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Experimental cholesterol pill cuts heart attack risk with 'convenient' once-daily dose

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Experimental cholesterol pill cuts heart attack risk with 'convenient' once-daily dose

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A new daily pill could provide an easier, more convenient way to lower cholesterol and reduce heart attack and stroke risk.

The experimental medication, called Obicetrapib, underwent a Phase 3 clinical trial at Monash University in Australia.

The trial included more than 2,500 people averaging 65 years of age. All had either been diagnosed with heart disease or had genetically high cholesterol, according to a university press release. 

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All participants were receiving “maximum tolerated doses” of cholesterol-lowering therapy.

One group received Obicetrapib and another group took a placebo, while still maintaining their existing cholesterol drugs. 

A new daily pill could provide an easier, more convenient way to lower cholesterol and reduce heart attack and stroke risk. (iStock)

After 12 weeks, the participants taking the new drug showed a 32.6% reduction in LDL cholesterol and a 33.5% drop in lipoprotein(a) [Lp(a)], the release stated.

The findings were presented last month at the European Atherosclerosis Society Congress in the U.K. and were also published in The New England Journal of Medicine.

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“We know that many people at high risk of heart attack or stroke don’t get their cholesterol levels low enough, even on the best available treatments,” said study lead Professor Stephen Nicholls, director of Monash University’s Victorian Heart Institute and Monash Health’s Victorian Heart Hospital, in the release.

“We know that many people at high risk of heart attack or stroke don’t get their cholesterol levels low enough, even on the best available treatments.”

“Obicetrapib offers a promising new option — not only did it lower LDL cholesterol by over 30%, but we also saw a reduction in Lp(a), which is much harder to treat and has been linked to increased heart disease risk.”

Low-density lipoprotein (LDL), which is sometimes called “bad cholesterol,” is associated with negative health effects when present in high amounts. (iStock)

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Low-density lipoprotein (LDL), which is sometimes called “bad cholesterol,” is associated with negative health effects when present in high amounts.

LDL can build up in the blood vessels and increase heart attack and stroke risk, the researchers cautioned.

Lipoprotein(a), or Lp(a), is a protein that is known to greatly increase the chances of a heart attack when it’s present in high levels in the blood.

Unlike LDL, Lp(a) is an inherited risk factor that can’t be modified with healthy behaviors or medications.

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Lipoprotein(a), or Lp(a), is a protein that is known to greatly increase the chances of a heart attack when it’s present in high levels in the blood. (iStock)

Obicetrapib was found to be “well-tolerated” by the participants, the researchers noted. 

“This could be a valuable tool in the fight against heart disease,” Nicholls added. “It’s convenient, it’s effective, and it may help close the gap for patients who’ve run out of options.”

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The study — which was funded by NewAmsterdam Pharma, a developer of Obicetrapib that is based in the Netherlands — did have some limitations, the researchers noted.

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Obicetrapib was found to be “well-tolerated” by the participants, the researchers noted.  (iStock)

For example, the participants were not chosen based on high Lp(a), which means the study did not determine how the drug impacted those with elevated levels of the protein.

Additionally, the study assessed changes in LDL levels, but did not measure actual heart attack or stroke outcomes.

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More studies are needed to follow patients for longer time periods and to include more diverse cohorts, the researchers acknowledged.

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Fox News Digital reached out to the researchers for additional comment.

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism


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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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