Health
Ozempic and other GLP-1 drugs could reduce arthritis symptoms in some, experts claim
Popular medications for weight loss and diabetes control could have a surprising bonus benefit, according to some anecdotal reports.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms.
It has been “well-established” that autoimmune patients who also have obesity “fare worse” than those who are at a healthy weight, according to Dr. Elizabeth Ortiz, M.D., a Texas-based rheumatologist and clinical adviser at WellTheory, a platform specializing in autoimmune disease treatment.
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“Any improvements in joint pain or joint inflammation are likely due to a combination of factors, of which weight loss is only one,” she told Fox News Digital.
“Our understanding of the interplay between obesity, adipose tissue and inflammation is incomplete, so as of today, it is difficult to ascribe an improvement in joint pain to any particular cause,” she continued in a written statement.
Some people with rheumatoid arthritis who use GLP-1 drugs — such as Wegovy and Ozempic — have reported an improvement in the severity and frequency of their arthritic symptoms. (iStock)
“We are beginning to learn of the direct anti-inflammatory effects of these medications — and that, with weight loss, is likely to be of benefit for autoimmune patients.”
Does this mean GLP-1s could be prescribed eventually for arthritic patients?
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“There are certainly compelling anecdotes and emerging research into the anti-inflammatory effects of these medications,” said Ortiz, “but we will need dedicated studies evaluating their effectiveness in conditions such as rheumatoid arthritis or psoriatic arthritis before they become a part of standard care.”
What we may see sooner, she predicted, is the use of GLP-1s as a means of addressing obesity and metabolic syndrome in those with autoimmune arthritis.
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” a doctor told Fox News Digital. (iStock)
“Obesity has been associated with worse autoimmune and inflammatory symptoms and with poorer response to standard therapy,” she said.
“Those with rheumatoid arthritis and other autoimmune diseases also carry a higher risk of cardiovascular disease than those without these conditions, and the addition of GLP-1 therapy to their immunomodulating therapy may prove to be a successful combination.”
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There are some potential risks to consider, the expert noted.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures.
“This can be a consequence of low muscle mass, something we are seeing in many taking the GLP-1s,” Ortiz said.
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
“This will need to be paid special attention to and weighed when determining how best to utilize these medications in autoimmune patients.”
The other potential limitation with the use of GLP-1s is cost, she added.
“Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” Ortiz said.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, has been a longtime proponent of semaglutide drugs — including Wegovy, Ozempic and Zepbound — which belong to the GLP-1 class of medications.
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, said obesity exacerbates inflammation throughout the body, primarily through visceral fat. He’s been a longtime proponent of semaglutide drugs. (Dr. Brett Osborn)
“These medications could reduce rheumatoid arthritis symptoms and improve patients’ quality of life by addressing underlying inflammation and obesity, according to a recent meta-analysis,” Osborn told Fox News Digital.
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Rheumatoid arthritis is marked by chronic inflammation, joint pain and flare-ups, the doctor noted, and those with higher body fat and BMIs face a greater risk of developing the condition.
“Why? Because obesity exacerbates inflammation throughout the body, primarily through visceral fat (the fat around your abdominal organs), which secretes cytokines, chemical mediators that heighten inflammation,” Osborn said.
Cost could be a limitation of using GLP-1 drugs for arthritis. “Autoimmune drug spend is already very high, and together with safety and effectiveness, the cost of GLP-1 treatment needs to be considered,” one doctor said. (Michael Siluk/UCG/Universal Images Group via Getty Images)
“This chronic inflammation can worsen RA symptoms and reduce the effectiveness of standard treatments,” the doctor added.
These medications help to reduce people’s consumption of simple carbohydrates — such as bread, pasta and rice — that contribute significantly to inflammation, according to Osborn.
“By curbing appetite and encouraging healthier eating patterns, GLP-1 drugs help decrease the consumption of these inflammation-triggering foods.”
Beyond rheumatoid arthritis, GLP-1 drugs can also help fight systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD) and other autoimmune conditions, the doctor noted.
“Targeting obesity first can improve overall health and reduce risks of conditions like heart attacks and strokes as well,” he added.
In addition to having a higher risk of cardiovascular disease, those with autoimmune diseases are more likely to have osteoporosis, a condition of weakened bones that can lead to fractures. (iStock)
“Obesity is a gateway disease underpinning nearly all non-infectious age-related diseases.”
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, according to Osborn.
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“Their ability to reduce inflammation and promote healthier eating patterns could significantly improve patients’ quality of life.”
Osborn noted, however, that more research is needed to fully understand the impact of GLP-1 drugs on autoimmune diseases.
GLP-1 drugs offer “exciting potential” for managing rheumatoid arthritis and other inflammatory diseases, a doctor said. (iStock)
“These genetic diseases are fueled by obesity-associated inflammation — however, an ‘obesity-first’ approach may not suit all patients and could lead to poorly controlled inflammation if underlying conditions are not addressed.”
Other potential risks associated with GLP-1 medications, such as the muscle loss Ortiz mentioned, “can be mitigated with careful surveillance by a seasoned physician,” said Osborn.
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Novo Nordisk, the manufacturer of Ozempic and Wegovy, declined to comment on the potential arthritis impact when contacted by Fox News Digital.
Health
Highly contagious stomach bug spreads fast, hitting certain patients hardest
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A highly contagious digestive virus is surging across the U.S., experts warn.
Rotavirus, a double-stranded RNA virus, causes acute gastroenteritis — inflammation of the stomach and intestines — which can lead to severe diarrhea, vomiting, fever and stomach pain.
The virus primarily affects infants and young children, but there have also been outbreaks in elderly populations, such as nursing homes.
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Data from the Centers for Disease Control and Prevention shows that in the week ending April 4, out of 2,329 rotavirus tests, 7.3% were positive for the infection. Last year’s highest infection rate was 6.77% as of the week ending April 19.
Rotavirus, a double-stranded RNA virus, causes acute gastroenteritis — inflammation of the stomach and intestines — which can lead to severe diarrhea, vomiting, fever and stomach pain. (iStock)
“We’re seeing a lot of rotavirus in the wastewater right now,” Dr. Marc Siegel, Fox News senior medical analyst, confirmed to Fox News Digital. “Testing for rotavirus is way down, but the percentage of positive tests is up.”
While the virus typically peaks in the spring, it is not currently slowing down, he noted.
Why cases may be rising
Patricia Pinto-Garcia, M.D., a medical editor at GoodRx who is based in California, said there are several possible reasons for the rotavirus spike.
“Vaccine rates are down overall among young children, as they decreased during COVID,” she told Fox News Digital. “This means there’s a growing number of infants and young children who are vulnerable to infection.”
The rotavirus vaccine series must be completed by the time a child is 8 months old, she noted.
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As a result of the declining vaccinations, herd immunity isn’t protecting vulnerable children, according to Pinto-Garcia. “Children who haven’t finished the vaccine series yet, are too young to get vaccinated, or can’t get the vaccine due to medical illness are more likely to get exposed to the illness because other children aren’t vaccinated,” she said.
Siegel noted that before the vaccine became available, rotavirus resulted in 55,000 to 70,000 in the U.S. per year.
“Vaccine rates are down overall among young children, as they decreased during COVID,” a doctor told Fox News Digital. “This means there’s a growing number of infants and young children who are vulnerable to infection.” (iStock)
“I am concerned that the vaccination rate has been declining over the past seven years and is continuing to decline in the current climate of vaccine skepticism,” he said.
Surveillance methods are also much better than they used to be, Pinto-Garcia noted, which means public health experts are able to pick up and track cases better than ever before.
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“But we see that rotavirus-related healthcare visits are also up, so improved detection is not the only reason we are seeing this spike,” she said.
The COVID pandemic also disrupted the pattern of infections, according to Pinto-Garcia, so it’s “tricky” to compare the current levels against older cycles.
“It’s possible that what we are seeing is still some post-pandemic rebound, but it’s unlikely that this year’s pattern is fully explained by just this factor,” she added.
Transmission and risk
Dr. Zachary Hoy, a pediatric infectious disease specialist at Pediatrix Medical Group based in Nashville, Tennessee, often sees young patients with rotavirus.
“Rotavirus is spread via the fecal-oral route, meaning that a person comes into contact with virus droplets from contact with other children or adults, or from contact with objects such as toys that have been contaminated with the virus from someone who is sick,” he told Fox News Digital. “This can lead to outbreaks, especially at schools where many young children share the same toys.”
“It’s possible that what we are seeing is still some post-pandemic rebound, but it’s unlikely that this year’s pattern is fully explained by just this factor.”
Rotavirus is associated with many dehydration cases in the hospital due to the degree of diarrhea, according to Hoy.
In some severe cases, the virus can lead to seizures due to electrolyte imbalances from dehydration and loss of electrolytes in the stool.
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“Younger children do not have the reserves that older children and adults have, so they can become more dehydrated quicker and develop more severe electrolyte imbalances, leading to more severe infections,” Hoy said.
“Patients with problems with their immune systems or on medications that can decrease their immune systems can have more severe and prolonged infections, too.”
Treatment and care
Because rotavirus is a viral infection, antibiotics are not effective against it. There is no specific antiviral treatment for the condition, with doctors typically recommending supportive care.
“The mainstay of treatment is hospitalization for rehydration via intravenous (IV) fluids,” Hoy told Fox News Digital. “Sometimes it can take up to two to three days of IV fluids to help get patients rehydrated.”
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Blood draws are often necessary to evaluate patients’ electrolyte levels, such as sodium, potassium, calcium and magnesium, according to the doctor.
“If these electrolyte levels are significantly low, sometimes patients need special IV solutions or individual electrolyte medications,” he added.
“The mainstay of treatment is hospitalization for rehydration via intravenous (IV) fluids,” a doctor told Fox News Digital. (iStock)
Dr. Daniel Park, medical director of the Pediatric Emergency Department at UNC Health in Chapel Hill, North Carolina, noted that most children recover with supportive care, but parents should seek medical attention if a child shows signs of dehydration. Those include decreased urination, lethargy or inability to keep fluids down.
“While rare, rotavirus can be life-threatening in vulnerable populations, especially very young infants or children with underlying medical conditions,” Park told Fox News Digital.
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Prevention strategies
Given the lack of antiviral medications for rotavirus, doctors emphasize the importance of prevention, primarily the vaccine.
There are two rotavirus vaccines – Rotateq (a three-dose series) and Rotarix (a two-dose series). They are given starting at age 2 months as oral drops, not injections, according to Hoy.
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“It’s important to get the rotavirus vaccines on schedule, because these younger infants are at greatest risk if they get rotavirus,” he advised.
Other recommended prevention methods include handwashing with soap and water.
Health
How Well Will You Age? Take Our Quiz to Find Out.
Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.
Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.
Health
Red hair may be increasing as study points to surprising evolution trend
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A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.
By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.
“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.
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The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”
Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.
Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)
Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.
“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.
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The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.
Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)
As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”
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While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.
However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.
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While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.
While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)
Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.
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The researchers urged caution in how these findings are interpreted.
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“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.
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