Health
Hair-loss drug tied to suicides, depression and anxiety in global study
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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).
Millions of men undergoing hair loss treatment may be putting their mental health on the line.
Finasteride, a hair-loss drug prescribed for androgenetic alopecia, the most common form of baldness, has been linked to a higher risk of suicide in global studies.
A recent review by Mayer Brezis, a professor at the Hebrew University of Jerusalem, which was published in The Journal of Clinical Psychiatry, argues that there is now enough evidence to mark depression, anxiety and suicidality as genuine risks of the drug.
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Finasteride has been linked to depression and suicide for more than 20 years, Brezis revealed, calling attention to the lack of action from manufacturers and regulators.
These concerns were raised in several studies as early as 2002. Four independent analyses and four studies indicating a “significant increase” in depression, anxiety and suicidal behavior were released between 2017 and 2023.
Multiple global studies have linked finasteride with an increase in depression, anxiety and suicidal behavior. (iStock)
“There has been, therefore, a two-decade delay in the realization of the incidences and the gravity of neuropsychiatric effects, allowing harm from a medicine prescribed for a cosmetic indication of hair loss,” the author wrote in the study.
“Over 20 years worldwide, hundreds of thousands may have endured depression, and hundreds may have died by suicide.”
Finasteride users have reported ongoing symptoms even after the drug is stopped, including insomnia, panic attacks, cognitive dysfunction and suicidal thoughts.
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In a Hebrew University of Jerusalem press release, Brezis reiterated that the evidence of this connection is “no longer anecdotal.”
“We now see consistent patterns across diverse populations. And the consequences may have been tragic,” he said.
Finasteride is a hair-loss drug prescribed for androgenetic alopecia. (iStock)
“The lesson is that before approving a medication for the market, regulators should require manufacturers to commit to performing and disclosing ongoing post-approval analytical studies, and this requirement needs to be enforced,” Brezis concluded in the review.
In 2011, the FDA reportedly acknowledged depression as a potential side effect of finasteride, adding suicidality in 2022.
The agency recorded 18 suicides linked to finasteride in 2011, although Brezis argued that the number should have “ranged in the thousands.”
In an additional statement sent to Fox News Digital, Brezis confirmed that physicians frequently prescribe finasteride “offhandedly because they are not aware of its risks.”
“My recommendation to patients and physicians: Stay away from this medication,” the researcher said. (iStock)
“Young people often get it from the internet without realizing it can cause anxiety, depression and even suicidal thoughts, in addition to sexual impairment,” he said. “Unfortunately, these adverse effects may persist after discontinuing the medication.
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“My recommendation to patients and physicians: Stay away from this medication,” he said. “My recommendation to the FDA: Take it off the market.”
Finasteride was reportedly invented by biopharmaceutical company Merck, which manufactures the drug under the brand names Proscar and Propecia. Other companies produce generic finasteride versions.
“Organon stands behind the safety and efficacy of its finasteride products.”
Organon, formerly part of Merck, is the manufacturer of Propecia and Proscar, two finasteride products. The company provided the below statement to Fox News Digital.
“Organon stands behind the safety and efficacy of its finasteride products. Regulatory agencies around the world thoroughly reviewed the safety and efficacy data for these medicines before their approval, and they, together with Organon, have continued to review additional safety and efficacy data in the decades that these products have been on the market as part of the rigorous, routine post-marketing surveillance process.”
The company encourages patients to speak with their doctors if they have any questions or concerns about their health or medication.
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A spokesperson for the U.S. Department of Health and Human Services also weighed in on the findings in a statement to Fox News Digital.
“The FDA advises patients to discuss the potential risks and benefits with their healthcare providers before using any pharmaceutical product,” the statement read. “This is particularly important as the FDA has not approved any topical finasteride products, which have been associated with numerous adverse effects reported to the agency.”
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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