Connect with us

Health

Aging slowdown could be surprise benefit of existing medication, research shows

Published

on

Aging slowdown could be surprise benefit of existing medication, research shows

Join Fox News for access to this content

You have reached your maximum number of articles. Log in or create an account FREE of charge to continue reading.

By entering your email and pushing continue, you are agreeing to Fox News’ Terms of Use and Privacy Policy, which includes our Notice of Financial Incentive.

Please enter a valid email address.

Having trouble? Click here.

A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging.

The immune-suppressing medication rapamycin, also known as sirolimus, is being used off-label as a means of extending longevity.

Advertisement

“By targeting a key pathway (mTOR) in cells, this drug has been shown to extend lifespan in animals and could be beneficial to prevent age-related diseases in humans,” Dr. Andrea B. Maier — a professor in healthy aging and dementia research at the Director of the Centre for Healthy Longevity at the National University of Singapore — told Fox News Digital.

AGING SPEEDS UP ‘MASSIVELY’ AT TWO POINTS IN ONE’S LIFETIME, STANFORD STUDY FINDS: ‘ABRUPT CHANGES’

Maier was co-author of a recent review study that explored how rapamycin affected healthy humans.

A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging. (iStock)

The review, which was published in the journal Lancet Healthy Longevity, found that the medication improved the effects of aging on the skin.

Advertisement

“Rapamycin and its derivatives improve the immune and cardiovascular function of healthy individuals or individuals with aging-related diseases,” Maier said in an email.

11 TIPS FOR ADULTS AGE 65 AND OVER TO ‘LIVE WELL’ OVER TIME, ACCORDING TO GERONTOLOGISTS

Daniel Tawfik, a molecular biologist and co-founder of Healthspan, a digital medical clinic that focuses on anti-aging and longevity-promoting therapies, said his team uses rapamycin to help slow down the rate of aging. 

“We view this through the lens of reducing the accumulation of damaged senescent cells,” Tawfik, who is based in Santa Monica, California, told Fox News Digital.

The immune-suppressing medication rapamycin is being used off-label as a means of extending longevity. (iStock)

Advertisement

Senescent cells are cells that no longer function properly, but linger in the body and can contribute to tissue deterioration and inflammation, the expert said.

“By lowering the rate at which healthy cells transform into senescent cells, rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health as we age,” he added.

Off-label use

In the U.S., rapamycin is approved by the Food and Drug Administration (FDA) for its immune-suppressing properties in patients with kidney transplants and certain cancers. 

It is not approved for use as an age-defying drug.  

“Sirolimus (rapamycin) has not been evaluated by the FDA for safety and effectiveness as an anti-aging treatment,” a press officer for the FDA confirmed to Fox News Digital.

Advertisement

“Rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health.”

Despite this, rapamycin is being used “off-label” for anti-aging purposes, according to Elaena Quattrocchi, a registered pharmacist and an associate professor at Long Island University College of Pharmacy in Brooklyn, New York.

“Off-label means the FDA has not approved the drug for this use,” she told Fox News Digital.

Rapamycin, which is also known as Sirolimus,  is being used “off-label” for anti-aging purposes, experts say. (iStock)

When prescribing a drug for off-label use, the provider must explain to the patient that the medication has not been approved for the indication for which they are prescribing it, Quattrocchi noted.

Advertisement

“People taking this medication must discuss with their primary care provider and pharmacist about the potential side effects and drug interactions,” she said.

Benefits of rapamycin

Tawfik’s company currently treats more than 3,500 patients with rapamycin, he told Fox News Digital. 

105-YEAR-OLD WOMAN GRADUATES FROM STANFORD UNIVERSITY 83 YEARS AFTER LEAVING CAMPUS: ‘AMAZING’

His team has seen numerous benefits of its off-label anti-aging use, he said, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity.

“Under proper medical supervision, many of our patients experience a marked reduction in inflammation and improvement in conditions related to autoimmunity,” Tawfik said.  

Advertisement

When prescribing a drug for off-label use, the provider should explain to the patient that the medication has not been approved for the indication for which they are prescribing it, according to experts. (iStock)

“For example, patients with osteoarthritis often report significant relief from joint pain after starting rapamycin.”

The expert also noted that certain biomarkers linked to healthspan and longevity — such as reduced inflammation markers and enhanced metabolic health — were seen in the bloodwork of the patients using rapamycin.

Screening and safety

Patients need a prescription for rapamycin, experts told Fox News Digital. 

Individuals are screened to determine whether they are candidates for the treatment. If it is prescribed, patients are monitored carefully when taking the drug.

Advertisement

“It is essential that rapamycin use is overseen by a physician.”

“It is essential that rapamycin use is overseen by a physician to ensure that dosing is effective yet safe, as high doses can lead to unwanted immunosuppression,” Tawfik warned. 

Maier echoed that rapamycin and its derivatives are not for self-medication use. 

“An important step is to first measure the patient’s biological age and investigate why the pace of aging might be faster,” she told Fox News Digital. 

Advertisement

“Then a tailored approach to match the measures with interventions at need is required.”

Quattrocchi and Tawfik both emphasized the importance of working with an accredited pharmacy that sources the drug directly from a reputable manufacturer.

Rapamycin and its derivatives are not for self-medication use, experts cautioned. (iStock)

Rapamycin is not recommended for immunocompromised individuals or those taking immunosuppressant medication, Tawfik cautioned.  

It is not typically used in younger adults, he added, since starting this regimen at such an early age is unnecessary.

Advertisement

Calls for more research

There are limited studies on the effects of rapamycin on humans and organ systems, Maier noted.

In researching studies of the drug, Maier’s research team found that adverse reactions in healthy individuals were classified “as mild or moderate and were reversible after the discontinuation of treatment.”

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

However, the study authors stated, “there were increased numbers of infections and increases in total cholesterol, LDL cholesterol and triglycerides in individuals with aging-related diseases.”

“Future studies should assess the remaining unexamined systems and test the effects of long-term exposure to rapamycin and its derivatives.”

Advertisement

Experts have reported numerous anti-aging benefits of rapamycin, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity. (iStock)

The majority of studies exploring rapamycin’s effects on aging have been conducted on mice and other animals as well as experimental models, researchers told Fox News Digital.

“The reason scientists are so interested in rapamycin is that in every species that’s been studied to date – yeast, worms, flies, mice – when they are given rapamycin, healthspan and lifespan are extended,” Tawfik noted.

For more Health articles, visit www.foxnews.com/health

“No other intervention has that degree of validation.”

Advertisement

Quattrocchi agreed that further research is needed into the drug’s proper dosing, adverse effects, and potential anti-aging benefits in healthy individuals and those with medical conditions.

Health

How Well Will You Age? Take Our Quiz to Find Out.

Published

on

How Well Will You Age? Take Our Quiz to Find Out.

Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.

Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.

Continue Reading

Health

Red hair may be increasing as study points to surprising evolution trend

Published

on

Red hair may be increasing as study points to surprising evolution trend

NEWYou can now listen to Fox News articles!

A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.

By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.

“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.

22 HEALTH CARE PREDICTIONS FOR 2025 FROM MEDICAL RESEARCHERS

Advertisement

The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”

Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.

Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)

Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.

“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.

Advertisement

COMMON EATING HABIT MAY TRIGGER PREMATURE IMMUNE SYSTEM AGING, STUDY FINDS

The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.

Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)

As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”

CLICK HERE FOR MORE HEALTH STORIES

Advertisement

While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.

However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.

While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)

Advertisement

Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

The researchers urged caution in how these findings are interpreted.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.

Advertisement

Continue Reading

Health

Aging in Place: How Technology Might Help You Grow Old at Home

Published

on

Aging in Place: How Technology Might Help You Grow Old at Home

Dr. Megan Jack, a neurosurgeon in Cleveland, often works 60 or 70 hours a week. And she’s completely unavailable when she’s in the operating room. That makes it tough to be a caregiver for her 76-year-old mother, who lives in a separate unit on Dr. Jack’s property, 30 minutes away from the hospital.

To help care for her mother, who has Alzheimer’s disease, Dr. Jack uses an array of high-tech tools, some of which didn’t exist just a few years ago. She manages her mother’s medications with a smart pill box. She changes her television channels with an app, sends appointment reminders through a digital message board — and, with her mother’s blessing, uses cameras for communication and monitoring.

“It’s been invaluable that I can both make sure she’s safe and make sure everything is going well,” Dr. Jack said, “but also give her the independence and the freedom that she still deserves.”

America is aging rapidly. Roughly 11,000 people are turning 65 each day in the United States. And many of them — 75 percent of people over 50, according to AARP’s most recent survey, from 2024 — hope to spend their remaining years in the comfort of their homes, rather than in assisted-living or other care facilities.

One thing that could help fulfill those wishes is the budding field of “age tech,” which encompasses tools that support older adults. Industry experts say that age tech is making homes safer for older adults and is easing the minds of their caregivers, especially those who live far away or work outside the home.

Advertisement

Dr. Jack said that age tech had “really allowed me to integrate caregiving into my life, as opposed to caregiving taking over my life.”

If older adults don’t have loved ones who are both close by and able to help, they might believe they don’t have a ton of options. They can live independently, or, if they can afford it and qualify medically, they can move to an assisted-living facility or a nursing home, without a lot of choices in between. In-home help can be expensive without Medicaid and can also be difficult to find, given the serious shortage of home care workers.

Age tech can help bridge some important gaps, said Emily Nabors, the associate director of innovation at the National Council on Aging, a nonprofit advocacy group. Already, AARP reports that 25 percent of caregivers are remotely monitoring their loved ones with apps, videos or wearables, nearly double the percentage from five years ago.

“We used to say homes are the health care settings of the future, but they really are health care settings now,” Ms. Nabors said. “Aging in place is very realistic.”

More than 700 companies are in AARP’s AgeTech Collaborative, a group that connects businesses, nonprofits and funders to help get new technologies off the ground. Altogether, the collaborative’s start-ups have raised nearly $1 billion in the past four years.

Advertisement

The products include smart walkers, glasses with lenses that provide real-time captions of conversations for those with hearing issues, and a concierge service that connects older people to drivers and deliveries, even if they don’t have a smartphone.

Ms. Nabors does foresee some affordability and access barriers to age tech, including the lack of high-speed internet in rural areas, but she said one vital resource would be local aging agencies, which can offer advice and, sometimes, free support.

Janet Marasa leaned on the agency near her home in Rockland County, N.Y., to get a free robotic pet for her mother, Carol DeMaio, 80, who has dementia. The pets, manufactured by a company called Joy for All, aim to offer emotional support without the upkeep.

Ms. DeMaio named the robotic dog Sabrina, after a golden retriever who died. The new Sabrina stays at the foot of her bed at night. As soon as Ms. DeMaio stirs awake, the dog reacts. “She said it gives her a reason to get up in the morning,” Ms. Marasa said.

The dog has been a boon to her, too. “It provides comfort and interaction that I can’t provide every second,” said Ms. Marasa, who lives with her mother but works full time for the county government. “It gives her something that she can feel like is totally her own.”

Advertisement

In Broward County, Fla., where the population of residents over 85 is expected to nearly triple over the next few decades, the local agency on aging has used state and federal money and private grants to provide technologies to nearly 4,000 of the county’s seniors at no cost.

Its offerings include a company that uses radar to sense falls and a program that allows seniors to make video calls through their televisions.

“The possibilities are endless,” Charlotte Mather-Taylor, the agency’s chief executive, said. “It’s pretty great to see all the new technology coming out so quickly, and I think that can only benefit our older population and also our caregivers.”

Even technologies not specifically marketed as age tech can help older adults maintain their independence, said Laurie Orlov, founder of the blog Aging and Health Technology Watch. She pointed to video-calling and telehealth platforms; remotely controlled thermostats and lights; and smart speakers, doorbells and watches.

“All technology can be customized to help older adults stay longer in their homes and help their family members feel good about it, or at least tolerate it,” Ms. Orlov said.

Advertisement

That will only become more true with the continued proliferation of artificial intelligence, Ms. Orlov added. Some older adults are already using conversational A.I. to get answers about things like the weather or their medications. (Relying too heavily on A.I. can, however, have negative consequences because chatbots often give flawed medical advice and can lead patients astray.) A.I. can also assist in pattern detection: alerting caregivers to signals that might indicate declines in someone’s cognition or mental health, such as changing their speech pattern or leaving the house less frequently.

One A.I.-powered age tech tool is ElliQ, a tabletop companion robot that looks like a sleek silver desk lamp with a screen. About a year and a half ago, Camille Wolsonovich got one for free, thanks to a local nonprofit, for her 90-year-old father, Bill Castellano. He lives alone in a senior community.

Ms. Wolsonovich, who runs a consulting business, relies on ElliQ to lead her father in exercises and remind him to take his pills and drink water. The robot also asks her father about his sleep and mood via automated check-ins.

“Everything’s just another layer that gives us more confidence, from a caregiving standpoint, that he’s good,” Ms. Wolsonovich said. “I don’t have to necessarily track everything all the time and be overbearing.”

As for Mr. Castellano? He plays trivia digitally and converses daily with ElliQ. The robot, which has a friendly female voice, asks questions, cracks jokes and remembers his likes, dislikes and friends. “She’s great company,” he said. “Everybody around me wants one.”

Advertisement

Clara Berridge studies the ethics of age tech at the University of Washington.

She has many privacy concerns, namely that most direct-to-consumer products aren’t subject to medical privacy laws, despite being privy to sensitive health information. Though she hopes the federal government will eventually step in to regulate these products, as it has in other countries, the onus remains on the consumer for now.

And even if an age tech product isn’t selling mom’s personal data to the lowest bidder, Dr. Berridge said there’s still the question of whether certain tools are ethical.

“It’s really important for caregivers to recognize that using these new technologies that give them more information about someone can represent greater intrusion into someone’s life,” she said.

What may be well-intentioned monitoring could reveal information that an older adult would rather keep private, such as issues with incontinence, or the comings and goings of a romantic partner.

Advertisement

“It can lead to somebody feeling infantilized,” Dr. Berridge said. “Like there’s not a place to hide within your own home.”

Her research shows that adult children often underestimate how much their parents can understand about technology and how much they want to be involved in tech-related decisions.

She encouraged caregivers to have transparent conversations about privacy implications and to avoid ultimatums or the idea that any decision must be permanent. She said caregivers should put themselves in their parents’ shoes: Is this something they’d want their own children monitoring?

Dr. Berridge is working on an advanced directive for technology, which outlines older people’s wishes for how technology is used in their care. Ultimately, she hopes that questions about age tech will become a standard part of planning for the future.

“If you’re at the start of what, for many people, ends up being a long road of supporting someone potentially through the end of their life,” she said, “seeking to understand each other’s concerns and priorities better is time very well spent.”

Advertisement
Continue Reading
Advertisement

Trending