BEIRUT — Israel said on Tuesday it had assassinated Iran’s top security official, Ali Larijani, a move that — if confirmed — represents a palpable hit to an Iranian leadership that has shown little interest in compromise after almost three weeks of war with the U.S. and Israel.

Killing Larijani, who led the country as de facto wartime leader after Iranian Supreme Leader Ayatollah Ali Khamenei died on the first day of the war, eliminates a veteran official seen as the consummate insider despite not having the religious credentials for the Islamic Republic’s highest offices.

For all his bellicose comments since the war began, Larijani was also seen as a pragmatist, and observers say his death might strengthen the resolve of what’s left of Iran’s leadership, rather than induce a willingness to compromise.

His post as secretary of Iran’s Supreme National Security Council gave Larijani control of the country’s top security body, where he tasked government forces with deploying deadly force to subdue anti-regime protests in January.

Also killed in the strikes, according to the Israeli military, was Gen. Gholam Reza Soleimani, the head of the Basij, the volunteer auxiliary wing of the Revolutionary Guards and an integral part of the state’s ability to keep order.

“Larijani and the Basij commander were eliminated overnight and joined the head of the annihilation program, Khamenei, and all the eliminated members of the axis of evil, in the depths of hell,” said Israeli Defense Minister Israel Katz in a statement on Tuesday.

Israeli officials have employed “axis of evil” to refer to Iran and its allied paramilitary groups, including Hamas and Hezbollah.

Larijani had served as parliamentary speaker for 12 years and became the point man on the nuclear negotiations as well as relations with allies such as China and Russia. He often acted as the government’s representative in the media.

Iran’s government did not confirm he and Soleimani had been killed. But soon after Katz’s announcement, Iranian authorities released an undated note said to have been written by Larijani in which he honored Iranian sailors killed in a U.S. attack. The image of the note was also posted to Larijani’s account on X.

There was no explanation why the note was released and whether it is signified Larijani was still alive.

“We are undermining this regime in the hope of giving the Iranian people an opportunity to remove it,” said Israeli Prime Minister Benjamin Netanyahu in a statement, adding that such an outcome “will not happen all at once, and it will not happen easily.”

“But if we persist,” Netanyahu added, “we will give them the chance to take their destiny into their own hands.”

Netanyahu and President Trump have repeatedly called on regular Iranians to topple the government.

Though assassinating Larijani counts as yet another intelligence coup for Israel and the U.S., both may come to regret the loss of a figure who, despite his defiant rhetoric since the war began Feb. 28, was considered a realist.

His killing adds to the evisceration of Iran’s upper echelons, raising the question as to who is left to negotiate an end of the war, but also who would have enough influence to make Iran’s deep state accept compromise.

Some observers say that’s the point.

“Why did the Israelis take out Larijani in this moment? Because Netanyahu is focused on blocking Trump’s pathways for a ceasefire and follow-up negotiations with Iran,” said Ellie Geranmayeh, a senior policy fellow at the European Council for Foreign Relations, adding that “Larijani would have been the man to get that job done.”

Khamenei’s assassination, Geranmayeh said, had already empowered more hard-line figures in government, and Larijani’s death “could act as an accelerator to that path.”

“Israel seems to be turning its attention to targeting those that could push for a political solution to the current crisis,” she said.

Larijani’s death would add to the murkiness surrounding Iran’s leadership. After Khamenei was killed and it remained unclear who would replace him, Trump added to the uncertainty by saying that the country’s new leader would need his approval, but also that the U.S. had killed many of the leaders whom he would have deemed acceptable.

After Khamenei’s son, Mojtaba Khamenei, was named the new supreme leader, Trump expressed his displeasure but repeatedly dodged questions about what the transition under the younger Khamenei would mean for the U.S. war effort and any potential path toward a resolution.

After the elder Khamenei’s death, Larijani emerged as a high-profile voice for Iran, saying that Trump must “pay the price” for the U.S. strikes on the country.

In response, Trump acted as if he didn’t know who Larijani was.

“I have no idea what he’s talking about, who he is. I couldn’t care less,” Trump told CBS News.

Benjamin Radd, a political scientist and senior fellow at the UCLA Burkle Center for International Relations, said Larijani was perceived to be “the last of the competent bunch” within Iranian leadership — an intellectual who had a complex understanding of the geopolitical reality on the ground, who had negotiated with the U.S. in the past, and who was “adept at maneuvering” all the various parts of the Iranian power structure.

Radd said Larijani “lost that mantle of being the pragmatist” when he strongly backed the deadly January crackdown on protesters, for which he was “more responsible than anyone else.”

He “absolutely was responsible for a tremendous amount of carnage and death and destruction,” Radd said.

And yet, with his death, “all of that diplomatic, institutional experience” that he did have “is gone” from within Iranian leadership, Radd said.

Those left in power, he said, are “generally not the sharpest people, they’re not the people who understand the subtleties of diplomacy, of what negotiating with the U.S. is like.”

Bulos reported from Beirut and Rector from Washington.