Health
Men’s cancer deaths expected to spike more than 90% by 2050, study finds
The prevalence of cancer among men is expected to skyrocket globally in the coming decades, according to a new study from the American Cancer Society (ACS).
To predict future risk, Australian researchers analyzed the mortality rates tied to 30 different types of cancer among adult men in 2022, based on data from the International Agency for Research on Cancer across 185 countries and territories.
Based on those findings, they predicted that between 2022 and 2050, men’s cancer cases will spike by around 84% — going from 10.3 million to 19 million.
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Male cancer deaths are expected to increase by 93% in that same time frame, reaching 10.5 million by 2050.
Cases are expected to more than double among men 65 and older, as well as for those who live in areas with a low or medium Human Development Index (HDI, a measure of a country’s average rankings in health, knowledge and standard of living).
The prevalence of cancer among men is expected to skyrocket globally in the coming decades, according to a new study from the American Cancer Society. (iStock)
Poorer survival is also projected for rare cancers, such as pancreatic.
The findings were published in Cancer, the journal of the ACS.
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In 2020, men were 43% more likely to die of cancer than women, and their diagnosis rate was 19% higher, statistics show.
Men have been shown previously to engage more in modifiable risk factors for cancer, including smoking and consuming alcohol.
They are also less likely to get regular screenings for male-specific cancers, the study authors noted.
Experts predict that between 2022 and 2050, men’s cancer cases will spike by around 84% — going from 10.3 million to 19 million. (iStock)
The 10 cancers with the highest age-standardized mortality rates among men are lung cancer, liver cancer, colorectal cancer, stomach cancer, prostate cancer, esophageal cancer, pancreatic cancer, leukemia, bladder cancer, and cancers of the brain and central nervous system.
To help reduce the impact of cancers on men, the researchers called for reducing modifiable risk factors and making male-specific screenings more accessible, among other efforts.
Men have previously been shown to engage more in modifiable risk factors for cancer, including smoking and consuming alcohol. (iStock)
“Strengthening health infrastructure, enhancing workforce quality and access, fostering national and international collaborations, and promoting universal health coverage are crucial to reducing cancer disparities and ensuring cancer equity among men globally,” the study authors wrote.
Potential limitations
The researchers acknowledged some limitations of the study, including the quality of the data provided by some countries and territories.
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“Estimates in low-HDI and medium-HDI countries could be less accurate because the majority of these jurisdictions have relatively low-quality cancer registries and/or civil and vital statistics registration systems,” the authors wrote.
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They also noted that some “measures of cancer burden, such as years of life lost or years lived with disability,” were not available in the original data and could not be included in the study.
Fox News Digital reached out to the ACS and physicians for comment.
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Surviving cancer as a child or young adult may have a lasting impact on aging, new research suggests.
Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, like chemotherapy and radiation, could speed up biological aging.
They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.
The team analyzed blood samples from a group of 1,400 long-term survivors treated at St. Jude Children’s Research Hospital, using epigenetic clocks — tools that estimate biological age by examining chemical tags on DNA.
Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.
Biological age is determined based on the damage cells accumulate over time, according to scientists. (iStock)
“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.
Most of the group consisted of acute lymphoblastic leukemia survivors, or Hodgkin lymphoma survivors. Participants were at least five years past their treatment, though some had survived for several decades.
They underwent neurocognitive testing to measure their attention span, memory and information processing speed.
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Chemotherapy was found to have the greatest impact on aging acceleration. The study suggests the treatment can alter DNA structure and cause cellular damage.
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“It’s no surprise to find out that young people with cancer who have chemo early in life are affected in terms of long-term aging,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing. (iStock)
Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.
“Chemo poisons and damages cellular function — hopefully the cancer cells more than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.
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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.
The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.
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“Young cancer survivors have many more decades of life to live,” lead study author AnnaLynn Williams, PhD, said in a press release. “If these accelerated aging changes are occurring early on and setting them on a different trajectory, the goal is to intervene to not only increase their lifespan, but improve their quality of life.”
The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline. (iStock)
There were some limitations to the study. The researchers could not adjust for chronic health conditions or education because they are directly impacted by treatment.
Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.
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The study was published in the journal Nature Communications.
Fox News Digital reached out to the researchers for comment.
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