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Patient in Groundbreaking Heart Transplant Dies

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Patient in Groundbreaking Heart Transplant Dies

The primary individual to have his failing coronary heart changed with that of a genetically altered pig in a groundbreaking operation died Tuesday afternoon on the College of Maryland Medical Heart, two months after the transplant surgical procedure.

David Bennett Sr., who lived in Maryland, was 57. He had extreme coronary heart illness, and had agreed to obtain the experimental pig’s coronary heart after he was rejected from a number of ready lists to obtain a human coronary heart.

It was unclear whether or not his physique had rejected the international organ. “There was no apparent trigger recognized on the time of his dying,” a hospital spokeswoman stated.

Hospital officers stated they may not remark additional on the reason for dying, as a result of his physicians had but to conduct an intensive examination. They plan to publish the ends in a peer-reviewed medical journal.

Dr. Bartley Griffith, the surgeon who carried out the transplant, stated the hospital’s workers was “devastated” by the lack of Mr. Bennett.

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“He proved to be a courageous and noble affected person who fought all the best way to the top,” Dr. Griffith stated. “Mr. Bennett turned recognized by thousands and thousands of individuals all over the world for his braveness and steadfast will to dwell.”

The guts transplant was one in every of various pioneering procedures in latest months through which organs from genetically altered pigs have been used to exchange organs in people. The method, known as xenotransplantation, gives new hope for tens of hundreds of sufferers with ailing kidneys, hearts and different organs, as there may be an acute scarcity of donated organs.

Mr. Bennett’s transplant was initially deemed profitable. It’s nonetheless thought of a major step ahead, as a result of the pig’s coronary heart was not instantly rejected and continued to operate for properly over a month, passing a crucial milestone for transplant sufferers.

Some 41,354 People obtained a transplanted organ final yr, greater than half of them kidneys, in response to the United Community for Organ Sharing, a nonprofit that coordinates the nation’s organ procurement efforts.

Credit score…David Bennett, by way of Related Press

However there’s a dire scarcity of organs, and a dozen or extra individuals on ready lists die every day. About 3,800 People obtained human donor hearts final yr as replacements, greater than ever earlier than, however demand stays excessive.

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Scientists have been making an attempt to supply pigs whose organs wouldn’t be rejected by the human physique, a analysis effort that has picked up steam over the previous decade due to new gene modifying and cloning applied sciences.

New York surgeons introduced in October that they’d efficiently hooked up a kidney grown in a genetically altered pig to a brain-dead human affected person, discovering that the organ labored usually and produced urine for 54 hours.

In January, surgeons on the College of Alabama at Birmingham reported that they’d for the primary time efficiently transplanted kidneys from a genetically modified pig into the stomach of a 57-year-old brain-dead man. The kidneys functioned and produced urine for 3 days.

U.A.B. surgeons stated they hoped to launch a small scientific trial with dwell human sufferers by the top of the yr.

Shortly after Mr. Bennett’s coronary heart surgical procedure in January, The Washington Put up reported that he had a legal report stemming from an assault 34 years in the past, through which he repeatedly stabbed a younger man in a match of jealousy, leaving him paralyzed.

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The sufferer, Edward Shumaker, spent 20 years in a wheelchair, paralyzed from the waist down, and suffered quite a few medical issues together with a stroke that left him cognitively impaired earlier than he died in 2007 at age 40, in response to his sister, Leslie Shumaker Downey, of Frederick, Md.

Mr. Bennett’s son, David Bennett Jr., who was a toddler on the time of the stabbing, has stated that he doesn’t wish to focus on his father’s previous, and emphasised that his father was contributing to medical science by present process the experimental transplant and hoped to “probably save affected person lives sooner or later.”

The guts given to Mr. Bennett got here from a genetically altered pig supplied by Revivicor, a regenerative medication firm based mostly in Blacksburg, Va.

The pig carried 10 genetic modifications. 4 genes have been knocked out, or inactivated, together with one which encodes a molecule that causes an aggressive human rejection response.

One other gene was additionally inactivated to stop the pig’s coronary heart from persevering with to develop after it was implanted. As well as, six human genes have been inserted into the genome of the donor pig — modifications designed to make the pig’s organs extra tolerable to the human immune system.

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On New 12 months’s Eve, the Meals and Drug Administration granted an emergency authorization for the experimental surgical procedure, which was performed every week later.

The transplanted coronary heart carried out properly initially, and there have been no indicators of rejection for a number of weeks. Mr. Bennett frolicked along with his household, did bodily remedy and watched the Tremendous Bowl, hospital officers stated.

However he was not discharged, and several other days in the past his situation began to deteriorate, hospital officers stated.

His son issued an announcement thanking the hospital and workers for his or her exhaustive efforts on behalf of his father.

“We hope this story might be the start of hope and never the top,” Mr. Bennett stated. “We additionally hope that what was realized from his surgical procedure will profit future sufferers and hopefully sooner or later, finish the organ scarcity that prices so many lives every year.”

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.

The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.

The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.

Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.

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The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.

After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.

As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.

Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.

The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.

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Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.

Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.

The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.

Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.

While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.

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Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.

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Political stress: Can you stay engaged without sacrificing your mental health?

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Political stress: Can you stay engaged without sacrificing your mental health?

It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.

“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”

Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.

Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.

The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.

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That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.

In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.

“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”

Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).

The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.

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For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.

Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.

“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.

Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.

There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.

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“Politics is many forms of stress all rolled into one,” Ford said.

Weinschenk observed this firsthand the day after the election.

“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”

That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.

Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.

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“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”

Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.

“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”

On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”

“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.

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Genessa Krasnow has been seeing a lot of that since the election.

The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.

“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.

“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”

That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.

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“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.

Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.

“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”

Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.

“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.

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The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”

“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

President-elect Donald Trump joined Elon Musk in Texas and watched the launch from a nearby location on Tuesday. While the Starship’s giant booster stage was unable to repeat a “chopsticks” landing, the vehicle’s upper stage successfully splashed down in the Indian Ocean.

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