalized and rarely investigated at all when anemia hasn’t shown up yet,” Johnson wrote. “That blind spot is what hid mine for a decade.”
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He also shared that for 11 years, he has had low levels of ferritin, a protein that stores iron inside the body’s cells. Ferritin releases iron when the body needs it, supports muscle function and carries out other essential processes.
“We continually tried to raise my iron levels with food and supplementation, but nothing would work,” he said.
The Los Angeles-based tech entrepreneur, 48, has previously shared publicly that he is hoping to live until the year 2140. (Getty Images)
Johnson acknowledged that some common biohacking techniques — including hard training, sauna and hyperbaric oxygen — all raise the body’s demand for iron.
“But none of them explained the core failure: Despite me taking iron orally, trailing every formulation and using every timing trick, none of the iron would stick.”
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Johnson underwent a colonoscopy and upper endoscopy, which examined his entire intestinal tract. Five biopsies were also taken from his stomach, which found “clear signs of early autoimmune gastritis: early atrophy confined to the acid-producing lining.”
In January 2026, the biohacker stated in a post on his website that “by 2039, my goal is immortality.”
“In the age of AI, multiomics, and custom-built DNA, proteins and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today’s stack,” Johnson said in his post. (Getty Images)
He detailed his strategy for defying aging, which includes embracing a strict regimen to slow or stop biological aging, using AI to accelerate longevity research, testing new treatments in lab-grown cells and organs, and reaching “longevity escape velocity” — in which medical advances would eventually extend lifespan faster than he ages.
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“I may fail at this task, but my team and I will try our best,” he wrote at the time.
There is currently no cure for AIG, which Johnson said he wants to change.
Johnson acknowledged that some common biohacking techniques — including hard training, sauna and hyperbaric oxygen — all raise the body’s demand for iron. (iStock)
“In the age of AI, multiomics, and custom-built DNA, proteins and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today’s stack.”
Johnson ended his post by urging others to prioritize their health.
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“Care for yourself, care for others, care for the planet and care for our animal friends. Care for life, as it’s the most precious gift there is.”
The longevity guru also shared an image showing the detailed findings of his five stomach biopsies.
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