Fitness

Proteomic fitness scores revolutionize disease prediction and personalized exercise plans

Published

6 months ago

June 5, 2024

Proteomic fitness scores revolutionize disease prediction and personalized exercise plans

A study published in Nature Medicine journal describes how proteomic scores of cardiorespiratory fitness can help predict disease risk as well as all-cause and disease-specific mortality risks beyond genetic risk scores.

Study Design: We developed and validated a circulating proteomic signature of CRF across four cohorts and various exercise modalities. In the UKB, we examined the relationship a proteomic CRF signature with a broad range of clinical endpoints and examined its interaction with polygenic risk. In HERITAGE, we examined the association of the proteomic CRF signature with response to exercise training and correlated changes in signature with changes in CRF. NAFLD, nonalcoholic fatty liver disease. Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks

Background

Cardiorespiratory fitness (CRF) is a useful prognostic marker of improved health, quality of life, and longevity. Assessing CRF in clinical settings is an effective approach to stratifying disease risk and promoting health.

However, the widespread use of CRF for clinical decision-making is restricted by some factors, including lack of availability and reproducibility of tests and high expenses. Training-responsive biomarkers of CRF is an alternative approach that may address these limitations and enable the identification of pharmacological targets that mimic the effects of exercise.

Exercise induces multiple changes in the metabolic state, which is depicted by changes in blood levels of metabolites associated with CRF. These molecular surrogates of CRF and training responses are associated with clinical prognosis.

In this study, scientists have established, validated, and characterized a proteomic signature of CRF by linking proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF assessment methods.

They have used data from 22,000 individuals from the UK Biobank to determine the association of the proteomic signature of CRF with a broad range of clinical outcomes (death, cardiovascular, metabolic, malignancy, neurological) and examine its interaction with genetic risk score.

Furthermore, they have used the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study data to evaluate the impact of a 20-week exercise training program on the proteomic signature of CRF.

Proteomic CRF score

The scientists developed a proteomic CRF score in the Coronary Artery Risk Development in Young Adults (CARDIA) study derivation dataset using exercise treadmill test time as the CRF measure. They further validated the proteomic CRF score across approximately 12,500 participants from four international cohorts.

They observed mechanistically reasonable directionality for proteins involved in innate immunity and inflammation, atherosclerosis, neuronal survival and growth, cell physiology, oxidative stress, energy expenditure, and substrate fuel utilization, adiposity, peripheral muscle responses to exercise, and autophagy.

Association between proteomic CRF score and clinical outcomes

The scientists analyzed proteomic profiles and survival data of 21,988 participants from the UK Biobank and observed a significant inverse association between proteomic CRF score and risk of all-cause mortality and disease-specific mortality.

They observed the proteomic CRF score’s consistent and robust protective effect on cardiovascular, metabolic, and neurological outcomes. They found that the proteomic CRF score improves risk prediction beyond standard clinical risk factors, with improved risk reclassification and discrimination.

By analyzing the interaction between the proteomic CRF score and genetic risk score of common diseases, they observed a significant additive effect between the proteomic CRF score and each genetic risk score on the corresponding disease outcome. The highest disease risk was observed in participants with the lowest proteomic CRF score and a high genetic risk score.

Impact of exercise on proteomic CRF score

The scientists observed an increase in the proteomic CRF score following a 20-week exercise training program. This change was associated with an alteration in peak oxygen consumption, independent of age, sex, race, body mass index (BMI), pre-training peak oxygen consumption, and pre-training proteomic CRF score.

Specifically, they observed that a higher proteomic CRF score is associated with greater peak oxygen consumption with training, independent of age, sex, and race. However, this association was not sustained after adjusting for BMI.

Furthermore, they observed that the proteomic CRF score components that exhibited significant post-training changes are correlated with a range of metabolic, vascular, and myocardial phenotypes.

Many of these components (proteins) were correlated with adiposity reduction, lipid metabolism, bone morphogenic pathway regulation, and ischemia-reperfusion injury management.

Study significance

The study describes the development of a circulating proteomic signature of CRF using a treadmill exercise test that showed a consistent relation across sub-maximal treadmill exams in 10,320 UK residents and maximal cardiopulmonary exercise exams in 1,587 US residents.

The proteomic signature of CRF exhibits robust and independent associations with a range of metabolic, cardiovascular, and neurological clinical outcomes. These associations seem to be additive to the genetic risk of corresponding diseases. This highlights the utility of proteomic CRF signature for multiomic evaluation of disease and mortality risks.

The study also highlights the dynamicity of proteomic CRF score following a 20-week exercise training program and an association between training-related changes in the score and peak oxygen consumption. This highlights the utility of proteomic CRF score for personalization of exercise recommendations.

How assessment of proteins in our blood—proteomic score— is sharpening our ability to predict diseases, beyond polygenic risk scores (PRS)https://t.co/ILswRnwVI8@NatureMedicine pic.twitter.com/87XGplGnq4
— Eric Topol (@EricTopol) June 4, 2024

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Fitness

Mrunal Thakur’s intense Pilates workout is the perfect mid-week motivation to crush your fitness goals. Watch

Published

4 hours ago

November 20, 2024

Press Room

Mrunal Thakur’s intense Pilates workout is the perfect mid-week motivation to crush your fitness goals. Watch

Nov 20, 2024 01:18 PM IST

Mrunal Thakur’s intense Pilates session is the mid-week motivation you need! Watch her crush it and get inspired to elevate your own fitness journey.

Mrunal Thakur is all set to inspire you to break a sweat this mid-week with an intense Pilates workout. Celebrity fitness coach Namrata Purohit recently shared a 60-second glimpse of Mrunal’s pilates session, captioned, “Mrunal, you’re really killing it. I’m so proud of you!” If you’ve been feeling sluggish, Mrunal’s dedication and hard work will surely motivate you to ditch the couch and take one step closer to your fitness goals. Scroll down to know more. (Also read: Katrina Kaif’s trainer Yasmin Karachiwala shares her ultimate workout routine to achieve that perfect Bollywood body )

Mrunal Thakur inspires fitness enthusiasts with her recent Pilates session.(Instagram/@namratapurohit)

Mrunal Thakur’s intense Pilates workout

In the video shared by celebrity fitness coach Namrata Purohit, Mrunal is seen giving her all during an intense Pilates session, dressed in a dark blue skin-tight jacket and matching tights. After the Pilates workout, she takes it up a notch with a set of pull-ups, showcasing her strength and dedication.

Her workout session offers several benefits. Pilates improves flexibility, builds core strength, and enhances the mind-body connection, promoting overall wellness and mental clarity. Pull-ups, on the other hand, strengthen the upper body, improve grip strength, and boost functional fitness. Incorporating both exercises into your routine can help you achieve a well-rounded fitness level, building strength, flexibility, and confidence.

How fans reacted

Mrunal Thakur’s video quickly garnered admiration from her fans. One user commented, “She makes it look so easy,” while another wrote, “That’s great!” A third user chimed in with, “Looking fab!” Along with these comments, many fans flooded the post with fire and heart emoticons.

On the work front

On the professional front, Mrunal Thakur was last seen in a cameo appearance in the recently released Telugu science fiction film Kalki 2898AD. She also has an exciting slate of projects lined up, including Pooja Meri Jaan, Son of Sardar 2, and Hai Jawani Toh Ishq Hona Hai.

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Fitness

Cortisol-Synchronized Workouts

Published

12 hours ago

November 19, 2024

Press Room

Well BYND Studio has introduced a scientifically-informed fitness schedule that synchronizes class offerings with the body’s natural cortisol patterns. The studio strategically positions high-energy classes during peak cortisol hours (7am-10am and 5pm), while scheduling restorative sessions in the evening to support natural wind-down periods. This thoughtful programming includes specialized classes like HIIT Pilates, Breathwork + Sound sessions, and Primal Flow movement training, each designed to complement specific energy states throughout the day.

The studio’s approach reflects a growing trend toward chronobiology-based fitness programming that optimizes workout timing for maximum physiological benefit. By integrating diverse modalities from traditional Pilates and yoga to innovative fusion classes like Glow & Flow, which incorporates facial sculpting techniques, Well BYND demonstrates how fitness facilities are evolving to provide more sophisticated, science-backed training methods. This holistic approach to exercise scheduling shows how the fitness industry is moving toward more personalized, biology-responsive programming.

Fitness

Lower your blood pressure by swapping just a few minutes of sitting for exercise

Published

20 hours ago

November 19, 2024

Press Room

Lower your blood pressure by swapping just a few minutes of sitting for exercise

Adding short bursts of exercise to your daily routine, such as cycling to the shops for 15 minutes or taking the stairs, lowers blood pressure, a study has found.

Increasing exercise habits – instead of say, watching a bit more TV or extending a snooze – is good for the heart, researchers said.

However, they warned that people may need to do more than simple walking to really see changes.

Published in the scientific journal Circulation, the study emphasised that everyday activities that raise the heart rate, such as cycling, climbing stairs or short bursts of running, have the biggest benefits.

Led by scientists from University College London (UCL) in Britain and the University of Sydney in Australia, the research looked at data for 14,761 people who wore activity trackers for 24 hours in a bid to explore the relationship between daily movement and blood pressure.

On average over the 24 hours, people spent around seven hours asleep, 10 hours in sedentary behaviour such as sitting, three hours standing, one hour slow walking, one hour fast walking, and 16 minutes taking exercise that increased their heart rate, such as running and cycling.

The study found that an extra five minutes of exercise that raises the heart rate, such as stair-climbing, running or cycling – in exchange of any of the other behaviours – could lower systolic blood pressure by 0.68 millimetres of mercury (mmHg) and diastolic blood pressure by 0.54mmHg.

Systolic is the “top number” in a blood pressure reading and represents pressure when the heart pushes blood out around the body.

Diastolic is the “bottom number” and is the pressure when the heart rests between beats.

At a population level, a 2mmHg reduction in systolic blood pressure and a 1mmHg reduction in diastolic blood pressure is equivalent to an approximately 10% reduction in the risk of heart disease, the researchers said.

To achieve such clinically meaningful improvements, people would need to reallocate 20-27 minutes from other behaviours to proper exercise for the top number, and 10-15 minutes for the bottom number, the study found.

For example, with systolic blood pressure, swapping 21 minutes of sedentary time, 22 minutes of standing or 26 minutes of slow walking for exercise such as cycling or jogging, would have this effect.

For diastolic blood pressure, the benefits would arise from swapping 10 minutes of fast walking, 11 minutes of sedentary time or 13 minutes of sleeping for proper exercise.

Study first author and UCL Department of Targeted Intervention senior research fellow Dr Jo Blodgett said: “Our findings suggest that, for most people, exercise is key to reducing blood pressure, rather than less strenuous forms of movement such as walking.

“The good news is that, whatever your physical ability, it doesn’t take long to have a positive effect on blood pressure.

“What’s unique about our exercise variable is that it includes all exercise-like activities, from climbing the stairs to a short cycling errand – many of which can be integrated into daily routines.

“For those who don’t do a lot of exercise, walking did still have some positive benefits for blood pressure.

“But if you want to change your blood pressure, putting more demand on the cardiovascular system through exercise will have the greatest effect.”

Consistently high blood pressure is one of the biggest causes of premature death globally and can lead to stroke, heart attack, heart failure and kidney damage.

The study was funded by the British Heart Foundation.

Its chief scientific officer Professor Dr Bryan Williams said: “We know that exercise can have real benefits for your cardiovascular health and also helps to lower blood pressure.

“We recommend doing 150 minutes of physical activity each week, and this interesting study shows that incorporating just a few extra minutes of physical activity each day could help further lower your blood pressure, albeit by a modest amount.

“Anything that gets your heart rate up can help.

“Incorporating short bursts of activity, such as walking while taking phone calls or setting an alarm to get up and move around every hour, are great ways to start building activity into your day.

“These small changes will help get you in the habit of living a healthier, more active lifestyle.” – By Jane Kirby/PA Media/dpa