Health
Intermittent fasting’s real benefit may come after you start eating again
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Research continues to uncover new details on how fasting may help extend life.
A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.
Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.
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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.
The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.
Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)
Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”
“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.
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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”
Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”
Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)
The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.
“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.
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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”
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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.
Limitations and cautions
Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.
“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”
The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)
Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”
“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.
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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.
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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.
Anyone considering intermittent fasting should consult with a doctor before starting.
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America’s youth have been increasingly abusing common over-the-counter medications, according to poison center records.
A health advisory from America’s Poison Centers, representing 53 poison centers across the country, alerted a “concerning rise” in cases of diphenhydramine abuse among teens ages 13 to 19.
Diphenhydramine is commonly found in allergy and sleep medications such as Benadryl and Zzzquil, as mentioned in the advisory.
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From 2024 to 2025, the total exposure to any substance among teens in this age group reportedly increased by 5.1%.
But cases involving diphenhydramine alone increased more rapidly, from 10,068 to 13,284 cases, a 32% spike.
Thirteen percent of diphenhydramine cases in 2026 have been linked to intentional abuse, an increase from 7.3% in 2020. (iStock)
The trend appears to be continuing into 2026, as the first five months saw 6,179 diphenhydramine-only cases in teens — more than double the prior year.
According to America’s Poison Centers, the exposure appears to be driven by recreational misuse rather than accidental over-medication. Thirteen percent of cases in 2026 were linked to intentional abuse, up from 7.3% in 2020.
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Taking diphenhydramine improperly or in large amounts can affect the brain and heart, and can lead to serious or life-threatening effects, the advisory warned.
Diphenhydramine is commonly found in over-the-counter allergy and sleep medications. (iStock)
Some symptoms of diphenhydramine poisoning include drowsiness, agitation, fast heart rate, nausea, vomiting, hallucinations, seizures, dangerous heart rhythm and loss of consciousness.
To avoid overexposure and complications, America’s Poison Centers advises the public to store all medications safely, up high, and out of reach of kids and teens. Label instructions should be followed carefully.
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“Talk with teens about the risks of misusing medications, including serious health effects and poisoning,” the notice suggested. “Be aware of social media trends or challenges that may encourage unsafe use of medications.”
Those who suspect misuse should contact the local Poison Control Center immediately.
America’s Poison Centers advises the public to “be aware of social media trends or challenges that may encourage unsafe use of medications.” (iStock)
In a statement to Fox News Digital, Benadryl manufacturer Kenvue commented that the “health and safety of people who use our products is our top priority.”
“The social media trend promoting misuse of diphenhydramine-containing products is extremely dangerous and should be stopped immediately,” a Kenvue spokesperson said. “Our hearts go out to those impacted by the misuse of diphenhydramine-containing products.”
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“We are working with social media platform safety teams to remove these dangerous posts and help stop this behavior from spreading,” they added. “We are also taking action to educate on the safe use and storage of over-the-counter medicines, including those with the ingredient diphenhydramine.”
“The social media trend promoting misuse of diphenhydramine-containing products is extremely dangerous and should be stopped immediately.”
Mary Leonard, SVP of communications and public affairs for the Consumer Healthcare Products Association, called the recent report “deeply concerning.”
“OTC medicines should never be used for recreational purposes, and intentional misuse should not be confused with the safe, effective use of these products,” she told Fox News Digital. “When used as directed, millions of Americans rely on OTC medicines containing diphenhydramine for relief from allergies, cold symptoms, motion sickness, minor skin irritations and occasional sleeplessness.”
“Because misuse of any medication can result in serious health consequences, the Drug Facts label clearly communicates dosing instructions, warnings and other important safety information.”
“OTC medicines should never be used for recreational purposes, and intentional misuse should not be confused with the safe, effective use of these products,” an industry spokesperson said. (iStock)
Kenvue shared the following three steps people can take to help prevent misuse.
- Report content related to this trend on the social media platform where it appears.
- Always store OTC medicines up and away in places children cannot access — preferably in locked cabinets or containers — and never leave medications on counters, bedside tables or in open bags, even temporarily.
- Carefully read and follow the instructions on the label and educate children on safe usage.
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“Dosing instructions and additional safety information are available on Benadryl.com, and always remember to consult a healthcare professional should you have questions,” the spokesperson added.
Fox News Digital reached out to Zzzquil maker P&G for comment.
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