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New ‘exercise pill’ could replace physical benefits of working out: study

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New ‘exercise pill’ could replace physical benefits of working out: study

Tired of working out? There may soon be a pill for that.

A new “exercise pill” could potentially replace some — not all — of the benefits of working out, according to a new study.

Scientists from the Washington University School of Medicine in St. Louis spent 10 years creating new compounds that seem to be able to mimic the physical benefits of a workout — at least in rodent cells — that could become ingredients for a future supplement.

The findings could result in a new way to treat muscle atrophy and other medical conditions. alones – stock.adobe.com

The team of researchers, who presented their findings at the spring meeting of the American Chemical Society (ACS), hope to replicate the physical effects of exercise, specifically the ability to enhance metabolism and growth, as well as improved muscle performance.

“We cannot replace exercise; exercise is important on all levels,” Bahaa Elgendy, a professor of anesthesiology and the project’s principal investigator, said in a media release. “If I can exercise, I should go ahead and get the physical activity. But there are so many cases in which a substitute is needed.”

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However, the findings could result in a new way to treat muscle atrophy and other medical conditions, including heart failure and neurodegenerative disease.

If the drug could mimic the physical effects of exercise, it could help offset the weakness in a person’s muscles that occur naturally as people age or for those affected by cancer, certain genetic conditions or any other reason a person may be unable to do regular physical activity.

Elgendy added that the “exercise pill” could potentially counter the loss of both muscle and fat caused by other drugs, such as new weight-loss medications.

When the scientists tested on mice, they found that the compound increased a fatigue-resistant muscle fiber, which in turn improved the rodents’ endurance when running on a treadmill.

But more testing needs to be done before the pill can be available for human use. The scientists will be testing the compound in other animals as the next step in the research process.

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6 Best Home Gym Essentials to Achieve Your Fitness Goals, According to a Physical Therapist

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6 Best Home Gym Essentials to Achieve Your Fitness Goals, According to a Physical Therapist

Achieving your fitness goals doesn’t require a monthly gym membership. From the comfort of your home, you can implement a few minutes of daily exercise with just the right equipment.

To help jumpstart your New Year’s goals, physical therapist Karena Wu recently revealed to the 3rd hour of TODAY some ways you can build a gym right at home. Whether you’re into high-intensity workouts or improving strength training, these budget-friendly picks can transform your living room into your own personalized fitness space.

Ready to lace up your sneakers? Keep reading to discover the best workout essentials to achieve your at-home fitness goals, according to an expert.

Best home gym essentials seen on TODAY

This multi-purpose training disc offers stability during workouts, helps engage the core, and provides other benefits in a portable design that makes exercise feasible wherever you go. “It can also be used as a seat cushion to help with posture and balance,” adds Wu.

From warming up to activating your muscles, resistance bands are a fitness essential every home gym should have. The pick above comes in various resistance intensities to suit every skill level.

“This is a smart jump rope with an app to track your jump counts, calorie and duration,” explains Wu. “The donuts add weight to make it feel like a real rope, but it is cordless, so it doesn’t scratch the ground. It is great for beginners and for in the home, so you don’t scratch your floor or hit the ceiling.”

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“Kettlebells are great for adding weight and instability to challenge your core,” suggests Wu. This collection of kettlebells is each color-coded to easily distinguish each weight while you work out. Though each weight is sold separately, the kettlebells start at just under $15 to help kickstart your training.

“Sliding core discs are great for adding strengthening, dynamic movements and stability training,” suggests Wu. This set comes double-sided, so regardless of your home flooring, you can perform mountain climbers or push-ups anywhere in your home.

From relieving muscle tightness to soothing muscle soreness post-workout, this tiny but mighty massage ball offers direct pressure on points. “This is a smaller ball, so it is meant for the hands and feet, but you could still use them elsewhere on the body,” notes Wu. “These are great to travel with, and don’t take up much space.”

More home gym essentials to shop

If your goal is to achieve 10,000 steps a day, a walking pad is a practical way to get your steps in. Enjoy a quick five-minute workout while watching your favorite show or use the machine to keep your legs moving while working from home.

You don’t have to book a reformer class to take advantage of the benefits of pilates. With a pilates ball, including this option from Bala, it helps offer strength and support to build your core and beyond.

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On the topic of pilates, support every movement and prevent slips with these Bombas grippy socks. They also deliver arch support, a comfortable cushion, among other perks, for a better workout.

According to the brand, the WeGym SafeGrip Square Dumbbells are designed to feel more secure in your hands compared to metal dumbbells for a comfortable grip with every lift.

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Use a foam roller to assist with recovery and prevent injury after an intense workout or strength training session.

We’re constantly browsing Lululemon’s sale section. So while we’re building our home gym, might as well build our fitness wardrobe, too, like the tank above, as we scroll.

One Shop TODAY editor calls the New Balance FuelCell Rebel V5 one of her “favorite everyday running shoes” in her recent round-up of the ‘best sneakers of 2025.’ From its breathable mesh to its supportive insole, there’s a lot to love about the shoe.

From yoga to pilates, this exercise mat can assist with stability and balance during your workout.

Weighted vests were a trending topic in 2025, and we don’t see them leaving in the new year. Whether you wear one on your runs or completing chores, weighted vests add a bit of intensity to any movement and workout.

A pilates ring delivers more than meets the eye. Use it to strengthen the core, help tone your arms, among other benefits.

This new launch is made with the brand’s softest fabric yet, and a good pair of tights can upgrade any at-home workout. “These leggings have a second-skin feel and no front seams for extra comfort,” says commerce editor and producer, Julie Ricevuto. “The waistband doesn’t roll or bunch during workouts, and the stretchy and flexible fabric make them super comfortable — they’re my new go-to leggings!”

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The ultimate splurge, this at-home rowing machine is worth it for those that want a full-body workout that engages more than 86% of the body’s muscles during use. It also provides immersive, on the water workouts led by expert athletes and olympians, along with personalized recommendations in order to help users get the most out of their at-home workout.

Meet the expert

Our team features a range of qualified experts and contributors in our broadcast segments to reveal the latest in trends, remarkable sale events and all things shopping across a variety of categories. Products were independently chosen by members of the Shop TODAY team, along with Karena Wu, to find the best fitness essentials to build a home gym.

  • Karena Wu is a physical therapist and the owner and Clinical Director of ActiveCare Physical Therapy.

How we chose

The Shop TODAY editors and writers search the internet to find the best products out there. We interview expert sources, comb through customer reviews and even use our own personal experiences to make shopping easier for our readers.

As an editorial team, we independently create content and determine coverage based on research, reporting and what we think TODAY.com readers would like to read about. The goal of our content is to provide a service and inform readers who are on the hunt for the latest products to help make their life better. Items are sold by retailer, not TODAY. Pricing and availability are accurate as of publish time.

How do you add Shop TODAY as a Preferred Source on Google?

Google’s new Preferred Sources feature allows users to manually select their favorite publishers and news outlets for a more customizable experience tailored directly to the reader. Once you’ve opted to receive our content, you’ll begin seeing more of our recent and trending articles displayed within your Top Stories news feed.

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The easiest way to add us as a preferred source is to click here and type in “TODAY.com.” Once the box is checked and you’ve refreshed the page, Shop TODAY content will start appearing in your feed.

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Not Crunches Or Planks – Surprisingly, Experts Recommend This Underrated Exercise For Ultimate Lower Body Strength

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Not Crunches Or Planks – Surprisingly, Experts Recommend This Underrated Exercise For Ultimate Lower Body Strength

We’re only halfway through January (officially the longest month of the entire year), and it’s already clear that 2026 is, much like its predecessor, all about strength training.

There is, however, a clear difference: we’re moving away from high-intensity, fast workouts and towards slower, more intentional moves that might be low-impact, but still pack a punch, benefits-wise. The best news? The moves are super simple – and the experts’ favourite one is the (appropriately monikered) crab walk exercise.

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Fitness

Scientists identify one fitness habit that may matter most for longevity

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Scientists identify one fitness habit that may matter most for longevity

The Harvard study also indicates a maximum exercise window: approximately three hours of vigorous activity or six hours of moderate-intensity activity per week.

“Doing higher activity level is perfectly fine, it is just that no additional health benefits would be gained further,” Hu says. “One who can run marathons everyday may not have a lower risk of dying than people who do regular brisk walking.”

The biological mechanisms behind this are unclear. Some experts theorize that overworking your body may increase chronic inflammation or arterial stiffness, both which have been shown to increase risk of cardiovascular disease.

“We need more data, especially from clinical trials, to examine associations of different types of exercise on various health outcomes,” Lee says.

Why exercise variety is key

Interestingly, Hu’s study found that regardless of how much a person worked out, variety improved participants’ longevity. When it came to reducing risk for cardiovascular disease, respiratory disease, or cancer, the most diverse exercise group had 13 to 41 percent lower risk compared to the least diverse group.

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