Health
Ketamine therapy shown effective in treating severe depression in veterans, study finds
Ketamine could be a viable remedy for veterans struggling with depression, new research has suggested.
The University of Michigan released a study on the effects of ketamine in cases of severe or treatment-resistant depression among veterans.
Half of the study participants experienced significant relief after undergoing six weeks of ketamine therapy, according to a Michigan Medicine press release.
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The study, published in the Journal of Clinical Psychiatry, looked into the data of 215 veterans receiving intravenous ketamine therapy at Veterans Affairs (VA) hospitals.
All the participants had also undergone previous depression treatments without any improvement.
Research from the University of Michigan found that ketamine therapy could be beneficial for veterans with depression. (Julia Rendleman for The Washington Post via Getty Images; iStock)
Nearly half of all patients saw a “meaningful drop” in depression scores after six weeks of infusions, according to the analysis by the University of Michigan and VA Ann Arbor Healthcare System (VAAAHS).
About 25% saw their depression score drop by half within six weeks of treatment, while 15% went into full remission despite the complexity of their mental health status.
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Almost all patients surveyed continued their treatment every few weeks or months.
“Further study is needed to determine optimal infusion frequency and potential for adverse effects with repeated ketamine infusions for depression,” the study findings stated.
Nearly half the participants in a new study saw a “meaningful drop” in depression scores after six weeks of IV ketamine infusions, the study found. (iStock)
In a statement sent to Fox News Digital, VA press secretary Terrence Hayes backed ketamine therapy as an option for veterans.
“VA supports the evidence-based use of ketamine infusions for treatment-resistant depression and severe suicidal ideation,” he said.
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“Many veterans with these mental health conditions are treated with IV ketamine annually – both at VA facilities and by community providers.”
Dr. Justin Gerstner, psychiatrist and chief medical officer at Ellie Mental Health in Minnesota, told Fox News Digital that he thinks these findings on ketamine are “great,” as the VA population is “in need of new, innovative treatments for depression.”
(Gerstner was not involved in the Michigan study.)
A doctor holds a vial of ketamine at the MindPeace Clinic in Richmond, Virginia. (Julia Rendleman for The Washington Post via Getty Images)
“This study shows that this helps some of the hardest-to-treat veterans with depression,” he said.
As more psychedelic-assisted therapies emerge to treat numerous mental health issues, the doctor said ketamine is among the ones that produce results “pretty quickly.”
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Another benefit of ketamine therapy, according to Gerstner, is that it eliminates the need for patients to take medication every day, as with other treatment methods.
Gerstner said he uses ketamine therapy in his own practice, where the response from clients has been “great.”
Carl Montalbino, 67, receives his ketamine treatment while nurse Melissa Dougher checks his vitals on July 5, 2022, at MindPeace Clinic in Richmond, Virginia. (Julia Rendleman for The Washington Post via Getty Images)
“It’s been quite transformative for a lot of our clients,” he told Fox News Digital. “It’s really a rewarding experience to be a part of that.”
Gerstner’s practice usually administers ketamine to clients via IV injection in two- to three-hour sessions, partnered with psychotherapy before and after treatment.
Potential risks and limitations
While ketamine can work as a “really powerful anti-depressant and anti-suicidal drug,” Gerstner said, he warned that it is “not the right answer for everybody or everything.”
“This is a really powerful medication and the way that it’s used can vary quite drastically.”
There are some risks and limitations involved, he said — including the potential for ketamine to be abused.
There isn’t too much regulation surrounding how ketamine treatments are administered, Gerstner noted, since the drug was previously approved for anesthetic use.
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“The field is wide open, and it’s a little bit like the Wild West,” he said. “This is a really powerful medication and the way that it’s used can vary quite drastically.”
Various clinics have seen success with administering the drug in different forms, including oral, IV and injectable, according to Gerstner.
Various clinics have seen success with the drug being administered in different forms, including oral, IV and injectable. (Julia Rendleman for The Washington Post via Getty Images)
For patients with severe treatment-resistant depression, a typical IV regimen is administered every two to three days in a hospital-based outpatient clinic, according to Michigan Medicine and VAAAHS.
“Those things are really all over the map,” Gerstner said. “It’s hard to regulate and there’s some risk in that, but it’s also what we have to do while learning what’s best.”
For veterans who are seeking better treatment, ketamine could be a “really important thing to consider for depression,” said Gerstner
“If they’re suffering with depression and feel like they’re not getting what they need, and they haven’t had a discussion about ketamine, it’s OK to ask [their provider] about it,” he added.
Fox News Digital reached out to the University of Michigan requesting additional comment on the research.
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Health
Cancer-linked herbicide in the spotlight after controversial order: ‘Toxic by design’
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There has been a shake-up in the Make America Healthy Again movement regarding glyphosate, a widely used herbicide that has been the subject of significant controversy.
The debate follows an executive order signed by President Donald Trump that ensures an adequate supply of elemental phosphorus and glyphosate-based herbicides related to national defense.
MAHA supporters have previously pushed a pesticide-free agenda, warning of potential health harms caused by glyphosate.
Dr. Marc Siegel, Fox News senior medical analyst, said he believes there is sufficient evidence linking glyphosate to neurodegenerative diseases, including ALS, Parkinson’s and multiple sclerosis, to warrant limiting exposure.
President Donald Trump signed an executive order that ensures an adequate supply of elemental phosphorus and glyphosate-based herbicides related to national defense. (AP Photo/Charlie Neibergall)
“With Parkinson’s, this association appears to be due to the gut, vagus nerve and brain axis, where the exposure affects the microbiome in the gut, which then ascends slowly up to the brain, causing the neurodegenerative disease years later,” Siegel told Fox News Digital.
“There is also a growing association being found between high-dose glyphosate or occupational exposure and metabolic disorders, liver disease and some cancers, specifically lymphoma.”
He added, “Growing research backs this. I favor limiting it.”
“When we apply them across millions of acres and allow them into our food system, we put Americans at risk.”
Studies have shown that glyphosate, which is used in products such as Roundup, owned by Monsanto, could raise cancer risk.
In one University of Washington study published in the journal Mutation Research, researchers found that exposure to it increased the risk of non-Hodgkin lymphoma by 41%.
The nonprofit Investigate Midwest, which analyzed data from both the U.S. Geological Survey and the National Cancer Institute, also recently found that pesticides may contribute to cancer rates.
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Among the top 500 counties for per-square-mile pesticide use, more than 60% had cancer rates above the national average of 460 cases per 100,000 people, according to the report.
Investigate Midwest, which is based in Illinois, interviewed more than 100 farmers, environmentalists, lawmakers and scientists as part of a partnership with the Pulitzer Center’s StoryReach U.S. Fellowship.
Among the top 500 counties for per-square-mile pesticide use, more than 60% had cancer rates above the national average of 460 cases per 100,000 people, according to one study. (iStock)
Iowa, which used 53 million pounds of pesticides last year, holds the nation’s title for second-highest cancer rate.
Bill Billings, a resident of Red Oak, Iowa, was diagnosed with cancer in 2014.
“The cancer specialist said, very directly, (my) cancer is a result of being exposed to chemicals,” Billings said in the report.
Kelly Ryerson, founder of Glyphosate Facts and owner of the Instagram account @glyphosategirl, told Fox News Digital her journey researching the herbicide began with her own health struggles.
Ryerson, who is based in California, previously struggled with chronic illness and autoimmune issues, which she said improved when she stopped eating gluten.
Iowa, which used 53 million pounds of pesticides last year, holds the nation’s title for second-highest cancer rate. (iStock)
After attending a medical conference at Columbia University’s Celiac Disease Center, Ryerson began to question modern farming practices rather than the gluten itself.
“A lot of times, farmers are spraying Roundup on our grains right before harvest to facilitate an easier harvest,” she said. “After that easier harvest, because everything’s dry at the same time, those crops go directly to the mill and may end up in our food supply, at alarmingly high levels.”
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In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization framework, classified glyphosate as “probably carcinogenic to humans.”
The classification was based on limited evidence of cancer in humans (notably non-Hodgkin lymphoma in some studies) and sufficient evidence in experimental animals.
“President Trump’s executive order reinforces the critical need for U.S. farmers to have access to essential, domestically produced crop protection tools, such as glyphosate,” a Monsanto spokesperson said. (Wolf von Dewitz/picture alliance via Getty Images)
A spokesperson for Monsanto told Fox News Digital it will comply with Trump’s order to produce glyphosate and elemental phosphorus.
“President Trump’s executive order reinforces the critical need for U.S. farmers to have access to essential, domestically produced crop protection tools, such as glyphosate,” the spokesperson said.
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HHS Secretary Robert F. Kennedy Jr. has long been a vocal critic of Roundup, working with his legal team in 2018 to award $289 million to a man who alleged the weed killer caused his non-Hodgkin lymphoma, according to reports.
Following backlash to Trump’s executive order, Kennedy said he supports the order but acknowledged that “pesticides and herbicides are toxic by design, engineered to kill living organisms.”
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“When we apply them across millions of acres and allow them into our food system, we put Americans at risk,” he posted on X. “Chemical manufacturers have paid tens of billions of dollars to settle cancer claims linked to their products, and many agricultural communities report elevated cancer rates and chronic disease.”
Fox News Digital reached out to the White House for comment.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
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