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Proteomic fitness scores revolutionize disease prediction and personalized exercise plans

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Proteomic fitness scores revolutionize disease prediction and personalized exercise plans

A study published in Nature Medicine journal describes how proteomic scores of cardiorespiratory fitness can help predict disease risk as well as all-cause and disease-specific mortality risks beyond genetic risk scores.

Study Design: We developed and validated a circulating proteomic signature of CRF across four cohorts and various exercise modalities. In the UKB, we examined the relationship a proteomic CRF signature with a broad range of clinical endpoints and examined its interaction with polygenic risk. In HERITAGE, we examined the association of the proteomic CRF signature with response to exercise training and correlated changes in signature with changes in CRF. NAFLD, nonalcoholic fatty liver disease. Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks

Background

Cardiorespiratory fitness (CRF) is a useful prognostic marker of improved health, quality of life, and longevity. Assessing CRF in clinical settings is an effective approach to stratifying disease risk and promoting health.

However, the widespread use of CRF for clinical decision-making is restricted by some factors, including lack of availability and reproducibility of tests and high expenses. Training-responsive biomarkers of CRF is an alternative approach that may address these limitations and enable the identification of pharmacological targets that mimic the effects of exercise.

Exercise induces multiple changes in the metabolic state, which is depicted by changes in blood levels of metabolites associated with CRF. These molecular surrogates of CRF and training responses are associated with clinical prognosis.

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In this study, scientists have established, validated, and characterized a proteomic signature of CRF by linking proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF assessment methods.

They have used data from 22,000 individuals from the UK Biobank to determine the association of the proteomic signature of CRF with a broad range of clinical outcomes (death, cardiovascular, metabolic, malignancy, neurological) and examine its interaction with genetic risk score.

Furthermore, they have used the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study data to evaluate the impact of a 20-week exercise training program on the proteomic signature of CRF.

Proteomic CRF score  

The scientists developed a proteomic CRF score in the Coronary Artery Risk Development in Young Adults (CARDIA) study derivation dataset using exercise treadmill test time as the CRF measure. They further validated the proteomic CRF score across approximately 12,500 participants from four international cohorts. 

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They observed mechanistically reasonable directionality for proteins involved in innate immunity and inflammation, atherosclerosis, neuronal survival and growth, cell physiology, oxidative stress, energy expenditure, and substrate fuel utilization, adiposity, peripheral muscle responses to exercise, and autophagy.

Association between proteomic CRF score and clinical outcomes

The scientists analyzed proteomic profiles and survival data of 21,988 participants from the UK Biobank and observed a significant inverse association between proteomic CRF score and risk of all-cause mortality and disease-specific mortality.

They observed the proteomic CRF score’s consistent and robust protective effect on cardiovascular, metabolic, and neurological outcomes. They found that the proteomic CRF score improves risk prediction beyond standard clinical risk factors, with improved risk reclassification and discrimination.  

By analyzing the interaction between the proteomic CRF score and genetic risk score of common diseases, they observed a significant additive effect between the proteomic CRF score and each genetic risk score on the corresponding disease outcome. The highest disease risk was observed in participants with the lowest proteomic CRF score and a high genetic risk score.

Impact of exercise on proteomic CRF score

The scientists observed an increase in the proteomic CRF score following a 20-week exercise training program. This change was associated with an alteration in peak oxygen consumption, independent of age, sex, race, body mass index (BMI), pre-training peak oxygen consumption, and pre-training proteomic CRF score.

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Specifically, they observed that a higher proteomic CRF score is associated with greater peak oxygen consumption with training, independent of age, sex, and race. However, this association was not sustained after adjusting for BMI.

Furthermore, they observed that the proteomic CRF score components that exhibited significant post-training changes are correlated with a range of metabolic, vascular, and myocardial phenotypes.

Many of these components (proteins) were correlated with adiposity reduction, lipid metabolism, bone morphogenic pathway regulation, and ischemia-reperfusion injury management.

Study significance

The study describes the development of a circulating proteomic signature of CRF using a treadmill exercise test that showed a consistent relation across sub-maximal treadmill exams in 10,320 UK residents and maximal cardiopulmonary exercise exams in 1,587 US residents.

The proteomic signature of CRF exhibits robust and independent associations with a range of metabolic, cardiovascular, and neurological clinical outcomes. These associations seem to be additive to the genetic risk of corresponding diseases. This highlights the utility of proteomic CRF signature for multiomic evaluation of disease and mortality risks.

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The study also highlights the dynamicity of proteomic CRF score following a 20-week exercise training program and an association between training-related changes in the score and peak oxygen consumption. This highlights the utility of proteomic CRF score for personalization of exercise recommendations.

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A few extra minutes of exercise and sleep may help you live a year longer

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A few extra minutes of exercise and sleep may help you live a year longer

Adding just a few minutes of exercise per day could impact a person’s life expectancy, a new study has found.

Combined with an extra 24 minutes of sleep and small improvements to diet quality, those daily changes could add up to several additional years of life. 

The research is one of two studies published this week that examine how small adjustments to day-to-day movement, sleep and diet are associated with substantial health improvements.

Sleep, physical activity and diet study

The study, published in eClinicalMedicine, followed up a group of people eight years after they signed up for UK Biobank, a massive project that collected data on demographics, health and lifestyle in the early 2000s.

The team of researchers, led by Nicholas Koemel of the University of Sydney, fitted 59,078 people with trackers to monitor their exercise and sleep patterns for a week.

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They also rated the participants’ self-reported diet at the time they signed up for UK Biobank to come up with a score out of 100.

According to the researchers, the study is the first of its kind to investigate the minimum combined doses of device-measured sleep and physical activity, alongside a comprehensive dietary score. 

“We were aiming to look at the interconnection between sleep, physical activity, and diet; and our lifespan — which is the number of years that we live — and our healthspan, that’s essentially the number of years we live free from chronic disease,” Dr Koemel said.

The research found that small improvements in all three areas made gains in both lifespan and healthspan.

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The study found that improvement of life expectancy by one year when participants added:

  • just five extra minutes of sleep per day,  plus
  • just under two minutes per day of moderate-to-vigorous physical activity, and 
  • an extra half serving of vegetables.

“One of the core findings from our study was that realistic improvements, these modest tiny tweaks across multiple behaviours, the sleep, physical activity, and diet, were able to create meaningful improvements in our lifespan and healthspan,” Dr Koemel said. 

While these baby steps could help, overall the  study found that the “optimal combination” of the three categories correlated with an additional nine years of life expectancy was:

  • seven to eight hours of sleep, 
  • just over 40 minutes of moderate exercise per day, 
  • and a healthy diet.

Moira Junge, an adjunct clinical professor and health psychologist at Monash University, praised the studies and said looking at the combination of sleep, exercise and diet over the long term is crucial in longevity research.

“We absolutely need to put it together, and research like this is proof that even small changes can make a really big difference to your health and wellbeing,” Dr Junge said.

Cutting sitting by half hour helps with life expectancy

The second study, published in The Lancet, examined participants who had low activity levels and spent hours sitting throughout the day. 

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Data from more than 135,000 adults across Norway, Sweden and the United States, combined with data from the UK Biobank examined the impact of daily physical activity and reductions in sedentary behaviours on mortality. 

The researchers found a nine per cent reduction in mortality risk when those sitting for eight or more hours a day reduced their sitting time by 30 minutes. 

Studies have linked long periods of sitting with increased risk of several chronic health conditions including cardiovascular disease, diabetes and some types of cancer.  (ABC News: Danielle Bonica)

Sedentary behaviour has previously been linked to higher rates of chronic health conditions, such as diabetes, colon cancer and cardiovascular diseases, prompting some claims that “sitting is the new smoking”.

The study also found that increasing physical activity by just five minutes a day could have a significant health impact, especially for minimally active people. 

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Increasing from one minute to six minutes of exercise per day was associated with an approximately 30 per cent reduction in mortality risk. Those who increased activity from one minute to 11 minutes per day saw an approximate 42 per cent reduction in mortality risk.

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In 2022, a reported four in 10 Australian adults (aged 18–64) were insufficiently physically active: not meeting the recommended 150–300 minutes of moderate to vigorous activity across five or more days per week. 

“In reality, there’s always going to be people who don’t meet the guidelines,” said Melody Ding, a professor of public health at University of Sydney who co-led the study.

But what we know is that especially for those who are extremely inactive, for them to get to do a little bit more, that’s where we get the most bang for their buck.

“It tells us in terms of the benefits of physical activity, that we don’t need to get everybody to do so much. This micro-dosing concept, especially for those who are inactive, could make a huge difference in terms of health outcomes,” she said.

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Something better than nothing

Dr Junge hoped the study findings could help people feel positive health outcomes are achievable. 

“I think that when people can feel like they’ve got mastery over something then they’re more likely to change their behaviour and more likely to have motivation to change. Health is a confidence game,” she said. 

Lauren Ball, a professor of community health and wellbeing at University of Queensland, said the two new studies reconfirm the importance of diet, physical activity and sleep for overall health and wellbeing. 

“The notion that modest increases in physical activity is beneficial is also supported by other studies, suggesting that doing something is always better than nothing,” she said. 

“The results also support behaviour change theories that suggest that improving one aspect of health behaviour, such as eating well, may increase motivation or self-efficacy for other health behaviours, such as being physically active. 

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This is an uplifting reminder for us all about the value of these health behaviours.

‘Not a silver bullet’

While these numbers might be inspiring for some, Dr Koemel said they were not a “silver bullet”.

“It’s something that’s easy to accidentally take away from this; that maybe we only need to do one minute of exercise, and that’s not the case,” he said. 

“We still have physical guidelines, and those are there for a reason. This is really about helping us go that extra step, and ask what we would need to do to take the first step in the right direction.” 

The studies found that mortality improvements were most significant in participants who were inactive.

But Dr Ding said there was a “saturation point”.

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“For example, in this study our data has shown that for those who are already doing 30 or 40 minutes per day; the active people who are meeting the guidelines, adding another five minutes, you don’t really see visible change.”

Despite this, Dr Koemel said looking at small daily changes across sedentary behaviours, sleep, diet and physical activity could have positive impacts more widely.

“We want to try to create opportunities where everybody can make change. The idea that we need to make these massive overhauls; wake up and and run a marathon or go to the gym every day of the week, that might not necessarily be the best starting place,” he said.

This gives that open door for us to go through and say, ‘Well, look, if we won’t be able to make massive changes or consume a perfect diet in the ideal world, here’s a starting place for everybody to put the best foot forward.’

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Trending Exercise & Fitness Gear for the new year…

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Trending Exercise & Fitness Gear for the new year…
“Exercising” topped the list of resolutions for 2026, followed by “eating better” and “saving money.” Beauty and Style Editor, Marianne Mychaskiw, joins California Live with trending exercise products that will help you keep your fitness resolution… Or motivate you to get started.
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You can now exercise with Dunkin’ weighted fitness bangles

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You can now exercise with Dunkin’ weighted fitness bangles

Dunkin’ has released a limited-edition set of weighted bangles on Tuesday, Jan. 12 through a collaboration with fitness accessory brand Bala, coinciding with the nationwide launch of its new Protein Milk option.

The 2-pound weighted bangles are available exclusively at ShopBala.com/dunkin-bala-bangles for $65 while supplies last. The wearable weights, which can be worn on arms or legs, feature Dunkin’s signature pink-and-orange color scheme and add resistance to walks, stretches, and everyday movement.

The bangles coordinate with Dunkin’s existing Dunk N’ Pump Collection.

Alongside the fitness accessory launch, Dunkin’ introduced Protein Milk as a new beverage addition available at locations nationwide. Customers can add 15 grams of protein to any medium drink that includes a milk or non-dairy base.

The coffee chain rolled out several protein-focused beverages featuring the new Protein Milk, including Megan’s Mango and Strawberry Protein Refreshers, a Caramel Chocolate Iced Protein Latte, and an Almond Iced Protein Matcha Latte.

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