Health
Ozempic and other GLP-1 drugs could reduce arthritis symptoms in some, experts claim
Popular medications for weight loss and diabetes control could have a surprising bonus benefit, according to some anecdotal reports.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms.
It has been “well-established” that autoimmune patients who also have obesity “fare worse” than those who are at a healthy weight, according to Dr. Elizabeth Ortiz, M.D., a Texas-based rheumatologist and clinical adviser at WellTheory, a platform specializing in autoimmune disease treatment.
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“Any improvements in joint pain or joint inflammation are likely due to a combination of factors, of which weight loss is only one,” she told Fox News Digital.
“Our understanding of the interplay between obesity, adipose tissue and inflammation is incomplete, so as of today, it is difficult to ascribe an improvement in joint pain to any particular cause,” she continued in a written statement.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms. (iStock)
“We are beginning to learn of the direct anti-inflammatory effects of these medications — and that, with weight loss, is likely to be of benefit for autoimmune patients.”
Does this mean GLP-1s could be prescribed eventually for arthritic patients?
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“There are certainly compelling anecdotes and emerging research into the anti-inflammatory effects of these medications,” said Ortiz, “but we will need dedicated studies evaluating their effectiveness in conditions such as rheumatoid arthritis or psoriatic arthritis before they become a part of standard care.”
What we may see sooner, she predicted, is the use of GLP-1s as a means of addressing obesity and metabolic syndrome in those with autoimmune arthritis.
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” a doctor told Fox News Digital. (iStock)
“Obesity has been associated with worse autoimmune and inflammatory symptoms and with poorer response to standard therapy,” she said.
“Those with rheumatoid arthritis and other autoimmune diseases also carry a higher risk of cardiovascular disease than those without these conditions, and the addition of GLP-1 therapy to their immunomodulating therapy may prove to be a successful combination.”
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There are some potential risks to consider, the expert noted.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures.
“This can be a consequence of low muscle mass, something we are seeing in many taking the GLP-1s,” Ortiz said.
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
“This will need to be paid special attention to and weighed when determining how best to utilize these medications in autoimmune patients.”
The other potential limitation with the use of GLP-1s is cost, she added.
“Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” Ortiz said.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, has been a longtime proponent of semaglutide drugs — including Wegovy, Ozempic and Zepbound — which belong to the GLP-1 class of medications.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, said obesity exacerbates inflammation throughout the body, primarily through visceral fat. He’s been a longtime proponent of semaglutide drugs. (Dr. Brett Osborn)
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” Osborn told Fox News Digital.
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Rheumatoid arthritis is marked by chronic inflammation, joint pain and flare-ups, the doctor noted, and those with higher body fat and BMIs face a greater risk of developing the condition.
“Why? Because obesity exacerbates inflammation throughout the body, primarily through visceral fat (the fat around your abdominal organs), which secretes cytokines, chemical mediators that heighten inflammation,” Osborn said.
Cost could be a limitation of using GLP-1 drugs for arthritis. “Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” one doctor said. (Michael Siluk/UCG/Universal Images Group via Getty Images)
“This chronic inflammation can worsen RA symptoms and reduce the effectiveness of standard treatments,” the doctor added.
These medications help to reduce people’s consumption of simple carbohydrates — such as bread, pasta and rice — that contribute significantly to inflammation, according to Osborn.
“By curbing appetite and encouraging healthier eating patterns, GLP-1 drugs help decrease the consumption of these inflammation-triggering foods.”
Beyond rheumatoid arthritis, GLP-1 drugs can also help fight systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD) and other autoimmune conditions, the doctor noted.
“Targeting obesity first can improve overall health and reduce risks of conditions like heart attacks and strokes as well,” he added.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures. (iStock)
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, according to Osborn.
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“Their ability to reduce inflammation and promote healthier eating patterns could significantly improve patients’ quality of life.”
Osborn noted, however, that more research is needed to fully understand the impact of GLP-1 drugs on autoimmune diseases.
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, a doctor said. (iStock)
“These genetic diseases are fueled by obesity-associated inflammation — however, an ‘obesity-first’ approach may not suit all patients and could lead to poorly controlled inflammation if underlying conditions are not addressed.”
Other potential risks associated with GLP-1 medications, such as the muscle loss Ortiz mentioned, “can be mitigated with careful surveillance by a seasoned physician,” said Osborn.
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Novo Nordisk, the manufacturer of Ozempic and Wegovy, declined to comment on the potential arthritis impact when contacted by Fox News Digital.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
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