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How to Keep the 'Ozempic Effect' Going: Exercise

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How to Keep the 'Ozempic Effect' Going: Exercise

FRIDAY, Feb. 23, 2024 (HealthDay News) — An open question for weight-loss drugs like Ozempic, Wegovy and Zepbound has been whether folks will keep the pounds off when they stop taking them.

Regular exercise could be the key to quitting the drugs without regaining weight, a new Danish study says.

“It is actually possible to stop taking the medication without large weight regain, if you follow a structured exercise regime,” said senior researcher Signe Sorensen Torekov, of the University of Copenhagen.

As little as a couple hours a week of exercise maintained the weight lost with the drugs, researchers found.

“Our study offers new hope, as we have shown that the majority of those who take weight-loss medication and exercise regularly are able to maintain the beneficial effects a year after treatment termination,” Torekov said in a university news release.

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For the study, researchers recruited four groups of test participants.

One group was given a weight-loss drug, a second group was asked to exercise regularly and a third group was given the drug and asked to work out. The fourth group received a placebo.

The results showed that the exercise groups experienced an improvement in their quality of life. And those taking the drug while exercising kept the weight off once they quit the medication.

The new study was published Feb. 19 in the journal Lancet eClinical Medicine.

“All it takes is two hours of exercise a week that gets the heart rate up and makes you pant,” said lead researcher Simon Birk Kjær Jensen, a postdoctoral researcher at the University of Copenhagen.

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“And it may differ from one person to the next,” Jensen added. “For people with severe obesity and low initial fitness level, a brisk walk may be sufficient, whereas people with higher fitness level may have to practice running or cycling.”

Based on this data, doctors should consider prescribing exercise along with weight-loss medications, to increase people’s chance of maintaining their weight loss.

“The study almost makes me want to advise against medical treatment without increased physical exercise, especially if you do not want to be taking the drugs for the rest of your life,” Torekov said. “The good news is that post-treatment weight loss maintenance is possible, but only when combined with exercise.”

More information

The Mayo Clinic has more about weight-loss drugs.

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SOURCE: University of Copenhagen, news release, Feb. 20, 2024

Fitness

Trending Exercise & Fitness Gear for the new year…

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Trending Exercise & Fitness Gear for the new year…
“Exercising” topped the list of resolutions for 2026, followed by “eating better” and “saving money.” Beauty and Style Editor, Marianne Mychaskiw, joins California Live with trending exercise products that will help you keep your fitness resolution… Or motivate you to get started.
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You can now exercise with Dunkin’ weighted fitness bangles

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You can now exercise with Dunkin’ weighted fitness bangles

Dunkin’ has released a limited-edition set of weighted bangles on Tuesday, Jan. 12 through a collaboration with fitness accessory brand Bala, coinciding with the nationwide launch of its new Protein Milk option.

The 2-pound weighted bangles are available exclusively at ShopBala.com/dunkin-bala-bangles for $65 while supplies last. The wearable weights, which can be worn on arms or legs, feature Dunkin’s signature pink-and-orange color scheme and add resistance to walks, stretches, and everyday movement.

The bangles coordinate with Dunkin’s existing Dunk N’ Pump Collection.

Alongside the fitness accessory launch, Dunkin’ introduced Protein Milk as a new beverage addition available at locations nationwide. Customers can add 15 grams of protein to any medium drink that includes a milk or non-dairy base.

The coffee chain rolled out several protein-focused beverages featuring the new Protein Milk, including Megan’s Mango and Strawberry Protein Refreshers, a Caramel Chocolate Iced Protein Latte, and an Almond Iced Protein Matcha Latte.

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Just 10 Minutes of Exercise May Help Slow Cancer Growth, New Study Suggests – Muscle & Fitness

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Just 10 Minutes of Exercise May Help Slow Cancer Growth, New Study Suggests – Muscle & Fitness

Exercise has long been known for its muscle building, heart saving, and mind stimulating benefits, but more and more research is beginning to shed light on how being active can inhibit the spread of cancer, with a new study suggesting that just 10 minutes of exercise can switch off the signals that lead to cancer growth. The study, undertaken by researchers at England’s Newcastle University and published by the JAMA Network, showed that even short burst of energetic exercise can trigger quick molecular changes within the bloodstream that can halt cancer growth and accelerate DNA repair.

How Was the Study Carried Out?

30 overweight or obese male and female volunteers aged between 50 and 78 (risk factors associated with cancer) who were otherwise healthy, were asked to complete cycling sessions for around ten minutes. Following this activity, blood samples were then taken to measure 249 different proteins, and how the intervention of exercise may have affected these proteins.

Does Exercise Lower Cancer Risk Long-Term?

The scientists discovered that 13 proteins increased after this exercise, including interleukin-6 (IL-6), a protein that is associated with DNA and damaged cell repair. “These results suggest that exercise doesn’t just benefit healthy tissues, it may also create a more hostile environment for cancer cells to grow,” said Dr. Samuel Orange, who is a Clinical Exercise Physiologist. “… it sends powerful signals through the bloodstream that can directly influence thousands of genes in cancer cells”

It is estimated that regular physical activity can reduce the risk of bowel cancer by around 20 percent. “It’s an exciting insight because it opens the door to find ways that mimic or augment the biological effects of exercise, potentially improving cancer treatment and, crucially, patient outcomes,” added Orange. “In the future, these insights could lead to new therapies that imitate the beneficial effects of exercise on how cells repair damaged DNA and use fuel for energy.”

The study also found that exercise supercharged activity in genes that support mitochondrial energy metabolism, enabling calls to use oxygen more efficiently, while genes that encourage rapid cell growth were essentially switched off, reducing the aggressiveness of cancer cells. “Even a single workout can make a difference,” commented Orange. “One bout of exercise, lasting just 10 minutes, sends powerful signals to the body. It’s a reminder that every step, every session, counts when it comes to doing your best to protect your health.”

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