Science
Omicron is considered a milder coronavirus, but scientists aren’t so sure
For greater than two years, Cathy Baron and Sara Alicia Costa managed to duck the coronavirus. However regardless of their being absolutely vaccinated and boosted, the Omicron variant lastly caught them.
Baron is an actress and dance teacher who lives in Santa Monica. Costa is an architect in Austin, Texas. Each are 40 and wholesome. However the two associates noticed two very totally different sides of the variant they anticipated to be gentler on its victims than earlier strains.
For Costa, the Omicron variant lived as much as its fame for mildness, inflicting complications and “one thing like a crummy chilly” for a few days. She was visiting Baron and browsing in Santa Monica every week after testing optimistic.
Baron’s sickness was deeply chastening. She was flattened for a number of days with a excessive fever and debilitating muscle aches and was too exhausted to show her pole dancing class for 3 weeks. Two months later, she’s nonetheless dealing with fatigue, mind fog and episodic coughing matches. She hopes by no means to repeat the expertise.
Baron and Costa are what scientists would dismiss as an “n of two.” If their expertise had been a examine, the pattern dimension can be far too small to attract any conclusions, particularly one as vital as whether or not the Omicron variant actually is much less virulent than the SARS-CoV-2 variants that got here earlier than it.
And but, their contrasting experiences are as telling as lots of the analysis research carried out so far which have tried to find out how harmful Omicron actually is.
“It’s a wonderful query,” stated Dr. Stanley Perlman, a College of Iowa virologist and a number one skilled on coronaviruses. Many researchers suppose they know the reply, and “I believe it’s true” that the Omicron variant is inflicting milder sicknesses, he stated. However the true image is “not clear,” he cautioned.
Omicron arrived in the US at a time when 60% of People had the safety of COVID-19 vaccines and roughly a 3rd of People (together with some who’d been vaccinated) had a previous an infection. Not solely was there a excessive degree of inhabitants immunity, those that did turn into in poor health had entry to therapies that weren’t obtainable to folks sickened by the preliminary pressure from Wuhan, China, or the Alpha and Delta variants that adopted.
Maybe these are the the explanation why these contaminated with Omicron have tended to expertise milder sicknesses.
“It’s extensively stated that Omicron is inherently much less pathogenic, however there is no such thing as a actual proof for that,” stated Dr. Christopher Chiu, a COVID-19 researcher at Imperial School London.
“Comparisons with Delta are like apples and oranges,” he stated. “Delta was circulating at a time when many had been nonetheless not vaccinated or beforehand contaminated. In distinction, Omicron is essentially inflicting breakthrough infections in individuals who have already got partial safety from immunity conferred by vaccines or an infection.”
Since its earliest look in November, researchers have seen that in contrast with earlier variants, Omicron was much less more likely to ship contaminated folks to the hospital or to their graves.
First in South Africa and later in communities throughout America, the brand new variant bucked expectations spawned by earlier surges. Within the two to 3 weeks after Omicron instances spiked, hospitalizations and deaths rose as properly — however extra slowly, they usually’d topped out at decrease ranges.
Nonetheless, as People have realized from arduous expertise, the Omicron variant is a extremely succesful killer. Simply over 200,000 of the nation’s COVID-19 deaths are doubtless attributable to some model of the Omicron variant, which arrived right here round Thanksgiving and have become dominant in January.
And don’t neglect, Perlman added: It’s nonetheless killing some 400 folks a day in the US.
How a lot of Omicron’s supposed mildness ought to be credited to the protecting impact of vaccines shouldn’t be actually recognized.
Throughout June, the Facilities for Illness Management and Prevention concluded that COVID-associated hospitalizations amongst unvaccinated adults had been 4.6 occasions increased than they had been amongst vaccinated folks. However the image is muddier than such knowledge would counsel.
People’ immune profiles run the gamut, making it arduous to fit folks into neat classes and evaluate how they fared when contaminated by totally different variants. Those that’ve been vaccinated are experiencing varied levels of waning immunity, even when they’ve been boosted. The identical goes for individuals who’ve recovered from infections. The readiness of their immune techniques is determined by how way back that they had the an infection, what variant contaminated them, their vaccination standing, and elements like age and the medicines they take.
With so many variables to contemplate, it’s arduous for researchers to attract a clear comparability between Omicron and its predecessors. However they’ve tried.
In a single examine printed in Nature, scientists confirmed that Omicron was drawn to a variety of human tissues. When noticed in petri dishes, the variant established itself in cells that mimicked the higher airways of the respiratory system, although with much less gusto than the Delta variant. As well as, Omicron was far much less adept at infecting decrease airway cells, together with lung tissue, than both Delta or the unique SARS-CoV-2 pressure that left Wuhan.
And in research that contaminated animals similar to hamsters and genetically engineered mice, the Omicron variant prompted much less weight reduction (a proxy of extreme illness) and touched off much less irritation within the lungs than both Delta or the unique pressure.
Including to the uncertainty is the truth that coronavirus testing was present process sweeping modifications simply because the Omicron variant took maintain. As at-home testing ramped up and fewer new infections had been reported to public well being businesses, the connection between instances on the one hand and hospitalizations and deaths on the opposite — a beforehand reliable measure of a variant’s potential to sicken — turned much less dependable.
The Omicron variant’s astonishing infectiousness and propensity to spin off new subvariants complicate the image much more. In a current assembly convened by the Meals and Drug Administration, even specialists from the company shrugged when requested to check the subvariants.
Collectively, these Omicron subvariants muscled Delta apart so shortly that medical doctors and researchers didn’t have time to gather teams of comparable sufferers, genetically sequence the viruses that contaminated them, and evaluate how their sicknesses proceeded.
That’s the form of examine which may make clear the divergent experiences of Cathy Baron and Sara Alicia Costa. They’re a seemingly well-matched pair of wholesome 40-year-old ladies, but Omicron attacked one among them like a lion and handled the opposite like a lamb. With the experiences of a whole bunch or 1000’s of individuals thrown in, such analysis would possibly reveal elements that nudge an Omicron an infection in a single route or the opposite.
There’s a extra direct strategy to find out how Omicron compares to earlier variants in its potential to sicken and kill. Researchers may intentionally infect volunteers with totally different variations of the coronavirus and observe their physiological responses to an infection over the course of an sickness.
Chiu and his colleagues at Imperial School London have simply such an enterprise in thoughts. They’re planning “human problem” research involving the Delta and Omicron variants to reflect one already carried out with the unique model of the virus.
The ensuing knowledge may yield a clearer image of precisely how Omicron behaves in wholesome people, and the way a previous an infection or totally different ranges of vaccination have an effect on a person’s sickness.
Chiu stated a brand new examine would search to enroll individuals who gained immunity by vaccination, a previous an infection, or a mix of each. That will give them extra perception into whether or not so-called hybrid immunity is a crucial bulwark in opposition to changing into sick within the Omicron period.
If analysis confirms that the Omicron variant is certainly milder than its predecessors, and that getting it confers some safety from future sickness, some could conclude it’s time to let the virus unfold.
Baron would take some convincing of that.
“When folks say, ‘let’s simply let it rip’ and permit ourselves to get contaminated over and over — that’s scary to me,” she stated. “I don’t wish to simply let it rip. I don’t wish to get it once more.”
Science
2024 was the hottest year on record, NASA and NOAA confirm
Amid a week of horrifying wildfires in Los Angeles, government agencies in the U.S. and around the world confirmed Friday that 2024 was the planet’s hottest year since recordkeeping began in 1880.
It’s the 11th consecutive year in which a new heat record has been set, NASA Administrator Bill Nelson said.
“Between record-breaking temperatures and wildfires currently threatening our centers and workforce in California, it has never been more important to understand our changing planet,” Nelson said.
Firefighters on Friday were battling to protect NASA’s Jet Propulsion Laboratory in La Cañada Flintridge from the Eaton fire, which has burned 13,690 acres and roughly 5,000 buildings thus far.
Research has shown that global warming is contributing significantly to larger and more intense wildfires in the western U.S. in recent years, and to longer fire seasons.
The devastating fires in Southern California erupted after an abrupt shift from wet weather to extremely dry weather, a bout of climate “whiplash” that scientists say increased wildfire risks. Research has shown that these rapid wet-to-dry and dry-to-wet swings, which can worsen wildfires, flooding and other hazards, are growing more frequent and intense because of rising global temperatures.
Extreme weather events in 2024 included Hurricane Helene in the southeastern U.S., devastating floods in Valencia, Spain, and a deadly heat wave in Mexico so intense that monkeys dropped dead from the trees, noted Russell Vose, chief of the monitoring and assessment branch of NOAA’s National Centers for Environmental Information.
“We aren’t saying any of these things were caused by changes in Earth’s climate,” Vose said. But since warmer air holds more moisture, the higher temperatures “could have exacerbated some events this year.”
Last year’s data also notes a step toward a major climate threshold. Keeping the average global surface temperature from rising 1.5 degrees Celsius above pre-industrial levels has long been seen as necessary to avoid many of the most harrowing climate impacts.
NOAA pegged 2024’s global average surface temperature at 1.46 degrees C above its preindustrial baseline, and NASA’s measurements put the increase at 1.47 degrees C. In 2023, NASA said the temperature was 1.36 degrees C higher than the baseline.
Considering the margin of error in their measurements, “that puts the NOAA and NASA models comfortably within the possibility that the real number is 1.5 degrees,” said Gavin Schmidt, director of NASA’s Goddard Institute for Space Studies.
Calculations from other organizations passed the 1.5-degree mark more clearly.
Berkeley Earth and the European Union’s Copernicus Climate Change Service both said the planet warmed to slightly more than 1.6 degrees C above pre-industrial times in 2024. The United Nations’ World Meteorological Organization said the increase was 1.55 degrees C and the U.K. Met Office, the country’s weather service, measured an increase of 1.53 degrees C.
Although 2024 probably marks the first calendar year in which the average temperature exceeded the 1.5-degree threshold, it doesn’t mean Earth has passed the crucial target set in the Paris Agreement, Vose said.
That describes “a sustained, multi-decade increase of 1.5 degrees,” something that’s not expected to occur until the 2030s or 2040s, the scientists noted.
“For a long time, the global mean temperature changes were a bit of an esoteric thing — nobody lives in the global mean,” Schmidt said. “But the signal is now so large that you’re not only seeing it at the global scale … you’re seeing it at the local level.”
“This is now quite personal,” he said.
The oceans, which store 90% of the planet’s excess heat, also recorded their highest average temperature since records began in 1955.
The Arctic has seen the most warming, which is concerning because the region is home to vast quantities of ice that stands to melt and raise sea levels, Schmidt said.
Temperatures there are rising 3 to 3.5 times faster than the overall global average, he added.
The only place where average surface temperatures have cooled is the area immediately around Antarctica, and that’s probably due to meltwater from shrinking ice sheets, Schmidt said.
A year ago, NOAA predicted there was only a 1 in 3 chance that 2024 would break the record set in 2023, Vose said. Then every month from January to July set a new high, and August was a tie. As a result, Friday’s declaration came as little surprise.
The longer-term trends are no better.
“We anticipate future global warming as long as we are emitting greenhouse gases,” Schmidt said. “That’s something that brings us no joy to tell people, but unfortunately that’s the case.”
Times staff writer Ian James contributed to this report.
Science
There's a reason you can't stop doomscrolling through L.A.'s fire disaster
Even for those lucky enough to get out in time, or to live outside the evacuation zones, there has been no escape from the fires in the Los Angeles area this week.
There is hardly a vantage point in the city from which flames or plumes of smoke are not visible, nowhere the scent of burning memories can’t reach.
And on our screens — on seemingly every channel and social media feed and text thread and WhatsApp group — an endless carousel of images documents a level of fear, loss and grief that felt unimaginable here as recently as Tuesday morning.
Even in places of physical safety, many in Los Angeles are finding it difficult to look away from the worst of the destruction online.
“To me it’s more comfortable to doomscroll than to sit and wait,” said Clara Sterling, who evacuated from her home Wednesday. “I would rather know exactly where the fire is going and where it’s headed than not know anything at all.”
A writer and comedian, Sterling is — by her own admission — extremely online. But the nature of this week’s fires make it particularly hard to disengage from news coverage and social media, experts said.
For one, there’s a material difference between scrolling through images of a far-off crisis and staying informed about an active disaster unfolding in your neighborhood, said Casey Fiesler, an associate professor specializing in tech ethics at the University of Colorado Boulder.
“It’s weird to even think of it as ‘doomscrolling,’ ” she said. “When you’re in it, you’re also looking for important information that can be really hard to get.”
When you share an identity with the victims of a traumatic event, you’re more likely both to seek out media coverage of the experience and to feel more distressed by the media you see, said Roxane Cohen Silver, distinguished professor of psychological science at UC Irvine.
For Los Angeles residents, this week’s fires are affecting the people we identify with most intimately: family, friends and community members. They have consumed places and landmarks that feature prominently in fond memories and regular routines.
The ubiquitous images have also fueled painful memories for those who have lived through similar disasters — a group whose numbers have increased as wildfires have grown more frequent in California, Silver said.
This she knows personally: She evacuated from the Laguna Beach fires in 1993, and began a long-term study of that fire’s survivors days after returning to her home.
“Throughout California, throughout the West, throughout communities that have had wildfire experience, we are particularly primed and sensitized to that news,” she said. “And the more we immerse ourselves in that news, the more likely we are to experience distress.”
Absorption in these images of fire and ash can cause trauma of its own, said Jyoti Mishra, an associate professor of psychiatry at UC San Diego who studied the long-term psychological health of survivors of the 2018 Camp fire.
The team identified lingering symptoms of post-traumatic stress disorder, depression and anxiety both among survivors who personally experienced fire-related trauma such as injury or property loss, and — to a smaller but still significant degree — among those who indirectly experienced the trauma as witnesses.
“If you’re witnessing [trauma] in the media, happening on the streets that you’ve lived on and walked on, and you can really put yourself in that place, then it can definitely be impactful,” said Mishra, who’s also co-director of the UC Climate Change and Mental Health Council. “Psychology and neuroscience research has shown that images and videos that generate a sense of personal meaning can have deep emotional impacts.”
The emotional pull of the videos and images on social media make it hard to look away, even as many find the information there much harder to trust.
Like many others, Sterling spent a lot of time online during the early days of the COVID-19 pandemic. Back then, Sterling said, the social media environment felt decidedly different.
“This time around I think I feel less informed about what’s going on because there’s been such a big push toward not fact-checking and getting rid of verified accounts,” she said.
The rise of AI-generated images and photos has added another troubling kink, as Sterling highlighted in a video posted to TikTok early Thursday.
“The Hollywood sign was not on fire last night. Any video or photos that you saw of the Hollywood sign on fire were fake. They were AI generated,” she said, posting from a hotel in San Diego after evacuating.
Hunter Ditch, a producer and voice actor in Lake Balboa, raised similar concerns about the lack of accurate information. Some social media content she’s encountered seemed “very polarizing” or political, and some exaggerated the scope of the disaster or featured complete fabrications, such as that flaming Hollywood sign.
The spread of false information has added another layer of stress, she said. This week, she started turning to other types of app — like the disaster mapping app, Watch Duty — to track the spreading fires and changing evacuation zones.
But that made her wonder: “If I have to check a whole other app for accurate information, then what am I even doing on social media at all?”
Science
Pink Fire Retardant, a Dramatic Wildfire Weapon, Poses Its Own Dangers
From above the raging flames, these planes can unleash immense tankfuls of bright pink fire retardant in just 20 seconds. They have long been considered vital in the battle against wildfires.
But emerging research has shown that the millions of gallons of retardant sprayed on the landscape to tame wildfires each year come with a toxic burden, because they contain heavy metals and other chemicals that are harmful to human health and the environment.
The toxicity presents a stark dilemma. These tankers and their cargo are a powerful tool for taming deadly blazes. Yet as wildfires intensify and become more frequent in an era of climate change, firefighters are using them more often, and in the process releasing more harmful chemicals into the environment.
Some environmental groups have questioned the retardants’ effectiveness and potential for harm. The efficiency of fire retardant has been hard to measure, because it’s one of a barrage of firefighting tactics deployed in a major fire. After the flames are doused, it’s difficult to assign credit.
The frequency and severity of wildfires has grown in recent years, particularly in the western United States. Scientists have also found that fires across the region have become faster moving in recent decades.
There are also the longer-term health effects of exposure to wildfire smoke, which can penetrate the lungs and heart, causing disease. A recent global survey of the health effects of air pollution caused by wildfires found that in the United States, exposure to wildfire smoke had increased by 77 percent since 2002. Globally, wildfire smoke has been estimated to be responsible for up to 675,000 premature deaths per year.
Fire retardants add to those health and environmental burdens because they present “a really, really thorny trade-off,” said Daniel McCurry, an assistant professor of civil and environmental engineering at the University of Southern California, who led the recent research on their heavy-metal content.
The United States Forest Service said on Thursday that nine large retardant-spraying planes, as well as 20 water-dropping helicopters, were being deployed to fight the Southern California fires, which have displaced tens of thousands of people. Several “water scooper” amphibious planes, capable of skimming the surface of the sea or other body of water to fill their tanks, are also being used.
Two large DC-10 aircraft, dubbed “Very Large Airtankers” and capable of delivering up to 9,400 gallons of retardant, were also set to join the fleet imminently, said Stanton Florea, a spokesman for the National Interagency Fire Center in Boise, Idaho, which coordinates national wildland firefighting efforts across the West.
Sprayed ahead of the fire, the retardants coat vegetation and prevent oxygen from allowing it to burn, Mr. Florea said. (Red dye is added so firefighters can see the retardant against the landscape.) And the retardant, typically made of salts like ammonium polyphosphate, “lasts longer. It doesn’t evaporate, like dropping water,” he said.
The new research from Dr. McCurry and his colleagues found, however, that at least four different types of heavy metals in a common type of retardant used by firefighters exceeded California’s requirements for hazardous waste.
Federal data shows that more than 440 million gallons of retardant were applied to federal, state, and private land between 2009 and 2021. Using that figure, the researchers estimated that between 2009 and 2021, more than 400 tons of heavy metals were released into the environment from fire suppression, a third of that in Southern California.
Both the federal government and the retardant’s manufacturer, Perimeter Solutions, have disputed that analysis, saying the researchers had evaluated a different version of the retardant. Dan Green, a spokesman for Perimeter, said retardants used for aerial firefighting had passed “extensive testing to confirm they meet strict standards for aquatic and mammalian safety.”
Still, the findings help explain why concentrations of heavy metals tend to surge in rivers and streams after wildfires, sometimes by hundreds of times. And as scrutiny of fire suppressants has grown, the Forestry Service has set buffer zones surrounding lakes and rivers, though its own data shows retardant still inadvertently drifts into those waters.
In 2022, the environmental nonprofit Forest Service Employees for Environmental Ethics sued the government in federal court in Montana, demanding that the Forest Service obtain a permit under the Clean Water Act to cover accidental spraying into waterways.
The judge ruled that the agency did indeed need to obtain a permit. But it allowed retardant use to continue to protect lives and property.
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