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Commentary: Farewell to Peter Duesberg, a godfather of scientific disinformation
It can hardly be disputed that science and medicine today are awash in disinformation.
It’s why respected scientists get physically assaulted and hauled before partisan committees in Congress to be smeared. It’s why childhood vaccine rates in some places are plummeting and measles is on the rampage across the country.
Therefore, it behooves us to look at the origins of this outbreak of politically manipulated pseudoscience. Nature has given us a peg, with the death Jan. 13 of former UC Berkeley scientist Peter Duesberg, at 89.
Peter Duesberg was an AIDS denialist. He is the precursor to contemporary denialists like RFK Jr., who brought AIDS denialism into the 21st century.
— Yale epidemiologist Gregg Gonsalves
At the dawn of research into what is now known as HIV/AIDS, Duesberg took the heterodox view that HIV was a harmless virus that had nothing to do with AIDS.
“That virus is a pussycat,” he said. He maintained that the cause of AIDS had to be found elsewhere, notably the lifestyles and drug habits of gay men. His claim motivated a phalanx of AIDS deniers, the forebears of the anti-vaccine militants today.
“Duesberg was a pioneer of disinformation on infectious disease,” says John P. Moore, professor of microbiology and immunology at Weill Cornell Medical College and the author of a devastating 1996 takedown in Nature of Duesberg’s claims.
Duesberg’s embrace of a dangerously wrong hypothesis to the point that it destroyed his career is almost a Shakespearean narrative.
The German native built a career in the U.S. as a brilliant virologist with significant discoveries to his credit and long had been revered among his colleagues. But that ended when he entered the HIV wars. By 1996, Richard Horton, then the editor of the Lancet, the British medical journal, could marvel: “He is now perhaps the most vilified scientist alive.”
Some of the adversaries against whom he leveled ad hominem attacks — he accused Anthony S. Fauci, the respected immunologist and long-term director of the National Institute of Allergies and Infectious Diseases, of committing mass murder by promoting the use of the highly toxic drug AZT against HIV — could barely hear his name without suffering apoplectic fits. AZT remains part of standard HIV therapies and is estimated to have saved or prolonged millions of lives.
Asked by science journalist William Booth to respond to a Duesberg statement, Robert Gallo, the co-discoverer of HIV, replied, “I cannot respond without shrieking.” Fauci derided Duesberg’s scientific claims as “absolute and total nonsense.”
But it would be a mistake to think that Duesberg’s baleful influence on medical science will end with his death.
Duesberg’s heirs are all around us. Actually, they’re more than that — they’re now in charge.
As secretary of Health and Human Services, Duesberg’s most highly placed follower, Robert F. Kennedy Jr., is presiding over what has become an overtly anti-vaccination and anti-science agency with a stranglehold on government health policy and funding.
“Peter Duesberg was an AIDS denialist,” says Gregg Gonsalves, a Yale epidemiologist who was active in the AIDS research community starting in the 1990s. “He is the precursor to contemporary denialists like RFK Jr., who brought AIDS denialism into the 21st century.”
Indeed, Kennedy has embraced the denialist position that HIV is not the cause of AIDS: In a 2023 interview with New York magazine, Kennedy attributed the conclusion that HIV and AIDS were inextricably linked to “phony, crooked studies to develop a cure that killed people,” referring to AZT.
In his 2021 book “The Real Anthony Fauci,” Kennedy highlighted Duesberg’s depiction of Fauci as an all-powerful scientific panjandrum intent on blocking his grant applications because his findings might be costly for Fauci’s patrons, Big Pharma.
Kennedy also picked up Duesberg’s broader brief against government science agencies such as the Centers for Disease Control and Prevention. Duesberg’s claim was that the CDC existed only to drum up medical emergencies so the NIH could solve them, ensuring the continued flow of taxpayer dollars into both agencies.
Starting in the mid-1970s, Duesberg asserted and Kennedy quoted, “‘the CDC increasingly needed a major epidemic’ to justify its existence.”
Kennedy added his own gloss: “Drumming up public fear of periodic pandemics was a natural way for NIAID and CDC bureaucrats to keep their agencies relevant.”
One can draw a straight line from that statement to the unapologetic malevolence with which Kennedy treats the CDC and NIH, insinuating that they’re rife with corruption and conflicts of interest. I sought a comment from Kennedy about Duesberg’s influence on his thinking, but received no reply.
Because AIDS isn’t caused by a virus, Duesberg maintained, the antiviral drugs used as therapies were worse than the disease. He specifically targeted AZT, then as now a common component of AIDS therapies.
The publicity his claims received encouraged untold patients to refuse AZT, causing a toll that may number in the millions. Duesberg met with South African President Thabo Mbeki and chaired a South Africa conference on alternative AIDS theories in 2000, and influenced Mbeki to deny AZT treatments for South African patients. That policy contributed to more than 300,000 deaths from AIDS in that country alone.
“That’s his biggest legacy in terms of the death toll,” Moore says.
Duesberg’s intellectual journey points to an eternal question in science: At what point does a theory become so discredited and the empirical evidence against it so strong, that its advocates should be ignored?
For Duesberg, that point may have come in 1989, when he published an article in the Proceedings of the National Academy of Sciences outlining his position in detail. The article was filled with with so many assertions about virus science that experienced virologists knew to be false that it “closed the book on him,” Moore told me.
But as Jon Cohen of Science magazine would observe, “the press was less skeptical.” Journalists saw Duesberg as an iconoclastic truth-teller because he carried “visible credentials,” as Gallo put it — after all, he was a professor at a leading research university and a member of the elite National Academy of Sciences.
The press feasted on Duesberg’s self-portrayal as the victim of ostracism arising from professional jealousies — a target of cancel culture before that was a thing. But it rang as false then as do those of RFK Jr.’s anti-science appointees who claim today to have been silenced for their unorthodox views while proclaiming their victimhood at university-sponsored symposiums and appearances on Fox News.
Duesberg’s position also appealed to “the unwary, desperate or gullible” with “twisted facts and illogical lines of argument,” Moore wrote in 1996.
He attracted followers eager to make their name by challenging the scientific consensus on HIV and AIDS.
One was Robert Willner, who had lost his medical license in Florida for claiming to have cured an AIDS patient by administering ozone. Willner went on the road with presentations that included his injecting himself with blood from an AIDS sufferer, as if to show that there was nothing to be feared from HIV. (Willner died in 1995 of a heart attack.)
In his 1989 article, Duesberg had insisted that the true cause of AIDS was drug use by abusers and nitrite poppers favored by homosexuals. AIDS had only been discovered and named, he wrote, because “the particular permissiveness toward these risk groups in metropolitan centers encouraged the clustering of cases that was necessary to detect AIDS.”
His advice was that AIDS prevention efforts should be “concentrated on AIDS risks rather than on transmission of HIV,” which — if followed — would have set AIDS research inexorably down the wrong path.
Duesberg kept making his argument well after evidence that the human immunodeficiency virus, HIV, causes AIDS became incontestable. It’s on that evidence that AIDS treatment is based today, with spectacular success — with proper treatment, an AIDS patient can live about as long as an uninfected individual. In the old days, an infection was a death sentence.
The memorial page posted by UC Berkeley after Duesberg’s death walked a tightrope in acknowledging his descent into infamy. In its first sentence, it labeled him as a “public controversialist,” a term new to me. It recounted, “In his later years, Peter enjoyed being a maverick and the center of controversy.”
But it candidly addresses the controversies he triggered by noting that his unorthodox stance “was amplified by political leaders to the detriment of public health.”
And it delivers a final verdict that “the scientific consensus is that HIV is indeed the primary cause of AIDS, and that the current suite of anti-retroviral agents is very effective in slowing or halting the progression of the disease and its spread in the population.”
Business
How our AI bots are ignoring their programming and giving hackers superpowers
Welcome to the age of AI hacking, in which the right prompts make amateurs into master hackers.
A group of cybercriminals recently used off-the-shelf artificial intelligence chatbots to steal data on nearly 200 million taxpayers. The bots provided the code and ready-to-execute plans to bypass firewalls.
Although they were explicitly programmed to refuse to help hackers, the bots were duped into abetting the cybercrime.
According to a recent report from Israeli cybersecurity firm Gambit Security, hackers last month used Claude, the chatbot from Anthropic, to steal 150 gigabytes of data from Mexican government agencies.
Claude initially refused to cooperate with the hacking attempts and even denied requests to cover the hackers’ digital tracks, the experts who discovered the breach said. The group pummelled the bot with more than 1,000 prompts to bypass the safeguards and convince Claude they were allowed to test the system for vulnerabilities.
AI companies have been trying to create unbreakable chains on their AI models to restrain them from helping do things such as generating child sexual content or aiding in sourcing and creating weapons. They hire entire teams to try to break their own chatbots before someone else does.
But in this case, hackers continuously prompted Claude in creative ways and were able to “jailbreak” the chatbot to assist them. When they encountered problems with Claude, the hackers used OpenAI’s ChatGPT for data analysis and to learn which credentials were required to move through the system undetected.
The group used AI to find and exploit vulnerabilities, bypass defences, create backdoors and analyze data along the way to gain control of the systems before they stole 195 million identities from nine Mexican government systems, including tax records, vehicle registration as well as birth and property details.
AI “doesn’t sleep,” Curtis Simpson, chief executive of Gambit Security, said in a blog post. “It collapses the cost of sophistication to near zero.”
“No amount of prevention investment would have made this attack impossible,” he said.
Anthropic did not respond to a request for comment. It told Bloomberg that it had banned the accounts involved and disrupted their activity after an investigation.
OpenAI said it is aware of the attack campaign carried out using Anthropic’s models against the Mexican government agencies.
“We also identified other attempts by the adversary to use our models for activities that violate our usage policies; our models refused to comply with these attempts,” an OpenAI spokesperson said in a statement. “We have banned the accounts used by this adversary and value the outreach from Gambit Security.”
Instances of generative AI-assisted hacking are on the rise, and the threat of cyberattacks from bots acting on their own is no longer science fiction. With AI doing their bidding, novices can cause damage in moments, while experienced hackers can launch many more sophisticated attacks with much less effort.
Earlier this year, Amazon discovered that a low-skilled hacker used commercially available AI to breach 600 firewalls. Another took control of thousands of DJI robot vacuums with help from Claude, and was able to access live video feed, audio and floor plans of strangers.
“The kinds of things we’re seeing today are only the early signs of the kinds of things that AIs will be able to do in a few years,” said Nikola Jurkovic, an expert working on reducing risks from advanced AI. “So we need to urgently prepare.”
Late last year, Anthropic warned that society has reached an “inflection point” in AI use in cybersecurity after disrupting what the company said was a Chinese state-sponsored espionage campaign that used Claude to infiltrate 30 global targets, including financial institutions and government agencies.
Generative AI also has been used to extort companies, create realistic online profiles by North Korean operatives to secure jobs in U.S. Fortune 500 companies, run romance scams and operate a network of Russian propaganda accounts.
Over the last few years, AI models have gone from being able to manage tasks lasting only a few seconds to today’s AI agents working autonomously for many hours. AI’s capability to complete long tasks is doubling every seven months.
“We just don’t actually know what is the upper limit of AI’s capability, because no one’s made benchmarks that are difficult enough so the AI can’t do them,” said Jurkovic, who works at METR, a nonprofit that measures AI system capabilities to cause catastrophic harm to society.
So far, the most common use of AI for hacking has been social engineering. Large language models are used to write convincing emails to dupe people out of their money, causing an eight-fold increase in complaints from older Americans as they lost $4.9 billion in online fraud in 2025.
“The messages used to elicit a click from the target can now be generated on a per-user basis more efficiently and with fewer tell-tale signs of phishing,” such as grammatical and spelling errors, said Cliff Neuman, an associate professor of computer science at USC.
AI companies have been responding using AI to detect attacks, audit code and patch vulnerabilities.
“Ultimately, the big imbalance stems from the need of the good-actors to be secure all the time, and of the bad-actors to be right only once,” Neuman said.
The stakes around AI are rising as it infiltrates every aspect of the economy. Many are concerned that there is insufficient understanding of how to ensure it cannot be misused by bad actors or nudged to go rogue.
Even those at the top of the industry have warned users about the potential misuse of AI.
Dario Amodei, the CEO of Anthropic, has long advocated that the AI systems being built are unpredictable and difficult to control. These AIs have shown behaviors as varied as deception and blackmail, to scheming and cheating by hacking software.
Still, major AI companies — OpenAI, Anthropic, xAI, and Google — signed contracts with the U.S. government to use their AIs in military operations.
This last week, the Pentagon directed federal agencies to phase out Claude after the company refused to back down on its demand that it wouldn’t allow its AI to be used for mass domestic surveillance and fully autonomous weapons.
“The AI systems of today are nowhere near reliable enough to make fully autonomous weapons,” Amodei told CBS News.
Business
iPic movie theater chain files for bankruptcy
The iPic dine-in movie theater chain has filed for Chapter 11 bankruptcy protection and intends to pursue a sale of its assets, citing the difficult post-pandemic theatrical market.
The Boca Raton, Fla.-based company has 13 locations across the U.S., including in Pasadena and Westwood, according to a Feb. 25 filing in U.S. Bankruptcy Court in the Southern District of Florida, West Palm Beach division.
As part of the bankruptcy process, the Pasadena and Westwood theaters will be permanently closed, according to WARN Act notices filed with the state of California’s Employment Development Department.
The company came to its conclusion after “exploring a range of possible alternatives,” iPic Chief Executive Patrick Quinn said in a statement.
“We are committed to continuing our business operations with minimal impact throughout the process and will endeavor to serve our customers with the high standard of care they have come to expect from us,” he said.
The company will keep its current management to maintain day-to-day operations while it goes through the bankruptcy process, iPic said in the statement. The last day of employment for workers in its Pasadena and Westwood locations is April 28, according to a state WARN Act notice. The chain has 1,300 full- and part-time employees, with 193 workers in California.
The theatrical business, including the exhibition industry, still has not recovered from the pandemic’s effect on consumer behavior. Last year, overall box office revenue in the U.S. and Canada totaled about $8.8 billion, up just 1.6% compared with 2024. Even more troubling is that industry revenue in 2025 was down 22.1% compared with pre-pandemic 2019’s totals.
IPic noted those trends in its bankruptcy filing, describing the changes in consumer behavior as “lasting” and blaming the rise of streaming for “fundamentally” altering the movie theater business.
“These industry shifts have directly reduced box office revenues and related ancillary revenues, including food and beverage sales,” the company stated in its bankruptcy filing.
IPic also attributed its decision to rising rents and labor costs.
The company estimated it owed about $141,000 in taxes and about $2.7 million in total unsecured claims. The company’s assets were valued at about $155.3 million, the majority of which coming from theater equipment and furniture. Its liabilities totaled $113.9 million.
The chain had previously filed for bankruptcy protection in 2019.
Business
Startup Varda Space Industries snags former Mattel plant in El Segundo
In an expansion of its business of processing pharmaceuticals in Earth’s orbit, Varda Space Industries is renting a large El Segundo plant where toy manufacturer Mattel used to design Hot Wheels and Barbie dolls.
The plant in El Segundo’s aerospace corridor will be an extension of Varda Space Industries’ headquarters in a much smaller building on nearby Aviation Boulevard.
Varda will occupy a 205,443-square-foot industrial and office campus at 2031 E. Mariposa Ave., which will give it additional capacity to manufacture spacecraft at scale, the company said.
Originally built in the 1940s as an aircraft facility, the complex has a history as part of aerospace and defense industries that have long shaped the South Bay and is near a host of major defense and space contractors. It is also close to Los Angeles Air Force Base, headquarters to the Space Systems Command.
Workers test AstroForge’s Odin asteroid probe, which was lost in space after launch this year.
(Varda Space Industries)
Varda is one of a new generation of aerospace startups that have flourished in Southern California and the South Bay over the last several years, particularly in El Segundo, often with ties to SpaceX.
Elon Musk’s company, founded in 2002 in El Segundo, has revolutionized the industry with reusable rockets that have radically lowered the cost of lifting payloads into space. Though it has moved its headquarters to Texas, SpaceX retains large-scale operations in Hawthorne.
Varda co-founder and Chief Executive Will Bruey is a former SpaceX avionics engineer, and the company’s spacecraft are launched on SpaceX’s workhorse Falcon 9 rockets from Vandenberg Space Force Base in Santa Barbara County.
Varda makes automated labs that look like cylindrical desktop speakers, which it sends into orbit in capsules and satellite platforms it also builds. There, in microgravity, the miniature labs grow molecular crystals that are purer than those produced in Earth’s gravity for use in pharmaceuticals.
It has contracts with drug companies and also the military, which tests technology at hypersonic speeds as the capsules return to Earth.
Its fifth capsule was launched in November and returned to Earth in late January; its next mission is set in the coming weeks. Varda has more than 10 missions scheduled on Falcon 9s through 2028.
For the last several decades, the Mariposa Avenue property served as the research and development center for Mattel Toys. El Segundo has also long been a center for the toy industry as companies like to set up shop in the shadow of Mattel.
The Mattel facility “has always been an exceptional property with a legacy tied to aerospace innovation, and leasing to Varda Space Industries feels like a natural continuation of that story,” said Michael Woods, a partner at GPI Cos., which owns the property.
“We are proud to support a company that is genuinely pushing the boundaries of what’s possible, and are excited to watch Varda grow and thrive here in El Segundo,” Woods said.
As one of the country’s most active hubs of aerospace and defense innovation, El Segundo has seen its industrial property vacancy fall to 3.4% on demand from space companies, government contractors and technology startups, real estate brokerage CBRE said.
Successful startups often have to leave the neighborhood when they want to expand, real estate broker Bob Haley of CBRE said. The 9-acre Mattel facility was big enough to keep Varda in the city.
Last year, Varda subleased about 55,000 square feet of lab space from alternative protein company Beyond Meat at 888 Douglas St. in El Segundo, which it started moving into in June.
Varda will get the keys to its new building in December and spend four to eight months building production and assembly facilities as it ramps up operations. By the end of next year, it expects to have constructed 10 more spacecraft.
In the future, Varda could consolidate offices there, given its size. Currently, though, the plan is to retain all properties, creating a campus of three buildings within a mile of one another that are served by the company’s transportation services, Chief Operating Officer Jonathan Barr said.
“We already have Varda-branded shuttles running up and down Aviation Boulevard,” he said.
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