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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients

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UC San Francisco’s psilocybin therapy shows promise for Parkinson’s patients


On a quiet plot of land in rural New Mexico, Jeff Deming feels like he’s really living, once again.

“Mentally, it’s day and night,” he said.

He’s able to do the things that make him happy, like woodworking, despite living with Parkinson’s Disease.

“Physically, I feel better than I did 2-3 years ago,” he said.

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Deming credits the treatment he received during a first-of-its-kind clinical study he participated in at the University of California, San Francisco: Psilocybin therapy for people with Parkinson’s Disease.

“This is very cliché, but it truly gave me my life back,” he said.

Psilocybin is a naturally occurring psychedelic compound found in ‘magic mushrooms.’ When administered in controlled, clinical research settings, it has shown promise in treating depression and anxiety, both of which are mood symptoms associated with Parkinson’s that are linked to a faster physical decline.

“The neurodegeneration that is happening isn’t just impacting motor circuitry – it’s impacting a lot of brain circuitry. That creates this huge burden of symptoms that we often overlook and don’t talk about enough, maybe,” said Dr. Ellen Bradley, of UCSF. “We were really surprised by how well this trial went.”

Bradley and a team of researchers at UCSF are trying to figure out how Psilocybin may help treat mood dysfunction and more in those living with the neurodegenerative disease.

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“This is a first step, and now we’ve opened the door to being able to really investigate the effects of Psilocybin for people with Parkinson’s,” she said.

12 patients participated in this first-round study, which involved a first and second course of Psilocybin treatment.

“We had folks do a lower dose of Psilocybin – a 10 mg dose initially – and monitored them for a couple of weeks to see how that went,” Bradley said. “If it did go well, if we didn’t have safety concerns, then they were eligible for the full therapeutic dose of 25 mg.”

All 12 patients were able to complete both courses of treatment without reporting any serious side effects, according to Bradley.

“We want to find out not just does Psilocybin therapy work, but if it does, how does it work? That mechanistic piece is so important,” she said. “Can it change the brain’s ability to adapt to its environment and to rewire itself?”

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While there were no serious adverse effects reported, every patient didn’t have the same life-changing experience as Deming says he experienced. Though many did report their motor and cognitive functions improved afterwards, per Bradley.

“We don’t have a reason to believe that this is a treatment that is going to be a good fit for every patient. That is never really our expectation in medicine. But our goal is to figure out when is it the right treatment and how much for which patient,” Bradley said.

Bradley says her team is scaling up their work and are in the process of recruiting for a larger study, due to the success with the initial research.

“That was really exciting just to see that promising safety profile in this initial pilot. That kind of gives us a green light to go forward with more in-depth research,” she said. “We really desperately need new treatments for Parkinson’s. It’s a very quickly growing disease that’s becoming more and more prevalent in our population, so, we really feel like we have to be investigating every possible route that could mean new treatments for patients.”

Two years removed from his controlled Psilocybin dosing, Deming says he feels better now than he did when he received his initial diagnosis four years ago.

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“Something about this experience just freed everything back up so I could think again, I could dream again,” he said.

He’d like to see more research into psychedelic therapies for a range of conditions, with the hopes that more people will be able to reclaim the reins of life, as he has.

“There’s been such a stigma against the research with it,” he said. “It is definitely worth looking more closely at.”
 

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San Francisco court clerks strike for better staffing, training

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San Francisco court clerks strike for better staffing, training


The people cheering and banging drums on the front steps of San Francisco’s Hall of Justice are usually quietly keeping the calendars and paperwork on track for the city’s courts.

Those court clerks are now hitting the picket lines, citing the need for better staffing and more training. It’s the second time the group has gone on strike since 2024, and this strike may last a lot longer than the last one.

Defense attorneys, prosecutors and judges agree that court clerks are the engines that keep the justice system running. Without them, it all grinds to a slow crawl.

“You all run this ship like the Navy,” District 9 Supervisor Jackie Fielder said to a group of city clerks.

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The strike is essentially a continuation of an averted strike that occurred in October 2025.

“We’re not asking for private jets or unicorns,” Superior Court clerk employee Ben Thompson said. “We’re just asking for effective tools with which we can do our job and training and just more of us.”

Thompson said the training is needed to bring current employees up to speed on occasional changes in laws.

Another big issue is staffing, something that clerks said has been an ongoing issue since October 2024, the last time they went on a one-day strike.

Court management issued their latest statement on Wednesday, in which the court’s executive officer, Brandon Riley, said they have been at an impasse with the union since December.

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The statement also said Riley and his team has been negotiating with the union in good faith. He pointed out the tentative agreement the union came to with the courts in October 2025, but it fell apart when union members rejected it.

California’s superior courts are all funded by the state. In 2024, Sacramento cut back on court money by $97 million statewide due to overall budget concerns.

While there have been efforts to backfill those funds, they’ve never been fully restored.

Inside court on Thursday, the clerk’s office was closed, leaving the public with lots of unanswered questions. Attorneys and bailiffs described a slightly chaotic day in court.

Arraignments were all funneled to one courtroom and most other court procedures were funneled to another one. Most of those procedures were quickly continued.

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At the civil courthouse, while workers rallied outside, a date-stamping machine was set up inside so people could stamp their own documents and place them in locked bins.

Notices were also posted at the family law clinic and small claims courts, noting limited available services while the strike is in progress.

According to a union spokesperson, there has been no date set for negotiations to resume, meaning the courthouse logjams could stretch for days, weeks or more.



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Which San Francisco Giants Prospects Are Real Depth vs. Marketing Names

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Which San Francisco Giants Prospects Are Real Depth vs. Marketing Names


The San Francisco Giants are likely to break camp with one of their top prospects on the 26-man roster. But they’re all getting plenty of work in camp.

The thing is, just because a prospect doesn’t make a 26-man opening day roster doesn’t mean they can’t help a Major League team at some point in the season. Others, for now, are working on developing talent.

In this exercise, five prospects that are part of Major League camp were selected to determine if they’re real depth this season or if they’re marketing names — for now. Marketing names can become real depth before one knows it, such as the first Giants prospect listed.

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Bryce Eldridge: Real Depth

San Francisco Giants Bryce Eldridge | Joe Camporeale-Imagn Images
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Eldridge has nothing left to prove at the minor league level after he was selected in the first round in the 2023 MLB draft. Back then, he was the classic example of a marketing name, one that creates buzz in the organization and with fans.

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But, after more than two years of development and a taste of the Majors, he’s real depth. He’s expected to make the opening day roster and share time at first base and designated hitter with Rafael Devers, one of the game’s most established sluggers.

On Wednesday, he hit his first spring training home run, one of three in the 13-12 loss to the Milwaukee Brewers.

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Blake Tidwell: Real Depth

Tennessee pitcher Blake Tidwell | Brianna Paciorka/News Sentinel / USA TODAY NETWORK

Tidwell was acquired from the New York Mets in July in the Tyler Rogers trade. He only pitched in four games for the Mets, so he still has prospect status. But that MLB service time, combined with his early impressions in camp, make him real depth for a team that only has one or two spots available on the pitching staff.

Tidwell may not make the team out of camp for opening day. But he’s one of those prospects that could make his way to San Francisco during the season due to injury or underperformance. It’s an example of using the time in spring training wisely and paving the way for a future promotion.

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Will Bednar: Real Depth

Mississippi St. Bulldogs pitcher Will Bednar. | Steven Branscombe-Imagn Images
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The Giants have been waiting for their first-round pick in the 2021 MLB draft to pay off, and this might be the year that Will Bednar finally makes the jump to the Majors. He’s in Major League camp and he’s been converted into a reliever in the past couple of seasons.

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He went 2-3 with a 5.68 ERA in 38 games, his full season as a reliever. But he’s impressed the new coaching staff during camp and there’s enough buzz around him to consider him a potential call-up during the season. He’s in his fifth professional season so the Rule 5 draft is a consideration this coming offseason.

Parks Harber: Marketing Name

For now, the young third baseman is going to create a lot of buzz in the farm system in 2026, but he isn’t a threat to anyone’s job yet. Picked up in the Camilo Doval trade, he only has 102 minor league games under his belt after he was signed as an undrafted free agent by the New York Yankees. He got his first spring training hit on Wednesday. His career slash of .312/.413/.528 is encouraging but he hasn’t played higher than High-A Eugene.

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Bo Davidson: Marketing Name

San Francisco Giants left fielder Bo Davidson. | Rick Scuteri-Imagn Images
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The Giants signed Davidson as an undrafted free agent and he’s starting to generate real buzz in spring training as a non-roster invitee. He’s not quite real depth yet because he has yet to play above Double-A Richmond. But the way he’s playing in the spring he should be at Sacramento sometime this season, which puts him in the position to be real depth.

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He’s hit well at every stop, but he showed off more power than ever last season. He hit a career-best 18 home runs and 70 RBI as he slashed .281/.376/.468. He played 42 games at Richmond last season.




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Three Takeaways as Giants Suffer First Spring Training Loss of Campaign

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Three Takeaways as Giants Suffer First Spring Training Loss of Campaign


The San Francisco Giants weren’t giving up that undefeated spring training slate without a fight, apparently.

Wednesday’s game between the Giants and the Milwaukee Brewers came down to a raucous ninth inning that saw the two teams combine for seven runs. Milwaukee had the final at-bat and rallied to win, 13-12.

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A lot happened in this one, not the least of which was Harrison Bader’s home run putting a dent in a food truck.

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Here are three important takeaways from the game.

Adrian Houser’s Giants Debut

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San Francisco Giants pitcher Adrian Houser. | Rick Scuteri-Imagn Images

Before this game got out of hand, Adrian Houser made his first spring training start and looked solid.

He pitched two innings, giving up three hits, one run and one walk. He also allowed a home run. He threw 36 pitches, 23 of which were strikes. The right-hander figures to be the third or fourth starter in the rotation, depending upon how San Francisco wants to line up Houser and Tyler Mahle behind Logan Webb and Robbie Ray.

Houser resurrected his career last season with the Chicago White Sox and the Tampa Bay Rays, as he combined to go 8-5 with a 3.31 ERA in 21 starts, with 92 strikeouts and 38 walks in 125 innings. It was his best season since going 10-6 with Milwaukee in 2021.

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Power Surge

San Francisco Giants first baseman Bryce Eldridge. | Neville E. Guard-Imagn Images
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The Giants are looking for more slug in their lineup in 2026. Part of that is a long-term project that included signing Willy Adames last offseason and trading for Rafael Devers last June. Both hit at least 30 home runs last season. That’s sustainable power for San Francisco. But they could use more and some of that was on display in Wednesday’s game.

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Bader’s home run got a lot of attention. But two other Giants hit home runs, each slugging their first of spring training. Luis Matos, an outfielder that was the designated hitter, slammed one in the second inning. Then, Bryce Eldridge, who played first base, hit one in the third inning.

San Francisco’s ability to compete offensively with the top teams in the National League won’ just hinge on Adames and Devers. It will hinge on what others can produce, too. From that standpoint Wednesday was a good day.

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Parkr Harber’s Instant Offense

San Francisco Giants infielder Parks Harber. | Mark J. Rebilas-Imagn Images

Parks Harber isn’t going to make the opening day roster. But that’s not expected. The top prospect, acquired in the Camilo Doval trade from the New York Yankees, is off to a solid start to his first spring training with the Giants.

He entered Wednesday’s game as a pinch-hitter and in his only at-bat he claimed a hit and drove in a run. It pushed his spring training batting average to .333. The downside? It was his first hit of spring training. But, the fact that a young player entered the game as a pinch hitter and drove in a run is a good sign for his ability to come off the bench later in his career and give the Giants something.

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