Health
Common pain reliever could cause medical complications in some people over 65, study suggests
New research has revealed that a common medication might not be safe for everyone.
Acetaminophen, brand name Tylenol, is a pain reliever and fever reducer that’s often included in other drugs, such as cold and flu medicines.
The U.K.-based study — published in Arthritis Care & Research, an official journal of the American College of Rheumatology — analyzed the safety of the drug in older individuals.
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The researchers looked at data for more than 180,000 acetaminophen users compared to 400,000 non-users from 1998 to 2018.
The findings revealed that the use of acetaminophen – sometimes also called paracetamol – was associated with an increased risk of serious medical complications.
Acetaminophen may be found in cough, cold and flu medications, as well as in creams, gels, salves and even suppositories, one gerontologist noted. (iStock)
This includes peptic ulcer bleeding, uncomplicated peptic-ulcers, lower gastrointestinal bleeding, heart failure, hypertension and chronic kidney disease.
In a University of Nottingham press release sent to Fox News Digital, lead study author Professor Weiya Zhang, PhD, clarified that long-term use of the drug should be “carefully considered.”
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“Due to its perceived safety, paracetamol has long been recommended as the first-line drug treatment for osteoarthritis by many treatment guidelines, especially in older people who are at higher risk of drug-related complications,” he wrote.
“While further research is now needed to confirm our findings, given its minimal pain-relief effect, the use of paracetamol as a first-line painkiller for long-term conditions such as osteoarthritis in older people needs to be carefully considered.”
“This is a good reminder that all medicines used chronically have side effects,” said one physician. (iStock)
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and senior medical analyst at Fox News, shared his reaction with Fox News Digital.
“It is generally accepted doctrine that acetaminophen is not associated with GI bleeding or advancing kidney disease, but the thinking is starting to change on this front,” said the doctor, who was not involved in the study.
“Yes, over-the-counter medications are still medications.”
There is evidence suggesting that acetaminophen “modulates the same cyclooxygenase-related pathways” as anti-inflammatory drugs like ibuprofen, which can “increase adverse GI side effects,” according to Siegel.
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The large U.K. study, the doctor commented, is limited by “being observational,” as well as by an “inability to track over-the-counter as opposed to prescriptions, which were tracked.”
Another potential limitation was that some users had other contributing factors and behaviors, such as smoking and obesity.
“By inhibiting prostacyclin, it can increase the risk of bleeding,” a doctor warned about the drug. (iStock)
“Still, this is a good reminder that all medicines used chronically have side effects, and we are not always sure what they are,” he said. “This is why we continue to do post-market analysis and to re-evaluate medicines.”
He continued, “And yes, over-the-counter medications are still medications. Acetaminophen is well-known for its liver toxicity, but there are other side effects as well, as this study suggests.”
Fox News Digital reached out to Kenvue, Inc., maker of Tylenol, requesting comment on the study.
Risks for older adults
Gerontologist Dr. Macie P. Smith in South Carolina, who was not involved in the study, also reacted to the findings.
“I am happy someone is talking about the side effects of certain medications and how they disproportionately impact … those over [age] 65,” she told Fox News Digital.
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Several medications are not recommended for the older adult population, Smith said.
“Simply because they could tolerate the medications at a younger age does not mean their body can tolerate the same medications at an older age, since their body and brain will change as they age,” she noted.
People over age 65 should consult with their doctor before taking medications, experts advise. (iStock)
Some of the complications mentioned in the study, such as GI bleeding, hypertension and kidney disease, can increase the risk of stroke, Alzheimer’s disease, dementia, even premature death, according to Smith.
“I would recommend that older adults consult with their primary care doctor before taking any over-the-counter medications, since acetaminophen can be found in cold and flu medications and in creams and [ointments],” she advised.
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“Anything that is identified as a medication or drug should be discussed with the doctor, as geriatrics is a specialized practice and those who fall under this category should receive specialized care.”
Smith also recommended that older adults use only one pharmacy, so the pharmacist can consult the patient’s “running ledger” of prescription medications.
“I would recommend that older adults consult with their primary care doctor before taking any over-the-counter medications.”
“If someone over the age of 65 comes in for over-the-counter medications, the pharmacist can easily and quickly check for medication side effects and possible interactions between their prescription and OTC medications,” she said.
Older brains and bodies might not be able to handle the types of medication they could at a younger age, experts say. (iStock)
Acetaminophen in particular should be “taken with caution” and under the direction of a doctor for those 65 and older, she cautioned.
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Smith urged older individuals and their caretakers to “read the important information that comes with any and all medications.”
She added, “Don’t hesitate to speak to the pharmacist and/or your doctor about the risks and the benefits, then make an informed decision and choose well.”
Fox News Digital reached out to a number of drug manufacturers for comment.
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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.
But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.
Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date.
The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum.
A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)
The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).
“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.
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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.
Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.
The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)
The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles.
Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.
“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”
Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging.
Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)
However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.
Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.
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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”
The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.
Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)
The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives.
Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be.
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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.
Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.
Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)
Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.
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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.
“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.
Fox News Digital has reached out to the researchers for comment.
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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