Health
Ozempic and other GLP-1 drugs could reduce arthritis symptoms in some, experts claim
Popular medications for weight loss and diabetes control could have a surprising bonus benefit, according to some anecdotal reports.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms.
It has been “well-established” that autoimmune patients who also have obesity “fare worse” than those who are at a healthy weight, according to Dr. Elizabeth Ortiz, M.D., a Texas-based rheumatologist and clinical adviser at WellTheory, a platform specializing in autoimmune disease treatment.
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“Any improvements in joint pain or joint inflammation are likely due to a combination of factors, of which weight loss is only one,” she told Fox News Digital.
“Our understanding of the interplay between obesity, adipose tissue and inflammation is incomplete, so as of today, it is difficult to ascribe an improvement in joint pain to any particular cause,” she continued in a written statement.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms. (iStock)
“We are beginning to learn of the direct anti-inflammatory effects of these medications — and that, with weight loss, is likely to be of benefit for autoimmune patients.”
Does this mean GLP-1s could be prescribed eventually for arthritic patients?
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“There are certainly compelling anecdotes and emerging research into the anti-inflammatory effects of these medications,” said Ortiz, “but we will need dedicated studies evaluating their effectiveness in conditions such as rheumatoid arthritis or psoriatic arthritis before they become a part of standard care.”
What we may see sooner, she predicted, is the use of GLP-1s as a means of addressing obesity and metabolic syndrome in those with autoimmune arthritis.
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” a doctor told Fox News Digital. (iStock)
“Obesity has been associated with worse autoimmune and inflammatory symptoms and with poorer response to standard therapy,” she said.
“Those with rheumatoid arthritis and other autoimmune diseases also carry a higher risk of cardiovascular disease than those without these conditions, and the addition of GLP-1 therapy to their immunomodulating therapy may prove to be a successful combination.”
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There are some potential risks to consider, the expert noted.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures.
“This can be a consequence of low muscle mass, something we are seeing in many taking the GLP-1s,” Ortiz said.
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
“This will need to be paid special attention to and weighed when determining how best to utilize these medications in autoimmune patients.”
The other potential limitation with the use of GLP-1s is cost, she added.
“Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” Ortiz said.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, has been a longtime proponent of semaglutide drugs — including Wegovy, Ozempic and Zepbound — which belong to the GLP-1 class of medications.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, said obesity exacerbates inflammation throughout the body, primarily through visceral fat. He’s been a longtime proponent of semaglutide drugs. (Dr. Brett Osborn)
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” Osborn told Fox News Digital.
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Rheumatoid arthritis is marked by chronic inflammation, joint pain and flare-ups, the doctor noted, and those with higher body fat and BMIs face a greater risk of developing the condition.
“Why? Because obesity exacerbates inflammation throughout the body, primarily through visceral fat (the fat around your abdominal organs), which secretes cytokines, chemical mediators that heighten inflammation,” Osborn said.
Cost could be a limitation of using GLP-1 drugs for arthritis. “Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” one doctor said. (Michael Siluk/UCG/Universal Images Group via Getty Images)
“This chronic inflammation can worsen RA symptoms and reduce the effectiveness of standard treatments,” the doctor added.
These medications help to reduce people’s consumption of simple carbohydrates — such as bread, pasta and rice — that contribute significantly to inflammation, according to Osborn.
“By curbing appetite and encouraging healthier eating patterns, GLP-1 drugs help decrease the consumption of these inflammation-triggering foods.”
Beyond rheumatoid arthritis, GLP-1 drugs can also help fight systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD) and other autoimmune conditions, the doctor noted.
“Targeting obesity first can improve overall health and reduce risks of conditions like heart attacks and strokes as well,” he added.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures. (iStock)
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, according to Osborn.
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“Their ability to reduce inflammation and promote healthier eating patterns could significantly improve patients’ quality of life.”
Osborn noted, however, that more research is needed to fully understand the impact of GLP-1 drugs on autoimmune diseases.
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, a doctor said. (iStock)
“These genetic diseases are fueled by obesity-associated inflammation — however, an ‘obesity-first’ approach may not suit all patients and could lead to poorly controlled inflammation if underlying conditions are not addressed.”
Other potential risks associated with GLP-1 medications, such as the muscle loss Ortiz mentioned, “can be mitigated with careful surveillance by a seasoned physician,” said Osborn.
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Novo Nordisk, the manufacturer of Ozempic and Wegovy, declined to comment on the potential arthritis impact when contacted by Fox News Digital.
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Doctor reveals what 30 days without alcohol does to the brain and body amid Dry January
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After a season of bingeing and drinking, your body may feel like it needs a break from the party.
Dry January — a modern trend that challenges people to abstain from drinking for the first month of the year — has become a popular way to “detox” from the holidays and start the new year on a healthy note.
Research has linked alcohol to a variety of health conditions, ranging from hangovers to higher cancer risk.
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In a recent podcast episode of “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health, shared how 30 days of not drinking alcohol can transform health.
Hyman, who is based in Massachusetts, called Dry January a “powerful way to see in real time how alcohol affects nearly every system of your body and how quickly those systems can recover.”
Dry January has become a popular way to “detox” from the holidays and start the new year on a healthy note. (iStock)
Alcohol’s toll on the brain and body
Hyman acknowledged that most people drink to feel happier and more comfortable in social situations. This effect is caused by the main ingredient in alcohol, called ethanol, which can also have toxic effects.
Instead of stimulating the brain, alcohol slows it down and loosens inhibitions. “You feel more relaxed, more social, more confident, maybe you feel a little euphoric,” Hyman said.
Alcohol’s effect on the brain can also lead to poorer decisions and slower reflexes, the doctor cautioned.
Drinking alcohol can cause cognitive decline and brain fog, experts warn. (iStock)
Drinking also impacts the prefrontal cortex of the brain, which Hyman described as “the adult in the room,” responsible for judgment, planning and restraint. “It goes offline early in drinking, which explains why people feel freer or act impulsively when they drink,” he said.
Even moderate drinking can cause metabolic stress, inflammation, impaired detoxification and hormonal shifts, Hyman said, which can impact nearly every organ system in the body.
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Alcohol consumption has also been linked to an increased risk of cancer, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins.
It can also prevent the body from falling into REM sleep, which is the deep rest recovery period when the immune system cleans out the day’s toxins, according to Hyman.
Alcohol can impact deep rest and mental health, according to experts. (iStock)
Memory loss, cognitive decline, anxiety, sleep disruption, dementia and cardiovascular disease are all known risks of long-term alcohol use, as well as liver complications like fatty liver disease.
“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” Hyman said.
The effects of 30 days with no alcohol
The first week after your last drink, the body begins to detoxify and reset, according to Hyman. Blood sugar and cortisol stress hormones level out, and the liver begins to process a “backlog of toxins.” The body also re-hydrates and re-energizes.
The first 30 days with no alcohol allows the body to balance itself out. (iStock)
The second week, the gut and brain will begin to re-balance, as hormones like serotonin and dopamine stabilize, gut inflammation drops and the microbiome begins to heal. Cravings for sugar and alcohol will wane and mental clarity returns, the doctor said.
Week three is marked by further decreases in inflammation, fatty liver and blood pressure. This can be noticeable in the skin, as puffiness and redness are reduced. Mood also begins to stabilize, with lower anxiety levels.
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In week four, the body experiences additional metabolic and immune benefits, Hyman shared, including more insulin sensitivity, which makes it easier to lose weight.
“You have a stronger immune response. You’re not getting sick as much. You have better deep sleep, balanced hormones, especially cortisol and testosterone,” he said. “And you see a big change in energy, confidence and focus.”
Abstaining from alcohol can help restore energy, according to experts. (iStock)
Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, said that Dry January isn’t a “detox,” but rather provides “feedback” from the body.
“It gives the body time to show people how it feels without alcohol. For many, that insight alone changes their relationship with drinking,” she said. “The biggest surprise isn’t what people give up, it’s how much better they feel.”
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The doctor confirmed that the first few days of not drinking may feel harder than expected, sometimes causing restlessness, cravings or disrupted sleep, but Dry January can ultimately change drinking habits for the remainder of the year.
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After a full year without alcohol, Chiang noted that health improvements are more profound. “We see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”
The risks of ‘all or nothing’
Some experts warn that adopting the Dry January trend could strengthen the urge to drink more in the other months, noting that some drinkers may find more success by slowly consuming fewer drinks per week.
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Thomas Stopka, Ph.D., an epidemiologist and professor in the public health and community medicine department at Tufts University School of Medicine in Massachusetts, shared in a Futurity report that for some people, “damp January” may be more suitable.
One expert warned that not all drinkers should quit “cold turkey,” as it could lead to severe withdrawals. (iStock)
“Dry January is well-intentioned, and it may work really well for the people who can stick to it, maybe even beyond January,” he said. “Other people may be more inclined to cut down on alcohol consumption rather than quit drinking completely for the month.”
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Stopka noted that successful harm-reduction approaches “aim to be judgment free.”
“Substance use disorder is a disease,” he said. “It takes time to treat the disease and to stay connected to the continuum of care — from prevention to treatment initiation to sustained therapy, whether through medication, self-help, or individual therapy or group support.”
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Those struggling with signs of alcohol use disorder should consult a medical professional for personalized guidance.
Fox News Digital reached out to several alcohol industry associations requesting comment.
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