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Ketamine therapy shown effective in treating severe depression in veterans, study finds

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Ketamine therapy shown effective in treating severe depression in veterans, study finds

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Ketamine could be a viable remedy for veterans struggling with depression, new research has suggested.

The University of Michigan released a study on the effects of ketamine in cases of severe or treatment-resistant depression among veterans.

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Half of the study participants experienced significant relief after undergoing six weeks of ketamine therapy, according to a Michigan Medicine press release.

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The study, published in the Journal of Clinical Psychiatry, looked into the data of 215 veterans receiving intravenous ketamine therapy at Veterans Affairs (VA) hospitals.

All the participants had also undergone previous depression treatments without any improvement.

Research from the University of Michigan found that ketamine therapy could be beneficial for veterans with depression. (Julia Rendleman for The Washington Post via Getty Images; iStock)

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Nearly half of all patients saw a “meaningful drop” in depression scores after six weeks of infusions, according to the analysis by the University of Michigan and VA Ann Arbor Healthcare System (VAAAHS).

About 25% saw their depression score drop by half within six weeks of treatment, while 15% went into full remission despite the complexity of their mental health status.

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Almost all patients surveyed continued their treatment every few weeks or months.

“Further study is needed to determine optimal infusion frequency and potential for adverse effects with repeated ketamine infusions for depression,” the study findings stated.

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Nearly half the participants in a new study saw a “meaningful drop” in depression scores after six weeks of IV ketamine infusions, the study found. (iStock)

In a statement sent to Fox News Digital, VA press secretary Terrence Hayes backed ketamine therapy as an option for veterans.

“VA supports the evidence-based use of ketamine infusions for treatment-resistant depression and severe suicidal ideation,” he said.

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“Many veterans with these mental health conditions are treated with IV ketamine annually – both at VA facilities and by community providers.”

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Dr. Justin Gerstner, psychiatrist and chief medical officer at Ellie Mental Health in Minnesota, told Fox News Digital that he thinks these findings on ketamine are “great,” as the VA population is “in need of new, innovative treatments for depression.”

(Gerstner was not involved in the Michigan study.)

A doctor holds a vial of ketamine at the MindPeace Clinic in Richmond, Virginia. (Julia Rendleman for The Washington Post via Getty Images)

“This study shows that this helps some of the hardest-to-treat veterans with depression,” he said.

As more psychedelic-assisted therapies emerge to treat numerous mental health issues, the doctor said ketamine is among the ones that produce results “pretty quickly.”

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Another benefit of ketamine therapy, according to Gerstner, is that it eliminates the need for patients to take medication every day, as with other treatment methods.

Gerstner said he uses ketamine therapy in his own practice, where the response from clients has been “great.”

Carl Montalbino, 67, receives his ketamine treatment while nurse Melissa Dougher checks his vitals on July 5, 2022, at MindPeace Clinic in Richmond, Virginia. (Julia Rendleman for The Washington Post via Getty Images)

“It’s been quite transformative for a lot of our clients,” he told Fox News Digital. “It’s really a rewarding experience to be a part of that.”

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Gerstner’s practice usually administers ketamine to clients via IV injection in two- to three-hour sessions, partnered with psychotherapy before and after treatment.

Potential risks and limitations

While ketamine can work as a “really powerful anti-depressant and anti-suicidal drug,” Gerstner said, he warned that it is “not the right answer for everybody or everything.”

“This is a really powerful medication and the way that it’s used can vary quite drastically.”

There are some risks and limitations involved, he said — including the potential for ketamine to be abused.

There isn’t too much regulation surrounding how ketamine treatments are administered, Gerstner noted, since the drug was previously approved for anesthetic use. 

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“The field is wide open, and it’s a little bit like the Wild West,” he said. “This is a really powerful medication and the way that it’s used can vary quite drastically.”

Various clinics have seen success with administering the drug in different forms, including oral, IV and injectable, according to Gerstner.

Various clinics have seen success with the drug being administered in different forms, including oral, IV and injectable. (Julia Rendleman for The Washington Post via Getty Images)

For patients with severe treatment-resistant depression, a typical IV regimen is administered every two to three days in a hospital-based outpatient clinic, according to Michigan Medicine and VAAAHS.

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“Those things are really all over the map,” Gerstner said. “It’s hard to regulate and there’s some risk in that, but it’s also what we have to do while learning what’s best.” 

For veterans who are seeking better treatment, ketamine could be a “really important thing to consider for depression,” said Gerstner

“If they’re suffering with depression and feel like they’re not getting what they need, and they haven’t had a discussion about ketamine, it’s OK to ask [their provider] about it,” he added.

Fox News Digital reached out to the University of Michigan requesting additional comment on the research.

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.

A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.

The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.

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“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.

“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.

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Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.

Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.

One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)

There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.

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“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.

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Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.

The key, she said, is adapting the mindset, not replicating it perfectly.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

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The goal is to reintroduce small, intentional moments that make you feel better.

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That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.

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Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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