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Scientists Just Made A Major Genetic Discovery That Could Lead To The Next Ozempic

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Scientists Just Made A Major Genetic Discovery That Could Lead To The Next Ozempic

Medications like Ozempic, Wegovy, and Zepbound have completely revolutionized the health space, helping people who have obesity or are overweight lose a significant amount of weight. But these medications have had shortages and can be incredibly expensive, making them inaccessible for many.

Now, research highlights a discovery that could pave the way for a new class of weight loss medications—and it’s linked to how your body responds to exercise. Here’s what the study discovered, plus what it could mean for the future of drugs like Ozempic.

Meet the expert: Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California.

What did the study find?

The study, which was published in June in the journal Molecular Metabolism, analyzed mouse and human models to explore how the protein PGC-1α impacts exercise and its effects on the body. In case you’re not familiar with it (and why would you be?), PGC-1α is a protein that is involved in several processes in the body, including thermogenesis. Thermogenesis works to help your body efficiently consume energy in your muscles.

When you work out, more PGC-1α is expressed in your muscles and more energy is burned. But people who lose weight slowly when they do regular physical activity may be missing variants of PGC-1α that regulate the body’s metabolism and response to short-term exercise.

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By targeting this protein, scientists think they can essentially help to rev up your metabolism. The researchers concluded in the study that increasing how much PGC-1α is expressed is “pivotal” for burning more energy and “essential” for regulating metabolism.

What does this study mean for fitness?

At this point, it’s hard to say. The scientists just discovered that it could be helpful to target this protein for weight loss, but the details and kinks of this haven’t been worked out just yet.

But it’s possible that people who already burn fat efficiently with the help of exercise wouldn’t be helped by a medication that targets PGC-1α, says Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California. Still, it’s super early on in the process, making it tough to determine for sure.

What does this mean for weight loss drugs?

It’s not clear at this point. Again, this is in very early stages and there’s a lot that still needs to be explored. However, there is a chance that this could lead to a new class of weight loss drugs, giving people with overweight and obesity more options, Ali says.

Right now, Ali sees this as a potential additional tool to help with weight loss versus the only tool someone would use.

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“The majority of weight loss is because of diet,” he says. “Exercise has a number of benefits, including enhanced weight loss, and it can improve cardiovascular health.”

If there’s a medication that could enhance how well you burn fat through exercise, “that would be an additional tool to use,” Ali says. But, he adds, “we’re a long way from that.”

Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Men’s Health, Women’s Health, Self, Glamour, and more. She has a master’s degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.

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The Best Fitness Trackers for Your Lifestyle, Workouts, and Goals

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The Best Fitness Trackers for Your Lifestyle, Workouts, and Goals

Like every piece of gear you wear on your body day in and day out, fitness trackers are incredibly personal. The right tracker for you should be comfortable, accurate, and tailored to your lifestyle, including your preferred workouts and health goals. Do you bike, row, or strength train? Do you run on trails for hours at a time, or do you just want a reminder to stand up every hour? Do you want to wear it on your wrist or your finger, or tuck it into your sports bra?

No matter what your needs are, there’s never been a better time to find a powerful, sophisticated tool to help optimize your workouts or jump-start your routine. We test dozens of fitness trackers every year while running, climbing, hiking, or just doing workout videos on our iPads at night, to bring you these picks.

Our top choice for most people is the Garmin Vivoactive 6 ($300), which works well with Android and iOS, but we also vouch for the latest Oura Ring 5 ($399) and the budget-friendly Google Fitbit Air ($100). For more wearables, check out our guides to the Best Smartwatches, Best Smart Rings, and Best Sleep Trackers.

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Best Fitness Tracker Overall

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Garmin makes some of the most accurate fitness trackers on the market, and the Vivoactive 6 is the best midrange option for most people. It strikes a solid balance between smartwatch features and fitness tracking, with support for both iPhone and Android users.

Why WIRED recommends: The Vivoactive 6 is accurate, comfortable, and packed with useful wellness features without feeling overwhelming. It uses Garmin’s proprietary algorithms to power features like Morning Report and Body Battery, which provide daily insights into your sleep, recovery, and readiness. It also has built-in satellite connectivity and GPS, so you can track outdoor workouts without bringing your phone along. There’s also incident detection, which alerts emergency contacts if it detects a serious fall.

Garmin’s biggest advantage remains its free Connect platform, which enables health and fitness tracking without requiring a subscription. The company also continues to add new software features through regular updates without putting them behind a paywall.

The trade-offs: Garmin launched Connect+, a $70-per-year subscription with extras like live tracking and access to Garmin’s AI-powered Active Intelligence. Former editor Adrienne So doesn’t think most people need it, but it’s worth noting if you’re looking for a completely subscription-free experience. The Vivoactive 6 may also feel like overkill for casual users who only want basic activity and sleep tracking.

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Why this unexpected exercise is most effective for building arm muscle in your 50s – and how to do it properly

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Why this unexpected exercise is most effective for building arm muscle in your 50s – and how to do it properly

When it comes to building strong, defined arms, traditional fitness advice will usually point you toward endless sets of bicep curls and tricep extensions. But according to Dr Stacy Sims, a leading women’s exercise physiologist specialising in perimenopause and menopause, isolation movements like these aren’t necessarily the most effective. Instead, she advocates for one functional compound movement: the farmer’s carry.

Speaking on podcast A Life of Greatness, when host Sarah Grynberg asks how to get arm muscles like Dr Sims, the 51-year-old explained: ‘In order to get shoulders like this, heavy farmer’s carries. I’ve been travelling so much this year, and I haven’t been in the gym being consistent with all the push presses and Olympic lifts that I love to do, but what I have been consistent in doing is heavy farmer’s carries.

‘It’s good for grip strength, learning how to walk properly, core strength, shoulders – so if there’s one move everyone should do, it’s heavy farmer’s carries.’

The magic of the move lies in its ability to engage your biceps, triceps, shoulders, forearms and hands all at once. And because your arms are working continuously to stabilise heavy loads against gravity, the exercise activates the deep muscle fibres that don’t fire up as efficiently in single-joint arm movements, like bicep curls. Here’s how to do it with proper form, plus how heavy to lift and a workout to try, straight from Dr Sims.

How to do a farmer’s carry

  1. Standing with feet hip-width apart and weights at the outside of the ankles, hinge your hips back and bend the knees, keeping your back flat.
  2. Tighten up your lower back and abdominals before reaching down to grab the weights.
  3. After gripping the weights, begin to stand tall by driving your heels into the ground, maintaining a tight form. Once you reach full standing position, tighten your armpits and make sure your shoulders are pulled back to activate the muscles in the rotator cuff area.
  4. Finally, begin to take small steps forward, maintaining a strong grip and form. If you’re returning in opposite direction, set the weights down, turn around, and then grab the weights again before walking in the opposite direction.

Set/reps for results: Aim for three sets. Try timing your farmer’s carry for 25 to 30 seconds or go for 10 steps forward and back.

Form tips: Start out with a light weight to ensure you don’t end up leaning too far forward or towards one side. Make sure to keep your back straight for safety. When it comes to moving, small strides will do. They’ll keep you balanced as you increase your weights.

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How heavy to lift

As for what “heavy” means to Dr Sims, she says: ‘How many people have heard that you should be able to farmer carry 75% of your body weight for a minute? That is made up from bro science. It’s a good metric but there’s no science behind it. So, a heavy farmer’s carry is you have two very heavy dumbbells by your side and you’re walking back and forth.’

Here’s a weight guide to follow:

  • Beginners: 2x 4-6kg
  • Intermediate: 2x 8-12kg
  • Advanced: 2x 12-20kg
Image no longer available

Farmer’s carry workout

Dr Sims shares a descending ladder workout to try.

  • 500m ski
  • 500m heavy farmer’s carry
  • 400m ski
  • 400m heavy farmer’s carry
  • 300m ski
  • 300m heavy farmer’s carry
  • 200m ski
  • 200m heavy farmer’s carry
  • 100m ski
  • 100m heavy farmer’s carry

‘If you really have anything left in the tank after this workout, you go back up in 100m,’ she adds.


womens health magazine cover featuring a fitness theme

One of our most frequently asked questions here at Women’s Health? How to build muscle and burn fat at the same time. So, we asked superstar trainer Oyinda Okunowo exactly how to do it. In this 4-week plan – created exclusively for Women’s Health COLLECTIVE members – you’ll get the workouts and nutrition guidance needed to help you on your way to better body composition. Tap the link below to unlock 14 days of free access to Oyinda’s plan and start training today.

Get the plan

Headshot of Bridie Wilkins

As Women’s Health UK’s fitness director and a qualified Pilates and yoga instructor, Bridie Wilkins has been passionately reporting on exercise, health and nutrition since the start of her decade-long career in journalism.

After earning a first-class degree in journalism and NCTJ accreditation, she secured her first role at Look Magazine, where she launched the magazine’s health and fitness column, Look Fit, before going on to become Health and Fitness writer at HELLO!

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Since, she has written for Stylist, Glamour, Cosmopolitan, Marie Claire, Elle, The Metro, Runner’s World and Red. Today, she oversees all fitness content across Women’s Health online and in print, spearheading leading cross-platform franchises, such as ‘Fit At Any Age’, which showcases the women proving that age is no barrier to exercise.

She has also represented the brand on BBC Radio London, plus various podcasts and Substacks – all with the aim to encourage more women to exercise and show them how. Outside of work, find her trying the latest Pilates studio, testing her VO2 max for fun (TY, Oura), or posting workouts on Instagram.   

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When is the best time to exercise in the heat?

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When is the best time to exercise in the heat?

The sun is a welcome addition to our exercise routines come summer – but the novelty of a sunny run or hike can quickly wear off as the temperature climbs. With heatwaves and record-breaking temperatures already this year, it’s important to know the best time to exercise in the heat for the weeks ahead.

Obviously, if you don’t like the heat and would rather be inside, then you can exercise in an air-conditioned gym or studio at any time of day. A good swimming workout is another way to stay cool. However, if you enjoy running, hiking, cycling, or a garden strength training workout, it makes sense to choose the coolest times of day. In the peak of the summer, this is before 10 am and after 5 pm, but the earlier (or later) you can go, the better.

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