Montana

Path to a better TB vaccine runs through Montana

Published

2 years ago

April 22, 2024

Path to a better TB vaccine runs through Montana

Jim Robbins

(KFF) A team of Montana researchers is playing a key role in the development of a more effective vaccine against tuberculosis, an infectious disease that has killed more people than any other.

The BCG (Bacille Calmette-Guérin) vaccine, created in 1921, remains the sole TB vaccine. While it is 40% to 80% effective in young children, its efficacy is very low in adolescents and adults, leading to a worldwide push to create a more powerful vaccine.

One effort is underway at the University of Montana Center for Translational Medicine. The center specializes in improving and creating vaccines by adding what are called novel adjuvants. An adjuvant is a substance included in the vaccine, such as fat molecules or aluminum salts, that enhances the immune response, and novel adjuvants are those that have not yet been used in humans. Scientists are finding that adjuvants make for stronger, more precise, and more durable immunity than antigens, which create antibodies, would alone.

Eliciting specific responses from the immune system and deepening and broadening the response with adjuvants is known as precision vaccination. “It’s not one-size-fits-all,” said Ofer Levy, a professor of pediatrics at Harvard University and the head of the Precision Vaccines Program at Boston Children’s Hospital. “A vaccine might work differently in a newborn versus an older adult and a middle-aged person.”

The ultimate precision vaccine, said Levy, would be lifelong protection from a disease with one jab. “A single-shot protection against influenza or a single-shot protection against covid, that would be the holy grail,” Levy said.

Jay Evans, the director of the University of Montana center and the chief scientific and strategy officer and a co-founder of Inimmune, a privately held biotechnology company in Missoula, said his team has been working on a TB vaccine for 15 years. The private-public partnership is developing vaccines and trying to improve existing vaccines, and he said it’s still five years off before the TB vaccine might be distributed widely.

It has not gone unnoticed at the center that this state-of-the-art vaccine research and production is located in a state that passed one of the nation’s most extreme anti-vaccination laws during the pandemic in 2021. The law prohibits businesses and governments from discriminating against people who aren’t vaccinated against covid-19 or other diseases, effectively banning both public and private employers from requiring workers to get vaccinated against covid or any other disease. A federal judge later ruled that the law cannot be enforced in health care settings, such as hospitals and doctors’ offices.

In mid-March, the Bill & Melinda Gates Medical Research Institute announced it had begun the third and final phase of clinical trials for the new vaccine in seven countries. The trials should take about five years to complete. Research and production are being done in several places, including at a manufacturing facility in Hamilton owned by GSK, a giant pharmaceutical company.

Known as the forgotten pandemic, TB kills up to 1.6 million people a year, mostly in impoverished areas in Asia and Africa, despite its being both preventable and treatable. The U.S. has seen an increase in tuberculosis over the past decade, especially with the influx of migrants, and the number of cases rose by 16% from 2022 to 2023. Tuberculosis is the leading cause of death among people living with HIV, whose risk of contracting a TB infection is 20 times as great as people without HIV.

“TB is a complex pathogen that has been with human beings for ages,” said Alemnew Dagnew, who heads the program for the new vaccine for the Gates Medical Research Institute. “Because it has been with human beings for many years, it has evolved and has a mechanism to escape the immune system. And the immunology of TB is not fully understood.”

The University of Montana Center for Translational Medicine and Inimmune together have 80 employees who specialize in researching a range of adjuvants to understand the specifics of immune responses to different substances. “You have to tailor it like tools in a toolbox towards the pathogen you are vaccinating against,” Evans said. “We have a whole library of adjuvant molecules and formulations.”

Vaccines are made more precise largely by using adjuvants. There are three basic types of natural adjuvants: aluminum salts; squalene, which is made from shark liver; and some kinds of saponins, which are fat molecules. It’s not fully understood how they stimulate the immune system. The center in Missoula has also created and patented a synthetic adjuvant, UM-1098, that drives a specific type of immune response and will be added to new vaccines.

One of the most promising molecules being used to juice up the immune system response to vaccines is a saponin molecule from the bark of the quillay tree, gathered in Chile from trees at least 10 years old. Such molecules were used by Novavax in its covid vaccine and by GSK in its widely used shingles vaccine, Shingrix. These molecules are also a key component in the new tuberculosis vaccine, known as the M72 vaccine.

But there is room for improvement.

“The vaccine shows 50% efficacy, which doesn’t sound like much, but basically there is no effective vaccine currently, so 50% is better than what’s out there,” Evans said. “We’re looking to take what we learned from that vaccine development with additional adjuvants to try and make it even better and move 50% to 80% or more.”

By contrast, measles vaccines are 95% effective.

According to Medscape, around 15 vaccine candidates are being developed to replace the BCG vaccine, and three of them are in phase 3 clinical trials.

One approach Evans’ center is researching to improve the new vaccine’s efficacy is taking a piece of the bacterium that causes TB, synthesizing it, and combining it with the adjuvant QS-21, made from the quillay tree. “It stimulates the immune system in a way that is specific to TB and it drives an immune response that is even closer to what we get from natural infections,” Evans said.

The University of Montana center is researching the treatment of several problems not commonly thought of as treatable with vaccines. They are entering the first phase of clinical trials for a vaccine for allergies, for instance, and first-phase trials for a cancer vaccine. And later this year, clinical trials will begin for vaccines to block the effects of opioids like heroin and fentanyl. The University of Montana received the largest grant in its history, $33 million, for anti-opioid vaccine research. It works by creating an antibody that binds with the drug in the bloodstream, which keeps it from entering the brain and creating the high.

For now, though, the eyes of health care experts around the world are on the trials for the new TB vaccines, which, if they are successful, could help save countless lives in the world’s poorest places.

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Montana

Film Trailer Released for the Montana Backcountry Discovery Route Project

Published

5 hours ago

January 13, 2026

Press Room

Film Trailer Released for the Montana Backcountry Discovery Route Project

Press Release | January 12, 2026

Backcountry Discovery Routes has released the official trailer for its newest route, the Montana Backcountry Discovery Route (MTBDR). A full-length expedition documentary will release February 7 at the Ellen Theatre in Bozeman, Montana, prior to its nationwide film tour.

This is a press release from BDR…

Photos By Miguel Santana / Courtesy of BDR

Seattle, WA – (January 9, 2026) — Backcountry Discovery Routes (BDR), the non-profit organization dedicated to creating and preserving off-highway riding opportunities for adventure and dual-sport motorcyclists, has released the official trailer for its newest route, the Montana Backcountry Discovery Route (MTBDR).

The full-length expedition documentary will make its world premiere during the MTBDR Route Release Event on Saturday, February 7, 2026, at the Ellen Theatre in Bozeman, Montana, before launching a nationwide film tour at motorcycle dealerships and clubs across the country.

About the Route

The MTBDR is BDR’s 23rd route and completes the final link in the Western BDR system, creating a continuous backcountry network across the western United States. The approximately 900-mile route begins in Island Park, Idaho, and travels north through Montana before ending near the U.S.–Canada border outside of Eureka.

Montana Backcountry Discovery Route Project

Crossing more than 13 mountain ranges, the MTBDR takes riders deep into Big Sky Country, weaving together alpine ridgelines, remote valleys, dense pine forests, historic mining towns, wide-open ranchlands, and rugged two-track roads. Highlights include the Gravelly Range, Ruby River Valley, Virginia City, Butte, and the wild landscapes of the East Pioneer, Highland, and Cabinet Mountains.

Blending scenic gravel, flowing forest roads, and optional harder sections for more experienced riders, the MTBDR offers an ideal balance of accessibility and challenge. The route is best enjoyed between July and September, depending on snow levels and seasonal closures.

With the release of the route, riders will have access to free GPS tracks, detailed travel resources, FAQs, route updates, and the official MTBDR Motorcycle Map, providing everything needed to plan a self-guided Montana backcountry adventure.

“The Montana BDR completes the last piece of the Western BDR puzzle, and it’s been one of the most anticipated routes we’ve ever created. It delivers on every level: big landscapes, remote riding, historic towns, and a true sense of exploration. This route does not disappoint.” ~ Bryce Stevens, MTBDR Co-Architect & BDR Co-Founder and Routes Development Director

Film & Route Release

The MTBDR documentary follows the BDR team and special guests as they verify and ride the route, capturing both the scale of Montana’s landscapes and the collaborative effort required to develop a route of this magnitude. The film also includes the next generation of BDR riders—the sons of BDR co-founders—reflecting the multi-generational nature of the community and how these routes are often best experienced when shared. It’s a reminder that the BDR legacy continues to grow, shaped by riders who are discovering these places for the first time.

The world film premiere and official route release will take place on Saturday, February 7, 2026, at the Ellen Theatre in Bozeman, Montana, with members of the BDR team, route architects, and industry partners in attendance. Tickets for the premiere are available at www.RideBDR.com/MTBDR.

Free GPS tracks, digital maps, FAQs, and travel resources will be released at 12:00 PM PST on February 7 at www.RideBDR.com. The waterproof MTBDR Motorcycle Map will be available for purchase through the BDR Online Store.

“As a Montana native, it’s incredibly rewarding to help bring this route to life. The MTBDR showcases the best of our state while supporting rural communities that rely on visitor travel. We’re excited to welcome riders from across the country to experience Montana responsibly and respectfully.” ~ Russ Ehnes, MTBDR Co-Architect & AMA Chairman of the Board

MTBDR Film Tour

Each year, nearly 100 motorcycle dealerships and clubs nationwide host screenings of BDR’s newest film, bringing the adventure riding community together for an evening of inspiration and connection.

Dealerships and clubs interested in hosting an MTBDR screening can now sign up at https://ridebdr.com/MTBDRscreenings
Riders interested in attending a screening in their area can check the listing of screening at https://ridebdr.com/MTBDRtour. More screenings are being added daily so check back if you don’t see a screening near you.

Route Sponsors

The MTBDR project was made possible through the support of key industry partners who share BDR’s commitment to adventure motorcycling, responsible travel, and public land access. Presenting sponsors include:

Triumph Motorcycles America returned for a second consecutive year as an OEM sponsor, providing Tiger 900 Rally Pro motorcycles for the expedition team. Triumph also supported the project with guest riders featured in the film, including Jeff Stanton of Jeff Stanton Adventures, a Triumph-accredited training and touring partner.
onX Offroad, the official navigation app of Backcountry Discovery Routes, supported the MTBDR by providing reliable, user-friendly navigation tools that helped the team verify the route and navigate safely throughout the expedition.
Quad Lock outfitted the MTBDR team with its patented phone mounting systems, allowing riders to securely mount their phones for navigation even on rough backcountry roads and rugged terrain.
Edelweiss Bike Travel, a leading global motorcycle tour company, continues its long-standing support of the adventure motorcycling community in the U.S. through its ongoing sponsorship of BDR routes and projects.

BDR is also grateful for the continued support of its industry partners, including:

Touratech, Mosko Moto, Motoz Tires, KLIM, Cardo Systems, Alpinestars, Rev’It!, Colorado Motorcycle Adventures, West 38 Moto, Rogue Moto, Moto Camp Nerd, SoCal Offroad School, Fox Racing, Black Dog Cycle Works, Doubletake Mirror, REVER, Cyclops, Emmaus Moto Tous, ADV Rider Training, Giant Loop, and others.

For more information about the MTBDR, film screenings, and route details, visit www.RideBDR.com/MTBDR.

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Montana Lottery Powerball, Lucky For Life results for Jan. 12, 2026

Published

17 hours ago

January 13, 2026

Press Room

The Montana Lottery offers multiple draw games for those aiming to win big. Here’s a look at Jan. 12, 2026, results for each game:

Winning Powerball numbers from Jan. 12 drawing

05-27-45-56-59, Powerball: 04, Power Play: 2

Check Powerball payouts and previous drawings here.

Winning Lucky For Life numbers from Jan. 12 drawing

21-23-24-28-39, Lucky Ball: 01

Check Lucky For Life payouts and previous drawings here.

Winning Lotto America numbers from Jan. 12 drawing

09-20-25-30-51, Star Ball: 10, ASB: 02

Check Lotto America payouts and previous drawings here.

Winning Big Sky Bonus numbers from Jan. 12 drawing

01-14-22-29, Bonus: 09

Check Big Sky Bonus payouts and previous drawings here.

Winning Powerball Double Play numbers from Jan. 12 drawing

11-23-24-54-56, Powerball: 05

Check Powerball Double Play payouts and previous drawings here.

Feeling lucky? Explore the latest lottery news & results

When are the Montana Lottery drawings held?

Powerball: 8:59 p.m. MT on Monday, Wednesday, and Saturday.
Mega Millions: 9 p.m. MT on Tuesday and Friday.
Lucky For Life: 8:38 p.m. MT daily.
Lotto America: 9 p.m. MT on Monday, Wednesday and Saturday.
Big Sky Bonus: 7:30 p.m. MT daily.
Powerball Double Play: 8:59 p.m. MT on Monday, Wednesday, and Saturday.
Montana Cash: 8 p.m. MT on Wednesday and Saturday.

Missed a draw? Peek at the past week’s winning numbers.

Winning lottery numbers are sponsored by Jackpocket, the official digital lottery courier of the USA TODAY Network.

Where can you buy lottery tickets?

Tickets can be purchased in person at gas stations, convenience stores and grocery stores. Some airport terminals may also sell lottery tickets.

You can also order tickets online through Jackpocket, the official digital lottery courier of the USA TODAY Network, in these U.S. states and territories: Arizona, Arkansas, Colorado, Idaho, Maine, Massachusetts, Minnesota, Montana, Nebraska, New Hampshire, New Jersey, New York, Ohio, Oregon, Puerto Rico, Washington D.C., and West Virginia. The Jackpocket app allows you to pick your lottery game and numbers, place your order, see your ticket and collect your winnings all using your phone or home computer.

Jackpocket is the official digital lottery courier of the USA TODAY Network. Gannett may earn revenue for audience referrals to Jackpocket services. GAMBLING PROBLEM? CALL 1-800-GAMBLER, Call 877-8-HOPENY/text HOPENY (467369) (NY). 18+ (19+ in NE, 21+ in AZ). Physically present where Jackpocket operates. Jackpocket is not affiliated with any State Lottery. Eligibility Restrictions apply. Void where prohibited. Terms: jackpocket.com/tos.

This results page was generated automatically using information from TinBu and a template written and reviewed by a Great Falls Tribune editor. You can send feedback using this form.

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Montana

Man dies in Highway 93 crash in Lake Co.

Published

1 day ago

January 12, 2026

Press Room

Man dies in Highway 93 crash in Lake Co.

RAVALLI, Mont. — A 35-year-old man is dead after a two vehicle crash on Highway 93 North near Ravalli on Sunday morning, according to Montana Highway Patrol.

The driver of a Honda Civic traveling northbound in the southbound lanes was declared dead on scene after colliding with a Ford F-150 that was traveling southbound.

The driver of the Ford F-150 was injured in the accident taken to St. Luke Community Healthcare in Ronan.

Montana Highway Patrol is investigating the crash.

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