Fitness
Scientists Just Made A Major Genetic Discovery That Could Lead To The Next Ozempic
Medications like Ozempic, Wegovy, and Zepbound have completely revolutionized the health space, helping people who have obesity or are overweight lose a significant amount of weight. But these medications have had shortages and can be incredibly expensive, making them inaccessible for many.
Now, research highlights a discovery that could pave the way for a new class of weight loss medications—and it’s linked to how your body responds to exercise. Here’s what the study discovered, plus what it could mean for the future of drugs like Ozempic.
Meet the expert: Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California.
What did the study find?
The study, which was published in June in the journal Molecular Metabolism, analyzed mouse and human models to explore how the protein PGC-1α impacts exercise and its effects on the body. In case you’re not familiar with it (and why would you be?), PGC-1α is a protein that is involved in several processes in the body, including thermogenesis. Thermogenesis works to help your body efficiently consume energy in your muscles.
When you work out, more PGC-1α is expressed in your muscles and more energy is burned. But people who lose weight slowly when they do regular physical activity may be missing variants of PGC-1α that regulate the body’s metabolism and response to short-term exercise.
By targeting this protein, scientists think they can essentially help to rev up your metabolism. The researchers concluded in the study that increasing how much PGC-1α is expressed is “pivotal” for burning more energy and “essential” for regulating metabolism.
What does this study mean for fitness?
At this point, it’s hard to say. The scientists just discovered that it could be helpful to target this protein for weight loss, but the details and kinks of this haven’t been worked out just yet.
But it’s possible that people who already burn fat efficiently with the help of exercise wouldn’t be helped by a medication that targets PGC-1α, says Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California. Still, it’s super early on in the process, making it tough to determine for sure.
What does this mean for weight loss drugs?
It’s not clear at this point. Again, this is in very early stages and there’s a lot that still needs to be explored. However, there is a chance that this could lead to a new class of weight loss drugs, giving people with overweight and obesity more options, Ali says.
Right now, Ali sees this as a potential additional tool to help with weight loss versus the only tool someone would use.
“The majority of weight loss is because of diet,” he says. “Exercise has a number of benefits, including enhanced weight loss, and it can improve cardiovascular health.”
If there’s a medication that could enhance how well you burn fat through exercise, “that would be an additional tool to use,” Ali says. But, he adds, “we’re a long way from that.”
Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Men’s Health, Women’s Health, Self, Glamour, and more. She has a master’s degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.
Physical activity saves lives, but now it turns out there’s a “precise dosage” at which it becomes especially effective in preventing heart disease.
Exercising is key to longevity; it’s been associated with everything from improved cardiovascular health to increased strength to a longer life. But there’s one exercise, in particular, that a doctor says women over 50 should add to their routine.
Meet the expert: Steven Bowers, D.O., board-certified family physician and author of Secrets of the World’s Healthiest People
Daily strength workouts may help boost all aspects of life, Steven Bowers, D.O., board-certified family physician and author of Secrets of the World’s Healthiest People, previously told Prevention. Physical fitness makes functional tasks like carrying grocery bags from the car, opening jars, and lifting heavy items easier.
There are plenty of moves to try, but Dr. Bowers says the one that should get top billing in your routine is the plank.
While planks challenge your whole body, they’re particularly great for strengthening your core. “Core muscle fibers tend to shrink and become less supple as we age, which can put more strain on your back,” he previously said. Having a strong core is important for balance and stability, and it can help you go about your day with more ease.
Wondering how long to hold a plank, and the proper form? First, place your forearms on the floor. Your elbows should be right below your shoulders, and your arms should be parallel—not turning in or out. Your feet should also be shoulder-width apart. Press your hands and toes into a mat on the ground, lifting your body, squeezing your glutes and quads for support. Your body should create one straight line from head to toe. Don’t lock your knees or arch your back, and keep your neck straight by looking slightly in front of you.
Hold this position for 20 seconds. “As you get more comfortable and your core gets stronger, hold the plank for as long as possible without sacrificing form or breath,” Dr. Bowers noted. It’s that simple! Whether you’re a pro or want to test your plank skills, adding the simple move to your routine may be what your core has been waiting for.
Shin splints are one of those nagging aches and pains most runners encounter at some point in their training—but that doesn’t mean you should just grin and bear it.
“We see it all the time in the clinic,” osteopath and clinical lead at The Livewell Clinic, Danny Sayandan tells Fit&Well.
Common themes, he says, are runners in worn-out shoes, heel striking instead of landing midfoot, or overstriding.
“It’s often linked to the least stretched muscle in the body—your calves—and most neglected muscle—the tibialis anterior—found on the front of the shin,” says Sayandan.
When they’re tight or undertrained, the impact of every footstrike gets pushed straight into the shins, triggering a dull ache down the front or inside of your shins.
The solution? Add these five exercises from Sayandan to your weekly workouts to stretch and strengthen these often overlooked muscles.
5 exercises to try if you get shin pain when running
1. Toe raise
Toe Raises – Ask Doctor Jo – YouTube
Watch On
Sets: 2 Reps: 12-15 each side
Why: Lifting your toes strengthens the front of your shin.
How:
- Stand with your feet hip-width apart.
- Lift your toes.
- Hold for two seconds.
- Lower your toes to the start.
2. Calf raise
Sets: 2 Reps: 12-15
Why: Build strength and endurance in the lower legs.
How:
- Stand with your feet together.
- Lift your heels to rise onto your toes and the balls of your feet.
- Pause, then lower slowly.
You can also perform these with your heels off a step (as in the video above), lowering your heels below the step to add a stretch to your calves.
As you get stronger, progress to single-leg calf raises, then begin to add weight with a dumbbell or kettlebell held in one hand.
3. Soleus wall hold
Sets: 2 Reps: 12-15 / Time: 30sec
Why: This bent-knee heel raise targets the deep-lying soleus muscle in your calves.
How:
- Stand with your feet hip-width apart, holding a bannister or other sturdy anchor point for support (an alternative is to rest your back on a wall, as in the video above).
- Bend your knees and push your hips back to lower into a squat, with your knees bent at 90˚.
- Hold this position and either perform 12-15 calf raises (see above), or rise up onto the balls of your feet and hold for 30 seconds.
4. Tibialis stretch
Anterior Tibialis Stretch Kneeling – Ask Doctor Jo – YouTube
Watch On
Sets: 2 Reps: 8-10
Why: This is a gentle stretch for the muscles in the front of the shin.
How:
- Kneel with your feet together, sitting on your heels with your hands or forearms on the floor to help control the load through your ankles.
- Push through your hands or forearms and carefully lift your knees to increase the stretch in the front of your shins.
- Hold for a few seconds, then lower.
Rather than an exercise, try to practice this continuously—and certainly as you move from exercise to exercise in this workout. Concentrate on landing softly through your midfoot to retrain your gait and reduce impact through your heel, ankle, calves and shins.
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