Science
Microplastics may be new risk factor for cardiovascular disease, researchers say
Add one more likely culprit to the long list of known cardiovascular risk factors including red meat, butter, smoking and stress: microplastics.
In a study released Wednesday in the New England Journal of Medicine, an international team of physicians and researchers showed that surgical patients who had a build-up of micro and nanoplastics in their arterial plaque had a 2.1 times greater risk of nonfatal heart attack, nonfatal stroke or death from any cause in the three years post surgery than those who did not.
It’s the first study to show these ubiquitous and pernicious fossil fuel-based particles are having a direct effect on human health, said study co-author, Antonio Ceriello, head of the diabetes department at IRCCS MultiMedica, a research hospital in Milan.
And it should serve as a caution to all people, governments and corporations that plastic is not just a nuisance and blight in the environment, but is also harming human health, he said.
As government officials, negotiators, environmental activists and corporate representatives get ready to gather next month in Ottawa to discuss a global ban on plastic pollution, many are hoping this study will help tip the scales to establish real and tangible regulations.
“This is a beginning … whereby people are going to see plastic is not just harmful to whales or sea turtles. It’s not just litter on a beach in some faraway country. It’s in them and it has the potential to cause harm. I think it’s going to change the narrative,” said Dr. Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College.
He compared the awareness of the plastic crisis to climate change — in which people understood it in an abstract, theoretical way until wildfires burned their homes, sustained heatwaves killed their crops and flooding destroyed their communities.
“To my knowledge, this is the first report to link microplastics with human disease,” said Landrigan, who was not involved in the study but wrote an accompanying essay urging the global community to deliver on a “mandatory global cap on plastic production.”
Matt Seaholm, president and chief executive of the Plastics Industry Assn., suggested more research needs to be done.
“We encourage lawmakers to evaluate where those particles come from before using any type of microplastics or nanoplastics arguments for the justification or passage of any laws, because every study has shown that they are not coming from packaging or single-use items,” he said.
Studies have shown that the two biggest contributors of microplastics in the environment are car tires and synthetic clothing. However, as the plastic industry expands and the number of single-use plastic items grow, so, too does their contribution to environmental contamination and pollution. Around 151 million tons of single-use plastics were produced
from fossil fuels in 2021. That number is expected to rise another 19 million tons by 2027.
The research on arterial plaque was conducted by a team of 40 scientists — including surgeons, engineers, statisticians and pathologists — from more than a dozen institutions, including Harvard Medical School, Brigham and Women’s Hospital in Boston and Case Western Reserve School of Medicine in Cleveland.
The 257 patients who completed the study all had asymptomatic extracranial high-grade internal carotid artery stenosis — in other words, their carotid arteries were blocked with plaque. The patients underwent carotid endarterectomies, a procedure in which the artery is opened and the plaque is cleaned out. Patients who’d had previous heart failure, valvular defects, cancer or other causes of hypertension were disqualified.
The researchers then examined the plaque and found polyethylene micro- and nano- particles in 150 of the patients. Thirty patients had polyvinyl chloride particles in their plaque. Images from electron microscopy showed visible, jagged-edged “foreign bodies” along with the biological plaque in these patients.
Polythylene, or PET, is the plastic used to make soda and water bottles. Polyvinyl chloride, or PVC, is the plastic used in water pipes, packaging, medical devices, toothbrushes, children’s toys and window frames, to name a few.
The two patient populations were roughly the same in terms of age, sex, weight, smoking status, geographical location, blood pressure and heart rate.
The one glaring difference, the authors noted, was the two groups’ susceptibility to heart disease in the months following the surgery — an indication that the presence of microplastics may have played a role. Indeed, indicators of inflammation were higher in the plastic-exposed group. Nonfatal heart attack, nonfatal stroke, or death from any cause occurred in eight of the 107 patients who did not have microplastics in their plaque and 30 of the 150 patients with microplastics.
The authors stressed they could only show correlation, not causality. Additional research would be necessary to establish a clear connection.
Study co-author Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service, said it was equally possible that chemicals piggy-backing on the particles — such as bisphenol A, phthalates and/or other plasticizers and additives — could be the culprits. The paper also notes that lab contamination and patient behaviors that are unknown to the researchers could also influence their results.
“I can’t tell you it’s the microplastics and I can’t tell you it’s the chemicals. I couldn’t tell you because no study has measured both and they both coexist,” he said. “The fact is that plastics are horrible for human health and costly.”
He noted a recent study he authored that showed the disease burden of these chemicals costs the U.S. healthcare system roughly $250 billion a year.
Ceriello and his co-authors noted scores of animal studies that showed harmful effects of microplastics. He also said the authors were still unclear as to how patients were being exposed, whether through inhalation or ingestion.
Recent studies have found micro- and nanoplastics in water bottled in plastic, as well as in dust.
“This is very solid and should be taken very seriously at the highest level of government,” said Judith Enck, the director of Beyond Plastics and a former regional director at the U.S. Environmental Protection Agency. “This tracks with other studies that have found microplastics in various organs, human blood, placenta and breast milk so this is not all that surprising, but still stunning.”
Plastic has been found everywhere scientists have looked: From the deepest ocean trenches to the highest alpine peaks. Petroleum-based plastics do not biodegrade. Over time, they break down into smaller and smaller pieces — known as microplastics, microfibers and nanoplastics — and have been found in household dust, drinking water and human tissue and blood.
“Cardiologists need to inform their patients to avoid plastic packaging — which is very hard to do,” Enck said.
Tracey Woodruff, director of UC San Francisco’s Program on Reproductive Health and the Environment in the Department of Obstetrics, Gynecology and Reproductive Sciences, said physicians and clinicians need to begin talking to their patients about the harms of plastic. She authored an essay that looked at the harmful effects of endocrine disruptors in the same edition as the heart study.
She said advice from doctors to eat organic, unprocessed foods already reduces exposures to plastics. But more is needed, especially in the medical fields of reproduction, obstetrics and pediatrics, she said, where the evidence of harm from plastic chemicals and endocrine disruptors has been well established.
The mounting evidence, she said, is getting “hard to ignore.”
Science
July Fourth fireworks may bring ‘hazardous’ air quality to Southern California. What you need to know
L.A.’s love of fireworks makes for a colorful Fourth of July, with dozens of official celebrations and countless illicit explosions expected for the holiday.
But as each sparkler, Roman candle, palm and peony dissipates, it leaves behind a cloud of noxious gases, soot and finely ground toxic metals — some of which ends up in the lungs of revelers and passersby below.
Hazardous levels of air pollution are expected across central and southern Los Angeles County, northern Orange County, and Riverside and San Bernardino counties from 5 p.m. Saturday evening through 3 p.m. Sunday, according to the South Coast Air Quality Management District. Unhealthy air quality is also expected in northern Los Angeles County and southern Orange County.
Pollution levels are expected to build from dusk onward Saturday, as light winds and increased firework activity lead to an increase in smoke, a South Coast AQMD advisory said. Soot and particulates will likely linger through Sunday afternoon before being dispersed by the wind.
Firework-related pollution can trigger coughs, breathing problems, asthma flares and heart attacks, according to Los Angeles County Public Health, and anyone experiencing severe or worsening cardiovascular symptoms like chest pain or difficulty breathing should seek medical attention immediately.
Pyrotechnics set off at home are even more likely to trigger cardiovascular problems, the American Lung Assn. says, as the burst of pollutants takes place closer to the ground.
July 4 and 5 are traditionally two of the worst days of the year for the region’s air quality, according to South Coast AQMD. This year’s celebration comes on the heels of a late June warehouse fire in Boyle Heights that released extraordinary amounts of soot and smoke across the county, on par with pollution generated by the previous year’s wildfires.
To limit negative health effects, the L.A. County public health department recommends avoiding strenuous physical activity and keeping doors and windows closed. As whole house fans and swamp coolers can suck additional pollutants inside, the department recommends using air purifiers or air conditioners as alternatives when possible.
Science
Contributor: Alcohol should be stigmatized like smoking
Few substances are as deeply woven into everyday life as alcohol. It is a fixture at holiday celebrations, work-related social gatherings, sporting events, airports, and brunch or dinner tables. All demonstrate how deeply alcohol has become embedded in social customs and cultural traditions.
Yet alcohol contributes to millions of deaths globally each year and is linked to cancer, liver disease, unintentional accidents, violence and, importantly, dependence and addiction. Despite this, the disconnect between alcohol’s cultural role and its serious health burden is striking. An estimated 2.3 billion people worldwide consume alcohol.
As a physician working in addiction medicine, I regularly care for patients whose alcohol use affects nearly every organ system. It is often not until these patients end up admitted to the hospital that they learn the effects of alcohol on various parts of their body besides their liver.
Newer evidence challenges assumptions about what was long considered “safe drinking.” Even moderate drinking carries risk and is not as harmless as people, including experts, once thought.
Many people associate alcohol risk primarily with addiction or dangerous behaviors such as driving while intoxicated. However, its effects extend far beyond this, into nearly every aspect of a person’s well-being.
While alcohol may transiently improve mood and ease social anxiety, long-term alcohol use can lead to a worsening of mood, cognition and sleep, which can further compound use.
A 2021 literature review found that consuming approximately two standard drinks roughly doubles the odds of sustaining injuries — with or without a vehicle involved. The review also found that heavy episodic (binge) drinking can increase the risk of injury by 50-fold, depending on the amount of alcohol consumed and the type of injury. While alcohol’s effects on the liver are well known, it can also lead to gastrointestinal complications and heart disease
The World Health Organization estimates that 2.6 million deaths each year are attributable to alcohol, accounting for nearly 1 in every 20 deaths worldwide.
While many people recognize the risks of alcohol addiction, people are generally much less aware of the links between alcohol use and cancer risk.
The World Health Organization classifies alcohol as a Group 1 carcinogen — the same category as tobacco and asbestos. In 2025, the U.S. surgeon general emphasized that alcohol increases the risk of at least seven cancers, including cancers of the breast, colorectal, liver, oral, esophagus and larynx. An advisory called for updated warning labels.
Yet fewer than half of Americans recognize alcohol as a risk factor for cancer, particularly for cancers such as breast cancer that are not commonly associated with alcohol use.
Throughout the 1990s and early 2000s, observational studies suggested that moderate alcohol consumption might offer cardiovascular benefits. Over the past decade, however, higher-quality studies have challenged these findings, suggesting that much of the apparent benefit may have reflected differences in the health and lifestyles of moderate drinkers rather than a protective effect of alcohol itself.
Current evidence increasingly suggests that even low levels of alcohol may increase cancer risk.
Federal guidelines acknowledge that adults should “consume less alcohol for better overall health.” However, the most recent version of the “Dietary Guidelines for Americans,” updated in January, removed the previous recommendation to limit intake to no more than one drink per day for women and two for men. It also omitted explicit discussion of alcohol’s links to cancer.
These changes have drawn criticism from public health experts, who argue that the revised language plays down the growing evidence of alcohol-related harms and provides less specific guidance to consumers. The current administrator of the Centers for Medicare & Medicaid Services characterized alcohol as a “social lubricant” that brings people together, rather than emphasizing its well-established health risks.
This may be true physiologically, at least temporarily, but obscures the fact that relying on it as a social lubricant can lead to chemical and psychological dependency. In my view, statements to that effect are shortsighted, prioritizing short-term social effects over more insidious and long-term issues, including addiction.
While many dangerous mind-altering substances are hidden from public perception, alcohol is often placed at the center of it – a trend that shows no sign of changing imminently.
Further, large companies often profit from ads that appeal to young people.
Looking back at the history of tobacco smoking provides some helpful insights. In 1965, 42.4% of the U.S. population smoked. By 2022, that figure had dropped to 11.6%.
This steep decline did not happen because of a single intervention, but through decades of accumulating scientific evidence, public education campaigns, warning labels, restrictions on advertising, smoke-free policies, higher tobacco taxes and shifts in social norms. Together, these efforts transformed smoking from a widely accepted social behavior into one broadly recognized as a major health risk and correspondingly, less socially accepted.
Although alcohol consumption has modestly declined in recent years, it remains deeply embedded in social life in ways cigarette smoking no longer is.
People often assume that if a substance is legal, common and widely socially accepted — even encouraged — it must also be safe. But public health history suggests those assumptions can and should change.
Emma Fenske is an addiction medicine fellow and internal medicine physician at Oregon Health & Science University. This article was produced in partnership with the Conversation.
Science
Boyle Heights blaze choked L.A. with astronomical soot pollution
The air near the Lineage refrigerated warehouse fire in Boyle Heights carried astronomically high levels of smoke and soot, surpassing some of the worst air pollution during the Los Angeles County fires in January 2025, according to preliminary data from air officials.
The fire spewed thick black smoke for days. From downtown Los Angeles to the San Gabriel Valley, tens of thousands were enveloped in unhealthful levels of smoke, even as some local officials told residents that the air posed no danger.
As the days wore on, worst off were communities nearest the blaze. On June 19, three days after the facility ignited, a temporary air quality monitoring station at Eastman Elementary in unincorporated East Los Angeles measured an extremely hazardous 755 micrograms per cubic meter of fine particles for more than an hour, according to the South Coast Air Quality Management District.
For comparison, a Caltech air monitor in Pasadena recorded about 650 micrograms per cubic meter during the Eaton fire.
These high levels of fine particles, known as PM 2.5, probably resulted in the surge of residents into local emergency rooms during the fire, according to local health officials. But even now with the smoke gone, people still have not been told what chemicals they were breathing in during the weeklong ordeal.
Michael Jerrett, an environmental health professor at the UCLA Fielding School of Public Health, said his concern is the composition of materials emitted when the building burned.
“These contain many particularly toxic components,” Jerrett said, “and we know little about how these mixtures affect health.”
There is no completely safe level of fine particulate pollution, he noted, meaning higher concentrations are always worse.
During the 2025 L.A. County fires, local air officials announced that several monitors downwind had detected elevated levels of brain-damaging lead and cancer-causing arsenic from toxic paint and construction materials used in older homes.
The Lineage warehouse, built in 2018, is likely to contain different materials of concern. Thick insulation foam required for a massive refrigeration operation, solar panels and refrigerants were burned, leaving many residents on edge.
Even though three public agencies conducted air monitoring, the picture is still murky.
“[Public officials] are speaking with a lot of confidence but not a lot of information,” said mark! Lopez, a community organizer with East Yard Communities for Environmental Justice. “We’ve gotten in the room with folks to discuss where the gaps lie and where assumptions are being made. And I think they are realizing these agencies supposed to protect our air and our health aren’t as reliable as they thought they were.”
In response to the Boyle Heights fire, the South Coast air district deployed a mobile monitoring vehicle to screen for toxic substances in the community near the fire, according to Nahal Mogharabi, a spokesperson for the air district. It found increased levels of bromine, a chemical commonly found in fire retardant, and chlorine, often released from burning plastic. Both were below short-term health-based exposure thresholds.
Toxic metals, including lead and arsenic, were not elevated, according to air district data.
“That was the reassuring piece, that they were not picking up any of the metals,” said Dr. Nichole Quick, chief medical advisor for the Los Angeles County Department of Public Health. “But … that smoke is unhealthy. “You don’t want to be breathing it, regardless.”
The U.S. Environmental Protection Agency set up air monitors around the perimeter of the facility to test for toxic air contaminants, has the results and has not made them public. Julia Giarmoleo, an EPA spokesperson, said the monitors did not detect elevated metals, but would not provide a copy of the data without a federal records request.
The Los Angeles Fire Department’s hazardous material team also tested for ammonia, which is used in refrigeration, and hydrogen fluoride, a toxic chemical that could be released by burning lithium-ion batteries and solar panels.
Fire officials previously said they measured low levels of hydrogen fluoride on the second day of the fire. But the department would not answer questions about its air monitoring. It also told a reporter to submit a public records request.
It remains unclear whether any agency has tested for hydrogen cyanide or isocyanates, highly toxic gases that could be released from burning chemical-laden insulating foam inside the building.
“The real issue is what monitoring has not been done to protect the fence-line community from the air toxics,” said Jane Williams, executive director of California Communities Against Toxics.
Without the EPA or LAFD data, what is known of the smoke’s toxicity rests on the air district’s mobile monitoring.
Jerrett, the UCLA researcher, said that is not ideal for understanding the kind of plume released by the Boyle Heights fire, which rapidly changed direction with the wind.
“This can in some instances lead to levels that look low, but they are resulting from a mismatch between the location of the vehicle and the plume,” he said.
The Boyle Heights blaze, similar to the Eaton and Palisades fires, has revealed the region’s air monitoring can’t always tell people what they’ve been exposed to in a disaster.
“We do need a better monitoring system in place,” he said.
Local officials are now shifting their focus to the rancid odors from millions of pounds of rotting food in the ruined wing of the warehouse. Decomposing food can release hydrogen sulfide, a toxic gas synonymous with landfills and garbage. Lineage hired contractors who are measuring this noxious gas and other pollution. Their data indicate they have not detected hydrogen sulfide.
As Lineage workers haul the rotting food to local landfills, they are using deodorizing mist and have discussed using shrink wrapping to suppress the stench and minimize issues for nearby homes.
At this point, the odors are believed to be an inconvenience rather than a public health threat, according to Quick, the county medical advisor. She said running air purifiers may help to reduce odors indoors.
“It’s very important for folks to understand that the odors themselves do not indicate any dangerous levels of toxins, mold, bacteria, and so forth,” Quick said. “But the odors are a public nuisance.”
The air district is still encouraging residents to report odors to its online complaint system or by calling (800) 288-7664.
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