Science
Risk for chronic fatigue soars among those who had COVID-19, study says
People who have had COVID-19 have a significantly higher risk of suffering chronic fatigue than those who haven’t had the disease, a new study published Wednesday shows.
“Our data indicate that COVID-19 is associated with a significant increase in new fatigue diagnoses,” according to the study, published by the Centers for Disease Control and Prevention in the journal Emerging Infectious Diseases.
“Physicians should be aware that fatigue might occur or be newly recognized [more than a year] after acute COVID-19,” the report said.
Specifically, the study looked at electronic health records of more than 4,500 patients in Washington state who had COVID-19 in 2020 and 2021 and compared them to patients who hadn’t had COVID. The study found the risk for chronic fatigue was more than four times greater in those who had the illness.
Scientists also looked at a more broad definition of fatigue, which includes chronic fatigue as well as diagnoses of weakness and malaise. The study found that the risk of fatigue among COVID-19 patients was 68% higher among people who’d had COVID than those who hadn’t.
Among the 4,589 COVID-19 patients in the study, scientists identified 434 as “incident fatigue cases,” in which the person was diagnosed with fatigue after recovering from COVID-19. Of those, 81 were also identified as having chronic fatigue, which is a subset of general fatigue.
The risk of chronic fatigue after COVID-19 was more common among women, older people and those who had other medical conditions, the study said.
The report illustrates the continuing burden of long COVID long after the emergency phase of the pandemic has ended. CDC survey data from last year said that up to 15% of U.S. adults had ever experienced long COVID and up to 6% of were currently experiencing long COVID.
Among those who have suffered long COVID — regardless of whether the person was hospitalized — fatigue is often a symptom.
Researchers for this study decided to focus on fatigue among COVID-19 patients because the symptom plays such a central role among those suffering from long COVID.
People who developed fatigue after COVID-19 had “far worse clinical outcomes,” the report said. Among more than 400 patients who dealt with post-COVID fatigue, 25.6% were hospitalized at some point following an acute bout of COVID-19 during the study’s time frame. By contrast, only 13.6% of more than 4,000 patients who didn’t develop post-COVID fatigue were later hospitalized.
Patients who had post-COVID fatigue were also at a higher risk of dying than those who did not develop fatigue, the report said.
The report also cautioned that doctors be alert for COVID patients who have a history of mood disorders; such patients “are also at increased risk for post-COVID-19 fatigue,” it said.
Doctors say the risk of long COVID is further reason to take prudent steps to avoid a coronavirus infection, including avoiding sick people, taking a test to verify a COVID-19 diagnosis and staying home if you are ill but asymptomatic. Masking up in crowded indoor settings, staying up to date on vaccinations and taking antiviral drugs like Paxlovid when experiencing COVID-19 symptoms may also help reduce the risk of long COVID.
People can get infected with coronavirus multiple times, the CDC said, and “each time a person is infected or reinfected … they have a risk of developing long COVID.”
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
-
Dallas, TX50 seconds agoThe Brandon Aubrey Deal | DZTV
-
Miami, FL7 minutes agoRanking the Miami Heat’s Top Trade Targets
-
Boston, MA13 minutes agoFormer Massachusetts doctor faces 81 new sexual assault charges
-
Denver, CO19 minutes agoHouston County murder suspect returns to face charges after her arrest in Denver
-
Seattle, WA25 minutes agoWest Seattle Tool Library to host annual tool sale this Saturday, April 25 | The White Center Blog
-
San Diego, CA31 minutes agoBalboa Park museums see attendance decline of 34% in first quarter
-
Milwaukee, WI37 minutes agoMilwaukee County overdose deaths continue to fall, but challenges remain
-
Atlanta, GA43 minutes agoDozens arrested during raid of drug