Maryland
University of Maryland Medical Center hopes new Baltimore cancer center will advance treatment, care
What if within the subsequent few years sufferers with most cancers of their lungs or blood may sit in a chair, get an infusion of their very own modified cells to wipe out their most cancers and go dwelling?
Most cancers researchers and docs across the nation are engaged on it — not solely changing rounds of poisonous chemotherapy with essentially the most superior immunotherapies but additionally making the leading edge therapies extra readily accessible and even comfy.
A giant piece of the hassle regionally begins coming collectively Friday when the College of Maryland Medical Heart breaks floor on a brand new $219 million most cancers middle.
The Roslyn and Leonard Stoler Heart for Superior Medication will rise in entrance of the downtown Baltimore hospital and home the Marlene and Stewart Greenebaum Complete Most cancers Heart. It’s slated to open in 2025.
Dr. Kevin Cullen, director of the Greenebaum Most cancers Heart, mentioned the brand new middle was designed in anticipation of medical advances and affected person wants.
“We’ll have the ability to provide a bone marrow transplant, for instance, in an extended-stay setting. You keep for therapy and go dwelling and are available again the following day,” Cullen mentioned forward of the groundbreaking. “We don’t have that functionality now.”
Cullen mentioned the middle already is among the many first within the area to supply some immunotherapy therapies that may solely broaden.
The constructing and analysis on the College of Maryland Faculty of Medication, which can collectively function the middle with the hospital, are made doable partly by state and federal “moonshot” investments and funding from the American Most cancers Society and others with a aim of creating higher therapies, and even cures, for extra forms of most cancers — the No. 2 killer in the USA with 600,000 deaths anticipated this 12 months.
Fundraising for the Maryland middle started in 2018 when Baltimore auto vendor Len Stoler and his spouse, Roslyn, gave $25 million towards the 198,000-square-foot constructing to allow therapy of hundreds of sufferers a 12 months.
The 9-story steel and glass constructing designed by the Nebraska-based architectural agency HDR will double the middle’s capability from the present constructing and accommodate affected person visits which can be estimated to rise greater than 50% by 2028.
Officers anticipate serving sufferers with more and more complicated cancers that require multidisciplinary therapy and prolonged follow-up care. A lot of the area will probably be dedicated to inpatient and outpatient care with a brand new entrance and foyer for the hospital. One other 42,000 sq. toes will probably be renovated within the present medical middle.
A big portion of the brand new middle’s start-up funding will come from a $216 million “moonshot” initiative launched by Gov. Larry Hogan, whose most cancers was handled on the middle. Hogan accelerated $100 million in funding for the middle in subsequent 12 months’s funds.
On the federal stage, most cancers analysis nationwide stands to achieve from a President Joe Biden initiative with a aim of reducing most cancers deaths in half within the subsequent 25 years and bettering life for survivors.
Congress already has allotted about $1.6 billion to broaden analysis into genetic mutations discovered in numerous cancers, develop vaccines to stop most cancers, deploy new diagnostic instruments to seek out cancers sooner and shut disparities in charges of illness.
A giant and promising entrance in these therapies focuses on immunotherapies, which practice individuals’s personal immune methods to focus on and kill most cancers cells.
Maintaining momentum would require extra funding and a spotlight, mentioned Dr. Arif Kamal, an oncologist and chief affected person officer on the American Most cancers Society.
The Nationwide Most cancers Institute, the biggest funder of most cancers analysis, can solely settle for one in 10 of the analysis functions it receives, Kamal mentioned.
“When receiving funding has a 90% probability of not understanding, promising scientists may be deterred, and we face the specter of them leaving the sphere and their potential groundbreaking discoveries by no means coming to mild,” he mentioned.
The most cancers society has contributed greater than $133 million in Maryland for analysis over time, with the College of Maryland hospitals and college receiving $23.8 million.
Kamal mentioned it’s an “thrilling and promising time” in most cancers care, and docs have elevated skill to deal with extra forms of cancers in much less damaging methods.
He cited a number of sorts of immunotherapies, equivalent to checkpoint inhibitors, which block proteins that cease the immune system from attacking most cancers. There’s additionally CAR T-cell remedy, which includes taking T-cells from a affected person’s blood and coaching them to connect to tumor cells earlier than being given again to sufferers by way of viruses.
The Maryland most cancers middle was the primary within the Maryland-Washington, D.C.-Virginia area to supply CAR T-cell remedy to deal with lymphoma, a blood most cancers, after having been concerned in trials to point out its effectiveness.
The FDA not too long ago permitted it to deal with lymphoma in sufferers whose chemotherapy failed as soon as slightly than a number of occasions, giving sufferers earlier entry, mentioned Dr. Aaron Rapoport, director of the transplant and mobile remedy program on the Maryland most cancers middle.
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In all, the College of Maryland middle is utilizing the therapy on 250 sufferers.
“Greater than half of these sufferers had no different choice and are seemingly cured of their most cancers,” Rapoport mentioned. “This turned out to be extremely efficient for sufferers, and we have been one of many main facilities demonstrating that.”
Rapoport mentioned there are numerous different advances within the works at Maryland and elsewhere, and a few are prone to be out there by the point the brand new most cancers middle opens in 2025. In addition they could also be given in outpatient settings slightly than involving hospital stays.
To arrange for that, the brand new middle will characteristic an expanded outpatient middle for bone marrow transplants and different immunotherapies. A cell-processing laboratory that handles sufferers’ blood will probably be on web site. There additionally will probably be an pressing care space the place most cancers sufferers can go as an alternative of the emergency room.
Such additions have been among the many adjustments made with enter from medical and different employees and the group, mentioned Cullen, the middle’s director.
The expanded affected person care areas will complement analysis areas largely housed close by within the hospital.
That analysis will press on throughout building, and can contain collaborations with different establishments together with Johns Hopkins Medication.
Dr. William Nelson, director of Hopkins’ Sidney Kimmel Complete Most cancers Heart, mentioned establishments have lengthy shared their work to make advances.
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Within the Nineteen Seventies, researchers checked out what may kill most cancers in a lab dish and decided “how a lot of that stuff we may get into an individual with out an excessive amount of collateral harm,” Nelson mentioned.
It cured some most cancers but additionally broken different organs, made hair fall out and made individuals really feel sick, he mentioned.
Right now docs have and are creating new instruments: They will stock gene defects in most cancers sufferers, goal particular gene defects with therapies, enhance the know-how to higher diagnose most cancers and decide which medication will or received’t work on particular sufferers. And that’s on prime of latest immunotherapies.
Nelson mentioned Hopkins, Maryland and different establishments want to determine the way to seize alternatives like authorities moonshot and personal {dollars} to construct on progress. Collaboration is one huge manner.
Hopkins scientists not too long ago introduced they have been awarded $8 million for novel most cancers analysis. It’s a part of a $50 million award from the Break Via Most cancers analysis basis to 5 prime most cancers facilities that may work collectively on cures for pancreatic, ovarian and mind cancers.
They hope to speed up analysis like scientists did with the mRNA vaccines in opposition to COVID-19 in lower than a 12 months. Then they should guarantee any new therapies are delivered as comfortably and equitably as doable.
“Take a illness like breast most cancers. You by no means must be within the hospital in a single day, for a mammogram, biopsy, lumpectomy, chemo, hormonal remedy,” Nelson mentioned. “Individuals have lives to stay. Go get in, get seen and get again to work or dwelling. That’s the longer term.”
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Maryland
Maryland Weather: Severe Storms Moving in From West
![Maryland Weather: Severe Storms Moving in From West Maryland Weather: Severe Storms Moving in From West](https://assets2.cbsnewsstatic.com/hub/i/r/2024/08/31/422a855f-71c5-4f72-89e9-eaf7e2840b03/thumbnail/1200x630/74b3d1b1856d7b1a33196394c2d71589/capture.png?v=25685eaa472b1a5dbb5bd46ae506d232)
BALTIMORE – Severe storms have been plaguing western Maryland this afternoon. They are on the move east and will push into Carroll County near the 6pm hour. These storms have a history of producing winds capable of downing trees. We are also seeing heavy rain and lightning.
Most of the activity will push north and south of the forecast area surrounding Baltimore with the marine layer or stable air mass keeping the severe weather west of the mountain regions.
The warm front associated with the severe weather is bring warm, humid air in overnight. Expect overnight lows in the low 70s with scattered showers and isolated severe storms.
A secondary cold front will bring another chance for an isolated strong storms on Sunday. The day won’t be a washout, there is the possibility of active weather in the afternoon and evening.
The front will bring bright sunny skies for Monday with low humidity. Perfect weather for the afternoon barbecue or last summer activity. Kids getting back to school this week should expect refreshing temperatures… possibly even a little chilly with overnight lows in the 50s.
High pressure will control our weather for the middle of the week. Expect sunny skies and low humidity through Friday. Overnight lows Tuesday and Wednesday will be in the mid 50s, with afternoon highs in the upper 70s. The chance of showers returns late Friday.
Maryland
How to watch Maryland football vs. UConn
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Maryland football is back and kicks off its season at home against UConn on Saturday.
The Terps will take on the Huskies for first time since 2013, when Maryland won, 32-21. The Terps are coming off an 8-5 season, in which they won their third straight bowl game, while UConn is coming off a disappointing 3-9 season and looking to play spoiler on the road.
With a victory, Maryland will move its week one winning streak to five games.
The numbers
Maryland: 0-0
UConn: 0-0
All-time series: Maryland leads, 2-1
DraftKings Sportsbook line: Maryland -19.5, O/U 44.5
How to watch and listen
When: Saturday, Aug. 31, 12 p.m. ET
Where: SECU Stadium, College Park, Maryland
TV: Fox Sports 1 — Connor Onion (play-by-play), Mark Helfrich (analyst)
Radio: 105.7 FM (Balt) / 980 AM (DC) – Johnny Holliday (play-by-play), Steve Suter (analyst), LaMont Jordan (sideline)
Streaming: Fox Sports
Catch up before the game
Previewing Maryland football’s season opener against UConn
Predictions for Maryland football’s 2024 season: Top players, bold takes and more
Breaking down every game on Maryland football’s schedule
Maryland
Maryland Supreme Court reinstates Adnan Syed murder conviction, orders new hearing
BALTIMORE— Maryland’s Supreme Court has upheld an appellate court’s decision to reinstate the murder conviction of Adnan Syed, whose case gained national attention in 2014 when it was featured on the first season of the “Serial” podcast.
The ruling says the case should be sent back to a lower court for a new hearing on whether it should be thrown out entirely. The decision reverses a lower court’s ruling that had cleared Syed’s name two years ago.
Syed had served more than 20 years for the 1999 murder of his ex-girlfriend, Hae Min Lee.
He was freed from prison in September 2022 after Baltimore prosecutors found flaws in the evidence presented at trial and a judge agreed to vacate his conviction.
However, Lee’s relatives appealed the decision, contending they didn’t receive sufficient notice to attend the hearing that set Syed free. In March 2023, the Maryland Appellate Court agreed and reinstated Syed’s conviction and ordered a redo of the hearing.
Syed appealed that ruling, bringing the matter to the Maryland Supreme Court. Friday’s ruling comes 11 months after arguments were made.
Justices found the circuit court violated the rights of Young Lee, Hae Min Lee’s brother.
“In an effort to remedy what they perceived to be an injustice to Mr. Syed, the prosecutor and the Circuit Court worked an injustice against Mr. Lee,” the court said.
Syed will remain free until the next hearing which has not been scheduled. The Supreme Court ordered the Lee family must have sufficient notice of the new hearing and a new judge must preside.
“If there’s actually evidence presented that shows that Adnan Syed should not have been convicted, we would be the first ones to congratulate Adnan Syed and argue he should be a free man,” said David Sanford, the attorney for the Lee family. “That hasn’t happened yet.”
In their dissenting opinions, several justices wrote when the case was vacated, any appeal by Young Lee should’ve been rendered moot. Those justices also argued there aren’t any specific victims’ rights that would require Young Lee be allowed to be present at that 2022 hearing.
Syed’s lawyer Erica Suter said that while they disagree with the ruling, the Lee family’s pain in this isn’t lost on them.
“Wrongful convictions devastate the wrongly accused, their family and the family of the victim,” Suter said. “Reinstating Adnan’s wrongful conviction does not provide justice or closure.”
Rabia Chaudry, Syed’s friend and advocate, went on Instagram Live to affirm that she will do what she can to keep Syed a free man.
“I will never not fight for his freedom and I know there are others, also, in his life who will never not fight for his freedom,” Chaudry said.
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