Health
Doctors told woman she was too young for a colonoscopy. Then she was diagnosed with Stage 3 colon cancer
When Brooks Bell was 38, doctors told her she was too young to have colon cancer, dismissing her textbook symptoms as “likely hemorrhoids.”
A few months later, after pushing for tests, the North Carolina-based entrepreneur was diagnosed with Stage III colon cancer.
Bell, now 43, is encouraging other younger adults to listen to their bodies and advocate for their health, particularly as colon cancer cases are rising among people under 50.
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The founder of a digital analytics company, Bell was traveling for a technology conference five years ago when she found blood in her stool.
“I called a doctor from my hotel room and explained what was going on, and she said that blood in the stool is very common,” Bell told Fox News Digital. “She said it was almost definitely a hemorrhoid and that I should just watch it, and that it would likely go away in a couple of days.”
Brooks Bell of North Carolina is pictured after chemotherapy at right. After her treatment and recovery, she was voted onto the Board of Directors of the Colorectal Cancer Alliance. (Brooks Bell)
It didn’t go away, and a few weeks later, Bell made an appointment with a different doctor.
“She checked me out and didn’t find a hemorrhoid, but said that was probably still what it was because of my young age,” she said.
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Bell was hoping the doctor would refer her to a gastroenterologist for a colonoscopy, but she didn’t.
“At that point, I didn’t really trust where this was going, because it was still bleeding after two months,” she said. “And so I called a gastroenterologist myself.”
Four days later, during the colonoscopy, the doctors found a tumor in Bell’s colon that was causing the bleeding.
“They told me they’d be in touch, but that it was almost certainly cancerous.”
Bell is pictured during a chemotherapy treatment. She received three months of intense chemo following her surgery. (Brooks Bell)
Bell’s cancer was Stage III, which she said was actually good news.
“It was still a small tumor and I had about an 87% chance of survival,” she said.
Bell immediately had surgery to remove 10 inches of her colon. Following that was three months of high-dose chemotherapy that was 50% more intense than most regimens.
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After treatment, there was the waiting game to make sure the disease didn’t recur.
“The first year was terrifying — I had lots of nightmares,” Bell shared. “Colon cancer has the highest rate of coming back in the first year, and then it drops off after that.”
Today, five years later, Bell is cancer-free.
Understanding risk factors
Dr. Austin Chiang, gastroenterologist and chief medical officer of Endoscopy at Medtronic, a medical equipment manufacturer in Philadelphia, Pennsylvania, said it’s hard to pinpoint the exact cause of rising colon cancer rates in young people, but he has noticed a few contributing factors.
“Related to diet, there’s been an increase in consumption of red meat and ultra-processed foods,” he told Fox News Digital.
Brooks Bell speaks with guests at the first-ever Colonoscopy Gala at the Contemporary Art Museum in downtown Raleigh, North Carolina, on Feb. 28, 2020. (Eamon Queeney for the Colonoscopy Gala)
“We’ve also seen an association with rising rates of obesity. The trouble is, even if this trend is related to either of those things, what we don’t yet understand is the mechanism behind it.”
To reduce risk, Chiang said his team often recommends limiting the consumption of red meat and alcohol, as well as not smoking, which is known as a big risk factor for cancer.
“Remaining physically active is also a good rule of thumb, but beyond that, there are no other known means to reliably reduce cancer risk,” he added.
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After hearing that exercise reduces the risk of cancer coming back, Bell committed to working out every day.
“I decided I was going to exercise harder than I ever exercised in my life,” she said. “The day I finished my treatment, I was out with my running shoes.”
She even decided to train for a triathlon — finishing the event exactly one year after finishing her cancer treatment.
Brooks Bell is pictured after completing her first triathlon, one year after her final chemotherapy treatment. (Brooks Bell)
Nutrition has also been a bigger focus for Bell since her cancer treatment — particularly since colon cancer is so closely linked to gut health.
“I eat as many vegetables as I can, and I really focus on my fiber intake,” she said. “A plant-based diet helps with your microbiome health, so that’s my main focus.”
In 2024, an estimated 106,590 new cases of colon cancer and 46,220 new cases of rectal cancer will be diagnosed in the U.S.
Bell occasionally eats dairy and some lean meats, but avoids red meat.
She also sees a functional doctor — a physician that focuses on identifying and eliminating the issues that cause disease as opposed to treating and reacting to symptoms — who helps ensure that she gets the right amount of supplements and antioxidants.
Colon cancer screening guidelines
Since 2021, the U.S. Preventive Services Task Force (USPSTF) has recommended that adults ages 45 to 75 get screened for colorectal cancer.
Prior to 2021, the guidance was to get screened starting at 50.
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“That change was a huge win,” said Bell. “I think we should be grateful for that — they don’t move guidelines very often. There was overwhelming evidence to get it to 45.”
There are some indications that screening should start at 40, Bell said — “so that would be the next goal.”
Dr. Austin Chiang, gastroenterologist and chief medical officer of Endoscopy at Medtronic, a medical equipment manufacturer in Philadelphia, said it’s hard to pinpoint the exact cause of rising colon cancer rates in young people. (Dr. Austin Chiang)
“The reason it’s not at 40 is the cost and limited availability of colonoscopies — it would put more strain on the system,” she said.
Beyond the rectal bleeding that Bell experienced, other colon cancer symptoms include changes in bowel habits, abdominal discomfort, weakness or fatigue, a feeling of the bowel not completely emptying, and unexplained weight loss, according to Mayo Clinic.
Barriers to care
One of the main barriers in terms of young people getting early screening and care is lack of awareness of the risk, Bell said.
“It wasn’t that my doctors were bad — it’s just that they didn’t know this was a risk,” she told Fox News Digital. “They just don’t think they’re staring down a cancer diagnosis when someone is so young.”
There is a tendency to associate colorectal cancer with older age.
“For primary care doctors, I think they’re supposed to kind of rule out everything else before sending you in for a big-ticket item like a colonoscopy.”
Chiang agreed that there is a tendency to associate colorectal cancer with older age.
“Because current screening guidelines recommend colonoscopies starting at age 45 for people of average risk, we’re less accustomed to seeing younger patients showing symptoms of colon cancer,” he told Fox News Digital.
Brooks Bell (far right, back) moderates a discussion at the White House as part of its Cancer Moonshot initiative. (Brooks Bell)
“What makes it even more difficult is that patients with early-onset cases often experience different symptoms, so there’s still learning to be done as we become more aware and cognizant of the risk.”
Many people don’t know they need to be screened starting at age 45, Chiang pointed out — “which is why it’s important to have a primary care doctor who can help keep track of that for you.”
There’s also a common misconception that colonoscopies are dangerous or uncomfortable, he added, which may create some fear.
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“Finally, there are social determinants that create barriers as well, like physical proximity to health care centers or inability to take a day off from work to be screened,” the doctor said.
There’s a common misconception that non-invasive, stool-based tests are equivalent to getting a colonoscopy, Chiang warned, but there are some limitations associated with that method.
“If you have a positive stool test, you aren’t able to locate where that result is coming from, and more importantly, you’re not able to remove it on the spot,” he said. “With a colonoscopy, doctors can do both of those things.”
Other than skin cancers, colorectal cancer is the third most commonly diagnosed cancer in the country. (iStock)
Colonoscopies also allow doctors to detect lesions early before they turn into cancer — “especially with the help of AI technology, like our GI Genius tool,” Chiang noted.
“Our hope is that tech like this will help to standardize patient care, so that everyone who comes in for a colonoscopy has the best detection rate possible.”
Committed to the cause
After her diagnosis, Bell immersed herself in studying as much as she could about the disease.
“It was alarming to learn how preventable it is, and how underfunded it is, and how it’s rising in young people, and the importance of colonoscopies,” she said.
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Intent on raising awareness, Bell joined the Board of the Colorectal Cancer Alliance, a nonprofit focused on colon cancer prevention.
In 2022, Bell founded the nonprofit Lead From Behind as a subsidiary of the Colorectal Cancer Alliance.
“The goal was to create a fresh brand focused on staying healthy and positioning colon cancer as the preventable cancer — and to help destigmatize colonoscopies.”
Brooks Bell is pictured after undergoing surgery to remove a section of her colon after her cancer diagnosis. (Brooks Bell)
Lead From Behind has drawn a handful of prominent voices to the cause, including pro football player Dak Prescott and actor Ryan Reynolds.
Bell has also spoken at the White House as part of its Cancer Moonshot initiative, which aims to reduce cancer deaths by 50% over the next five years.
She is also hard at work on a new initiative focused on raising funds for colonoscopies for underinsured individuals.
“I want to try to continue to shift our culture to make colonoscopies and colon cancer prevention part of our conversations about wellness — so it’s just something that healthy, smart people do automatically as as they get into their 40s,” she said.
In 2024, an estimated 106,590 new cases of colon cancer and 46,220 new cases of rectal cancer will be diagnosed in the U.S., according to the American Cancer Society (ACS).
Other than skin cancers, colorectal cancer is the third most commonly diagnosed cancer in the country.
For more Health articles, visit www.foxnews.com/health.
Health
Aging process could accelerate due to ‘forever chemicals’ exposure, study finds
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
Health
Melissa Joan Hart, 49, Opens up About Weight Loss in Perimenopause
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Health
Alzheimer’s prevention breakthrough found in decades-old seizure drug
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A drug that has long been used to treat seizures has shown promise as a potential means of Alzheimer’s prevention, a new study suggests.
The anti-seizure medication, levetiracetam, was first approved by the FDA in November 1999 under the brand name Keppra as a therapy for partial-onset seizures in adults. The approval has since expanded to include children and other types of seizures.
Northwestern University researchers recently found that levetiracetam prevented the formation of toxic amyloid beta peptides, which are small protein fragments in the brain that are commonly seen in Alzheimer’s patients.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons, according to the study findings, which were published in Science Translational Medicine.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons. (iStock)
“While many of the Alzheimer’s drugs currently on the market, such as lecanemab and donanemab, are approved to clear existing amyloid plaques, we’ve identified this mechanism that prevents the production of the amyloid‑beta 42 peptides and amyloid plaques,” said corresponding author Jeffrey Savas, associate professor of behavioral neurology at Northwestern University Feinberg School of Medicine, in a press release.
“Our new results uncovered new biology while also opening doors for new drug targets.”
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The brain is better able to avoid the pathway that produces toxic amyloid‑beta 42 proteins in younger years, but the aging process gradually weakens that ability, Savas noted.
“This is not a statement of disease; this is just a part of aging. But in brains developing Alzheimer’s, too many neurons go astray, and that’s when you get amyloid-beta 42 production,” he said.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease. (iStock)
That then leads to tau (“tangles”) — abnormal clumps of protein inside brain neurons — which can kill brain cells, trigger neuroinflammation and lead to dementia.
In order for levetiracetam to function as an Alzheimer’s blocker, high-risk patients would have to start taking it “very, very early,” Savas said — up to 20 years before elevated amyloid-beta 42 levels would be detected.
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“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death,” the researcher noted.
The researchers also did a deep dive into previous human clinical data to determine whether Alzheimer’s patients who were taking the anti-seizure drug had slower cognitive decline. They reported that the patients in that category had a “significant delay” in the span from cognitive decline to death compared to those not taking the drug.
“This analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” the researcher said. (iStock)
“Although the magnitude of change was small (on the scale of a few years), this analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” Savas said.
Looking ahead, the research team aims to find people who have genetic forms of Alzheimer’s to participate in testing, Savas said.
Limitations and caveats
The study had several limitations, including that it relied on animal models and cultured cells, with no human trials conducted.
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Because the study was observational in nature, it can’t prove that the medication caused the prevention of the toxic brain proteins, the researchers acknowledged.
Savas noted that levetiracetam “is not perfect,” cautioning that it breaks down in the body very quickly.
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The team is currently working to create a “better version” that would last longer in the body and “better target the mechanism that prevents the production of the plaques.”
“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death.”
The medication’s common documented side effects include drowsiness, weakness, dizziness, irritability, headache, loss of appetite and nasal congestion.
It has also been linked to potential mood and behavior changes, including anxiety, depression, agitation and aggression, according to the prescribing information. In rare cases, it could lead to severe allergic reactions, skin reactions, blood disorders and suicidal ideation.
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Funding for the study was provided by the National Institutes of Health and the Cure Alzheimer’s Fund.
Fox News Digital reached out to the drug manufacturer and the researchers for comment.
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