Health
Ask a health expert: ‘Should I take Paxlovid if I have COVID?’
If you’ve tested positive for COVID-19, you might be wondering if it’s necessary to take an antiviral medication, such as Paxlovid.
Pfizer’s Paxlovid (nirmatrelvir and ritonavir) gained full approval from the U.S. Food and Drug Administration (FDA) on May 25, 2023.
Another drug, Lagevrio (molnupiravir), is authorized for emergency use by the FDA under an Emergency Use Authorization (EUA) — but does not have full approval.
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As noted on Pfizer’s website, Paxlovid is intended for the treatment of mild to moderate COVID symptoms to prevent severe illness, hospitalization or death in high-risk individuals.
Paxlovid, which must be prescribed by a doctor, works best when taken within five days of a COVID diagnosis or when the first symptoms appear, according to Sean Marchese, a registered nurse at The Mesothelioma Center in Florida, who has a background in oncology clinical trials.
Sean Marchese, a registered nurse at The Mesothelioma Center in Florida, offered guidance on when to take Paxlovid after a COVID diagnosis. (Sean Marchese/Getty Images)
“Patients should take the medication as soon as possible if they know or suspect they might have COVID to ensure it is most effective,” he told Fox News Digital.
For those who do not have significant risk factors for Paxlovid, Marchese said, “starting treatment as soon as possible is essential, even if you only have mild symptoms.”
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Similar to some antibiotics, Paxlovid is offered on a “dose card” that allows you to punch out 30 pills during treatment, said Marchese. The standard treatment is three pills twice daily over five days.
Some patients may require a second course of Paxlovid if they have a rebound or relapse of COVID-19.
Who should avoid Paxlovid?
For those who have had COVID for more than a week, Paxlovid may be less effective and could potentially be harmful, Marchese advised.
There is a higher risk of harm from taking Paxlovid for those who have organ damage, such as reduced kidney or liver function, according to Marchese.
Paxlovid works best when taken within five days of a COVID diagnosis or when the first symptoms appear, according to a registered nurse. There are other key facts about it that patients must know. (REUTERS/Jennifer Lorenzini/File Photo)
“Pediatric patients under 12 years of age or those weighing under 88 pounds should also avoid Paxlovid,” he said.
People with cancer should discuss potential interactions between their prescribed medications and Paxlovid, the expert advised.
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“Some cancer medications may inhibit the effects of Paxlovid,” Marchese said.
“Conversely, treatment with Paxlovid may reduce the effectiveness of some cancer medications.”
As Pfizer notes on its website, physicians should “consider the benefit of Paxlovid treatment in reducing hospitalization and death, and whether the risk of potential drug-drug interactions for an individual patient can be appropriately managed.”
“Vaccination efforts continue to be the most effective guard against COVID-19,” the nurse told Fox News Digital. (Michael Nagle/Bloomberg via Getty Images)
People with HIV-1 infections should consult their provider before taking Paxlovid, the expert said, as the medication could interfere with long-term HIV treatment.
“Other interactions with Paxlovid include cholesterol-lowering statins, such as Lipitor,” he warned.
Potential side effects
Some patients report a “rebound” effect with Paxlovid, where they may test positive for COVID-19 after the course of treatment but show no symptoms, noted Marchese.
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“In these cases, reinfection is unlikely, and hospitalization or severe disease is rare,” he said.
Potential side effects of the antiviral medication include hives or rashes on the skin or trouble breathing.
Those who have had COVID for more than a week should consult a health care provider before taking Paxlovid, the expert advised. (iStock)
“Those with hypersensitivity disorder should be especially cautious and notify their providers immediately if they experience any side effects,” noted Marchese.
Other potential side effects include diarrhea, increased blood pressure, muscle aches and nausea.
“Vaccination efforts continue to be the most effective guard against COVID-19,” Marchese said. “People who have a higher risk of complications or immune deficiency, such as cancer patients, should stay vigilant with the COVID-19 vaccinations and their other recommended vaccines.”
Paxlovid was originally offered for free by the U.S. government. But as of Dec. 15, 2023, it transitioned to commercial distribution, according to the Health & Human Services website.
Pfizer also operates programs to ensure affordable access for patients.
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Fox News Digital reached out to Pfizer with the opportunity to provide additional comment.
For more Health articles, visit www.foxnews.com/health.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
Health
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