Health
Barrie R. Cassileth, Who Transformed Cancer Care, Dies at 83
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However Dr. Cassileth was additionally fast to notice the boundaries of her personal analysis, and to claim her openness to the potential efficacy of therapies exterior the mainstream. She was each a member the American Most cancers Society’s Subcommittee on Questionable Strategies of Most cancers Administration and an adviser to the Nationwide Institutes of Well being’s Workplace of Various Medication, now known as the Nationwide Heart for Complementary and Various Medication.
She took a historic perspective. Most cancers was as soon as thought of incurable, and so the main target of remedy was restricted to palliative care, serving to ease a affected person’s ache. However with the rise of chemotherapy and radiation and the rising risk of survival, consolation and high quality of life took a again seat. Her mission, she stated, was to deliver that again, utilizing evidence-based, noninvasive therapies.
“She was a legend in our subject,” Dr. Ting Bao, the director of integrative breast oncology at Memorial Sloan Kettering, stated in an interview.
Barrie Joyce Rabinowitz was born on April 22, 1938, in Philadelphia. Her father, Albert Rabinowitz, owned an organization that manufactured socks; later, he and her mom, Rosalind (Kaizen) Rabinowitz, ran an organization that designed and put in kitchens.
She is survived by her siblings, Stephen Rabinowitz and Ruth Rabinowitz; her daughters, Jodi Cassileth Greenspan and Wendy Cassileth; her son, Gregory Cassileth; and 6 grandchildren.
She attended Bennington Faculty in Vermont and spent a summer time instructing artwork in Pownal, a village close to the Massachusetts border. Figuring out of a one-room schoolhouse, she befriended the mother and father of two of her college students. The mom, Ms. Rabinowitz quickly realized, had terminal most cancers, and the expertise of watching her undergo targeted her pursuits on serving to alleviate such ache.
She graduated with a level in social sciences in 1959, a yr after marrying Peter Cassileth. They later divorced. Her second marriage, to H. Taylor Vaden, a communications govt, additionally resulted in divorce. Her third husband, Richard Cooper, a hematologist, died in 2016.
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Health
The Carnivore Diet: Is There Science Behind the Fad? | Woman's World
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Health
For diabetes patients, inhaled insulin is shown just as effective as injections and pumps
![For diabetes patients, inhaled insulin is shown just as effective as injections and pumps](https://static.foxnews.com/foxnews.com/content/uploads/2024/06/diabetes-insulin-inhaler.jpg)
Most of the 38 million people living with diabetes in the U.S. use daily injections or insulin pumps to keep glucose at safe levels — but new research suggests that a third option could be just as effective.
In a study led by Dr. Irl B. Hirsch, M.D., medical director of the Diabetes Care Center of the University of Washington Medical Center, an inhaled form of insulin — similar to an asthma inhaler — worked just as well as injections or pumps to control type 1 diabetes.
The research was presented last week at the American Diabetes Association (ADA)’s 84th Scientific Sessions in Orlando, Florida.
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The clinical trial tested a product called Afrezza, an inhaled insulin made by MannKind Corporation in California.
Afrezza, the only inhaled insulin on the market, has been available since getting FDA approval in June 2014.
An inhaled form of insulin worked just as well as injections or pumps to control type 1 diabetes in a recent study. (iStock/MannKind)
Benefits of a third option
“In those with type 1 diabetes, insulin is required for survival,” Hirsch told Fox News Digital in an interview.
“With continuous glucose sensing, glucose control has been dramatically improved — but not everyone reaches the target with multiple injections or pumps, and there are many pros and cons with each therapy,” he said.
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With pumps, people must wear the device, which can lead to skin problems.
They also have to purchase extra accessories.
Blood glucose levels can also drop with exercise, Hirsch warned, which can be problematic.
![Afrezza inhaler](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/06/1200/675/Inhaler.Insulin.jpg?ve=1&tl=1)
Afrezza, an inhaled insulin pictured here, is made by MannKind Corporation in California. (MannKind)
“Injections overall can be more convenient for some, but they don’t do as well as pump patients,” he said.
With Afrezza, the product is inhaled into the lungs before meals, and the fast-acting insulin minimizes the glucose spike often seen after eating, Hirsch noted.
“Patients with type 1 diabetes should consider this as another option for their mealtime insulin, and talk to their doctor about this choice.”
During the 17-week study, researchers evaluated the results of 141 adults who were assigned to either use the Afrezza inhaler or continue with traditional methods of injection or pump delivery.
At the 17-week mark, all participants switched to the inhaler for another 13 weeks.
![Dr. Irl B. Hirsch](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/06/1200/675/Dr.-Irl-B.-Hirsch52.jpg?ve=1&tl=1)
Dr. Irl B. Hirsch, M.D., medical director of the Diabetes Care Center of the University of Washington Medical Center, led the new study. (MannKind)
All groups were assessed with continuous glucose monitoring at the start of the study, at 17 weeks and again at 30 weeks.
Among the inhaled insulin group, 30% of participants reached their target glucose levels (less than 7% blood sugar) compared to 17% of the people using injections and pumps.
There was no difference in hypoglycemia (low blood sugar) between the groups.
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“In general, there was no difference in our primary endpoint, HbA1c, a reflection of average blood sugar,” Hirsch said.
“But that alone is misleading — many patients did better with their glucose control, while others did worse.”
![Afrezza inhaler](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/06/1200/675/Afrezza-269-scaled.jpg?ve=1&tl=1)
With Afrezza, the product is inhaled into the lungs before meals, and the fast-acting insulin minimizes the glucose spike often seen after eating, a doctor said. (MannKind)
“The point is, inhaling insulin isn’t for everyone, but some did better than they did on their pumps.”
The people who saw the best results inhaled insulin between meals and at bedtime, Hirsch added.
At the end of the study, more than half of the participants said they would opt to stay on the inhaled insulin therapy.
“The biggest takeaway is that patients with type 1 diabetes should consider this as another option for their mealtime insulin, and talk to their doctor about this choice,” he recommended.
‘Adds value’
The American Diabetes Association acknowledged the promise of the study findings in an email to Fox News Digital.
“We look forward to our Scientific Sessions every year to see data like the INHALE-3 study’s findings, which have the potential to expand diabetes care,” Raveendhara Bannuru, M.D., PhD, the ADA’s vice president of medical affairs and quality improvement outcomes in Boston, Massachusetts, told Fox News Digital via email.
![diabetes CGM](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2023/09/1200/675/iStock-1367251295.jpg?ve=1&tl=1)
“With continuous glucose sensing, glucose control has been dramatically improved,” a doctor told Fox News Digital. (iStock)
“We are hopeful for the continuous development of alternative insulin delivery methods that could offer options for people living with diabetes,” the group also said in the statement.
“The INHALE-3 trial demonstrated that inhaled insulin, combined with insulin degludec, effectively reduces A1c levels without increasing hypoglycemia or weight gain in people with type 1 diabetes. This adds value to the options in insulin therapy.”
Potential risks and limitations
While more people met their glycemic targets with Afrezza, some subjects saw worse readings when switching from usual methods to inhaled insulin — “potentially due to missing doses of inhaled insulin during the day and/or underdosing going into bedtime,” the researchers wrote.
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“We didn’t see any concerns,” Hirsch said when asked about side effects.
“As expected, a few people coughed immediately when dosing their insulin, but no major concerns were seen and everyone continued on their inhaled insulin.”
![Insulin injection](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2023/05/1200/675/insulin-injection.jpg?ve=1&tl=1)
“Not everyone reaches the target with multiple injections or pumps, and there are many pros and cons with each therapy,” a doctor said. (iStock)
The most common side effects noted in the study were hypoglycemia, cough and throat pain or irritation.
Afrezza has been linked to a risk of acute bronchospasm in patients with chronic lung disease, such as asthma or COPD, according to the manufacturer.
“Inhaling insulin isn’t for everyone, but some did better than they did on their pumps.”
Before starting Afrezza, patients should see a doctor for a physical examination and testing to measure lung function.
Patients who smoke or who recently quit smoking should not take the inhaled medication.
For more Health articles, visit www.foxnews/health
Fox News Digital reached out to MannKind requesting additional comment.
Health
Surgeon general declares firearm violence in America a public health crisis
![Surgeon general declares firearm violence in America a public health crisis](https://static.foxnews.com/foxnews.com/content/uploads/2024/06/GettyImages-1717037957-scaled-e1719315853750.jpg)
The United States surgeon general is declaring gun violence a national public health crisis.
Surgeon General Vivek Murthy issued an advisory on Tuesday stating that firearm-related violence and its immediate psychological ramifications on victims and bystanders has severely compromised public health.
“Today, for the first time in the history of our office, I am issuing a Surgeon General’s Advisory on firearm violence,” Murthy said in a video announcement. “It outlines the urgent threat firearm violence poses to the health and well-being of our country.”
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U.S. Surgeon General Dr. Vivek Murthy released a special advisory on firearm violence on Tuesday, calling gun-related incidents a public health crisis. (Nathan Congleton/NBC via Getty Images)
“As a doctor, I’ve seen the consequences of firearm violence up close and the lives of the patients that cared for over the years,” the surgeon general continued. “These are moms and dads, sons and daughters, all of whom were robbed of their physical and mental health by senseless acts of violence.”
The advisory states that 54% of adults in America have experienced a firearm-related incident. These experiences with firearm violence include individuals who have been threatened with a gun (21%), lost a family member in a gun-related death (19%), witnessed a shooting (17%), and been wounded by a firearm (4%).
The 54% figure also includes adults who have fired a gun in self-defense (4%). The gun-related death statistic includes those who committed suicide via firearm.
The report noted different demographics are affected in different ways by gun violence.
Black individuals suffer the highest rate of gun deaths. American Indians, Alaskan Natives, elderly white people, and military veterans are at the highest risk suicide by firearm.
“Beyond these precious lives that are lost to firearm violence, there are wider ripples of harm to those who are injured, who witnessed the incidents, who live in urban and rural communities where such violence takes place, and who constantly read and hear about firearm violence,” Murthy stated.
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![Vivek Murthy](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2024/06/1200/675/GettyImages-1953493545-scaled-e1719314559178.jpg?ve=1&tl=1)
Murthy wrote in the report that the direct casualties of gun violence are compounded by psychological ramifications inflicted on victims and bystanders. (Tom Williams/CQ-Roll Call, Inc via Getty Images)
He added, “The collective trauma and fear that Americans are experiencing is contributing to the mental health challenges that we are facing today. Nearly 6 in 10 U.S. adults say they worry about a loved one being a victim of firearm violence.”
The public advisory on firearm-related violence is the first document of its kind released by the Surgeon General’s Office.
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