Health
Exposure to toxin increases colorectal cancer risk among younger adults, study finds
Amid the alarming trend of colorectal cancer cases rising among young people, a new study has pinpointed a potential source.
Researchers from University of California San Diego have linked a bacterial toxin called colibactin to the increase in early-onset cases.
Colibactin is produced by certain strains of Escherichia coli (E. coli) that exist in the colon and rectum, according to the researchers.
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Exposure to the bacterial toxin during early childhood can alter the DNA of colon cells in a way that increases the risk of developing colorectal cancer before age 50, the study found.
In the study, the researchers analyzed 981 colorectal cancer genomes from early-onset and late-onset colorectal cancer patients across 11 countries. (iStock)
The study, which was funded by Cancer Research UK, was published in the journal Nature on April 23.
“The key takeaway is that exposure to colibactin is likely a major contributor to early-onset colorectal cancer,” senior author Ludmil Alexandrov, professor in the Shu Chien-Gene Lay Department of Bioengineering and the Department of Cellular and Molecular Medicine at UC San Diego, told Fox News Digital.
“They could be decades ahead of schedule for developing colorectal cancer.”
In the study, the researchers analyzed 981 colorectal cancer genomes from early-onset and late-onset colorectal cancer patients across 11 countries.
Those who had prior exposure to colibactin were found to have specific mutations in their DNA, which have been shown to mainly occur in the first decade of life — “placing children on an accelerated path to developing cancer as young adults.”
Exposure to the bacterial toxin during early childhood can alter the DNA of colon cells in a way that increases the risk of developing colorectal cancer before age 50, the study found. (iStock)
That group was 3.3 times more likely to develop early-onset colorectal cancer compared to those who were diagnosed after 70.
These mutations were found to make up 15% of the early genetic alterations that increase colorectal cancer risk.
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“We detected the mutational signature of colibactin in over 50% of colorectal tumors from patients under 40, compared to less than 10% in tumors from older individuals,” Alexandrov noted.
“If someone acquires one of these driver mutations by the time they’re 10 years old, they could be decades ahead of schedule for developing colorectal cancer, getting it at age 40 instead of 60,” noted Alexandrov.
The fact that a microbial exposure in the first few years of life can leave a “lasting genomic imprint” and likely contribute to cancer in adulthood is both “remarkable and sobering,” according to the researcher.
“It’s a reminder that there are likely many other such exposures we’ve yet to uncover, and that the way we nurture and protect children during these formative years may have long-term implications for their lifelong health,” he told Fox News Digital.
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“From my perspective, investing in early-life prevention, healthy living and research is not just important — it’s essential.”
Dr. Emil Lou, MD, PhD, a board-certified oncologist and internal medicine physician at the University of Minnesota, agrees that the microbiome – “the constellation of microbes that includes bacteria that live under normal circumstances in our gut” — is one potential culprit of early-onset colorectal cancer.
“It is less surprising now than it was a decade ago that any form of bacteria – more specifically, a toxin derived from bacteria – could be associated with and potentially be the primary cause of cancer,” Lou, who was not involved in the study, told Fox News Digital.
“What is especially concerning is the long period of time that might lapse between exposure to the bacteria early in life, and the time before the related cancer is diagnosed.”
Potential limitations
Alexandrov pointed out that the study provides “strong genomic evidence” of a “striking association” between colibactin and early-onset colorectal cancer, but cannot prove causation.
“Demonstrating unequivocal causality — proving that colibactin alone is sufficient to initiate cancer in humans — remains a significant challenge,” he told Fox News Digital.
Colorectal cancer cases have doubled among adults under 50 for each of the past two decades, statistics show. (iStock)
“Definitive proof of causality would require long-term prospective studies beginning in early childhood to monitor microbial colonization and track cancer development over several decades.”
Lou agreed with this limitation, noting the complexity of cancer factors.
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“There are many aspects of our environment – both within and outside of our bodies – that can play a role in development of cancer,” he said. “It is difficult to say or conclude whether any given single factor – in this case, the bacteria-derived toxin – is the true or even a major cause of colorectal cancer.”
“Providing evidence of potential association sets the foundation for more in-depth studies to determine whether there is true cause and effect,” Lou added.
“If current trends continue, colorectal cancer is projected to become the leading cause of cancer-related death among young adults by 2030.”
Alexandrov noted that while the findings don’t yet warrant changes to screening or treatment guidelines, they do highlight the “critical role of early-life microbial exposures” in terms of long-term cancer risk.
“We are actively working on developing screening tests to detect the long-term effects of colibactin exposure, with the goal of translating these findings into practical prevention strategies in the near future,” he added.
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Colorectal cancer cases have doubled among adults under 50 for each of the past two decades, statistics show.
“If current trends continue, colorectal cancer is projected to become the leading cause of cancer-related death among young adults by 2030,” the researchers concluded.
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One of the most widely known risks linked to the COVID-19 vaccine is myocarditis, especially in young males — and now a new Stanford study has shed some light on why this rare effect can occur.
Myocarditis, which is inflammation of the heart, occurs in about one in 140,000 people who receive the first dose of the vaccine and one in 32,000 after the second dose, according to a Stanford press release. Among males 30 and younger, that rises to one in 16,750.
Symptoms of the condition include chest pain, shortness of breath, fever and palpitations, which can occur just one to three days after vaccination. Another marker is heightened levels of cardiac troponin, which indicates that the heart muscle has been damaged.
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In most cases, people who experience myocarditis recover quickly and restore full heart function, according to study author Joseph Wu, MD, PhD, the director of the Stanford Cardiovascular Institute and a professor of medicine and radiology.
One of the most widely known risks linked to the COVID-19 vaccine is myocarditis, especially in young males. (iStock)
“It’s not a heart attack in the traditional sense,” Wu told Fox News Digital. “There’s no blockage of blood vessels as found in most common heart attacks. When symptoms are mild and the inflammation hasn’t caused structural damage to the heart, we just observe these patients to make sure they recover.”
In rare cases, however, severe heart inflammation can lead to hospitalizations, critical illness or death, Wu noted.
Finding the cause
The new Stanford study — conducted in collaboration with The Ohio State University — aimed to determine the reasons for the myocarditis. The research team analyzed blood samples from vaccinated people, some with myocarditis and some without.
They found that those with myocarditis had two proteins in their blood, CXCL10 and IFN-gamma, which are released by immune cells. Those proteins then activate more inflammation.
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“We think these two are the major drivers of myocarditis,” said Wu. “Your body needs these cytokines to ward off viruses. It’s essential to immune response, but can become toxic in large amounts.”
In mouse and heart tissue models, high levels of these proteins led to signs of heart irritation, similar to mild myocarditis.
Prevention mechanism
“One of the most striking findings was how much we could reduce heart damage in our models by specifically blocking these two cytokines, without shutting down the entire (desired) immune response to the vaccine,” Wu told Fox News Digital, noting that a targeted, “fine‑tuning” immune approach might be enough to protect the heart.
Myocarditis, which is inflammation of the heart, occurs in about one in 140,000 people who receive the first dose of the vaccine and one in 32,000 after the second dose. (iStock)
“This points to a possible future way to prevent or treat myocarditis in people who are at the highest risk, while keeping the benefits of vaccination,” he added.
The team also found that genistein, an estrogen-like natural compound found in soybeans, reduced inflammation in lab tests, but this has not yet been tested in humans.
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The findings were published in the journal Science Translational Medicine.
“This is a very complex study,” Fox News senior medical analyst Dr. Marc Siegel told Fox News Digital. “Myocarditis is very rare, and the immune mechanism makes sense.”
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“Myocarditis is worse with COVID — much more common, and generally much more severe.”
Wu agreed, adding that COVID infection is about 10 times more likely to cause myocarditis compared to mRNA-based vaccines.
‘Crucial tool’
The researchers emphasized that COVID-19 vaccines have been “heavily scrutinized” for safety and have been shown to have an “excellent safety record.”
In rare cases, however, severe heart inflammation can lead to hospitalizations, critical illness or death. (iStock)
“mRNA vaccines remain a crucial tool against COVID‑19, and this research helps explain a rare side effect and suggests ways to make future vaccines even safer, rather than a reason to avoid vaccination,” Wu said.
“The overall benefits of COVID‑19 vaccination still clearly outweigh the small risk of myocarditis for nearly all groups.”
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The study did have some limitations, primarily the fact that most of the data came from experimental systems (mice and human cells in the lab), which cannot fully capture how myocarditis develops and resolves in real patients, according to Wu.
“This points to a possible future way to prevent or treat myocarditis in people who are at the highest risk.”
“These findings do not change what people should do right now, because our work is still at the preclinical (mouse and human cells) stage,” he said. “Clinical studies will be needed to confirm whether targeted treatments are safe and effective.”
The researcher also added that myocarditis risk could rise with other types of vaccines.
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“Other vaccines can cause myocarditis and inflammatory problems, but the symptoms tend to be more diffuse,” he said in the release. “Plus, mRNA-based COVID-19 vaccines’ risks have received intense public scrutiny and media coverage. If you get chest pains from a COVID vaccine, you go to the hospital to get checked out, and if the serum troponin is positive, then you get diagnosed with myocarditis. If you get achy muscles or joints from a flu vaccine, you just blow it off.”
The study was funded by the National Institutes of Health and the Gootter-Jensen Foundation.
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Cannabis has been linked to some significant medical benefits, but recent research calls those into question.
A major new analysis published in JAMA examined more than 2,500 scientific papers from the last 15 years, including other reviews, clinical trials and guidelines focused on medical marijuana.
“While many people turn to cannabis seeking relief, our review highlights significant gaps between public perception and scientific evidence regarding its effectiveness for most medical conditions,” Dr. Michael Hsu of University of California – Los Angeles (UCLA) Health Sciences, author of the study, said in a press release.
Many medical claims about cannabis are not supported by strong scientific evidence, according to a comprehensive review published in JAMA. (iStock)
The researchers — led by UCLA with contributions from Harvard, UC San Francisco, Washington University School of Medicine and New York University — set out to determine how strong the research is on the effectiveness of medical cannabis and to offer evidence-based clinical guidance.
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The review found that evidence supporting most medical uses of cannabis or cannabinoids is limited or insufficient, the release stated.
“Whenever a substance is widely used, there is likely to be a very wide set of outcomes,” Alex Dimitriu, MD, double board-certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine, told Fox News Digital.
“Cannabis is now used by about 15 to 25% of U.S. adults in the past year, for various reasons ranging from recreational to medicinal. This study points to the reality that this widely used substance is not a panacea,” said Dimitriu, who was not involved in the study.
There are very few conditions for which cannabinoid therapies have clear, well-established benefits backed by high-quality clinical data, according to the researchers.
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The strongest evidence supports FDA-approved cannabinoid medications for treating specific conditions, including HIV/AIDS-related appetite loss, chemotherapy-induced nausea and vomiting, and certain severe pediatric seizure disorders.
The review identified significant safety concerns, with high-potency cannabis use among young people linked to higher rates of mental health issues. (iStock)
For many other conditions that are commonly treated with cannabis — such as chronic pain, insomnia, anxiety or post-traumatic stress disorder — evidence from randomized trials did not support meaningful benefit.
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The analysis also examined safety concerns — in particular, how young people using high-potency cannabis may be more likely to suffer higher rates of psychotic symptoms and anxiety disorder.
Daily inhaled cannabis use was also linked to increased risks of coronary heart disease, myocardial infarction (heart attack) and stroke when compared with non-daily use.
Daily inhaled cannabis use is associated with increased cardiovascular risks, including coronary heart disease, heart attack and stroke. (iStock)
Based on these findings, the review emphasizes that clinicians should weigh potential benefits against known risks when discussing cannabis with patients.
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The authors suggest that clinicians screen patients for cardiovascular risk, evaluate mental health history, check for possible drug interactions and consider conditions where risks may outweigh benefits.
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They recommend open, realistic conversations and caution against assuming that cannabis is broadly effective for medical conditions.
The review highlights the need for caution, urging clinicians to weigh risks, screen patients appropriately and avoid assuming cannabis is broadly effective. (iStock)
“Patients deserve honest conversations about what the science does and doesn’t tell us about medical cannabis,” Hsu said.
This article is a narrative review rather than a systematic review, so it did not use the strict, standardized methods that help reduce bias in how studies are selected and evaluated, the researchers noted.
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The review notes further limitations, including that some evidence comes from observational research rather than randomized trials, which means it cannot establish cause and effect.
The trial results also may not apply to all populations, products or doses.
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