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Cancer vaccine shows promising results for certain patients

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Cancer vaccine shows promising results for certain patients

There could be new hope on the horizon for kidney cancer patients in the form of an experimental vaccine.

Researchers at Dana-Farber Cancer Institute, Harvard Medical School, Yale Cancer Center and other universities have announced early findings from a study of an anti-tumor vaccine for patients with advanced kidney cancer.

“Patients with stage 3 or 4 kidney cancer are at high risk of recurrence,” said co-senior author and co-principal investigator Toni Choueiri, MD, director of the Lank Center for Genitourinary Cancer at Dana-Farber, in a press release.

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“The tools we have to lower that risk are not perfect, and we are relentlessly looking for more.”

There could be new hope on the horizon for kidney cancer patients in the form of an experimental vaccine. (iStock)

After undergoing surgery to remove a malignant tumor, the study’s nine participants received a cancer vaccine that was intended to “train” their immune systems to identify and attack any lingering cancer cells, according to the press release.

Each vaccine was personalized to match the individual patient’s tumor type based on cancer cells that were removed during surgery. These cells contain “neoantigens,” which are “tiny fragments of mutant proteins,” the release stated. The researchers used “predictive algorithms” to determine which neoantigens should be included in the vaccine to provide the highest level of immunity. 

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Five of the patients also received ipilimumab, a type of immunotherapy drug.

All nine patients showed a “successful anti-cancer immune response” after getting the vaccine. After an average of 34.7 months, they all remained cancer-free.

Within three weeks of receiving the vaccine, patients showed an “immune response,” with T-cells spiking by more than 166 times, the release said. (T-cells, also known as T lymphocytes, are immune cells that help to fight cancer and prevent infection.)

“The tools we have to lower that risk are not perfect and we are relentlessly looking for more.”

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In the study, the T cells were found to remain in the patient’s body for up to three years and attacked the existing tumor cells.

“We observed a rapid, substantial, and durable expansion of new T cell clones related to the vaccine,” said Patrick Ott, MD, PhD, director of the Center for Cancer Vaccines at Dana-Farber.

“These results support the feasibility of creating a highly immunogenic personalized neoantigen vaccine in a lower mutation burden tumor and are encouraging, though larger-scale studies will be required to fully understand the clinical efficacy of this approach.”

For most stage 3 or 4 kidney cancer patients, the standard treatment is surgical removal of the tumor, which is often followed by an immunotherapy drug. (iStock)

The results of the clinical trial were reported in the journal Nature on Feb. 5. 

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“We’re very excited about these results, which show such a positive response in all nine patients with kidney cancer,” Choueiri noted.

For most stage 3 or 4 kidney cancer patients, the standard treatment is surgical removal of the tumor, which is often followed by an immunotherapy drug called Pembrolizumab (Keytruda).

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“Pembrolizumab induces an immune response that reduces the risk of the cancer coming back,” according to Dana-Farber. “However, about two-thirds of patients can still recur and have limited treatment options.”

First author David A. Braun, MD, PhD, a medical oncologist and physician-scientist at Yale Cancer Center and Yale School of Medicine, noted that the approach used in this study was “truly distinct from vaccine attempts in kidney cancer.”

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“We pick targets that are unique to the cancer and different from any normal part of the body, so the immune system can be effectively ‘steered’ toward the cancer in a very specific way,” a researcher said in the release.  (iStock)

“We pick targets that are unique to the cancer and different from any normal part of the body, so the immune system can be effectively ‘steered’ toward the cancer in a very specific way,” Braun said in the release. 

“We learned which specific targets in the cancer are most susceptible to immune attack and demonstrated that this approach can generate long-lasting immune responses, directing the immune system to recognize cancer. We believe this work can form a foundation for the development of neoantigen vaccines in kidney cancer.”

‘Exciting and promising’

Charles Nguyen, MD, a medical oncologist who specializes in kidney cancer at City of Hope in Orange County, California, noted that kidney cancer is among the 10 most common cancers among men and women in the U.S. 

“This is a very exciting and promising tool for many of our patients with kidney cancer, where we can one day make a cure possible for all.”

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“Patients with early stage (localized) kidney cancer are often first treated with surgery to remove the tumor — however, many patients have a risk of the cancer coming back years after surgery, and there is a great interest in finding ways to lower the risk of cancer recurrence,” Nguyen, who was not involved in the study, told Fox News Digital.

“This exciting clinical trial evaluated a personalized cancer vaccine that uses genetic information from each patient’s cancer to train and enhance the patient’s immune system to recognize the cancer and prevent it from recurring.” 

      

While Nguyen acknowledged that this was a small study, all nine patients who received the vaccine were cancer-free even three years later. 

“This is a very exciting and promising tool for many of our patients with kidney cancer, where we can one day make a cure possible for all.”

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Side effects and limitations

Some patients did experience side effects from the vaccine, including local reactions at the vaccine injection site and flu-like symptoms, although “no higher-grade side effects were reported.”

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The researchers also acknowledged that there were some limitations associated with the study.

“There were limitations in the antigen-prediction tools available at the time and in the ability to target only a single antigen,” they wrote.

Some patients did experience side effects from the vaccine, including local reactions at the vaccine injection site and flu-like symptoms. (IStock)

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“Moreover, it was conducted in the setting of active metastatic disease in a number of study participants.”

Future research with larger clinical trials are planned to confirm the vaccine’s effectiveness and full potential, the release stated. 

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Funding for this study was provided by the Gateway for Cancer Research, the U.S. Department of Defense, Yale Cancer Center, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Trust Family Foundation, Michael Brigham, Pan-Mass Challenge, Hinda L. and Arthur Marcus Foundation, The Loker Pinard Fund for Kidney Cancer Research at Dana-Farber Cancer Institute, National Institutes of Health, Conquer Cancer Foundation/Sontag Foundation, the release stated.

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Deadly Legionnaires’ disease outbreak sparks concern in major US city: Know the symptoms

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Deadly Legionnaires’ disease outbreak sparks concern in major US city: Know the symptoms

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Amid warnings of a Legionnaires’ disease outbreak on Manhattan’s Upper East Side, health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups.

New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms.

As of July 6, the New York City Health Department had confirmed 23 cases and 17 hospitalizations associated with the respiratory infection. No deaths have been reported.

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Officials are investigating contaminated cooling towers as the likely source. They have emphasized that the illness is not spread person-to-person and is not linked to the city’s drinking water.

Health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups. (iStock)

“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early,” said NYC Health Commissioner Dr. Alister Martin in a press release. “New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin.”

What is Legionnaires’?

Legionnaires’ disease is a type of pneumonia caused by Legionella bacteria.

The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC.

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That can include shower heads, sink faucets, hot tubs, water features/fountains, plumbing systems and other water systems.

When people swallow or breathe in droplets of water that contain Legionella, they can potentially become ill.

Although human transmission is possible in rare cases, the disease is not typically transmitted among people, per the Centers for Disease Control and Prevention.

Symptoms of infection

Infections can lead to severe pneumonia in older people and those with compromised immune systems, according to Dr. Andrew Handel, a pediatric infectious diseases expert at Stony Brook Children’s Hospital on Long Island, New York.

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Symptoms of Legionnaires’ disease usually show up between two and 14 days after exposure.

New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms. (iStock)

“Legionella infections cause symptoms that are similar to other forms of pneumonia — fever, coughing, difficulty breathing, shortness of breath and chest pain,” Handel previously told Fox News Digital.

“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early.”

The signs are similar to other types of pneumonia, and include the following:

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  • Cough
  • Fever
  • Shortness of breath
  • Muscle aches and headaches

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Some patients may also experience nausea, diarrhea and confusion, the CDC noted.

Diagnosis, treatment and prevention

A medical professional can diagnose the infection with laboratory tests and chest X-rays.

The condition is typically treated with antibiotics. In cases of severe infection, hospitalization may be required for breathing support and IV hydration.

Around 10% of people who contract Legionnaires’ disease will die from those complications — and the mortality risk rises to 25% for those who get Legionnaires’ while staying in a healthcare facility, according to the CDC.

The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC. (iStock)

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“Treatment needs to be early and aggressive,” Dr. Nathan Goodyear, an Arizona-based integrative medicine expert, previously told Fox News Digital. “Legionella infection is an intracellular infection that requires antibiotic treatment.”

Antibiotics that are appropriate for Legionella infection include Levofloxacin and Azithromycin. 

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“Therapy can be prescribed orally in healthy individuals… but intravenous antibiotics often prove to be the initial option for treatment secondary to the pathogenicity of the disease,” Goodyear said.

Currently, there are no vaccines for Legionnaires’ disease. 

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The best strategy to prevent infection is to reduce the growth and spread of the Legionella bacteria. The CDC recommends that building owners and managers use a water management program to reduce the risk.

“New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin,” city officials stated. (iStock)

To prevent serious illness from Legionnaires’, Goodyear recommends that all smokers kick the habit, and also emphasizes the need to “aggressively support” chronic pulmonary disease.

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“Increasing immune support (vitamin D3, vitamin C, Zinc) is required to counter the immune dysfunction associated with advancing age.”

Obesity is another foundational risk factor for all chronic inflammatory diseases, the doctor added.

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Katie Couric couldn’t remember the year or the president during frightening brain episode

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Katie Couric couldn’t remember the year or the president during frightening brain episode

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Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27.

In a post on Substack titled “The Day I’ll Never Remember,” she detailed a sudden episode that left her unable to recall the current month, year and president.

“I thought it was 2024. And I believed Joe Biden was president,” she wrote.

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The event occurred while Couric was attending the Aspen Ideas Festival in Colorado, during which she participated in two public panels — one on AI and one on journalism — both of which she cannot remember at all.

“I have no idea what we talked about, or of what occurred when the panels ended,” she said.

Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27. (Getty Images)

John Molner — Couric’s husband, who was in attendance at the festival and the two panels — also shared his account.

After the event, someone told Molner that Katie wasn’t feeling well. When he reached her, an EMT and a doctor were tending to her. “I could tell something was off,” he wrote. “It could have been altitude sickness, but Katie was definitely not all there.”

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At the hospital, when Couric struggled to recall the year, the president and her grandchildren’s names, doctors began checking for a stroke.

An MRI revealed no signs of stroke, which was a relief, but “Katie’s ‘fog’ became a lot more apparent,” Molner wrote.

John Molner, Couric’s husband, who was in attendance at the festival and the two panels, also shared his account. (Getty Images)

“She repeatedly asked me the same questions: ‘What was I doing before we got to the hospital?’ ‘Why am I at the hospital?’”

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Couric was ultimately diagnosed with transient global amnesia, a sudden, temporary episode of memory loss that prevents a person from forming new memories and may also erase some recent memories, according to Mayo Clinic.

“The cause seems to be as mysterious as the brain itself.”

It is not caused by a stroke, seizure or head injury, and it usually resolves completely within 24 hours.

“[It’s] just a very weird neural episode that’s pretty uncommon and, at least in most cases, is a ‘one and done’ experience,” Molner said.

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Couric said she finally began feeling “like herself” again around 9 p.m. and went to sleep at 2 a.m.

As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.”

As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.” (Getty Images)

Data shows that approximately three to eight people per 100,000 will have an episode of transient global amnesia, with people 50 years of age and older at higher risk.

The specific cause of TGA is not known, but some experts believe it stems from a “temporary dysfunction in the brain’s hippocampus — the area responsible for creating new memories,” Couric shared.

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“Doctors believe this is driven by brief interruptions in blood or oxygen flow, or microscopic spasm in the blood vessels.”

Episodes could potentially be triggered by intense physical exertion, emotional distress, extreme temperature changes or migraines, experts say.

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Approximately 15% of patients will have a recurrence 10 years later.

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“Why did this happen to me? Was the altitude an issue? Was I dehydrated? Tired? Stressed? The literature doesn’t seem to indicate that these are contributing factors, but the cause seems to be as mysterious as the brain itself,” Couric wrote.

Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise. (iStock)

“All I know is that those hours will be forever lost. Someone described it as my brain failing to hit the ‘record button.’”

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“While this was a freaky occurrence, it could have been much more serious. So ultimately, I’m relieved — even though several hours of a Saturday in June will always be missing for me.”

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Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise.

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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