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Aging speeds up 'massively' at two points in one's lifetime, Stanford study finds: ‘Abrupt changes’

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Aging speeds up 'massively' at two points in one's lifetime, Stanford study finds: ‘Abrupt changes’

Aging may not be quite as gradual as it seems.

A new study from Stanford University in California has revealed that there are two periods when aging seems to accelerate.

These two spurts tend to occur around age 44 and again at age 60, the study found.

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In the study, 108 participants ranging from 25 to 75 years old gave blood and biological samples over the course of several years, according to a Stanford University press release.

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A new study from Stanford University in California has revealed that there are two periods when aging seems to accelerate. (iStock)

The researchers analyzed more than 135,000 molecules and microorganisms (bacteria, viruses and fungi), finding that most of them don’t change in a “gradual, chronological fashion.”

“We’re not just changing gradually over time; there are some really dramatic changes,” said Michael Snyder, PhD, professor of genetics and the study’s senior author, in the release.

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“It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that’s true no matter what class of molecules you look at.”

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The findings were published in the journal Nature Aging last month.

For those in their 60s, age-related changes tend to impact the organs and immune system, according to a doctor. (iStock)

Dr. Brittany Ferri, a New York-based occupational therapist with the National Council on Aging, agreed that aging doesn’t always happen steadily.

“Big changes can happen at certain points in your life,” Ferri, who was not involved in the study, told Fox News Digital. “People tend to experience shifts that will impact their health going forward.”

“Certain phases will bring noticeable shifts in how the body functions.”

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In their 40s, people are likely to face more stress or make lifestyle changes that could affect their well-being, and by the 60s, age-related changes will impact the organs and immune system, according to Ferri.

“With aging happening in distinct stages, certain phases will bring noticeable shifts in how the body functions,” she added.

The aging-health connection

These “abrupt changes” can have an impact on people’s health as they age, the study found.

“During your 40s and 60s, key molecules and microbes related to heart health and the immune system change considerably,” Ferri told Fox News Digital after reviewing the findings. 

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“In your 40s, changes in molecules that affect how your body processes fats and alcohol could raise your risk of heart disease if they’re not managed well,” she went on.

“In your 60s, shifts in your immune system can make you more prone to age-related health problems.”

The researchers noted that they were not surprised by the shift in the early 60s, as this is a time when age-related diseases and conditions tend to emerge. (iStock)

The researchers noted that they were not surprised by the shift in the early 60s, as this is a time when age-related diseases and conditions tend to emerge.

The surge in the mid-40s, however, was not expected. While they initially thought this shift was due to menopause or perimenopause in women, they realized it was also occurring for men at that age.

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“This suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women,” first author Xiaotao Shen, PhD, a former Stanford Medicine postdoctoral scholar, said in the release. 

“Identifying and studying these factors should be a priority for future research.”

The researchers emphasized the importance of healthy behaviors, like regular exercise and proper nutrition, to counteract the aging spurts. (iStock)

The main limitation is that these changes could be caused by lifestyle or behavioral factors that tend to emerge in the 40s and 60s, Snyder acknowledged.

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Looking ahead, the team plans to conduct further research into these aging spurts.

“I’m a big believer that we should try to adjust our lifestyles while we’re still healthy.”

They also emphasized the importance of healthy behaviors to counteract these changes.

“That could look like increasing exercise to protect your heart and maintain muscle mass at both ages or decreasing alcohol consumption in your 40s as your ability to metabolize alcohol slows,” the researchers wrote.

For those in their 40s, it’s important to eat healthy, manage stress, and cut back on alcohol to support the changes in metabolism and heart health, a doctor advised. (iStock)

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Added Snyder, “I’m a big believer that we should try to adjust our lifestyles while we’re still healthy.”

For those in their 40s, it’s important to eat healthy, manage stress, and cut back on alcohol to support the changes in metabolism and heart health, according to Ferri. 

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“In your 60s, try to focus on staying active to help boost your immune system and stay at a healthy weight,” she recommended.

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The Stanford study was funded by the National Institutes of Health and the Stanford Data Science Initiative. 

Fox News Digital reached out to the researchers for comment.

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.

A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.

The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.

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“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.

“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.

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Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.

Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.

One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)

There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.

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“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.

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Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.

The key, she said, is adapting the mindset, not replicating it perfectly.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

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The goal is to reintroduce small, intentional moments that make you feel better.

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That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.

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Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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