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COVID-19: Children under 5 may get opportunity to get vaccinated

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COVID-19: Children under 5 may get opportunity to get vaccinated

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Pfizer Inc. and associate BioNTech SE accomplished an utility to the Meals and Drug Administration to authorize emergency use of its three-dose COVID-19 vaccine for kids 6 months to underneath the age of 5, in response to a number of reviews.  

“Pfizer and BioNTech accomplished a rolling utility to the U.S. Meals and Drug Administration (FDA) for emergency use authorization (EUA) of the 3-µg [microgram] dose of the Pfizer-BioNTech COVID-19 vaccine for kids 6 months via 4 years of age on June 1, 2022,” the corporate mentioned in launch. 

As of April 29, 10 younger individuals developed symptomatic COVID-19 inside seven days after the third dose, so the research mentioned the three-dose vaccine efficacy was roughly 80.3%, in response to the press launch.

The vaccine was deemed protected and effectively tolerated amongst youngsters studied, however the firm mentioned the information continues to be preliminary as a result of the trial protocol specifies a minimum of 21 circumstances develop COVID-19 from seven days after the third dose earlier than it completes its last assessment, the discharge added. 

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Dr. Manjul Shukla transfers a Pfizer COVID-19 vaccine right into a syringe at a cell vaccination clinic in Worcester, Mass.
(AP Picture/Steven Senne, File)

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The FDA responded that it’s accepted the appliance.

“We acknowledge dad and mom are anxious to have their younger youngsters vaccinated towards COVID-19, and whereas the FDA can’t predict how lengthy its analysis of the information and knowledge will take, we’ll assessment any EUA request we obtain as shortly as attainable utilizing a science-based strategy,” the FDA mentioned. 

The company can be reviewing Moderna’s request to permit its vaccine underneath emergency use for kids underneath the age of 6, which was requested April 28. 

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View of the Pfizer Global Research and Development Laboratories in San Diego.

View of the Pfizer World Analysis and Improvement Laboratories in San Diego.
(Sandy Huffaker/Corbis by way of Getty Photos)

The FDA’s unbiased advisory panel mentioned it might maintain a public listening to in mid-June to debate the dangers and advantages of each Pfizer’s and Moderna’s vaccines in youthful youngsters

Moderna mentioned its vaccine was 51% efficient towards asymptomatic and delicate an infection in the course of the omicron surge amongst youngsters aged 6 months to underneath age 2 and 37% efficient for these aged 2 to five, in response to ABC Information. 

COVID, MENTAL HEALTH AND SCHOOLS: OUR KIDS ARE SUFFERING AND IT’S NOT ALRIGHT

Pfizer’s vaccines are one-tenth an grownup’s dose, whereas Moderna’s are one-quarter of its grownup dose, per the information outlet. 

However dad and mom could also be reluctant to race to vaccinate their younger youngsters. 

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A health worker administers a dose of a Pfizer COVID-19 vaccine during a vaccination clinic at the Reading Area Community College in Reading, Pa.

A well being employee administers a dose of a Pfizer COVID-19 vaccine throughout a vaccination clinic on the Studying Space Group School in Studying, Pa.
(AP Picture/Matt Rourke)

Solely 18 % of oldsters of kids underneath the age of 5 are “keen” to vaccinate their youngsters, with roughly 4 in ten dad and mom of kids underneath the age 5 opting to “wait and see” earlier than having their youngsters vaccinated, in response to an April 2022 ballot from the Kaiser Household Basis. 

Pfizer and BioNTech first requested authorization from the FDA in February to vaccinate the younger youngsters with a two-dose collection. However after disappointing outcomes, the businesses added an additional dose to supply a extra sturdy immune response, in response to the Journal. 

The FDA subsequently postponed its assessment to attend for the extra testing on the third dose. 

“Our COVID-19 vaccine has been studied in hundreds of kids and adolescents, and we’re happy that our formulation for the youngest youngsters, which we rigorously chosen to be one-tenth of the dose energy for adults, was effectively tolerated and produced a robust immune response,” mentioned Albert Bourla, chairman and CEO of Pfizer. 

 

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“The research suggests {that a} low 3-ug dose of our vaccine, rigorously chosen primarily based on tolerability knowledge, gives younger youngsters with a excessive degree of safety towards the current COVID-19 strains,” added Dr. Ugur Sahin, CEO and co-founder of BioNTech.  

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Words and game of Scrabble keep married couple in wedded bliss for decades

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Words and game of Scrabble keep married couple in wedded bliss for decades

A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.

They’re still playing in tournaments built around the game decades after they began doing so.

Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.

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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.

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But it was a “special match” in 2000 that brought the couple together — and has kept them together now.

Graham and Helen Harding on their wedding day. They’ve been playing in Scrabble tournaments for some 30 years.  (Courtesy Graham and Helen Harding via SWNS)

Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.

They have been taking part in the UK Open Scrabble Championship in Reading this week.

“The more words you know, the more ammunition you’ve got.”

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“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.

7 HEALTHY LIFESTYLE CHANGES THAT COULD HELP REDUCE RISK OF DEPRESSION, SAYS STUDY: ‘ENORMOUS BENEFITS’

“But it is a Scrabble vocabulary — not necessarily everyday English.”

Added Helen Harding, “The more words you know, the more ammunition you’ve got.”

Graham and Helen Harding at their wedding.

Graham and Helen Harding’s wedding cake. They bonded over their love of Scrabble – and are still playing in tournaments together.  (Courtesy Graham and Helen Harding via SWNS)

The couple said they were “vague acquaintances” for about five years after they first met.

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Then they got together after a special match in Swindon.

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They maintained a long-distance relationship before they got married in 2004.

The couple even brought their Scrabble board to their wedding. 

Graham and Helen Harding at their wedding.

The couple likely have played thousands of games between them.  (Courtesy Graham and Helen Harding via SWNS)

It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”

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They each took up the hobby early in life well before they met each other. 

The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported. 

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Deep sleep can keep two big health problems at bay, new studies suggest

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Deep sleep can keep two big health problems at bay, new studies suggest

It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.

Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.

The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.

ANOTHER REASON TO GET MORE SLEEP AND THIS ONE MIGHT SURPRISE YOU

Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.

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Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”

“It’s like turning on the dishwasher before you go to bed and waking up with a clean brain.” (iStock)

The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists. 

The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.

But the scientists indicated that what drives the system was unclear until now, according to the study.

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Is all sleep created equal? The researchers wanted to find out.

To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.

TRUMP’S DAYLIGHT SAVING PLAN AND SLEEP: WHAT YOU MUST KNOW

They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.

The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.

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Senior couple sleeping

During deep sleep, toxic proteins that form sticky plaques linked to neurological disorders such as Alzheimer’s disease are removed, scientists say in a new study.  (iStock)

Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.” 

She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”  

‘I CAN’T SLEEP BECAUSE OF RACING THOUGHTS AT NIGHT — HOW CAN I STOP THEM?’: ASK A DOCTOR

Hauglund said she wanted to understand whether all sleep is created equal. 

To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.

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“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice. 

Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.

man sleeps in bed

Two new studies indicate the importance of getting a good night’s sleep — with one study saying a lack of sleep may be sabotaging the brain’s ability to keep intrusive thoughts at bay. (iStock)

The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.

Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.” 

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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.

Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”

For more Health articles, visit www.foxnews.com/health

Meanwhile, a lack of sleep may be doing more damage than just making people groggy.

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It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.

young woman asleep

Anyone who suffers from sleep deprivation may find that the brain’s defense against unwanted memories is weakened, say experts. (iStock)

Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post. 

“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss

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How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss


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Kathy Bates Weight Loss: Tips That Helped Her Lose 100 Lbs | Woman’s World




















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