Health
Some breast cancer patients could be at risk of another type of cancer, study reveals
Women with breast cancer who have received chemotherapy are at an increased risk of developing lung cancer, a new study suggests.
Epic Research, a health data group based in Delaware, found that women in this category have a 57% higher lung cancer risk than those who received radiation.
In comparison to patients who received endocrine therapy, those who have undergone chemo have a 171% increase in lung cancer risk, the study found.
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In a statement sent to Fox News Digital, the Epic Research team said the key takeaway from their research is that primary lung cancer is more than twice as prevalent in women who were previously diagnosed with breast cancer — compared to those who did not have it.
“Furthermore, women who had breast cancer and received chemotherapy have the greatest risk of subsequent primary lung cancer,” the researchers wrote.
Women with breast cancer who have received chemotherapy are at an increased risk of developing lung cancer, a new study is suggesting. (iStock)
“This suggests that patients diagnosed with breast cancer are at an increased risk of developing second primary lung cancer, especially if their treatment included chemotherapy.”
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The research group studied more than two million women ages 50 to 84 who received a screening mammogram between 2010 and 2023.
Patients with an elevated breast cancer risk due to a previous breast or lung cancer diagnosis, those who had been screened within the past three months and those who started mammogram screenings prior to age 50 were excluded from the study.
“This could potentially limit the generalizability of our findings,” the researchers said.
The research group (not pictured) studied more than two million women ages 50 to 84 who received a mammogram screening between 2010 and 2023. (iStock)
The team encouraged patients with a history of breast cancer — especially those who have had chemotherapy — to monitor for the development of primary lung cancer.
“It is important to remember that while our study found a correlation between breast cancer, its treatments and subsequent primary lung cancer, this does not mean that every woman who has had breast cancer will develop lung cancer,” the researchers said.
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Fox News medical contributor Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center, told Fox News Digital that one cancer can cause a “higher genetic risk” for others.
“We don’t know the exact etiology, but one cancer puts you in a higher genetic risk pool for other cancers, either because of cancer genes that increase the risk of both, or because of a tendency for mutations that is increased in this pool,” he said.
“It could also be because of environmental factors or carcinogens, including diet, or the result of toxicities from the treatment for breast cancer,” Siegel added.
The researchers encouraged patients with a history of breast cancer, especially those who have had chemotherapy, to monitor for the development of primary lung cancer. (iStock)
Jack Manley, M.D., head of new markets and growth at Viz.ai, a San Francisco-based AI-powered disease detection platform, shared with Fox News Digital that Epic Research’s findings and methodology speak to “the power of incorporating multi-modal data in predictive algorithms.”
Said Manley as well, “Companies with capabilities to incorporate both structured and unstructured EHR (electronic health record) data with conventional imaging will have a higher predictive performance than those that don’t.”
He was not involved in the study.
“Currently, a large majority of patients with pulmonary nodules (a possible indicator of early lung cancer) are missed on conventional imaging, while less than half of these detected patients receive subsequent guideline-recommended follow up,” he said.
Artificial intelligence tools are “well-positioned” to address these challenges, Manley noted — but EHR integration is “key to finding those patients at the highest risk.”
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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