Health
A second booster helped protect older people from Omicron infection, but waned quickly, an Israeli study says.
A second booster shot of the Pfizer-BioNTech Covid vaccine supplies further short-term safety towards Omicron infections and extreme sickness amongst older adults, in accordance with a big new examine from Israel.
However the booster’s effectiveness towards an infection specifically wanes after simply 4 weeks and virtually disappears after eight weeks. Safety towards extreme sickness didn’t ebb within the six weeks after the additional dose, however the follow-up interval was too quick to find out whether or not a second booster supplied higher long-term safety towards extreme illness than a single booster.
The examine centered on adults ages 60 and older, and didn’t present knowledge on the effectiveness of a second booster in youthful populations.
The findings, printed on Tuesday within the New England Journal of Medication, recommend that further boosters are possible to offer fleeting safety towards Omicron infections in older recipients, and are in line with proof that vaccine effectiveness towards an infection wanes quicker than towards extreme illness.
“For confirmed an infection, a fourth dose appeared to offer solely short-term safety and a modest absolute profit,” the researchers wrote.
The outcomes come within the midst of a debate over whether or not and when People may want further boosters. The Meals and Drug Administration is convening a panel of out of doors advisers on Wednesday for dialogue on the broader U.S. booster technique.
The fast unfold of the extremely transmissible Omicron variant, which might evade a few of the physique’s immune defenses, has intensified the dialogue of whether or not second boosters are broadly vital.
Final month, the F.D.A. licensed second booster pictures of the Pfizer-BioNTech and Moderna vaccines for adults ages 50 and older, in addition to immunocompromised individuals ages 12 and older. The company additionally licensed an mRNA booster for adults who’ve already obtained two doses of the Johnson & Johnson vaccine.
It’s prone to be a troublesome promote: Whereas 66 % of People have been vaccinated, simply 30 % have obtained a booster shot.
It’s clear that the Omicron variant has blunted the effectiveness of Covid vaccines, however knowledge on the advantages of a second booster stays restricted. A earlier examine from Israel, which has not but been printed in a scientific journal, discovered that older adults who obtained a second booster had been 78 % much less prone to die of Covid-19 than those that had obtained only one booster shot.
However scientists criticized the examine’s methodology, and the advantages of a second booster for younger, wholesome adults are much less clear. Some consultants be aware that almost all adults who’ve been vaccinated and boosted as soon as are already prone to be shielded from extreme sickness and demise.
On Jan. 2, Israel licensed a fourth dose of the Pfizer-BioNTech vaccine for adults ages 60 and older and members of different high-risk populations who had obtained their third pictures at the very least 4 months earlier. Israel’s vaccination marketing campaign has relied closely on the Pfizer-BioNTech vaccine.
The brand new examine is predicated on data from the Israeli Ministry of Well being on greater than 1.2 million older adults who had been eligible for the fourth shot between Jan. 10 and March 2, when Omicron was the dominant variant within the nation.
The researchers in contrast the speed of confirmed virus infections and circumstances of extreme Covid-19 amongst those that had obtained a fourth dose to those that had obtained simply three doses.
Safety towards an infection appeared to peak 4 weeks after the fourth shot: the speed of confirmed infections was twice as excessive within the three-dose group as within the four-dose group. By eight weeks after the fourth shot, nevertheless, the extra safety towards an infection had virtually disappeared, the researchers discovered.
Charges of extreme illness had been 3.5 occasions increased within the three-dose group than the four-dose group 4 weeks after the booster shot, the researchers discovered. That safety didn’t seem to wane and truly ticked up barely by the sixth week after the shot, when charges of extreme illness had been 4.3 occasions increased within the three-dose group.
However the examine coated a comparatively quick interval, and whether or not the advantages towards sickness maintain up over the long term stays unknown. The examine didn’t report knowledge on deaths.
As Los Angeles battles the worst wildfires in the city’s history, thousands of people have been displaced or have seen their homes burn to the ground.
Around 130,000 people were ordered to evacuate and some 10,000 structures were destroyed, according to the Associated Press. At least 10 people have died as a result of the blazes.
The devastation of the fires has undoubtedly taken a grave toll on the psyches of those affected, experts agree.
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Fox News Digital spoke with celebrities and mental health experts, who offered the following guidance for the people impacted.
Recognize your feelings
For those who have experienced a loss from the fires, common reactions include shock, disbelief and confusion, according to David Kessler, a grief counselor in Los Angeles and founder of Grief.com.
“I call it grief brain,” he told Fox News Digital.
Luke Dexter reacts as he sifts through the remains of his father’s fire-ravaged beachfront property in the aftermath of the Palisades Fire on Jan. 10, 2025 in Malibu, Calif. (AP Photo/John Locher) (AP Newsroom)
“Your mind is trying to comprehend what happened, and it’s a hard thing for it to do, because this is unimaginable that your house, your safety, is suddenly gone.”
Not all grief is related to death, Kessler noted, as there are many different types of losses.
“I always say grief is a change you didn’t want — and certainly a fire is a change we didn’t want,” he added.
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It’s important to “self-validate” the reality of the loss, he said.
“People might give you toxic positivity of, ‘well, at least no one died,’” he said. “And while that’s true, the reality is you still have lost your home. Don’t let anyone minimize that.”
“The loss of a home is devastating and it can take years to recover.”
“I think we’re going to deal with a lot of depression after this, a lot of sadness.”
Actor Steve Guttenberg, who lives in Pacific Palisades, California, where fires erupted on Tuesday, shared how the disaster has impacted his own mental health.
“I’ve seen so much tragedy the last three or four days that I’ve got to be careful to … keep a hold of my mind,” he said in an interview with Fox News Digital.
“And I think that we’re going to deal with a lot of depression after this, a lot of sadness. And it’s going to be really tough because this is like nothing you’ve ever seen.”
Actor Steve Guttenberg, who lives in Pacific Palisades, California, where fires erupted on Tuesday, shared how the disaster has impacted his own mental health. (AGUSTIN PAULLIER/AFP via Getty Images; Fox News)
Gutenberg noted that while it’s “very normal” to be down, he is trying not to let himself “go down that hole.”
“But I’m pretty sad about this,” he added.
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Jonathan Alpert, a psychotherapist in Manhattan and Washington, D.C., noted that the grief following the Los Angeles fires is “profound.”
“It’s not just about the physical loss of homes or belongings — it’s also about the sense of safety and normalcy that has been lost,” he told Fox News Digital.
“It’s important for people to feel emotions and not ignore them. This is a normal reaction to such overwhelming loss and tragedy.”
Reach out for support
Guttenberg emphasized the importance of maintaining connections with others and drawing support from the community during a disaster of this magnitude.
“We’re social animals — we need people,” he said. “So I’m reaching out to my friends. There’s no way to meet right now because it’s so dangerous — so the best thing you cn do … is call and reach out and maybe you can drive somewhere.”
Experts agreed that it’s essential to avoid isolating yourself after a loss. “We need to be taken care of. We need other people around us.” (AP Newsroom)
Most of the people in town have evacuated, he pointed out. “There’s probably 10% of the population left here. Or less.”
Kessler reiterated that connection is critical after this type of trauma. “We need to be taken care of. We need other people around us. People equal safety,” he said.
“We need other people around us. People equal safety.”
Pastor Jesse Bradley of Grace Community Church outside Seattle, Washington, agreed that it’s essential to avoid isolating yourself after a loss.
“We need God and we need each other. Community is vital,” he told Fox News Digital.
“Family, friends and neighbors care about you. God sends His love through these people. Reject isolation. Don’t shut down and don’t shut people out.”
Take action
“In times of crisis such as this, regaining even small amounts of control can be grounding,” Alpert said.
He recommends creating a plan for what’s next, whether it’s finding temporary housing, accessing local resources or starting the process of rebuilding.
“Taking action — no matter how small — can help you move forward.”
Ben Treger hugs his wife Sarah Treger after finding his grandfather’s watches at the remains of their Pacific Palisades home on Thursday, Jan. 9, 2025. “If you do have survivor’s guilt, I always say the best thing is to take action,” one expert advised. (Juan Carlo/Imagn)
Kessler agreed, noting that people who are in the area but did not experience loss may feel a sense of relief mixed with guilt.
“If you do have survivor’s guilt, I always say the best thing is to take action,” he advised.
In the longer term, advocacy efforts can be a powerful tool in dealing with trauma, Alpert noted.
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“Working to improve fire prevention policies, supporting relief efforts or helping neighbors rebuild can provide a sense of purpose and empowerment during this difficult time,” he said.
Some people may be angry about the systems that failed to prevent the fires in the first place, Alpert acknowledged, and this anger can be a “powerful motivator.”
“Taking action — no matter how small — can help you move forward.”
“Use that energy to demand better, but don’t get stuck on the anger,” he advised.
“By holding leaders accountable for the policies — or lack thereof — that contributed to this devastation, and by asking the right questions and demanding answers, you might start to feel better.”
Seek professional help as needed
“The L.A. fires no doubt will not just leave physical scars, but deep emotional ones, too,” Alpert said.
“For many people, the fear, panic and helplessness experienced during the fires don’t just disappear — they linger, creating flashbacks, anxiety and difficulty functioning.”
“For many people, the fear, panic and helplessness experienced during the fires don’t just disappear — they linger, creating flashbacks, anxiety and difficulty functioning.” (iStock)
In many cases, this can lead to post-traumatic stress disorder (PTSD). Symptoms of this condition can include vivid memories of the fires, nightmares, hypervigilance or avoidance of anything that reminds someone of the event, Alpert said.
“It’s important to see this not as weakness, but rather, the mind’s and body’s way of trying to cope with extreme stress.”
“While the fires were devastating, they don’t diminish your strength or character.”
As you seek help, it’s also important to understand that PTSD doesn’t define you, he added.
“It’s a part of your experience, not your identity. While the fires were devastating, they didn’t diminish your strength or character.”
Lean on your faith
For those who have experienced traumatic grief, Kessler emphasized the importance of faith and spirituality.
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“They help ground us in a world full of fear,” he said. “And when we’ve lost everything, it can feel like our faith is the one thing we have to hold onto.”
During a time of crisis, Guttenberg said it’s important to “rely on anything that you believe in.”
Cesar Plaza becomes emotional while looking at his home destroyed by the Eaton Fire in Altadena, California, on Jan. 9, 2025. “It’s easy to be consumed with what you no longer have,” a pastor told Fox News Digital. (AP Photo/Nic Coury) (AP Newsroom)
“If you believe in your mom and dad, you rely on them, your brothers and sisters, your friends, your family. God, the universe.”
Above all, he added, “Just remember, you’re not alone. God is always with you. Jesus is always with you. You’ve got to hang on to that.”
Find ways to exercise gratitude
During times of hardship, it’s important to recognize the good things that are still in your life, Pastor Bradley said.
“It’s easy to be consumed with what you no longer have,” he told Fox News Digital.
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“You need to be intentional to take inventory of the blessings in your life. For example, you might lose a home or business, but you still have family.”
This mindset will help you keep a healthy perspective and protect gratitude, Bradley added.
Health
Scientists May Be Able to Make Grapefruits Compatible With Medications They Currently Interfere With
You may be among the millions of people who have seen a surprisingly specific warning like this on the labels of drugs you take:
Avoid eating grapefruit or drinking grapefruit juice while using this medication.
Such warnings are issued for dozens of substances, including docetaxel, a cancer drug; erythromycin, an antibiotic; and some statins, the cholesterol-lowering drugs prescribed to more than a third of American adults over 40.
The problem is a set of molecules, furanocoumarins. High levels of furanocoumarins interfere with human liver enzymes, among other processes. In their presence, medications can build up to unhealthy levels in the body. And grapefruits and some related citrus fruits are full of them.
But there is no such warning for other kinds of citrus, such as mandarins and other oranges. Citrus researchers at the Volcani Center in Israel reported Wednesday in the journal The New Phytologist that, by crossing mandarins and grapefruit, they’ve uncovered genes that produce furanocoumarins in some citrus fruits. It’s a finding that opens the possibility of creating grapefruit that doesn’t require a warning label.
Scientists had worked out the compounds’ structures and pieced together a basic flowchart of how they are made years ago, said Yoram Eyal, a professor at the Volcani Center. But the precise identities of enzymes catalyzing the process — the proteins that snip off a branch here, or add a piece there — remained mysterious. He and his colleagues knew that one way to identify them was to breed citrus high in furanocoumarins with those without. If the offspring of such a cross had varying levels of the substances, it should be possible, by digging into their genetics, to pinpoint the genes for the proteins.
“We were afraid to approach it, because it’s very time-consuming and it takes many years,” he said, noting how involved it can be to grow new trees from seeds and assess their genetics. “But finally, we decided we have to dive in.”
When they examined the offspring of a mandarin and a grapefruit, the researchers saw something remarkable. Fifty percent of the young plants had high levels of furanocourmains, and 50 percent had none. That particular signature meant something very specific, in terms of how the ability to make these substances is inherited.
“We saw there was only one gene that could have controlled it,” said Livnat Goldenberg, a Volcani Center researcher who is the lead author of the new study.
The researchers soon identified the gene controlling the production of furanocoumarins in leaves and fruit, which produces an enzyme called 2-oxoglutarate-dependent dioxygenase, or 2OGD for short. Mandarins, it turns out, have a mutated form of this gene that keeps the enzyme from functioning properly. This version cropped up in all the mandarin and orange varieties the researchers checked, explaining why they do not cause the same problems as grapefruit in people taking prescription medications. In these plants, furanocoumarin production is paused.
With gene editing technology, it should be possible to alter the gene in grapefruit as well, Dr. Eyal suggests. The team at the Volcani Center is now exploring that project.
Looking at how widespread this mutated version is in mandarins and some other citrus, the scientists speculate that some gene nearby on the genome must play an important role in a highly prized trait. A long-ago citrus breeder, selecting for some unknown quality, must have unwittingly spread this furanocoumarin-busting version of the gene to an ancestor of modern varieties of mandarins and oranges.
All these years later, that person’s work is coming to light, under the gaze of geneticists, who may, someday, put grapefruit back on the menu.
Cases of tularemia, also known as “rabbit fever,” are on the rise in the U.S., according to a new report from the Centers for Disease Control and Prevention (CDC).
Caused by the bacteria Francisella tularensis, the disease commonly infects rabbits, hares and rodents. However, it is zoonotic, which means it can spread from animals to humans.
The bacteria is a “tier-1 select agent,” a classification given to agents and toxins that “present the greatest risk of deliberate misuse with significant potential for mass casualties or devastating effects to the economy, critical infrastructure or public confidence, and pose a severe threat to public health and safety,” per the CDC.
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Although tularemia is relatively rare, with only 2,462 diagnoses between 2011 and 2022, cases have risen 56% compared to the prior decade (2001 to 2010), as reported in the CDC’s Morbidity and Mortality Weekly Report.
Cases of tularemia, also known as “rabbit fever,” are on the rise in the U.S., according to a new report from the CDC. (iStock)
“Increased reporting of probable cases might be associated with an actual increase in human infection, improved tularemia detection or both,” the report states.
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